iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094060

Ensembl Protein ID

ENSPSIP00000004298.1

UniProt Accession

K7F8D8; K7F8D8_PELSI

Genbank Protein ID

ENSPSIP00000004298

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGCU01197110

Gene Name

ITK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004038.1	ENSPSIT00000004321.1	ENSPSIP00000004298.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-10	40.5	175	228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v ++ydy aqn  eLtl++G+  + i  ++ +  W+   ++ +g +G +P+ +v++
   Q: 175  LVMAIYDYRAQNPQELTLQRGEEYYAI--DKSEDHWWLV-QDKNGHEGYVPSSYVVQ 228
           689************************..6666667755.5*************976 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MNNCVLLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKSKLAY FEHRHGKKRI LKGSIELSRI 60
KCVEIVKSDI TIPCNYKYPF QVLHDNYLLY VFAPDRESRQ RWVFTLKEET RNNNNLVPKY 120

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Nucleotide Sequence
(Fasta)

ATGAATAATT GTGTTCTCCT GGAAGAGCAG CTGATCAAAA AATCCCAGCA GAAGAGACGG 60
ACCTCTCCCT CTAACTTCAA AGTGCGCTTC TTCGTTTTAA CCAAATCCAA GCTGGCTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0007202--P:activation of phospholipase C activity
GO:0002250--P:adaptive immune response
GO:0032609--P:interferon-gamma production
GO:0032633--P:interleukin-4 production
GO:0035556--P:intracellular signal transduction
GO:0001865--P:NK T cell differentiation
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bdi-014122	Brachypodium distachyon	34.47	6.00e-23	102.00
IUUC-Gma-043143	Glycine max	31.34	1.00e-21	98.20
IUUC-Lpe-051166	Leersia perrieri	29.96	7.00e-24	105.00
IUUC-Oba-075471	Oryza barthii	31.18	3.00e-19	90.10
IUUC-Obr-076765	Oryza brachyantha	29.84	4.00e-23	103.00
IUUC-Ogl-077331	Oryza glaberrima	32.67	5.00e-24	106.00
IUUC-Oin-079172	Oryza indica	32.67	4.00e-24	106.00
IUUC-Olo-080286	Oryza longistaminata	32.67	4.00e-24	106.00
IUUC-Ome-081400	Oryza meridionalis	32.67	3.00e-24	106.00
IUUC-Oni-082734	Oryza nivara	32.67	5.00e-24	106.00
IUUC-Opu-083538	Oryza punctata	32.18	2.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	32.67	3.00e-24	106.00
IUUC-Osa-085779	Oryza sativa	32.67	4.00e-24	106.00
IUUC-Sit-109809	Setaria italica	28.79	2.00e-24	107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence