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Tag Content
UUCD2 ID IUUC-Cfa-020051
UUCD1 version UUC-CaF-00996
Ensembl Protein ID ENSCAFP00000012675.3
UniProt Accession F6UMQ8; F6UMQ8_CANLF
Genbank Protein ID ENSCAFP00000012675
Protein Name Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16
Genbank Nucleotide ID AAEX03016478
Gene Name USP16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000008633.3 ENSCAFT00000013702.3 ENSCAFP00000012675.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.30e-90 303.5 194 823
Active Site
Position(s) Description Evidence
203 Nucleophile ECO:0000256|HAMAP-Rule:MF_03062}
759 Proton acceptor ECO:0000256|HAMAP-Rule:MF_03062}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 273
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 274  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEQQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 362
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 363  STIMCDECRTVSLVHESFLDLSLPVLDDQNGKKSineknlkktmededkeseeekdndsymkersdipsgtskhlqkkakkqakkqakn 451
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  qrrqqkiqgkvlhlndictidhpednecevemslqgevdvksnhiseeeithkeycvnqkdlngqekmiesvidnqksteevdmdnvnm 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  dndlevlessptectrnlngayltegssgevdissgfrnlnlnaalqpdeinieilneshspgtkvyevvnedpetafctlanreafht 629
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 630  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanikgerkrvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 716
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 717  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKAraanshlsnlvlhgdipqdfemqsTKGQWFHISDTHVQA 805
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 806  VPTTKVLN---SQAYLLFYER 823
           ********...********98 PP
   
Organism Canis familiaris
Functional Description
(View)

Functional Description


     Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
 Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Protein Sequence
(Fasta)
MGKKRTKGKT VPIDDSSESL EPMCRHIRKG LEQGNLKRAL LNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRDSQEQH ALKHYMTPRS EPHCLVLSLD NWSVWCYLCD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020051|DUB,USP|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGTTATTT TGTGTCAGTA AGTAATCCAT AAAGTGCCAA CATGGGAAAG AAACGGACAA 60
AGGGAAAAAC TGTTCCAATT GATGATTCTT CTGAATCTTT AGGTATATTT CACCAATTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020051|DUB,USP|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000997 Aegilops tauschii 31.01 4.00e-29 124.00
IUUC-Aml-001931 Ailuropoda melanoleuca 97.09 0.00e+00 1486.00
IUUC-Atr-003015 Amborella trichopoda 32.45 4.00e-37 150.00
IUUC-Apl-004145 Anas platyrhynchos 61.48 0.00e+00 900.00
IUUC-Aca-004314 Anolis carolinensis 59.51 0.00e+00 892.00
IUUC-Aly-006422 Arabidopsis lyrata 29.91 4.00e-29 124.00
IUUC-Ath-006732 Arabidopsis thaliana 33.23 3.00e-33 137.00
IUUC-Afl-008729 Aspergillus flavus 31.15 3.00e-14 73.60
IUUC-Aor-009965 Aspergillus oryzae 31.15 1.00e-14 75.50
IUUC-Ame-011659 Astyanax mexicanus 49.54 3.00e-111 396.00
IUUC-Bta-013362 Bos taurus 89.47 0.00e+00 1430.00
IUUC-Bdi-014624 Brachypodium distachyon 30.56 5.00e-28 119.00
IUUC-Bol-015941 Brassica oleracea 30.27 7.00e-32 132.00
IUUC-Bra-016751 Brassica rapa 29.74 8.00e-30 126.00
IUUC-Cja-019177 Callithrix jacchus 90.33 0.00e+00 1468.00
IUUC-Cpo-021886 Cavia porcellus 82.29 0.00e+00 1311.00
IUUC-Csa-024103 Chlorocebus sabaeus 90.81 0.00e+00 1481.00
IUUC-Cho-024315 Choloepus hoffmanni 78.12 4.00e-131 461.00
IUUC-Cin-025775 Ciona intestinalis 49.65 5.00e-40 156.00
IUUC-Csv-026075 Ciona savignyi 50.95 2.00e-58 220.00
IUUC-Cme-027348 Cyanidioschyzon merolae 39.19 4.00e-20 93.20
IUUC-Dre-028388 Danio rerio 46.31 0.00e+00 653.00
IUUC-Dno-029409 Dasypus novemcinctus 88.98 0.00e+00 1421.00
IUUC-Dor-030443 Dipodomys ordii 78.76 0.00e+00 651.00
IUUC-Ete-032807 Echinops telfairi 83.73 0.00e+00 684.00
IUUC-Eca-033479 Equus caballus 91.16 0.00e+00 1484.00
IUUC-Eeu-034835 Erinaceus europaeus 84.56 0.00e+00 678.00
IUUC-Fca-036320 Felis catus 97.09 0.00e+00 1546.00
IUUC-Fal-037029 Ficedula albicollis 60.02 0.00e+00 851.00
IUUC-Gmo-039480 Gadus morhua 52.23 6.00e-114 405.00
IUUC-Gga-040527 Gallus gallus 63.21 0.00e+00 913.00
IUUC-Gac-042343 Gasterosteus aculeatus 50.80 9.00e-113 401.00
IUUC-Gma-044402 Glycine max 29.34 3.00e-33 137.00
IUUC-Ggo-045598 Gorilla gorilla 90.08 0.00e+00 1467.00
IUUC-Hsa-046598 Homo sapiens 89.96 0.00e+00 1459.00
IUUC-Hvu-047146 Hordeum vulgare 29.23 3.00e-29 124.00
IUUC-Itr-047951 Ictidomys tridecemlineatus 90.81 0.00e+00 1447.00
IUUC-Lch-050536 Latimeria chalumnae 56.31 4.00e-127 448.00
IUUC-Lpe-050703 Leersia perrieri 30.75 2.00e-29 124.00
IUUC-Loc-051814 Lepisosteus oculatus 57.25 3.00e-128 452.00
IUUC-Laf-053732 Loxodonta africana 87.35 0.00e+00 1422.00
IUUC-Mcc-054661 Macaca mulatta 91.05 0.00e+00 1484.00
IUUC-Meu-055967 Macropus eugenii 73.80 1.00e-157 550.00
IUUC-Mtr-057945 Medicago truncatula 31.63 1.00e-33 138.00
IUUC-Mga-059551 Meleagris gallopavo 62.59 0.00e+00 919.00
IUUC-Mmr-061747 Microcebus murinus 90.45 0.00e+00 1442.00
IUUC-Mdo-062220 Monodelphis domestica 69.17 0.00e+00 1053.00
IUUC-Mmu-063582 Mus musculus 81.91 0.00e+00 1256.00
IUUC-Mac-064941 Musa acuminata 32.94 1.00e-37 151.00
IUUC-Mpu-066339 Mustela putorius furo 96.61 0.00e+00 1538.00
IUUC-Mlu-067511 Myotis lucifugus 85.97 0.00e+00 1346.00
IUUC-Nle-069252 Nomascus leucogenys 90.93 0.00e+00 1485.00
IUUC-Opr-070969 Ochotona princeps 84.47 0.00e+00 1317.00
IUUC-Ont-071786 Oreochromis niloticus 50.82 7.00e-115 408.00
IUUC-Ocu-074704 Oryctolagus cuniculus 91.35 0.00e+00 1416.00
IUUC-Oba-075094 Oryza barthii 30.67 2.00e-30 128.00
IUUC-Obr-076743 Oryza brachyantha 31.68 2.00e-31 131.00
IUUC-Ogl-077739 Oryza glaberrima 30.67 2.00e-30 128.00
IUUC-Ogu-078851 Oryza glumaepatula 30.67 2.00e-30 128.00
IUUC-Oin-079402 Oryza indica 30.67 2.00e-30 128.00
IUUC-Olo-080431 Oryza longistaminata 30.67 2.00e-30 127.00
IUUC-Ome-081580 Oryza meridionalis 30.67 2.00e-30 127.00
IUUC-Oni-082644 Oryza nivara 30.67 2.00e-30 128.00
IUUC-Opu-083452 Oryza punctata 30.43 2.00e-30 128.00
IUUC-Oru-084546 Oryza rufipogon 30.67 2.00e-30 128.00
IUUC-Osa-085858 Oryza sativa 30.67 2.00e-30 128.00
IUUC-Ola-086795 Oryzias latipes 47.78 1.00e-111 397.00
IUUC-Oga-088713 Otolemur garnettii 90.57 0.00e+00 1444.00
IUUC-Oar-089887 Ovis aries 90.08 0.00e+00 1441.00
IUUC-Ptr-091670 Pan troglodytes 90.33 0.00e+00 1473.00
IUUC-Pan-092293 Papio anubis 91.05 0.00e+00 1484.00
IUUC-Psi-093101 Pelodiscus sinensis 65.12 0.00e+00 942.00
IUUC-Ppa-095622 Physcomitrella patens 30.11 2.00e-33 138.00
IUUC-Pfo-097202 Poecilia formosa 52.37 2.00e-115 409.00
IUUC-Pab-098773 Pongo abelii 92.40 0.00e+00 1150.00
IUUC-Pop-099136 Populus trichocarpa 30.39 1.00e-39 158.00
IUUC-Pca-101069 Procavia capensis 71.71 0.00e+00 879.00
IUUC-Ppe-101794 Prunus persica 30.77 2.00e-34 141.00
IUUC-Pva-103092 Pteropus vampyrus 88.80 0.00e+00 704.00
IUUC-Rno-105237 Rattus norvegicus 83.21 0.00e+00 1276.00
IUUC-Sha-106889 Sarcophilus harrisii 73.55 0.00e+00 1122.00
IUUC-Ssl-108648 Sclerotinia sclerotiorum 27.75 3.00e-11 63.90
IUUC-Sit-110283 Setaria italica 32.75 4.00e-30 127.00
IUUC-Sly-111487 Solanum lycopersicum 29.77 9.00e-39 155.00
IUUC-Stu-112820 Solanum tuberosum 29.50 2.00e-37 151.00
IUUC-Sar-113530 Sorex araneus 84.06 0.00e+00 1325.00
IUUC-Sbi-113785 Sorghum bicolor 40.00 1.00e-25 112.00
IUUC-Ssc-116091 Sus scrofa 91.46 0.00e+00 1423.00
IUUC-Tgu-117478 Taeniopygia guttata 60.24 0.00e+00 875.00
IUUC-Tsy-119042 Tarsius syrichta 76.15 0.00e+00 919.00
IUUC-Tni-120015 Tetraodon nigroviridis 45.66 2.00e-178 619.00
IUUC-Tca-121701 Theobroma cacao 28.83 2.00e-37 151.00
IUUC-Tae-125351 Triticum aestivum 31.38 3.00e-27 117.00
IUUC-Tur-126788 Triticum urartu 28.92 8.00e-27 115.00
IUUC-Tbe-127309 Tupaia belangeri 75.68 0.00e+00 1133.00
IUUC-Ttr-128271 Tursiops truncatus 92.62 0.00e+00 1464.00
IUUC-Vpa-130674 Vicugna pacos 89.70 0.00e+00 1345.00
IUUC-Xtr-131869 Xenopus tropicalis 51.81 0.00e+00 788.00
IUUC-Xma-134195 Xiphophorus maculatus 52.84 1.00e-115 410.00
IUUC-Zma-135157 Zea mays 31.37 6.00e-27 116.00
Created Date 25-Jun-2017

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