iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.20e-09	38.4	300	337

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 5    aleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +++++ke++P+++  viq++L a+tg+++ +++nLLeg+
   Q: 300  LAQRVKEVLPHVPLNVIQRDL-ARTGCVDLTITNLLEGA 337
           689******************.***************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Protein Sequence
(Fasta)

MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV 60
LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGATGGCG GCGACAGCGG CCCCACTTTC CTGAAGCGGC TGCGATGGAA CCTCCCCCAG 60
CTCCGGGGCC GGAGCGGCTC TTTGACTCGC ACCGGTAAGC GCTGCGGAGG GAAGAGACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

SMART

SM00546--CUE

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0043130--F:ubiquitin binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

rno:680423

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002330	Ailuropoda melanoleuca	93.10	2.00e-172	598.00
IUUC-Apl-003946	Anas platyrhynchos	55.87	2.00e-102	365.00
IUUC-Aca-004676	Anolis carolinensis	54.17	8.00e-27	112.00
IUUC-Ago-007976	Ashbya gossypii	36.36	3.40e-01	28.10
IUUC-Acl-008157	Aspergillus clavatus	28.40	2.50e-01	28.90
IUUC-Bta-012397	Bos taurus	91.46	0.00e+00	673.00
IUUC-Bdi-014890	Brachypodium distachyon	31.73	6.00e-05	42.40
IUUC-Cel-018644	Caenorhabditis elegans	33.90	3.00e-36	145.00
IUUC-Cja-018775	Callithrix jacchus	76.43	7.00e-169	587.00
IUUC-Cfa-020710	Canis familiaris	92.88	0.00e+00	639.00
IUUC-Cpo-022111	Cavia porcellus	92.93	0.00e+00	684.00
IUUC-Csa-023411	Chlorocebus sabaeus	92.20	0.00e+00	667.00
IUUC-Cin-025458	Ciona intestinalis	38.24	2.00e-13	67.40
IUUC-Dre-027938	Danio rerio	52.87	2.00e-110	392.00
IUUC-Dno-028873	Dasypus novemcinctus	91.46	0.00e+00	661.00
IUUC-Dor-030537	Dipodomys ordii	82.17	1.00e-177	615.00
IUUC-Ete-032422	Echinops telfairi	62.96	4.00e-122	431.00
IUUC-Eca-033757	Equus caballus	91.71	0.00e+00	665.00
IUUC-Eeu-034556	Erinaceus europaeus	73.62	2.00e-169	588.00
IUUC-Fca-035438	Felis catus	92.44	0.00e+00	672.00
IUUC-Fal-036911	Ficedula albicollis	53.85	4.00e-95	341.00
IUUC-Gmo-039147	Gadus morhua	50.49	4.00e-97	348.00
IUUC-Gga-041239	Gallus gallus	58.31	7.00e-112	397.00
IUUC-Gac-041814	Gasterosteus aculeatus	49.51	2.00e-99	355.00
IUUC-Ggo-044745	Gorilla gorilla	90.64	1.00e-139	489.00
IUUC-Hsa-046167	Homo sapiens	91.46	0.00e+00	663.00
IUUC-Itr-048661	Ictidomys tridecemlineatus	93.99	0.00e+00	635.00
IUUC-Lch-050576	Latimeria chalumnae	51.90	6.00e-99	354.00
IUUC-Lpe-051312	Leersia perrieri	31.07	8.00e-03	35.40
IUUC-Loc-052028	Lepisosteus oculatus	54.78	1.00e-107	383.00
IUUC-Laf-053886	Loxodonta africana	90.52	8.00e-180	623.00
IUUC-Mcc-055399	Macaca mulatta	87.07	1.00e-173	602.00
IUUC-Meu-056355	Macropus eugenii	63.64	7.00e-119	420.00
IUUC-Mga-060065	Meleagris gallopavo	53.82	3.00e-94	338.00
IUUC-Mmu-064080	Mus musculus	97.94	9.00e-166	576.00
IUUC-Mpu-066233	Mustela putorius furo	92.44	0.00e+00	670.00
IUUC-Mlu-067489	Myotis lucifugus	91.71	0.00e+00	666.00
IUUC-Nle-070040	Nomascus leucogenys	90.97	6.00e-141	493.00
IUUC-Ont-071616	Oreochromis niloticus	50.37	2.00e-99	355.00
IUUC-Ocu-074618	Oryctolagus cuniculus	92.02	0.00e+00	662.00
IUUC-Ogl-077799	Oryza glaberrima	32.38	3.00e-02	33.50
IUUC-Ogu-078481	Oryza glumaepatula	48.57	3.00e-04	40.00
IUUC-Ome-081941	Oryza meridionalis	48.57	3.00e-04	40.00
IUUC-Oni-082488	Oryza nivara	48.57	3.00e-04	40.40
IUUC-Ola-086583	Oryzias latipes	41.70	1.00e-81	296.00
IUUC-Oga-089100	Otolemur garnettii	91.46	0.00e+00	668.00
IUUC-Oar-089813	Ovis aries	91.22	0.00e+00	671.00
IUUC-Ptr-091436	Pan troglodytes	91.71	0.00e+00	663.00
IUUC-Pan-092755	Papio anubis	91.95	0.00e+00	667.00
IUUC-Psi-093736	Pelodiscus sinensis	70.43	5.00e-54	203.00
IUUC-Pma-094429	Petromyzon marinus	50.82	2.00e-89	322.00
IUUC-Pfo-097015	Poecilia formosa	47.94	8.00e-94	337.00
IUUC-Pab-098382	Pongo abelii	91.95	0.00e+00	666.00
IUUC-Pca-100900	Procavia capensis	84.58	2.00e-83	303.00
IUUC-Pva-103248	Pteropus vampyrus	71.46	7.00e-150	523.00
IUUC-Sha-107434	Sarcophilus harrisii	77.06	2.00e-103	368.00
IUUC-Stu-112774	Solanum tuberosum	28.04	1.20e-02	35.00
IUUC-Sar-113104	Sorex araneus	70.37	4.00e-96	344.00
IUUC-Ssc-116047	Sus scrofa	88.89	1.00e-165	575.00
IUUC-Tgu-117436	Taeniopygia guttata	56.49	4.00e-104	371.00
IUUC-Tru-118227	Takifugu rubripes	47.86	6.00e-95	340.00
IUUC-Tni-120873	Tetraodon nigroviridis	48.07	7.00e-96	343.00
IUUC-Ttr-128895	Tursiops truncatus	75.11	5.00e-169	587.00
IUUC-Xtr-131917	Xenopus tropicalis	56.00	4.00e-56	210.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence