iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106220

UUCD1 version

UUC-SaC-00053

Ensembl Protein ID

YLR368W

UniProt Accession

Q05930; D6VZ05; MDM30_YEAST

Genbank Protein ID

AAB67566.1; DAA09671.1

Protein Name

Mitochondrial distribution and morphology protein 30

Genbank Nucleotide ID

U19103; BK006945

Gene Name

MDM30; YLR368W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YLR368W	YLR368W	YLR368W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18353967; 15797387; 18775025

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	31.58	2.10e-02	38.90	IUUC-Hsa-047002

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.

Protein Sequence
(Fasta)

MTKRRNLFMV GSSFTIDHLP PEIWLCISKL VGTSDLHNLC LINRRLYLTI TSDEIWKRRC 60
YDRWINRESL DILTGNDYDS IPVSQWYSYY LRRAKWENKI FCLLWGLTEE TNPQHFREKY 120

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Nucleotide Sequence
(Fasta)

ATGACAAAGA GGAGAAACCT CTTTATGGTT GGTTCTTCCT TCACAATAGA TCATTTACCT 60
CCAGAAATAT GGCTTTGTAT TTCTAAGCTG GTCGGGACGT CTGACCTGCA TAACTTGTGT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

SMART

SM00256--FBOX

Gene Ontology

GO:0005739--C:mitochondrion
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001300--P:chronological cell aging
GO:0008053--P:mitochondrial fusion
GO:0007005--P:mitochondrion organization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051603--P:proteolysis involved in cellular protein catabolic process
GO:0010793--P:regulation of mRNA export from nucleus
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

sce:YLR368W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000068	Aegilops tauschii	24.11	1.30e+00	26.60
IUUC-Aml-001541	Ailuropoda melanoleuca	34.00	2.00e-03	35.40
IUUC-Aly-005981	Arabidopsis lyrata	30.95	3.20e-02	31.20
IUUC-Ath-007451	Arabidopsis thaliana	33.33	1.70e-02	32.30
IUUC-Ago-007845	Ashbya gossypii	22.04	1.00e-33	135.00
IUUC-Acl-008159	Aspergillus clavatus	35.90	1.80e-02	31.20
IUUC-Ang-009828	Aspergillus niger	36.36	1.90e-02	31.60
IUUC-Ame-011867	Astyanax mexicanus	34.92	2.00e-04	38.50
IUUC-Bta-013260	Bos taurus	31.03	2.00e-04	38.50
IUUC-Bol-015252	Brassica oleracea	29.41	3.10e-02	31.20
IUUC-Cel-018440	Caenorhabditis elegans	33.87	1.00e-03	34.70
IUUC-Cja-019627	Callithrix jacchus	31.58	2.00e-04	38.50
IUUC-Cfa-020598	Canis familiaris	31.03	2.00e-04	38.50
IUUC-Cpo-021355	Cavia porcellus	33.33	2.00e-04	38.10
IUUC-Cre-022694	Chlamydomonas reinhardtii	26.42	6.00e-03	30.80
IUUC-Csa-023967	Chlorocebus sabaeus	31.58	2.00e-04	38.50
IUUC-Cho-025049	Choloepus hoffmanni	28.57	1.10e-02	32.30
IUUC-Dor-030275	Dipodomys ordii	36.67	9.60e-02	29.30
IUUC-Ete-032638	Echinops telfairi	32.76	5.00e-05	40.40
IUUC-Eeu-034676	Erinaceus europaeus	33.93	1.00e-04	39.30
IUUC-Fca-035703	Felis catus	31.03	2.00e-04	38.50
IUUC-Ggr-039847	Gaeumannomyces graminis	41.03	9.10e-02	30.40
IUUC-Gma-043764	Glycine max	28.57	7.00e-03	33.90
IUUC-Ggo-044501	Gorilla gorilla	31.58	2.00e-04	38.50
IUUC-Hsa-047002	Homo sapiens	31.58	2.00e-04	38.50
IUUC-Hvu-047672	Hordeum vulgare	23.64	8.20e-01	27.30
IUUC-Lch-050047	Latimeria chalumnae	32.43	2.40e-01	28.50
IUUC-Laf-054310	Loxodonta africana	31.03	1.00e-04	38.90
IUUC-Mcc-055406	Macaca mulatta	31.58	2.00e-04	38.50
IUUC-Mmr-061614	Microcebus murinus	31.03	3.00e-04	37.70
IUUC-Mmu-063540	Mus musculus	36.36	4.00e-05	40.80
IUUC-Mac-065299	Musa acuminata	23.81	1.00e-03	36.20
IUUC-Mpu-066040	Mustela putorius furo	31.03	2.00e-04	38.50
IUUC-Mlu-067763	Myotis lucifugus	28.17	1.00e-04	39.30
IUUC-Nle-069186	Nomascus leucogenys	31.58	2.00e-04	38.50
IUUC-Opr-070860	Ochotona princeps	32.73	3.00e-04	38.10
IUUC-Ont-071669	Oreochromis niloticus	28.57	2.00e-04	38.50
IUUC-Ocu-074378	Oryctolagus cuniculus	31.58	3.00e-04	36.60
IUUC-Oba-075971	Oryza barthii	32.08	1.10e-02	33.50
IUUC-Obr-076265	Oryza brachyantha	32.08	5.00e-03	34.30
IUUC-Ogl-077475	Oryza glaberrima	32.08	1.00e-02	33.50
IUUC-Ogu-078805	Oryza glumaepatula	32.08	1.10e-02	33.50
IUUC-Oin-079302	Oryza indica	32.08	1.10e-02	33.50
IUUC-Olo-080546	Oryza longistaminata	32.08	1.10e-02	33.10
IUUC-Ome-081755	Oryza meridionalis	32.08	1.10e-02	33.50
IUUC-Oni-082770	Oryza nivara	32.08	1.00e-02	33.10
IUUC-Opu-083932	Oryza punctata	32.08	1.10e-02	33.50
IUUC-Oru-085232	Oryza rufipogon	25.44	6.00e-03	33.90
IUUC-Osa-085574	Oryza sativa	32.08	1.00e-02	33.50
IUUC-Olu-087899	Ostreococcus lucimarinus	26.47	7.70e-02	29.60
IUUC-Oga-088925	Otolemur garnettii	31.03	3.00e-04	38.10
IUUC-Oar-090074	Ovis aries	31.03	2.00e-04	38.50
IUUC-Ptr-091462	Pan troglodytes	31.58	2.00e-04	38.50
IUUC-Pan-092326	Papio anubis	31.58	2.00e-04	38.50
IUUC-Pfo-096548	Poecilia formosa	25.93	6.10e-02	30.40
IUUC-Pab-097597	Pongo abelii	31.58	2.00e-04	38.50
IUUC-Pop-099001	Populus trichocarpa	32.65	8.00e-03	32.70
IUUC-Pva-102622	Pteropus vampyrus	31.03	2.00e-04	38.50
IUUC-Rno-105168	Rattus norvegicus	36.36	5.00e-05	40.40
IUUC-Smo-109266	Selaginella moellendorffii	34.85	2.00e-03	34.70
IUUC-Sly-111386	Solanum lycopersicum	23.81	6.00e-02	30.40
IUUC-Ssc-115881	Sus scrofa	31.03	1.00e-04	38.10
IUUC-Tru-118647	Takifugu rubripes	28.85	8.00e-04	36.60
IUUC-Tni-120516	Tetraodon nigroviridis	26.79	1.00e-03	35.80
IUUC-Tae-123503	Triticum aestivum	36.17	3.00e-03	33.10
IUUC-Ttr-128934	Tursiops truncatus	31.03	2.00e-04	38.10
IUUC-Vpa-130081	Vicugna pacos	33.33	2.10e-01	28.10
IUUC-Vvi-131081	Vitis vinifera	32.18	2.00e-04	39.70
IUUC-Xtr-132268	Xenopus tropicalis	39.53	2.30e-02	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence