iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108292

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1

Genbank Nucleotide ID

CU329672

Gene Name

ubp1; SPCC16A11.12c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC16A11.12c	SPCC16A11.12c.1	SPCC16A11.12c.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-90	301.9	279	847

Active Site

Position(s)	Description	Evidence
288	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
806	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           +Gl NlgN+CYmNS+LQc+++++el++++l+ ++++++n +np ++ g+++ s+++l++ +  + + ++vsp++++ ++++++  fsgy+
   Q: 279  CGLYNLGNSCYMNSALQCMIHTHELTKYFLSdSYEKDINYNNPLGMMGKVALSYASLLKMIHhTADMHSVSPSSFKFIIGEFNTYFSGYR 368
           7******************************99**************************999888999********************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           qqD+qEf+af+ld+l+e+l++ + kp+ e  +  ++    +           ++ ++k+n+s+i++lFqg +ks++ c  c ++s+ ++p
   Q: 369  QQDSQEFIAFFLDGLHEDLNRIQIKPYFERPDLFDE----HplhvqrvanqCWDIHTKRNDSIIVQLFQGMYKSTLECSICYQKSTAFDP 454
           *********************888888877665432....12233577888*************************************** PP
   S: 169  fldlslpvpgkeetkke......................................................................... 185
           f++l+lp+p + +  ++                                                                         
   Q: 455  FMYLTLPLPTSAKWRHKvvyvppfgtqspvelylellmestviqmkfqateklqkmglecgeltacdiyrgkvykvlknkdkiskkihkw 544
           ************998889************************************************************************ PP
   S: 186  .......................................................................................... 185
                                                                                                     
   Q: 545  dhvvlygstangltipivhgckrpampgsyqsndvfgfplqlnvrsrnvltndlvkeivelyrvyagidvaigtlqlglkrmeskagkwe 634
           ****************************************************************************************** PP
   S: 186  ........................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                   +l+dcL +f+k+e+l+ ++ +yc+ ck+ + a+k
   Q: 635  cikeievkrfeiveeeeividdktvimclwndqqyeklfyncewifekiqfhmesiTLEDCLLEFSKPEQLDLQDSWYCPGCKAFRPATK 724
           ****************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfs.eeqksrekinkkvefple.Ldlspfcts.....peekqkekkkYeLiavvvHsGslssGHYvayvkne 302
           +l++++lP++L++hL+Rfs +  +  +r+k  + v +p   L+l++f++      +  +++++  Y+L+av +H+G +s+GHY+ay+++ 
   Q: 725  RLEIWRLPKILVIHLNRFSGHgGDLRRRRKRRDLVVYPVFdLNLKQFLSPfikdhEWLSSQKSMLYDLYAVDNHHGFMSNGHYTAYARDA 814
           ******************65415677899*********999****9999877777444444599*************************9 PP
   S: 303  kgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + + +++fdD+ + e++ e++++   s+aYvlfY+ 
   Q: 815  SSQtFFKFDDTAICEIDPEDIVT---SSAYVLFYRA 847
           8889*******************...********96 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MASTATQNAS TRYSQIWIDQ PASLPFQDSI NLIKEDKEKW KKEKTAFLID YDWFEGYVDF 60
IYGEGDNPGP ITQWRLLDEK NELKHSLEES IDYSIVSASL WHMLVEWFGL EGLAIERKVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGAAAACT CAAACTTGAC AGAGGGCAGC AATATGCGTC ACCTGTATAA ATCCTTTTTC 60
ACCATTTGGT ACAACAAGTT TACTTAAACC AACAACTCCA TTCCCCCAAT TTTTTGCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPCC16A11.12c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-007343	Arabidopsis thaliana	31.08	6.00e-88	317.00
IUUC-Bdi-014523	Brachypodium distachyon	28.03	2.00e-79	288.00
IUUC-Bol-016299	Brassica oleracea	35.33	3.00e-77	281.00
IUUC-Bra-016885	Brassica rapa	30.30	3.00e-91	327.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	51.31	7.00e-52	195.00
IUUC-Cin-025292	Ciona intestinalis	28.44	4.00e-92	330.00
IUUC-Mor-056985	Magnaporthe oryzae	45.00	2.00e-67	249.00
IUUC-Mac-064956	Musa acuminata	31.20	2.00e-93	335.00
IUUC-Olo-080315	Oryza longistaminata	32.54	1.00e-84	306.00
IUUC-Ome-081271	Oryza meridionalis	32.39	1.00e-84	305.00
IUUC-Osa-086139	Oryza sativa	32.23	2.00e-83	302.00
IUUC-Sja-107748	Schizosaccharomyces japonicus	44.90	0.00e+00	674.00
IUUC-Smo-108686	Selaginella moellendorffii	34.45	2.00e-84	304.00
IUUC-Tca-121001	Theobroma cacao	29.68	5.00e-89	320.00
IUUC-Tae-125401	Triticum aestivum	28.23	4.00e-85	307.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence