iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004420

UUCD1 version

UUC-AnC-00841

Ensembl Protein ID

ENSACAP00000016018.3

UniProt Accession

G1KSE8; G1KSE8_ANOCA

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Gene Name

RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000016306.3	ENSACAT00000016338.3	ENSACAP00000016018.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.60e-06	26.1	15	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iC++ f + p++lpC+H+ +++C+         +++ +  CP Cr
   Q: 15   CNICMDIFVE-PVTLPCQHTLCKSCFqLT------VEKATLCCPFCR 54
           99*******9.9**************444......5**********8 PP

Organism

Anolis carolinensis

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSKDSEAPLL SDCQCNICMD IFVEPVTLPC QHTLCKSCFQ LTVEKATLCC PFCRRRVSSW 60
ARYNARRNTL VNSELWAKIQ KHFPEECQRR ISGQDIEDTF LPQPLRCLSK PGELRQEYEA 120

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Nucleotide Sequence
(Fasta)

GACTCAAAGC AAAACAATGT TAAAAAATAA CTTTAAAATA TACCCTTTGA GACGCCTGAT 60
TTGGCCATGG TAGTCCACGC CTTAGTTACA TCCCGCTTTG ATTACTGCAA CATTCTCTAC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0031491--F:nucleosome binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0035518--P:histone H2A monoubiquitination
GO:0036351--P:histone H2A-K13 ubiquitination
GO:0036352--P:histone H2A-K15 ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100561030

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	35.37	2.00e-10	60.10
IUUC-Aml-001573	Ailuropoda melanoleuca	40.70	7.00e-73	268.00
IUUC-Atr-002992	Amborella trichopoda	40.00	7.00e-10	57.80
IUUC-Apl-003963	Anas platyrhynchos	45.80	5.00e-71	261.00
IUUC-Ame-011521	Astyanax mexicanus	52.43	2.00e-40	159.00
IUUC-Bta-013002	Bos taurus	38.28	5.00e-67	248.00
IUUC-Cja-019945	Callithrix jacchus	66.94	9.00e-47	181.00
IUUC-Cfa-020533	Canis familiaris	43.19	6.00e-76	278.00
IUUC-Cpo-021643	Cavia porcellus	55.50	2.00e-46	180.00
IUUC-Csa-023638	Chlorocebus sabaeus	41.62	1.00e-75	277.00
IUUC-Cho-024319	Choloepus hoffmanni	68.97	5.00e-46	178.00
IUUC-Cin-025679	Ciona intestinalis	40.37	2.00e-23	102.00
IUUC-Csv-026052	Ciona savignyi	40.18	1.00e-22	99.40
IUUC-Dre-028519	Danio rerio	53.93	1.00e-38	153.00
IUUC-Dno-029294	Dasypus novemcinctus	53.04	1.00e-46	180.00
IUUC-Ete-032714	Echinops telfairi	65.74	5.00e-41	162.00
IUUC-Eca-033343	Equus caballus	43.60	1.00e-77	283.00
IUUC-Eeu-034633	Erinaceus europaeus	36.51	7.00e-12	64.30
IUUC-Fca-036251	Felis catus	42.57	1.00e-75	276.00
IUUC-Fal-037048	Ficedula albicollis	45.80	3.00e-86	312.00
IUUC-Gmo-039400	Gadus morhua	52.59	1.00e-33	134.00
IUUC-Gga-040444	Gallus gallus	46.50	6.00e-92	331.00
IUUC-Gac-041735	Gasterosteus aculeatus	51.26	3.00e-42	164.00
IUUC-Gma-044332	Glycine max	36.59	2.00e-11	63.50
IUUC-Ggo-044940	Gorilla gorilla	40.74	1.00e-23	103.00
IUUC-Hsa-046424	Homo sapiens	70.00	4.00e-48	185.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	62.70	2.00e-41	163.00
IUUC-Lch-050649	Latimeria chalumnae	60.82	3.00e-45	175.00
IUUC-Loc-051847	Lepisosteus oculatus	36.09	2.00e-53	202.00
IUUC-Laf-053938	Loxodonta africana	38.68	1.00e-74	273.00
IUUC-Mcc-055360	Macaca mulatta	42.11	6.00e-72	265.00
IUUC-Meu-056684	Macropus eugenii	60.44	4.00e-44	172.00
IUUC-Mtr-058007	Medicago truncatula	36.59	3.00e-11	62.80
IUUC-Mga-059699	Meleagris gallopavo	47.22	6.00e-90	324.00
IUUC-Mmr-060779	Microcebus murinus	65.83	8.00e-45	174.00
IUUC-Mdo-062225	Monodelphis domestica	42.76	7.00e-75	274.00
IUUC-Mmu-064239	Mus musculus	65.05	2.00e-38	153.00
IUUC-Mpu-066141	Mustela putorius furo	42.33	3.00e-81	295.00
IUUC-Mlu-067945	Myotis lucifugus	41.08	1.00e-71	264.00
IUUC-Nle-069769	Nomascus leucogenys	65.60	3.00e-45	176.00
IUUC-Opr-070905	Ochotona princeps	56.52	2.00e-39	157.00
IUUC-Ont-071477	Oreochromis niloticus	57.66	1.00e-37	150.00
IUUC-Oan-073587	Ornithorhynchus anatinus	70.63	2.00e-48	183.00
IUUC-Ocu-073832	Oryctolagus cuniculus	39.97	1.00e-71	264.00
IUUC-Ome-081482	Oryza meridionalis	38.16	7.00e-10	58.20
IUUC-Ola-086478	Oryzias latipes	58.68	3.00e-38	149.00
IUUC-Oga-088318	Otolemur garnettii	41.24	3.00e-67	249.00
IUUC-Oar-089647	Ovis aries	39.23	3.00e-71	262.00
IUUC-Ptr-090516	Pan troglodytes	40.17	3.00e-71	262.00
IUUC-Pan-092302	Papio anubis	41.82	2.00e-72	266.00
IUUC-Psi-093604	Pelodiscus sinensis	49.19	6.00e-106	377.00
IUUC-Pfo-096441	Poecilia formosa	62.60	3.00e-40	159.00
IUUC-Pab-097729	Pongo abelii	68.64	2.00e-46	180.00
IUUC-Pca-100552	Procavia capensis	69.23	7.00e-38	151.00
IUUC-Ppe-102024	Prunus persica	37.80	3.00e-10	60.80
IUUC-Pva-102780	Pteropus vampyrus	40.63	2.00e-69	256.00
IUUC-Rno-105461	Rattus norvegicus	68.33	1.00e-46	180.00
IUUC-Sha-106809	Sarcophilus harrisii	42.13	1.00e-76	280.00
IUUC-Sly-111317	Solanum lycopersicum	39.02	2.00e-12	66.60
IUUC-Stu-112446	Solanum tuberosum	37.80	2.00e-12	66.20
IUUC-Sar-113579	Sorex araneus	65.83	4.00e-45	176.00
IUUC-Sbi-113834	Sorghum bicolor	35.71	2.00e-10	59.70
IUUC-Tgu-117187	Taeniopygia guttata	70.94	1.00e-59	221.00
IUUC-Tru-118182	Takifugu rubripes	57.89	2.00e-38	152.00
IUUC-Tni-120205	Tetraodon nigroviridis	57.89	2.00e-41	162.00
IUUC-Tca-121416	Theobroma cacao	39.47	2.00e-11	62.80
IUUC-Tvi-122557	Trichoderma virens	33.33	2.00e-06	47.40
IUUC-Tae-123092	Triticum aestivum	35.37	2.00e-10	60.10
IUUC-Tur-126688	Triticum urartu	35.53	2.00e-10	59.30
IUUC-Tbe-127622	Tupaia belangeri	56.77	5.00e-45	175.00
IUUC-Ttr-128988	Tursiops truncatus	43.43	1.00e-75	277.00
IUUC-Vpa-130302	Vicugna pacos	69.49	1.00e-46	181.00
IUUC-Vvi-131424	Vitis vinifera	38.16	9.00e-10	57.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence