iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044465

UUCD1 version

UUC-GoG-00810

Ensembl Protein ID

ENSGGOP00000021521.1

UniProt Accession

G3S0C7; G3S0C7_GORGO

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000008591.2	ENSGGOT00000028430.1	ENSGGOP00000021521.1
ENSGGOG00000008591.2	ENSGGOT00000008636.2	ENSGGOP00000008404.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.30e-119	397.9	578	908

Active Site

Position(s)	Description	Evidence
879	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s++  +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 578  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSADVGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 664
           679999*************.***************************************9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 665  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 750
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 751  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 839
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 840  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 908
           ******************8888888868888********************************986555 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAGAG CGATGGAGCA ACTCAACCGC CTGACGCGCT CGCTGCGCCG CGCGCGCACC 60
GTGGAGTTGC CCGAGGGTGA GCCGGGTCGC GGGGCCAGGC TGGCCGCGGG GCTGGGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.50	1.00e-81	300.00
IUUC-Aml-001490	Ailuropoda melanoleuca	94.53	0.00e+00	1793.00
IUUC-Atr-002582	Amborella trichopoda	43.31	2.00e-97	352.00
IUUC-Apl-003400	Anas platyrhynchos	87.89	0.00e+00	1149.00
IUUC-Aca-005375	Anolis carolinensis	87.95	0.00e+00	1654.00
IUUC-Aly-006157	Arabidopsis lyrata	43.99	1.00e-98	356.00
IUUC-Ath-007160	Arabidopsis thaliana	42.66	7.00e-93	337.00
IUUC-Afu-009022	Aspergillus fumigatus	42.43	4.00e-95	345.00
IUUC-Ani-009412	Aspergillus nidulans	42.56	7.00e-97	350.00
IUUC-Ate-010253	Aspergillus terreus	42.56	2.00e-95	346.00
IUUC-Ame-011847	Astyanax mexicanus	81.43	0.00e+00	1567.00
IUUC-Bta-012831	Bos taurus	93.95	0.00e+00	1744.00
IUUC-Bdi-014884	Brachypodium distachyon	42.89	7.00e-96	347.00
IUUC-Bol-016533	Brassica oleracea	52.55	3.00e-78	284.00
IUUC-Bra-016726	Brassica rapa	44.22	3.00e-99	358.00
IUUC-Cja-019160	Callithrix jacchus	95.94	0.00e+00	1823.00
IUUC-Cfa-020346	Canis familiaris	94.41	0.00e+00	1790.00
IUUC-Cpo-021766	Cavia porcellus	93.64	0.00e+00	1775.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	42.89	5.00e-99	354.00
IUUC-Csa-023768	Chlorocebus sabaeus	95.83	0.00e+00	1815.00
IUUC-Cho-024688	Choloepus hoffmanni	93.86	0.00e+00	1174.00
IUUC-Cin-025417	Ciona intestinalis	50.96	5.00e-137	481.00
IUUC-Csv-025993	Ciona savignyi	42.87	0.00e+00	714.00
IUUC-Cne-027095	Cryptococcus neoformans	38.90	6.00e-81	297.00
IUUC-Cme-027267	Cyanidioschyzon merolae	42.00	6.00e-88	319.00
IUUC-Dre-027819	Danio rerio	82.21	0.00e+00	1555.00
IUUC-Dno-029027	Dasypus novemcinctus	94.00	0.00e+00	1778.00
IUUC-Dor-030327	Dipodomys ordii	89.95	0.00e+00	1624.00
IUUC-Ete-032966	Echinops telfairi	90.36	0.00e+00	1699.00
IUUC-Eca-034339	Equus caballus	94.52	0.00e+00	1791.00
IUUC-Eeu-034544	Erinaceus europaeus	63.93	4.00e-178	618.00
IUUC-Fca-035617	Felis catus	98.00	0.00e+00	1332.00
IUUC-Fal-036687	Ficedula albicollis	87.83	0.00e+00	1683.00
IUUC-Gmo-039508	Gadus morhua	87.95	0.00e+00	828.00
IUUC-Gga-040845	Gallus gallus	88.04	0.00e+00	1704.00
IUUC-Gac-041894	Gasterosteus aculeatus	81.84	0.00e+00	1510.00
IUUC-Gma-044216	Glycine max	43.99	2.00e-99	358.00
IUUC-Hsa-045731	Homo sapiens	96.05	0.00e+00	1818.00
IUUC-Hvu-047697	Hordeum vulgare	42.66	5.00e-95	344.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	94.85	0.00e+00	1792.00
IUUC-Lch-050436	Latimeria chalumnae	86.17	0.00e+00	1616.00
IUUC-Lpe-051550	Leersia perrieri	43.12	5.00e-97	351.00
IUUC-Loc-052287	Lepisosteus oculatus	82.08	0.00e+00	1591.00
IUUC-Lma-053159	Leptosphaeria maculans	40.50	4.00e-93	338.00
IUUC-Laf-053846	Loxodonta africana	94.96	0.00e+00	1797.00
IUUC-Mcc-055845	Macaca mulatta	95.94	0.00e+00	1817.00
IUUC-Meu-056060	Macropus eugenii	89.11	0.00e+00	633.00
IUUC-Mtr-057633	Medicago truncatula	44.22	5.00e-100	360.00
IUUC-Mga-059935	Meleagris gallopavo	90.37	0.00e+00	1681.00
IUUC-Mmr-060960	Microcebus murinus	95.18	0.00e+00	1805.00
IUUC-Mdo-061851	Monodelphis domestica	89.95	0.00e+00	1742.00
IUUC-Mmu-063657	Mus musculus	93.31	0.00e+00	1771.00
IUUC-Mac-065229	Musa acuminata	43.31	2.00e-97	352.00
IUUC-Mpu-066161	Mustela putorius furo	99.25	0.00e+00	828.00
IUUC-Mlu-067354	Myotis lucifugus	92.74	0.00e+00	1726.00
IUUC-Nle-069112	Nomascus leucogenys	95.94	0.00e+00	1816.00
IUUC-Opr-070686	Ochotona princeps	89.32	0.00e+00	811.00
IUUC-Ont-072398	Oreochromis niloticus	81.22	0.00e+00	1508.00
IUUC-Oan-073194	Ornithorhynchus anatinus	91.81	0.00e+00	1669.00
IUUC-Ocu-074397	Oryctolagus cuniculus	82.77	0.00e+00	1501.00
IUUC-Oba-075757	Oryza barthii	42.89	3.00e-96	348.00
IUUC-Obr-076553	Oryza brachyantha	43.34	6.00e-97	350.00
IUUC-Ogl-077520	Oryza glaberrima	42.89	4.00e-96	348.00
IUUC-Ogu-078278	Oryza glumaepatula	42.89	4.00e-96	348.00
IUUC-Oin-079767	Oryza indica	42.89	4.00e-96	348.00
IUUC-Olo-080380	Oryza longistaminata	42.73	9.00e-95	343.00
IUUC-Ome-081925	Oryza meridionalis	42.73	1.00e-94	343.00
IUUC-Oni-082619	Oryza nivara	42.89	4.00e-96	348.00
IUUC-Opu-083684	Oryza punctata	42.73	8.00e-95	343.00
IUUC-Oru-084501	Oryza rufipogon	42.89	4.00e-96	348.00
IUUC-Osa-086251	Oryza sativa	42.73	3.00e-96	346.00
IUUC-Ola-086777	Oryzias latipes	77.52	0.00e+00	1489.00
IUUC-Oga-088684	Otolemur garnettii	95.18	0.00e+00	1808.00
IUUC-Oar-089428	Ovis aries	93.88	0.00e+00	1749.00
IUUC-Ptr-090529	Pan troglodytes	95.94	0.00e+00	1817.00
IUUC-Pan-091702	Papio anubis	95.83	0.00e+00	1815.00
IUUC-Psi-093969	Pelodiscus sinensis	87.60	0.00e+00	1628.00
IUUC-Pno-094871	Phaeosphaeria nodorum	40.50	5.00e-93	337.00
IUUC-Ppa-095834	Physcomitrella patens	43.64	9.00e-96	347.00
IUUC-Pfo-097364	Poecilia formosa	82.65	0.00e+00	1532.00
IUUC-Pab-098574	Pongo abelii	96.05	0.00e+00	1818.00
IUUC-Pop-099468	Populus trichocarpa	44.22	1.00e-99	359.00
IUUC-Pca-100525	Procavia capensis	70.09	9.00e-168	584.00
IUUC-Ppe-101641	Prunus persica	43.76	2.00e-98	355.00
IUUC-Pva-102365	Pteropus vampyrus	83.11	0.00e+00	1525.00
IUUC-Pgr-103465	Puccinia graminis	40.25	8.00e-99	357.00
IUUC-Ptt-103813	Puccinia triticina	37.84	4.00e-87	318.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	40.73	5.00e-94	341.00
IUUC-Rno-105153	Rattus norvegicus	93.09	0.00e+00	1772.00
IUUC-Sha-107319	Sarcophilus harrisii	89.84	0.00e+00	1737.00
IUUC-Smo-109640	Selaginella moellendorffii	43.18	3.00e-97	352.00
IUUC-Sit-110598	Setaria italica	43.57	1.00e-96	349.00
IUUC-Sly-111706	Solanum lycopersicum	44.44	2.00e-99	359.00
IUUC-Stu-112894	Solanum tuberosum	34.47	2.00e-54	207.00
IUUC-Sar-113449	Sorex araneus	81.04	2.00e-176	612.00
IUUC-Sbi-114042	Sorghum bicolor	43.86	6.00e-97	350.00
IUUC-Sre-114958	Sporisorium reilianum	44.99	8.00e-108	384.00
IUUC-Ssc-115865	Sus scrofa	94.41	0.00e+00	1790.00
IUUC-Tgu-117225	Taeniopygia guttata	87.83	0.00e+00	1702.00
IUUC-Tru-118026	Takifugu rubripes	79.05	0.00e+00	1489.00
IUUC-Tsy-119407	Tarsius syrichta	82.02	0.00e+00	1498.00
IUUC-Tni-120234	Tetraodon nigroviridis	79.66	0.00e+00	1197.00
IUUC-Tca-121479	Theobroma cacao	43.99	2.00e-100	362.00
IUUC-Tae-125214	Triticum aestivum	42.16	1.00e-94	342.00
IUUC-Tur-126774	Triticum urartu	28.92	2.00e-46	180.00
IUUC-Tbe-127708	Tupaia belangeri	87.68	0.00e+00	874.00
IUUC-Ttr-128667	Tursiops truncatus	94.19	0.00e+00	1787.00
IUUC-Uma-129355	Ustilago maydis	45.66	2.00e-108	386.00
IUUC-Vpa-130200	Vicugna pacos	94.24	0.00e+00	1732.00
IUUC-Vvi-131078	Vitis vinifera	43.76	2.00e-99	359.00
IUUC-Xtr-132176	Xenopus tropicalis	84.27	0.00e+00	1628.00
IUUC-Xma-133936	Xiphophorus maculatus	81.95	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence