iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108091

UUCD1 version

UUC-ScP-00020

Ensembl Protein ID

SPAC23H4.18c.1:pep

UniProt Accession

O13959; RBX1_SCHPO

Genbank Protein ID

AAD54393.1; CAB58559.1

Protein Name

RING-box protein pip1; Pop-interacting protein 1

Genbank Nucleotide ID

AF179228; CU329670

Gene Name

pip1; SPAC23H4.18c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC23H4.18c	SPAC23H4.18c.1	SPAC23H4.18c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	11504566

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.60e-09	35.6	41	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv..................lpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+++++d +++                  + C+H+fh++C+ +w       +++  CPl+
   Q: 41   CAICRNHIMD-LCIecqantdsaaaqectvawGTCNHAFHFHCISRW------LNTRNVCPLD 96
           ********77.55444444444444444333488*************......********97 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.

Protein Sequence
(Fasta)

MEDEMQIDKK EVEIEQKPPR FEIKKWNAVA LWQWDIVVDN CAICRNHIMD LCIECQANTD 60
SAAAQECTVA WGTCNHAFHF HCISRWLNTR NVCPLDNREW EFQRYGH 107

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATTATCTT ATGTTTGAGT ATTGCTTAGC GAAGCTGCAA TTTTCAACCC CCTTTATCAC 60
ACCGCTTAAA CATCTCATCT TAAAACGAAG TAGCGGCTTT GCTCTATTTT ACTCATCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2

PROSITE

PS50089--ZF_RING_2

Pfam

PF12678--zf-rbx1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006351--P:transcription, DNA-templated

KEGG

spo:SPAC23H4.18c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001061	Aegilops tauschii	37.74	9.00e-05	40.00
IUUC-Aml-001798	Ailuropoda melanoleuca	74.07	3.00e-45	171.00
IUUC-Atr-002900	Amborella trichopoda	84.95	2.00e-46	175.00
IUUC-Apl-003762	Anas platyrhynchos	88.46	2.00e-38	147.00
IUUC-Aca-005328	Anolis carolinensis	74.07	3.00e-45	171.00
IUUC-Aly-005923	Arabidopsis lyrata	86.36	7.00e-44	166.00
IUUC-Ath-007535	Arabidopsis thaliana	82.02	7.00e-42	159.00
IUUC-Ago-007991	Ashbya gossypii	55.66	4.00e-35	137.00
IUUC-Acl-008332	Aspergillus clavatus	82.02	6.00e-43	163.00
IUUC-Afl-008537	Aspergillus flavus	84.88	2.00e-42	162.00
IUUC-Afu-008985	Aspergillus fumigatus	82.02	5.00e-43	164.00
IUUC-Ani-009342	Aspergillus nidulans	80.90	7.00e-43	163.00
IUUC-Ang-009778	Aspergillus niger	84.88	2.00e-42	162.00
IUUC-Aor-009918	Aspergillus oryzae	84.88	2.00e-42	162.00
IUUC-Ame-010814	Astyanax mexicanus	83.93	1.00e-25	105.00
IUUC-Bgr-012224	Blumeria graminis	84.09	1.00e-44	169.00
IUUC-Bta-012426	Bos taurus	74.07	3.00e-45	171.00
IUUC-Bci-013839	Botrytis cinerea	86.21	2.00e-43	165.00
IUUC-Bdi-014973	Brachypodium distachyon	83.70	8.00e-45	169.00
IUUC-Bol-015671	Brassica oleracea	82.61	7.00e-45	170.00
IUUC-Bra-017034	Brassica rapa	82.61	7.00e-45	170.00
IUUC-Cel-018195	Caenorhabditis elegans	70.75	2.00e-43	165.00
IUUC-Cja-018788	Callithrix jacchus	87.06	6.00e-43	163.00
IUUC-Cfa-020188	Canis familiaris	50.00	1.00e-22	95.90
IUUC-Cpo-021365	Cavia porcellus	74.07	3.00e-45	171.00
IUUC-Cre-022904	Chlamydomonas reinhardtii	56.98	2.00e-25	105.00
IUUC-Csa-024198	Chlorocebus sabaeus	74.07	3.00e-45	171.00
IUUC-Cho-024344	Choloepus hoffmanni	83.64	2.00e-25	104.00
IUUC-Cin-025449	Ciona intestinalis	76.47	4.00e-45	170.00
IUUC-Csv-026356	Ciona savignyi	48.19	3.00e-20	87.40
IUUC-Cgl-026522	Colletotrichum gloeosporioides	85.06	1.00e-43	165.00
IUUC-Cne-027067	Cryptococcus neoformans	65.91	9.00e-33	130.00
IUUC-Cme-027268	Cyanidioschyzon merolae	63.37	2.00e-35	138.00
IUUC-Dre-027434	Danio rerio	74.07	3.00e-45	171.00
IUUC-Dno-029252	Dasypus novemcinctus	87.06	2.00e-42	161.00
IUUC-Dor-030861	Dipodomys ordii	66.67	1.00e-28	115.00
IUUC-Dse-031355	Dothistroma septosporum	85.06	5.00e-43	163.00
IUUC-Dme-031585	Drosophila melanogaster	73.15	2.00e-45	171.00
IUUC-Ete-033111	Echinops telfairi	39.53	3.00e-14	68.20
IUUC-Eca-033758	Equus caballus	74.07	3.00e-45	171.00
IUUC-Fca-035586	Felis catus	74.07	3.00e-45	171.00
IUUC-Fal-037097	Ficedula albicollis	86.42	8.00e-40	152.00
IUUC-Fox-037881	Fusarium oxysporum	85.19	2.00e-39	152.00
IUUC-Fso-038373	Fusarium solani	72.28	1.00e-43	166.00
IUUC-Gmo-039457	Gadus morhua	74.04	1.00e-42	162.00
IUUC-Ggr-039970	Gaeumannomyces graminis	86.21	3.00e-43	164.00
IUUC-Gga-040328	Gallus gallus	74.07	3.00e-45	171.00
IUUC-Gac-041578	Gasterosteus aculeatus	74.07	3.00e-45	171.00
IUUC-Gma-042692	Glycine max	87.50	2.00e-44	168.00
IUUC-Ggo-045249	Gorilla gorilla	83.64	3.00e-26	107.00
IUUC-Hsa-046279	Homo sapiens	74.07	3.00e-45	171.00
IUUC-Hvu-047597	Hordeum vulgare	84.78	6.00e-45	170.00
IUUC-Itr-048174	Ictidomys tridecemlineatus	74.07	3.00e-45	171.00
IUUC-Kpa-049330	Komagataella pastoris	65.22	5.00e-36	140.00
IUUC-Lch-049667	Latimeria chalumnae	74.07	3.00e-45	171.00
IUUC-Loc-052481	Lepisosteus oculatus	50.00	1.00e-22	95.90
IUUC-Lma-053052	Leptosphaeria maculans	82.61	7.00e-44	166.00
IUUC-Laf-053827	Loxodonta africana	72.22	2.00e-43	164.00
IUUC-Mcc-055208	Macaca mulatta	74.07	3.00e-45	171.00
IUUC-Meu-056143	Macropus eugenii	87.80	3.00e-41	156.00
IUUC-Mor-057158	Magnaporthe oryzae	85.06	7.00e-43	163.00
IUUC-Mpo-057409	Magnaporthe poae	86.21	3.00e-43	164.00
IUUC-Mtr-058505	Medicago truncatula	87.50	2.00e-44	168.00
IUUC-Mla-059071	Melampsora laricipopulina	64.52	3.00e-42	161.00
IUUC-Mga-059797	Meleagris gallopavo	74.07	3.00e-45	171.00
IUUC-Mvi-060401	Microbotryum violaceum	82.76	6.00e-42	160.00
IUUC-Mmr-061077	Microcebus murinus	74.07	3.00e-45	171.00
IUUC-Mdo-062218	Monodelphis domestica	74.07	3.00e-45	171.00
IUUC-Mmu-064224	Mus musculus	74.07	3.00e-45	171.00
IUUC-Mac-064737	Musa acuminata	87.50	3.00e-44	168.00
IUUC-Mpu-066572	Mustela putorius furo	74.07	3.00e-45	171.00
IUUC-Mlu-067821	Myotis lucifugus	74.07	3.00e-45	171.00
IUUC-Nfi-068412	Neosartorya fischeri	82.02	6.00e-43	163.00
IUUC-Nle-069309	Nomascus leucogenys	74.07	3.00e-45	171.00
IUUC-Opr-070307	Ochotona princeps	74.07	3.00e-45	171.00
IUUC-Ont-071677	Oreochromis niloticus	74.77	2.00e-46	174.00
IUUC-Oan-072926	Ornithorhynchus anatinus	87.50	1.00e-39	151.00
IUUC-Oba-075405	Oryza barthii	84.95	2.00e-44	168.00
IUUC-Obr-076843	Oryza brachyantha	84.95	1.00e-44	170.00
IUUC-Ogl-077608	Oryza glaberrima	84.95	2.00e-44	168.00
IUUC-Ogu-078316	Oryza glumaepatula	84.95	2.00e-44	168.00
IUUC-Oin-079918	Oryza indica	51.28	2.00e-38	149.00
IUUC-Olo-080968	Oryza longistaminata	63.29	6.00e-24	99.40
IUUC-Ome-081246	Oryza meridionalis	70.18	4.00e-44	167.00
IUUC-Oni-082052	Oryza nivara	84.95	2.00e-44	168.00
IUUC-Opu-084035	Oryza punctata	83.70	4.00e-45	171.00
IUUC-Oru-084941	Oryza rufipogon	84.95	2.00e-44	168.00
IUUC-Osa-085800	Oryza sativa	84.95	2.00e-44	168.00
IUUC-Ola-087352	Oryzias latipes	74.07	2.00e-45	171.00
IUUC-Olu-087676	Ostreococcus lucimarinus	52.38	3.00e-25	104.00
IUUC-Oga-088880	Otolemur garnettii	74.07	3.00e-45	171.00
IUUC-Oar-089286	Ovis aries	74.07	3.00e-45	171.00
IUUC-Ptr-091402	Pan troglodytes	74.07	3.00e-45	171.00
IUUC-Pan-091687	Papio anubis	86.36	2.00e-44	168.00
IUUC-Psi-093640	Pelodiscus sinensis	74.07	1.00e-45	172.00
IUUC-Pma-094723	Petromyzon marinus	86.75	2.00e-41	157.00
IUUC-Pno-094822	Phaeosphaeria nodorum	74.76	2.00e-44	168.00
IUUC-Ppa-095242	Physcomitrella patens	82.80	1.00e-45	172.00
IUUC-Pfo-096055	Poecilia formosa	74.07	2.00e-45	171.00
IUUC-Pab-098577	Pongo abelii	74.07	3.00e-45	171.00
IUUC-Pop-099697	Populus trichocarpa	84.95	2.00e-46	175.00
IUUC-Pca-100719	Procavia capensis	74.07	3.00e-45	171.00
IUUC-Ppe-101360	Prunus persica	85.87	1.00e-46	175.00
IUUC-Pva-102885	Pteropus vampyrus	83.64	6.00e-26	107.00
IUUC-Pgr-103470	Puccinia graminis	71.43	1.00e-44	169.00
IUUC-Ptt-103909	Puccinia triticina	65.06	3.00e-26	108.00
IUUC-Pte-104144	Pyrenophora teres	80.43	1.00e-40	155.00
IUUC-Pyt-104533	Pyrenophora triticirepentis	82.61	6.00e-44	166.00
IUUC-Rno-105912	Rattus norvegicus	74.07	3.00e-45	171.00
IUUC-Sce-106407	Saccharomyces cerevisiae	62.37	1.00e-33	132.00
IUUC-Sha-107549	Sarcophilus harrisii	74.07	3.00e-45	171.00
IUUC-Sja-108003	Schizosaccharomyces japonicus	82.08	2.00e-50	188.00
IUUC-Ssl-108634	Sclerotinia sclerotiorum	86.21	1.00e-43	165.00
IUUC-Smo-109681	Selaginella moellendorffii	83.52	3.00e-44	167.00
IUUC-Sit-110419	Setaria italica	84.27	1.00e-43	165.00
IUUC-Sly-111256	Solanum lycopersicum	86.36	2.00e-44	168.00
IUUC-Stu-112567	Solanum tuberosum	84.78	5.00e-46	173.00
IUUC-Sar-113409	Sorex araneus	83.64	6.00e-26	107.00
IUUC-Sbi-113799	Sorghum bicolor	84.04	1.00e-44	169.00
IUUC-Sre-115142	Sporisorium reilianum	75.49	5.00e-44	166.00
IUUC-Tgu-116923	Taeniopygia guttata	87.34	1.00e-38	148.00
IUUC-Tru-117710	Takifugu rubripes	73.83	7.00e-45	170.00
IUUC-Tsy-119251	Tarsius syrichta	50.00	1.00e-22	95.90
IUUC-Tni-119934	Tetraodon nigroviridis	74.07	1.00e-45	172.00
IUUC-Tca-121820	Theobroma cacao	86.36	4.00e-44	167.00
IUUC-Tre-122212	Trichoderma reesei	85.19	6.00e-40	153.00
IUUC-Tvi-122357	Trichoderma virens	71.56	1.00e-43	166.00
IUUC-Tae-123888	Triticum aestivum	87.50	4.00e-44	167.00
IUUC-Tur-125958	Triticum urartu	87.50	5.00e-44	166.00
IUUC-Tme-126940	Tuber melanosporum	76.42	8.00e-47	176.00
IUUC-Tbe-127918	Tupaia belangeri	87.80	3.00e-41	156.00
IUUC-Ttr-128306	Tursiops truncatus	87.80	3.00e-41	156.00
IUUC-Uma-129482	Ustilago maydis	78.89	6.00e-42	159.00
IUUC-Vda-129917	Verticillium dahliae	79.17	3.00e-44	167.00
IUUC-Vpa-130142	Vicugna pacos	84.52	4.00e-39	150.00
IUUC-Vvi-130957	Vitis vinifera	87.50	2.00e-44	168.00
IUUC-Xtr-132382	Xenopus tropicalis	50.00	1.00e-22	95.10
IUUC-Xma-133061	Xiphophorus maculatus	74.07	2.00e-45	171.00
IUUC-Yli-134542	Yarrowia lipolytica	57.14	7.00e-35	136.00
IUUC-Zma-135466	Zea mays	84.95	2.00e-44	168.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence