iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041102

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase OTU1

Genbank Nucleotide ID

AJ851744

Gene Name

YOD1; RCJMB04_24h21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000037597.1	ENSGALT00000064315.1	ENSGALP00000048440.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/OTU	30.85	3.00e-36	146.00	IUUC-Sce-106323
ULD/UDP/UFD/UBX	30.85	3.00e-36	146.00	IUUC-Sce-106323

Active Site

Position(s)	Description	Evidence
111	N/A	{ECO:0000250\|UniProtKB:Q96FW1}
114	Nucleophile	{ECO:0000250\|UniProtKB:Q5VVQ6}
221		{ECO:0000250\|UniProtKB:Q5VVQ6}
296		{ECO:0000250\|UniProtKB:Q96FW1}

Organism

Gallus gallus

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).

Protein Sequence
(Fasta)

MLRLRCKARS GTQPLPGLTA HSRLRDMQAA LAALTGVPAP AQRLLLGFPP RSLDLSDGER 60
RLGELGIHSG DTLIVEEDTS KPSAGSPVVA KRTMAVREAV PVLARRVVPA DNSCLFTSVY 120

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Nucleotide Sequence
(Fasta)

GCGCGAAGGA TGTTGCGGCT GCGCTGCAAG GCCCGGAGCG GCACCCAGCC GCTGCCCGGC 60
CTCACGGCAC ACTCCCGTCT CCGCGACATG CAGGCCGCTC TGGCCGCCCT CACCGGCGTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF02338--OTU

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

gga:428266

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000271	Aegilops tauschii	50.53	8.00e-47	179.00
IUUC-Aml-001860	Ailuropoda melanoleuca	73.03	9.00e-132	462.00
IUUC-Atr-002548	Amborella trichopoda	52.91	3.00e-55	207.00
IUUC-Apl-004025	Anas platyrhynchos	93.75	2.00e-121	427.00
IUUC-Aca-004505	Anolis carolinensis	87.17	2.00e-159	554.00
IUUC-Aly-005999	Arabidopsis lyrata	48.33	2.00e-51	194.00
IUUC-Ath-006774	Arabidopsis thaliana	48.33	5.00e-51	193.00
IUUC-Ago-007741	Ashbya gossypii	38.89	1.00e-39	156.00
IUUC-Acl-008278	Aspergillus clavatus	32.43	2.00e-43	169.00
IUUC-Afl-008710	Aspergillus flavus	41.86	2.00e-43	169.00
IUUC-Afu-009009	Aspergillus fumigatus	35.26	2.00e-46	179.00
IUUC-Ani-009430	Aspergillus nidulans	33.23	8.00e-44	170.00
IUUC-Ang-009508	Aspergillus niger	42.25	6.00e-38	150.00
IUUC-Aor-009992	Aspergillus oryzae	40.17	1.00e-43	169.00
IUUC-Ate-010440	Aspergillus terreus	35.01	1.00e-46	179.00
IUUC-Ame-011038	Astyanax mexicanus	70.86	2.00e-129	454.00
IUUC-Bgr-012262	Blumeria graminis	36.06	2.00e-36	145.00
IUUC-Bta-012864	Bos taurus	72.37	7.00e-130	456.00
IUUC-Bci-013986	Botrytis cinerea	36.49	4.00e-37	148.00
IUUC-Bdi-014194	Brachypodium distachyon	51.46	1.00e-52	198.00
IUUC-Bol-016166	Brassica oleracea	49.28	1.00e-51	195.00
IUUC-Bra-017783	Brassica rapa	49.76	8.00e-52	196.00
IUUC-Cja-019488	Callithrix jacchus	73.03	2.00e-132	464.00
IUUC-Cpo-021728	Cavia porcellus	74.26	1.00e-133	469.00
IUUC-Cre-022819	Chlamydomonas reinhardtii	46.08	2.00e-41	161.00
IUUC-Csa-024237	Chlorocebus sabaeus	73.68	3.00e-132	463.00
IUUC-Cho-024544	Choloepus hoffmanni	74.01	1.00e-132	466.00
IUUC-Cin-025549	Ciona intestinalis	46.23	5.00e-76	277.00
IUUC-Cgl-026552	Colletotrichum gloeosporioides	32.08	2.00e-35	143.00
IUUC-Cne-027022	Cryptococcus neoformans	42.92	8.00e-45	173.00
IUUC-Cme-027196	Cyanidioschyzon merolae	36.68	9.00e-43	167.00
IUUC-Dre-027799	Danio rerio	70.20	4.00e-121	427.00
IUUC-Dno-029863	Dasypus novemcinctus	72.70	8.00e-130	456.00
IUUC-Dor-030804	Dipodomys ordii	68.75	3.00e-120	424.00
IUUC-Dse-031494	Dothistroma septosporum	40.57	4.00e-41	161.00
IUUC-Dme-032065	Drosophila melanogaster	42.32	1.00e-72	266.00
IUUC-Ete-033193	Echinops telfairi	72.04	2.00e-129	454.00
IUUC-Eca-033993	Equus caballus	72.70	5.00e-131	460.00
IUUC-Fca-035949	Felis catus	73.03	1.00e-131	462.00
IUUC-Fal-037473	Ficedula albicollis	88.14	8.00e-115	405.00
IUUC-Fox-037779	Fusarium oxysporum	29.56	4.00e-29	121.00
IUUC-Fso-038370	Fusarium solani	29.75	6.00e-29	121.00
IUUC-Gmo-038778	Gadus morhua	57.24	2.00e-90	325.00
IUUC-Ggr-039940	Gaeumannomyces graminis	36.59	3.00e-40	158.00
IUUC-Gac-041954	Gasterosteus aculeatus	70.07	1.00e-125	442.00
IUUC-Gma-043608	Glycine max	50.24	7.00e-54	202.00
IUUC-Ggo-044753	Gorilla gorilla	73.03	9.00e-131	459.00
IUUC-Hsa-045714	Homo sapiens	73.96	4.00e-126	443.00
IUUC-Hvu-047600	Hordeum vulgare	51.92	1.00e-53	202.00
IUUC-Itr-048026	Ictidomys tridecemlineatus	73.68	5.00e-133	466.00
IUUC-Kpa-049360	Komagataella pastoris	31.25	1.00e-42	166.00
IUUC-Lch-049900	Latimeria chalumnae	72.04	9.00e-121	426.00
IUUC-Lpe-050984	Leersia perrieri	42.65	4.00e-35	140.00
IUUC-Loc-052567	Lepisosteus oculatus	70.82	1.00e-130	459.00
IUUC-Lma-053247	Leptosphaeria maculans	32.83	5.00e-44	171.00
IUUC-Laf-053361	Loxodonta africana	72.70	4.00e-131	460.00
IUUC-Meu-056137	Macropus eugenii	69.08	2.00e-120	425.00
IUUC-Mor-057191	Magnaporthe oryzae	33.66	3.00e-28	119.00
IUUC-Mpo-057565	Magnaporthe poae	37.38	3.00e-33	135.00
IUUC-Mtr-058196	Medicago truncatula	50.72	5.00e-52	196.00
IUUC-Mla-059096	Melampsora laricipopulina	32.83	2.00e-40	159.00
IUUC-Mga-059489	Meleagris gallopavo	97.01	5.00e-135	472.00
IUUC-Mvi-060300	Microbotryum violaceum	38.71	2.00e-39	156.00
IUUC-Mmr-061618	Microcebus murinus	71.71	3.00e-127	447.00
IUUC-Mdo-061909	Monodelphis domestica	75.99	1.00e-137	483.00
IUUC-Mmu-063434	Mus musculus	73.36	9.00e-133	466.00
IUUC-Mac-064676	Musa acuminata	50.72	8.00e-54	202.00
IUUC-Mpu-066733	Mustela putorius furo	73.36	1.00e-132	465.00
IUUC-Mlu-066990	Myotis lucifugus	71.80	8.00e-130	456.00
IUUC-Nfi-068249	Neosartorya fischeri	34.88	8.00e-46	177.00
IUUC-Ncr-068764	Neurospora crassa	31.79	1.00e-33	136.00
IUUC-Nle-069094	Nomascus leucogenys	73.36	8.00e-131	459.00
IUUC-Oan-073585	Ornithorhynchus anatinus	77.30	2.00e-138	484.00
IUUC-Oba-075949	Oryza barthii	50.24	2.00e-51	194.00
IUUC-Obr-076096	Oryza brachyantha	50.72	5.00e-52	196.00
IUUC-Ogl-077106	Oryza glaberrima	49.76	6.00e-51	193.00
IUUC-Ogu-078024	Oryza glumaepatula	50.24	3.00e-51	194.00
IUUC-Oin-079635	Oryza indica	49.76	3.00e-51	194.00
IUUC-Olo-080299	Oryza longistaminata	50.24	5.00e-51	193.00
IUUC-Ome-081359	Oryza meridionalis	50.24	3.00e-51	194.00
IUUC-Oni-082459	Oryza nivara	49.76	6.00e-51	193.00
IUUC-Opu-083167	Oryza punctata	51.69	8.00e-53	199.00
IUUC-Oru-084577	Oryza rufipogon	49.76	3.00e-51	194.00
IUUC-Osa-085746	Oryza sativa	56.86	4.00e-13	65.50
IUUC-Ola-086890	Oryzias latipes	73.27	3.00e-132	464.00
IUUC-Olu-087585	Ostreococcus lucimarinus	42.71	4.00e-43	167.00
IUUC-Oga-088190	Otolemur garnettii	72.94	4.00e-130	457.00
IUUC-Oar-089631	Ovis aries	73.36	2.00e-131	461.00
IUUC-Pan-091892	Papio anubis	73.68	1.00e-131	462.00
IUUC-Pma-094491	Petromyzon marinus	55.59	2.00e-85	308.00
IUUC-Pno-094993	Phaeosphaeria nodorum	33.64	4.00e-43	168.00
IUUC-Ppa-095791	Physcomitrella patens	52.17	6.00e-54	202.00
IUUC-Pfo-096301	Poecilia formosa	71.62	4.00e-131	460.00
IUUC-Pab-097873	Pongo abelii	74.01	1.00e-131	462.00
IUUC-Pop-099482	Populus trichocarpa	51.21	7.00e-55	206.00
IUUC-Pca-100817	Procavia capensis	70.39	3.00e-123	434.00
IUUC-Ppe-101624	Prunus persica	51.94	1.00e-54	205.00
IUUC-Pva-102120	Pteropus vampyrus	72.37	5.00e-131	460.00
IUUC-Pgr-103368	Puccinia graminis	39.07	1.00e-41	163.00
IUUC-Ptt-103923	Puccinia triticina	39.81	6.00e-43	167.00
IUUC-Pte-104199	Pyrenophora teres	38.05	3.00e-41	161.00
IUUC-Pyt-104502	Pyrenophora triticirepentis	32.63	2.00e-43	169.00
IUUC-Rno-105605	Rattus norvegicus	73.68	5.00e-133	466.00
IUUC-Sce-106323	Saccharomyces cerevisiae	30.50	1.00e-34	140.00
IUUC-Sha-107176	Sarcophilus harrisii	79.47	3.00e-125	440.00
IUUC-Sja-107812	Schizosaccharomyces japonicus	38.31	3.00e-38	151.00
IUUC-Spo-108085	Schizosaccharomyces pombe	31.14	5.00e-42	164.00
IUUC-Smo-109050	Selaginella moellendorffii	49.28	4.00e-53	200.00
IUUC-Sit-110056	Setaria italica	49.51	1.00e-51	195.00
IUUC-Sly-111869	Solanum lycopersicum	51.67	2.00e-46	178.00
IUUC-Stu-112452	Solanum tuberosum	51.46	7.00e-54	202.00
IUUC-Sar-113629	Sorex araneus	77.05	1.00e-52	200.00
IUUC-Sbi-114422	Sorghum bicolor	51.21	2.00e-53	201.00
IUUC-Sre-115105	Sporisorium reilianum	42.08	4.00e-33	135.00
IUUC-Ssc-115553	Sus scrofa	73.03	5.00e-132	463.00
IUUC-Tgu-116921	Taeniopygia guttata	89.02	7.00e-118	416.00
IUUC-Tru-117830	Takifugu rubripes	68.77	5.00e-126	443.00
IUUC-Tsy-119320	Tarsius syrichta	73.36	6.00e-131	459.00
IUUC-Tni-119706	Tetraodon nigroviridis	69.74	4.00e-123	433.00
IUUC-Tca-121238	Theobroma cacao	50.24	3.00e-52	197.00
IUUC-Tae-124711	Triticum aestivum	51.69	5.00e-53	201.00
IUUC-Tme-126966	Tuber melanosporum	33.23	2.00e-48	185.00
IUUC-Tbe-127712	Tupaia belangeri	77.89	2.00e-88	317.00
IUUC-Ttr-129168	Tursiops truncatus	71.38	4.00e-130	457.00
IUUC-Uma-129461	Ustilago maydis	40.98	8.00e-39	154.00
IUUC-Vda-129890	Verticillium dahliae	36.11	9.00e-27	113.00
IUUC-Vpa-130616	Vicugna pacos	71.38	6.00e-129	453.00
IUUC-Vvi-131250	Vitis vinifera	50.72	1.00e-52	199.00
IUUC-Xtr-132126	Xenopus tropicalis	74.01	5.00e-134	469.00
IUUC-Xma-133596	Xiphophorus maculatus	71.62	4.00e-130	457.00
IUUC-Yli-134562	Yarrowia lipolytica	33.79	1.00e-39	156.00
IUUC-Zma-135205	Zea mays	50.24	2.00e-52	197.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence