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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063151
Ensembl Protein ID ENSMUSP00000014546.8
UniProt Accession Q61187; TS101_MOUSE
Genbank Protein ID AAC53586.1; AAC83576.1; AAH05424.1; AAH85308.1
Protein Name Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Genbank Nucleotide ID U52945; AF060868; BC005424; BC085308
Gene Name Tsg101
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000014402.15 ENSMUST00000014546.14 ENSMUSP00000014546.8
ENSMUSG00000014402.15 ENSMUST00000209538.1 ENSMUSP00000147748.1
ENSMUSG00000014402.15 ENSMUST00000211076.1 ENSMUSP00000147701.1
ENSMUSG00000014402.15 ENSMUST00000210664.1 ENSMUSP00000147749.1
ENSMUSG00000014402.15 ENSMUST00000143413.2 ENSMUSP00000121314.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/UBC-like/UBD_UEV UBD_UEV 14991575; 26811492
Classification
Family E-value Score Start End
UBD/UBC-like/UBD_UEV 4.10e-68 228.8 2 145
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/UBC-like/UBD_UEV
   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwlletYPekPPfvsvk 89
           Avses+lkk++skyk+++ltvr+++n+i++yk+lkp+++s+v+nDg+sreL++ltGtipv++rg++ynipi+lwll+tYP++PP+++vk
   Q: 2    AVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVK 90
           89*************************************************************************************** PP
   S: 90   ekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           ++++m tik++ +hvd+nGki+lp+Lh+Wk+p+s+l+el+q++iv++++epp++srp
   Q: 91   PTSSM-TIKTG-KHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRP 145
           *****.*****.*******************************************98 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
Protein Sequence
(Fasta)
MAVSESQLKK MMSKYKYRDL TVRQTVNVIA MYKDLKPVLD SYVFNDGSSR ELVNLTGTIP 60
VRYRGNIYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHDWKHP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063151|UBD,UBD_UEV|Mus musculus
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Nucleotide Sequence
(Fasta)
CGGCTTCCTG CTTCGCAGGG GCGGGGCGGC GGCGGCGGCG ATTGTCTGGC GGCCTGGGGC 60
GGCCCCGTGG CGCCTACCCT CTGCCTGTGG GGACGGAGGA GCGCGCCATG GCGGTGTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063151|UBD,UBD_UEV|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0341--Growth regulation
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR017916--SB_dom
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N
PROSITE

PS51312--SB
PS51322--UEV
Pfam

PF05743--UEV
PF09454--Vps23_core
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0000813--C:ESCRT I complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0031902--C:late endosome membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0048306--F:calcium-dependent protein binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0042803--F:protein homodimerization activity
GO:0003714--F:transcription corepressor activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0046790--F:virion binding
GO:0007050--P:cell cycle arrest
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0008333--P:endosome to lysosome transport
GO:1990182--P:exosomal secretion
GO:0030216--P:keratinocyte differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1903543--P:positive regulation of exosomal secretion
GO:2000397--P:positive regulation of ubiquitin-dependent endocytosis
GO:1903774--P:positive regulation of viral budding via host ESCRT complex
GO:0048524--P:positive regulation of viral process
GO:1902188--P:positive regulation of viral release from host cell
GO:0006513--P:protein monoubiquitination
GO:0015031--P:protein transport
GO:0001558--P:regulation of cell growth
GO:1903551--P:regulation of extracellular exosome assembly
GO:0043405--P:regulation of MAP kinase activity
GO:1903772--P:regulation of viral budding via host ESCRT complex
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046755--P:viral budding
KEGG mmu:22088
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001072 Aegilops tauschii 25.83 1.00e-23 103.00
IUUC-Aml-002415 Ailuropoda melanoleuca 93.86 0.00e+00 705.00
IUUC-Atr-002875 Amborella trichopoda 29.12 2.00e-36 147.00
IUUC-Apl-003473 Anas platyrhynchos 86.22 0.00e+00 664.00
IUUC-Aca-004573 Anolis carolinensis 88.01 0.00e+00 654.00
IUUC-Aly-006164 Arabidopsis lyrata 42.16 2.00e-20 93.20
IUUC-Ath-006575 Arabidopsis thaliana 27.52 3.00e-29 122.00
IUUC-Ago-007755 Ashbya gossypii 24.24 6.00e-05 42.40
IUUC-Acl-008218 Aspergillus clavatus 40.31 5.00e-27 115.00
IUUC-Afl-008597 Aspergillus flavus 40.60 4.00e-27 116.00
IUUC-Afu-009017 Aspergillus fumigatus 39.53 8.00e-25 108.00
IUUC-Ani-009468 Aspergillus nidulans 41.67 4.00e-22 99.80
IUUC-Ang-009755 Aspergillus niger 37.30 6.00e-24 105.00
IUUC-Aor-010072 Aspergillus oryzae 39.10 4.00e-27 116.00
IUUC-Ate-010400 Aspergillus terreus 40.31 7.00e-27 115.00
IUUC-Ame-011620 Astyanax mexicanus 77.95 0.00e+00 628.00
IUUC-Bgr-012136 Blumeria graminis 37.23 1.00e-23 104.00
IUUC-Bta-012557 Bos taurus 94.37 0.00e+00 701.00
IUUC-Bci-013881 Botrytis cinerea 36.69 6.00e-26 112.00
IUUC-Bdi-014325 Brachypodium distachyon 32.11 5.00e-14 72.00
IUUC-Bol-015144 Brassica oleracea 38.76 8.00e-26 110.00
IUUC-Bra-017605 Brassica rapa 39.52 4.00e-25 108.00
IUUC-Cel-018697 Caenorhabditis elegans 42.36 3.00e-35 142.00
IUUC-Cja-018963 Callithrix jacchus 88.27 0.00e+00 693.00
IUUC-Cfa-020472 Canis familiaris 94.37 0.00e+00 706.00
IUUC-Cpo-022001 Cavia porcellus 95.65 0.00e+00 711.00
IUUC-Cre-022918 Chlamydomonas reinhardtii 29.54 1.00e-30 127.00
IUUC-Csa-023959 Chlorocebus sabaeus 94.63 0.00e+00 675.00
IUUC-Cho-024389 Choloepus hoffmanni 54.55 2.00e-37 150.00
IUUC-Cin-025688 Ciona intestinalis 45.04 5.00e-98 350.00
IUUC-Cne-026904 Cryptococcus neoformans 27.60 3.00e-15 76.60
IUUC-Cme-027280 Cyanidioschyzon merolae 40.00 1.00e-17 84.00
IUUC-Dre-027913 Danio rerio 78.21 6.00e-172 596.00
IUUC-Dno-029672 Dasypus novemcinctus 93.86 0.00e+00 716.00
IUUC-Dor-030175 Dipodomys ordii 97.00 8.00e-93 333.00
IUUC-Dse-031375 Dothistroma septosporum 31.11 6.00e-25 108.00
IUUC-Dme-031736 Drosophila melanogaster 47.58 9.00e-96 343.00
IUUC-Ete-032343 Echinops telfairi 89.26 0.00e+00 673.00
IUUC-Eca-033926 Equus caballus 94.63 0.00e+00 704.00
IUUC-Eeu-034940 Erinaceus europaeus 86.70 0.00e+00 692.00
IUUC-Fca-035491 Felis catus 94.12 0.00e+00 691.00
IUUC-Fal-037508 Ficedula albicollis 88.52 0.00e+00 659.00
IUUC-Fox-037937 Fusarium oxysporum 33.08 2.00e-21 97.40
IUUC-Fso-038091 Fusarium solani 36.03 1.00e-24 107.00
IUUC-Gmo-039427 Gadus morhua 75.38 1.00e-166 578.00
IUUC-Ggr-039724 Gaeumannomyces graminis 37.31 4.00e-25 109.00
IUUC-Gga-040998 Gallus gallus 88.01 0.00e+00 688.00
IUUC-Gac-041356 Gasterosteus aculeatus 77.63 3.00e-180 624.00
IUUC-Gma-043566 Glycine max 38.10 2.00e-24 106.00
IUUC-Ggo-044967 Gorilla gorilla 94.63 0.00e+00 675.00
IUUC-Hsa-046686 Homo sapiens 94.63 0.00e+00 675.00
IUUC-Hvu-047430 Hordeum vulgare 25.83 7.00e-24 104.00
IUUC-Itr-047929 Ictidomys tridecemlineatus 98.21 3.00e-109 387.00
IUUC-Kpa-049287 Komagataella pastoris 30.25 8.00e-16 78.20
IUUC-Lch-050597 Latimeria chalumnae 84.95 0.00e+00 671.00
IUUC-Lpe-051090 Leersia perrieri 38.02 2.00e-20 93.20
IUUC-Loc-052399 Lepisosteus oculatus 78.77 2.00e-174 605.00
IUUC-Lma-053249 Leptosphaeria maculans 27.19 2.00e-13 70.90
IUUC-Laf-053766 Loxodonta africana 94.88 0.00e+00 708.00
IUUC-Mcc-055641 Macaca mulatta 94.63 0.00e+00 675.00
IUUC-Meu-055919 Macropus eugenii 88.96 2.00e-167 581.00
IUUC-Mor-056970 Magnaporthe oryzae 37.69 5.00e-24 105.00
IUUC-Mpo-057345 Magnaporthe poae 35.38 2.00e-22 100.00
IUUC-Mtr-058436 Medicago truncatula 29.81 3.00e-35 142.00
IUUC-Mla-059037 Melampsora laricipopulina 36.30 2.00e-26 113.00
IUUC-Mga-059263 Meleagris gallopavo 87.53 0.00e+00 666.00
IUUC-Mvi-060463 Microbotryum violaceum 28.12 2.00e-16 81.30
IUUC-Mmr-060915 Microcebus murinus 94.63 0.00e+00 703.00
IUUC-Mdo-062449 Monodelphis domestica 91.30 0.00e+00 672.00
IUUC-Mac-065020 Musa acuminata 36.43 4.00e-23 102.00
IUUC-Mpu-066621 Mustela putorius furo 93.86 0.00e+00 705.00
IUUC-Mlu-067336 Myotis lucifugus 94.63 0.00e+00 689.00
IUUC-Nfi-068530 Neosartorya fischeri 40.31 6.00e-25 108.00
IUUC-Ncr-068785 Neurospora crassa 36.03 4.00e-25 109.00
IUUC-Nle-069972 Nomascus leucogenys 94.63 0.00e+00 675.00
IUUC-Opr-071150 Ochotona princeps 65.98 2.00e-117 416.00
IUUC-Ont-071366 Oreochromis niloticus 76.41 2.00e-180 624.00
IUUC-Oan-073290 Ornithorhynchus anatinus 93.04 1.00e-103 369.00
IUUC-Ocu-074351 Oryctolagus cuniculus 94.88 0.00e+00 706.00
IUUC-Oba-075338 Oryza barthii 37.14 4.00e-11 62.00
IUUC-Obr-076135 Oryza brachyantha 26.59 1.00e-28 120.00
IUUC-Ogl-077182 Oryza glaberrima 37.38 5.00e-17 82.00
IUUC-Ogu-078281 Oryza glumaepatula 37.19 4.00e-20 92.40
IUUC-Oin-079068 Oryza indica 36.28 1.00e-16 80.90
IUUC-Olo-080460 Oryza longistaminata 35.80 1.00e-08 52.80
IUUC-Ome-081781 Oryza meridionalis 26.36 1.00e-17 84.30
IUUC-Oni-082517 Oryza nivara 26.08 4.00e-16 79.30
IUUC-Opu-084101 Oryza punctata 37.38 5.00e-17 82.00
IUUC-Oru-084556 Oryza rufipogon 37.96 6.00e-17 82.00
IUUC-Osa-086264 Oryza sativa 37.38 5.00e-17 82.00
IUUC-Ola-087252 Oryzias latipes 92.62 2.00e-68 250.00
IUUC-Olu-087610 Ostreococcus lucimarinus 26.88 2.00e-15 76.60
IUUC-Oga-088304 Otolemur garnettii 94.88 0.00e+00 705.00
IUUC-Oar-089734 Ovis aries 94.37 0.00e+00 701.00
IUUC-Ptr-091476 Pan troglodytes 94.63 0.00e+00 675.00
IUUC-Pan-092341 Papio anubis 94.63 0.00e+00 675.00
IUUC-Psi-093470 Pelodiscus sinensis 90.39 0.00e+00 650.00
IUUC-Pma-094143 Petromyzon marinus 63.54 1.00e-131 462.00
IUUC-Pno-095069 Phaeosphaeria nodorum 31.09 4.00e-13 69.70
IUUC-Ppa-095933 Physcomitrella patens 30.37 1.00e-37 150.00
IUUC-Pfo-096321 Poecilia formosa 76.13 6.00e-171 593.00
IUUC-Pab-098527 Pongo abelii 94.05 5.00e-172 596.00
IUUC-Pop-099323 Populus trichocarpa 27.37 5.00e-37 148.00
IUUC-Pca-101044 Procavia capensis 76.98 4.00e-154 537.00
IUUC-Ppe-101458 Prunus persica 40.00 1.00e-26 114.00
IUUC-Pva-103014 Pteropus vampyrus 84.91 6.00e-168 583.00
IUUC-Pgr-103615 Puccinia graminis 37.59 4.00e-22 99.80
IUUC-Ptt-103826 Puccinia triticina 43.14 8.00e-18 85.10
IUUC-Pte-104171 Pyrenophora teres 33.09 6.00e-21 95.90
IUUC-Pyt-104433 Pyrenophora triticirepentis 33.01 2.00e-10 60.50
IUUC-Rno-105957 Rattus norvegicus 98.98 0.00e+00 729.00
IUUC-Sce-106262 Saccharomyces cerevisiae 26.19 2.00e-09 57.00
IUUC-Sha-107607 Sarcophilus harrisii 92.55 3.00e-169 587.00
IUUC-Spo-108175 Schizosaccharomyces pombe 30.56 1.40e-02 34.70
IUUC-Ssl-108672 Sclerotinia sclerotiorum 37.50 1.00e-26 114.00
IUUC-Smo-108973 Selaginella moellendorffii 40.83 4.00e-22 99.00
IUUC-Sly-111373 Solanum lycopersicum 37.30 2.00e-24 106.00
IUUC-Stu-112844 Solanum tuberosum 36.51 2.00e-23 103.00
IUUC-Sar-113653 Sorex araneus 81.49 4.00e-171 593.00
IUUC-Sbi-114390 Sorghum bicolor 35.54 4.00e-20 92.40
IUUC-Sre-115200 Sporisorium reilianum 36.84 1.00e-23 104.00
IUUC-Ssc-115888 Sus scrofa 98.24 6.00e-112 396.00
IUUC-Tgu-117506 Taeniopygia guttata 81.95 0.00e+00 670.00
IUUC-Tru-118063 Takifugu rubripes 77.75 2.00e-168 585.00
IUUC-Tsy-118851 Tarsius syrichta 71.84 2.00e-139 488.00
IUUC-Tni-120010 Tetraodon nigroviridis 76.84 5.00e-166 577.00
IUUC-Tca-121182 Theobroma cacao 37.30 8.00e-21 94.70
IUUC-Tre-122040 Trichoderma reesei 36.15 2.00e-22 100.00
IUUC-Tvi-122660 Trichoderma virens 38.97 2.00e-26 113.00
IUUC-Tae-124561 Triticum aestivum 25.83 1.00e-23 103.00
IUUC-Tur-126651 Triticum urartu 38.26 2.00e-20 93.20
IUUC-Tme-127184 Tuber melanosporum 45.54 4.00e-26 113.00
IUUC-Tbe-127894 Tupaia belangeri 82.50 4.00e-89 321.00
IUUC-Ttr-128264 Tursiops truncatus 85.93 0.00e+00 682.00
IUUC-Uma-129407 Ustilago maydis 35.53 2.00e-24 107.00
IUUC-Vda-130002 Verticillium dahliae 29.41 1.00e-15 77.80
IUUC-Vpa-130156 Vicugna pacos 90.00 3.00e-91 328.00
IUUC-Vvi-131062 Vitis vinifera 28.77 7.00e-32 131.00
IUUC-Xtr-132332 Xenopus tropicalis 77.86 3.00e-60 223.00
IUUC-Xma-133186 Xiphophorus maculatus 76.19 2.00e-172 598.00
IUUC-Yli-134500 Yarrowia lipolytica 33.55 6.00e-13 68.60
IUUC-Zma-135391 Zea mays 36.13 9.00e-20 91.30
Created Date 25-Jun-2017

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