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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064272
Ensembl Protein ID ENSMUSP00000031984.6
UniProt Accession Q04692; Q3UGK6; Q3UYR6; SMRCD_MOUSE
Genbank Protein ID CAA49560.1; BAC65736.1; AAH42442.1; BAE22146.1; BAE28202.1
Protein Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; ATP-dependent helicase SMARCAD1; Enhancer trap locus homolog 1
Genbank Nucleotide ID X69942; AK122454; BC042442; AK134442; AK147884
Gene Name Smarcad1; Etl1; Kiaa1122
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029920.9 ENSMUST00000031984.8 ENSMUSP00000031984.6
ENSMUSG00000029920.9 ENSMUST00000205118.2 ENSMUSP00000145340.1
ENSMUSG00000029920.9 ENSMUST00000204114.2 ENSMUSP00000145228.1
ENSMUSG00000029920.9 ENSMUST00000203411.1 ENSMUSP00000145262.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 45.03 1.00e-117 419.00 IUUC-Sce-106399
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
 DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).
Protein Sequence
(Fasta)
MNLFNLDRFR FEKRSKIEEA PEAAPQPSQA RPSSPISLSA EEENAEGEGS RANTPDSDVT 60
EKTEDSSVPE PPDNERKASL SCFQNQRAIQ EYIDLSSDTE DVSPNCSSTV QEKKFSKDTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064272|UBD,CUE|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGCCTGGGC TGCGTGTTGC GTCATCACTA CGCGCTCCGT GGCTTGCCCA GCGCTGCCTT 60
GGAAGGTCCC GGCCAGGCTA CCGTCGCCTC CCTCAAAGAA TTATTTTGTT CTTGTCCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064272|UBD,CUE|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR003892--CUE
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS51140--CUE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00271--Helicase_C
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0000792--C:heterochromatin
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0051304--P:chromosome separation
GO:0000729--P:DNA double-strand break processing
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0000018--P:regulation of DNA recombination
KEGG mmu:13990
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000567 Aegilops tauschii 37.75 1.00e-101 364.00
IUUC-Aml-002063 Ailuropoda melanoleuca 90.48 0.00e+00 1786.00
IUUC-Atr-003078 Amborella trichopoda 35.98 2.00e-103 370.00
IUUC-Apl-003860 Anas platyrhynchos 71.50 0.00e+00 1362.00
IUUC-Aca-004485 Anolis carolinensis 69.33 0.00e+00 1372.00
IUUC-Aly-006561 Arabidopsis lyrata 38.73 2.00e-103 370.00
IUUC-Ath-006832 Arabidopsis thaliana 39.09 7.00e-105 375.00
IUUC-Ago-007758 Ashbya gossypii 45.68 1.00e-132 468.00
IUUC-Acl-008226 Aspergillus clavatus 45.01 6.00e-133 468.00
IUUC-Afl-008556 Aspergillus flavus 45.38 6.00e-130 458.00
IUUC-Afu-008799 Aspergillus fumigatus 43.95 3.00e-132 466.00
IUUC-Ani-009127 Aspergillus nidulans 45.56 2.00e-130 460.00
IUUC-Ang-009676 Aspergillus niger 44.42 9.00e-133 468.00
IUUC-Aor-010184 Aspergillus oryzae 44.10 3.00e-130 459.00
IUUC-Ate-010559 Aspergillus terreus 43.85 7.00e-130 458.00
IUUC-Ame-011933 Astyanax mexicanus 59.03 0.00e+00 880.00
IUUC-Bta-012963 Bos taurus 88.45 0.00e+00 1745.00
IUUC-Bci-013670 Botrytis cinerea 41.90 5.00e-119 422.00
IUUC-Bdi-014286 Brachypodium distachyon 38.21 3.00e-103 369.00
IUUC-Bol-016519 Brassica oleracea 39.38 4.00e-105 375.00
IUUC-Bra-017239 Brassica rapa 39.19 3.00e-104 373.00
IUUC-Cel-018253 Caenorhabditis elegans 44.29 8.00e-140 491.00
IUUC-Cja-019465 Callithrix jacchus 89.47 0.00e+00 1763.00
IUUC-Cfa-020637 Canis familiaris 88.05 0.00e+00 1768.00
IUUC-Cpo-021822 Cavia porcellus 90.77 0.00e+00 1713.00
IUUC-Csa-023315 Chlorocebus sabaeus 93.57 0.00e+00 1573.00
IUUC-Cin-025444 Ciona intestinalis 49.62 1.00e-173 603.00
IUUC-Cgl-026383 Colletotrichum gloeosporioides 40.41 7.00e-106 379.00
IUUC-Cne-027090 Cryptococcus neoformans 36.36 1.00e-115 410.00
IUUC-Dre-028385 Danio rerio 56.59 0.00e+00 870.00
IUUC-Dno-028932 Dasypus novemcinctus 91.14 0.00e+00 1811.00
IUUC-Dse-031394 Dothistroma septosporum 36.46 3.00e-103 370.00
IUUC-Dme-031640 Drosophila melanogaster 45.69 4.00e-156 545.00
IUUC-Eca-033276 Equus caballus 91.36 0.00e+00 1811.00
IUUC-Fca-035936 Felis catus 88.62 0.00e+00 1746.00
IUUC-Fal-037636 Ficedula albicollis 66.09 0.00e+00 1306.00
IUUC-Fso-038229 Fusarium solani 35.49 1.00e-111 397.00
IUUC-Gmo-039654 Gadus morhua 57.06 0.00e+00 887.00
IUUC-Ggr-039922 Gaeumannomyces graminis 34.17 3.00e-90 327.00
IUUC-Gga-040646 Gallus gallus 66.03 0.00e+00 1352.00
IUUC-Gac-042320 Gasterosteus aculeatus 66.04 0.00e+00 797.00
IUUC-Gma-042832 Glycine max 39.31 2.00e-105 377.00
IUUC-Ggo-044875 Gorilla gorilla 83.11 0.00e+00 1635.00
IUUC-Hsa-046992 Homo sapiens 90.96 0.00e+00 1798.00
IUUC-Hvu-047408 Hordeum vulgare 39.06 9.00e-104 371.00
IUUC-Itr-047881 Ictidomys tridecemlineatus 96.56 0.00e+00 1094.00
IUUC-Kpa-049212 Komagataella pastoris 43.21 1.00e-127 450.00
IUUC-Lpe-050987 Leersia perrieri 37.92 1.00e-101 364.00
IUUC-Loc-052272 Lepisosteus oculatus 53.44 0.00e+00 1004.00
IUUC-Lma-053118 Leptosphaeria maculans 42.67 2.00e-123 437.00
IUUC-Laf-053436 Loxodonta africana 89.48 0.00e+00 1736.00
IUUC-Mcc-055209 Macaca mulatta 93.67 0.00e+00 1626.00
IUUC-Mor-056994 Magnaporthe oryzae 33.82 3.00e-93 336.00
IUUC-Mpo-057305 Magnaporthe poae 35.00 1.00e-96 348.00
IUUC-Mtr-058432 Medicago truncatula 39.78 2.00e-104 373.00
IUUC-Mla-058972 Melampsora laricipopulina 38.95 1.00e-122 433.00
IUUC-Mga-059572 Meleagris gallopavo 63.78 0.00e+00 1218.00
IUUC-Mvi-060209 Microbotryum violaceum 39.94 4.00e-141 496.00
IUUC-Mmr-061416 Microcebus murinus 91.61 0.00e+00 1112.00
IUUC-Mdo-062869 Monodelphis domestica 79.15 0.00e+00 1590.00
IUUC-Mac-064963 Musa acuminata 35.22 2.00e-95 343.00
IUUC-Mpu-065755 Mustela putorius furo 90.28 0.00e+00 1797.00
IUUC-Mlu-067604 Myotis lucifugus 88.05 0.00e+00 1744.00
IUUC-Nfi-068310 Neosartorya fischeri 43.76 1.00e-131 464.00
IUUC-Ncr-068841 Neurospora crassa 33.63 2.00e-110 394.00
IUUC-Nle-069227 Nomascus leucogenys 91.06 0.00e+00 1799.00
IUUC-Opr-071088 Ochotona princeps 84.45 0.00e+00 1299.00
IUUC-Ont-072291 Oreochromis niloticus 65.83 0.00e+00 820.00
IUUC-Oan-073460 Ornithorhynchus anatinus 82.37 0.00e+00 1348.00
IUUC-Ocu-074811 Oryctolagus cuniculus 92.30 0.00e+00 1755.00
IUUC-Oba-075463 Oryza barthii 37.63 1.00e-101 363.00
IUUC-Obr-076342 Oryza brachyantha 37.63 2.00e-104 373.00
IUUC-Ogu-078837 Oryza glumaepatula 37.63 4.00e-102 365.00
IUUC-Oin-079623 Oryza indica 38.49 4.00e-102 366.00
IUUC-Ome-081105 Oryza meridionalis 37.63 2.00e-102 367.00
IUUC-Oni-082598 Oryza nivara 37.63 5.00e-102 365.00
IUUC-Opu-084040 Oryza punctata 37.63 5.00e-102 365.00
IUUC-Oru-084219 Oryza rufipogon 38.49 2.00e-102 367.00
IUUC-Osa-085461 Oryza sativa 37.63 3.00e-102 366.00
IUUC-Ola-087307 Oryzias latipes 66.77 0.00e+00 796.00
IUUC-Olu-087812 Ostreococcus lucimarinus 38.79 5.00e-99 355.00
IUUC-Oga-089064 Otolemur garnettii 90.09 0.00e+00 1775.00
IUUC-Oar-090054 Ovis aries 90.96 0.00e+00 1774.00
IUUC-Ptr-091228 Pan troglodytes 91.24 0.00e+00 1804.00
IUUC-Pan-092769 Papio anubis 90.81 0.00e+00 1681.00
IUUC-Psi-093202 Pelodiscus sinensis 70.80 0.00e+00 1366.00
IUUC-Pma-094725 Petromyzon marinus 52.60 0.00e+00 890.00
IUUC-Pno-095130 Phaeosphaeria nodorum 41.35 3.00e-109 389.00
IUUC-Ppa-095559 Physcomitrella patens 40.45 1.00e-107 384.00
IUUC-Pfo-096546 Poecilia formosa 66.15 0.00e+00 831.00
IUUC-Pab-097698 Pongo abelii 91.83 0.00e+00 1792.00
IUUC-Pop-099986 Populus trichocarpa 39.43 2.00e-105 376.00
IUUC-Ppe-101649 Prunus persica 39.74 3.00e-103 369.00
IUUC-Pva-102138 Pteropus vampyrus 88.74 0.00e+00 1734.00
IUUC-Pgr-103272 Puccinia graminis 35.70 6.00e-121 428.00
IUUC-Ptt-103880 Puccinia triticina 35.91 6.00e-127 449.00
IUUC-Pte-104260 Pyrenophora teres 42.53 1.00e-116 414.00
IUUC-Pyt-104532 Pyrenophora triticirepentis 40.00 2.00e-70 261.00
IUUC-Rno-105903 Rattus norvegicus 96.58 0.00e+00 1815.00
IUUC-Sce-106399 Saccharomyces cerevisiae 44.86 4.00e-126 446.00
IUUC-Sha-106783 Sarcophilus harrisii 77.57 0.00e+00 1508.00
IUUC-Sja-107887 Schizosaccharomyces japonicus 41.16 4.00e-142 499.00
IUUC-Spo-108154 Schizosaccharomyces pombe 42.50 3.00e-146 513.00
IUUC-Smo-108759 Selaginella moellendorffii 40.30 2.00e-104 372.00
IUUC-Sit-110023 Setaria italica 38.11 3.00e-101 363.00
IUUC-Sly-111423 Solanum lycopersicum 38.92 8.00e-104 371.00
IUUC-Sbi-114688 Sorghum bicolor 37.92 2.00e-103 370.00
IUUC-Sre-114983 Sporisorium reilianum 36.61 2.00e-113 404.00
IUUC-Ssc-116030 Sus scrofa 88.53 0.00e+00 1769.00
IUUC-Tgu-117451 Taeniopygia guttata 76.37 0.00e+00 1182.00
IUUC-Tru-118600 Takifugu rubripes 55.16 0.00e+00 843.00
IUUC-Tsy-119130 Tarsius syrichta 81.92 0.00e+00 1467.00
IUUC-Tni-119758 Tetraodon nigroviridis 56.81 0.00e+00 880.00
IUUC-Tca-121797 Theobroma cacao 39.89 4.00e-106 379.00
IUUC-Tre-121883 Trichoderma reesei 40.56 6.00e-102 365.00
IUUC-Tvi-122333 Trichoderma virens 40.15 1.00e-109 391.00
IUUC-Tae-122848 Triticum aestivum 37.75 1.00e-101 364.00
IUUC-Tur-126594 Triticum urartu 37.75 4.00e-101 362.00
IUUC-Tme-127106 Tuber melanosporum 42.70 3.00e-125 443.00
IUUC-Tbe-127911 Tupaia belangeri 96.63 0.00e+00 989.00
IUUC-Ttr-128597 Tursiops truncatus 89.29 0.00e+00 1731.00
IUUC-Uma-129321 Ustilago maydis 36.32 2.00e-111 397.00
IUUC-Vpa-130686 Vicugna pacos 83.20 0.00e+00 1556.00
IUUC-Vvi-131046 Vitis vinifera 39.01 1.00e-105 377.00
IUUC-Xtr-132740 Xenopus tropicalis 64.58 0.00e+00 1132.00
IUUC-Xma-134260 Xiphophorus maculatus 65.83 0.00e+00 823.00
IUUC-Yli-134634 Yarrowia lipolytica 40.54 2.00e-137 483.00
IUUC-Zma-135493 Zea mays 37.92 1.00e-102 368.00
Created Date 25-Jun-2017

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