iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050602

Ensembl Protein ID

ENSLACP00000011836.1

UniProt Accession

H3AQB5; H3AQB5_LATCH

Genbank Protein ID

ENSLACP00000011836

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AFYH01015728

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000010416.1	ENSLACT00000011926.1	ENSLACP00000011836.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.90e-48	163.0	79	268

Active Site

Position(s)	Description	Evidence
86	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
89	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
262		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs.........................................................llgvfdddslsda 33
           +i+kt++DGnC++rA+++s                                                         ll+ f+++s+sd+
   Q: 79   YIRKTRPDGNCFYRAFGFShlealledskelqkykteamnkiaeradqnkkkcplpfhgkfmdlielvekqasvtdLLNAFNEQSISDY 167
           89*************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+L+++i v+++d++e   gg +++++fpe + ++
   Q: 168  LVVYLRLLTSGYLQRESHFFEHFIEGGRTVKEFCQQEVEPMSKeSDHIHIIALAQALNVSILVEYMDRGE---GGSTNHHIFPEGS-DP 252
           *********************************************************************9...9************.** PP
   S: 122  pivLlYrsgHYdaLva 137
           +++LlYr+gHYd+L++
   Q: 253  KVYLLYRPGHYDILYK 268
           **************96 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

FDPVENVKEL FPCFCFSGVN CLAYDEAIMA QQDRIQQEIA TMNPLVSARL ELSVLYKEYA 60
QDDHVYQQKI KDLHKKYAYI RKTRPDGNCF YRAFGFSHLE ALLEDSKELQ KYKTEAMNKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGATCCCG TAGAAAATGT GAAGGAGTTG TTTCCTTGCT TTTGTTTTTC AGGAGTGAAC 60
TGCCTGGCAT ACGATGAGGC TATCATGGCA CAACAGGATC GCATTCAGCA GGAGGTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	81.03	6.00e-119	420.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	1.00e-17	80.50
IUUC-Aca-004648	Anolis carolinensis	77.04	7.00e-113	399.00
IUUC-Aly-005710	Arabidopsis lyrata	39.26	2.00e-45	176.00
IUUC-Ath-007112	Arabidopsis thaliana	39.11	2.00e-44	172.00
IUUC-Afl-008439	Aspergillus flavus	29.17	3.00e-07	48.50
IUUC-Ame-010662	Astyanax mexicanus	77.38	2.00e-115	407.00
IUUC-Bta-013533	Bos taurus	80.16	7.00e-118	416.00
IUUC-Bol-016100	Brassica oleracea	37.41	2.00e-43	169.00
IUUC-Bra-017705	Brassica rapa	35.37	2.00e-36	145.00
IUUC-Cel-018295	Caenorhabditis elegans	34.73	1.00e-33	136.00
IUUC-Cja-019190	Callithrix jacchus	81.35	5.00e-119	420.00
IUUC-Cfa-020430	Canis familiaris	80.47	2.00e-119	421.00
IUUC-Cpo-022355	Cavia porcellus	80.95	3.00e-119	420.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	35.66	2.00e-38	152.00
IUUC-Csa-023286	Chlorocebus sabaeus	78.54	9.00e-117	412.00
IUUC-Cin-025507	Ciona intestinalis	39.44	1.00e-37	149.00
IUUC-Csv-026273	Ciona savignyi	46.12	1.00e-60	226.00
IUUC-Dre-028315	Danio rerio	73.81	1.00e-108	385.00
IUUC-Dno-029165	Dasypus novemcinctus	78.50	3.00e-90	323.00
IUUC-Dor-030943	Dipodomys ordii	80.95	3.00e-119	420.00
IUUC-Dme-031922	Drosophila melanogaster	50.59	1.00e-67	249.00
IUUC-Ete-032296	Echinops telfairi	86.57	1.00e-66	246.00
IUUC-Eca-033695	Equus caballus	80.56	6.00e-118	416.00
IUUC-Fca-036441	Felis catus	80.00	1.00e-119	422.00
IUUC-Gmo-038908	Gadus morhua	75.00	9.00e-112	395.00
IUUC-Ggr-040020	Gaeumannomyces graminis	30.18	5.00e-28	119.00
IUUC-Gga-040460	Gallus gallus	74.21	7.00e-108	382.00
IUUC-Gac-042417	Gasterosteus aculeatus	74.80	6.00e-111	393.00
IUUC-Gma-043712	Glycine max	39.78	1.00e-45	176.00
IUUC-Ggo-044552	Gorilla gorilla	88.06	3.00e-67	247.00
IUUC-Hsa-046766	Homo sapiens	81.35	3.00e-119	421.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	80.95	3.00e-119	420.00
IUUC-Laf-053705	Loxodonta africana	80.95	3.00e-119	420.00
IUUC-Mcc-055745	Macaca mulatta	75.93	1.00e-115	409.00
IUUC-Meu-056569	Macropus eugenii	70.63	3.00e-99	354.00
IUUC-Mtr-057712	Medicago truncatula	40.37	5.00e-44	171.00
IUUC-Mvi-060358	Microbotryum violaceum	33.13	3.00e-13	68.90
IUUC-Mmr-061123	Microcebus murinus	80.19	2.00e-96	344.00
IUUC-Mdo-062613	Monodelphis domestica	76.89	3.00e-95	340.00
IUUC-Mmu-063658	Mus musculus	80.95	3.00e-119	420.00
IUUC-Mac-065274	Musa acuminata	35.63	9.00e-35	140.00
IUUC-Mpu-066172	Mustela putorius furo	81.35	3.00e-119	421.00
IUUC-Mlu-066966	Myotis lucifugus	81.75	1.00e-119	422.00
IUUC-Nle-069519	Nomascus leucogenys	88.06	2.00e-67	249.00
IUUC-Ont-071901	Oreochromis niloticus	75.30	7.00e-112	396.00
IUUC-Oni-082026	Oryza nivara	29.41	1.00e-14	73.90
IUUC-Oru-084761	Oryza rufipogon	29.41	1.00e-14	73.90
IUUC-Ola-087331	Oryzias latipes	67.89	2.00e-74	271.00
IUUC-Oga-088064	Otolemur garnettii	81.35	3.00e-119	421.00
IUUC-Oar-089251	Ovis aries	78.46	1.00e-116	412.00
IUUC-Ptr-091430	Pan troglodytes	81.35	5.00e-119	420.00
IUUC-Psi-093823	Pelodiscus sinensis	76.47	1.00e-110	392.00
IUUC-Pma-094366	Petromyzon marinus	68.55	3.00e-88	317.00
IUUC-Pfo-096734	Poecilia formosa	75.70	1.00e-102	365.00
IUUC-Pab-097919	Pongo abelii	79.72	7.00e-95	339.00
IUUC-Pop-099401	Populus trichocarpa	39.13	6.00e-43	167.00
IUUC-Ppe-101977	Prunus persica	40.15	2.00e-45	176.00
IUUC-Pva-102499	Pteropus vampyrus	81.27	2.00e-118	417.00
IUUC-Rno-105233	Rattus norvegicus	80.95	3.00e-119	420.00
IUUC-Sha-107081	Sarcophilus harrisii	80.95	2.00e-118	418.00
IUUC-Sly-111640	Solanum lycopersicum	39.48	7.00e-41	160.00
IUUC-Ssc-116202	Sus scrofa	81.35	3.00e-119	421.00
IUUC-Tru-117664	Takifugu rubripes	71.98	1.00e-107	382.00
IUUC-Tca-121467	Theobroma cacao	38.97	6.00e-44	171.00
IUUC-Tur-126493	Triticum urartu	35.29	6.30e-01	27.70
IUUC-Tbe-128116	Tupaia belangeri	88.06	2.00e-67	249.00
IUUC-Ttr-128622	Tursiops truncatus	80.56	8.00e-117	412.00
IUUC-Vvi-131389	Vitis vinifera	40.07	8.00e-45	173.00
IUUC-Xma-134191	Xiphophorus maculatus	75.30	2.00e-102	365.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence