iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131951

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

OTU deubiquitinase, ubiquitin aldehyde-binding 2; Otub2 protein

Genbank Nucleotide ID

AAMC01020693

Gene Name

otub2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000010313.3	ENSXETT00000022703.3	ENSXETP00000022703.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.30e-33	116.5	39	227

Active Site

Position(s)	Description	Evidence
45	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
48	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
221		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsda 33
           ++kt++DG+C++r + ++                                                          ll  f++++ sd 
   Q: 39   VRKTRADGSCFYRGLCFAylefllgkqqeilrfkhlvvqsksevvmagfqehlfkhhyetflsivemaeldgsissLLTAFNQQCSSDS 127
           799************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           +v+++r+ +s+yl+++++f+++fi e++++ +fc + ve++a  +++i+i+aL q+L++p++v++vd+ e     ++++++fpe    +
   Q: 128  VVQYVRLVASAYLRNRAEFYQHFIREGMTVVDFCAQNVEQMAMeCDHIQIIALTQALEIPLQVEYVDKTE----NVINHHIFPEGC-SP 211
           *********************************************************************8....5***********.** PP
   S: 122  pivLlYrsgHYdaLva 137
           ++ +l+ ++H+++L++
   Q: 212  SVFMLFLEHHFNILYR 227
           **************97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSEEFISEKF DLALLIEENS KVSVYQRKLK DLQNQYHSVR KTRADGSCFY RGLCFAYLEF 60
LLGKQQEILR FKHLVVQSKS EVVMAGFQEH LFKHHYETFL SIVEMAELDG SISSLLTAFN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGACACGGA GCTGAGAGAC AATGGTGAGT GTACTGTAAG GTGTAGAGAG AAAGGCAGGA 60
TACCGAAGCA GGGCTTAGAG TAGCGGCCAT TTCATTTTGC TGAGCCACTT ACGTTATTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

xtr:100124322

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	52.04	3.00e-72	264.00
IUUC-Apl-003233	Anas platyrhynchos	29.23	4.00e-06	42.00
IUUC-Aca-004648	Anolis carolinensis	41.67	7.00e-49	186.00
IUUC-Aly-005710	Arabidopsis lyrata	31.10	3.00e-29	122.00
IUUC-Ath-007112	Arabidopsis thaliana	32.11	1.00e-28	120.00
IUUC-Ame-010740	Astyanax mexicanus	45.33	5.00e-56	210.00
IUUC-Bta-012766	Bos taurus	52.94	4.00e-73	267.00
IUUC-Bol-016100	Brassica oleracea	32.89	8.00e-28	117.00
IUUC-Bra-017705	Brassica rapa	31.52	8.00e-26	110.00
IUUC-Cel-018295	Caenorhabditis elegans	25.33	2.00e-24	105.00
IUUC-Cja-019480	Callithrix jacchus	49.78	1.00e-70	259.00
IUUC-Cfa-021106	Canis familiaris	52.04	2.00e-72	265.00
IUUC-Cpo-022187	Cavia porcellus	53.39	8.00e-73	266.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	31.87	9.00e-28	117.00
IUUC-Csa-023493	Chlorocebus sabaeus	51.13	5.00e-71	260.00
IUUC-Cho-024411	Choloepus hoffmanni	40.91	3.00e-41	160.00
IUUC-Cin-025507	Ciona intestinalis	34.00	3.00e-22	98.20
IUUC-Csv-026273	Ciona savignyi	36.62	1.00e-36	146.00
IUUC-Dre-027843	Danio rerio	46.67	4.00e-58	218.00
IUUC-Dno-029346	Dasypus novemcinctus	53.39	1.00e-73	268.00
IUUC-Dor-031012	Dipodomys ordii	51.58	8.00e-72	262.00
IUUC-Dme-031922	Drosophila melanogaster	37.28	8.00e-41	160.00
IUUC-Ete-032266	Echinops telfairi	50.23	1.00e-68	252.00
IUUC-Eca-033356	Equus caballus	52.25	6.00e-72	263.00
IUUC-Eeu-034775	Erinaceus europaeus	53.39	6.00e-73	266.00
IUUC-Fca-035363	Felis catus	51.57	2.00e-72	264.00
IUUC-Gmo-038908	Gadus morhua	43.86	4.00e-53	201.00
IUUC-Ggr-040020	Gaeumannomyces graminis	26.69	1.00e-18	88.20
IUUC-Gga-040460	Gallus gallus	42.67	8.00e-52	196.00
IUUC-Gac-042417	Gasterosteus aculeatus	45.18	1.00e-55	209.00
IUUC-Gma-043712	Glycine max	33.33	5.00e-30	124.00
IUUC-Ggo-045023	Gorilla gorilla	51.13	5.00e-71	260.00
IUUC-Hsa-046984	Homo sapiens	51.13	5.00e-71	259.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	53.39	6.00e-73	266.00
IUUC-Lch-050514	Latimeria chalumnae	51.57	6.00e-70	256.00
IUUC-Loc-052003	Lepisosteus oculatus	40.43	1.00e-50	192.00
IUUC-Laf-054382	Loxodonta africana	53.39	2.00e-73	268.00
IUUC-Mcc-055516	Macaca mulatta	51.13	4.00e-71	260.00
IUUC-Meu-056038	Macropus eugenii	54.01	1.00e-62	231.00
IUUC-Mtr-057712	Medicago truncatula	34.54	4.00e-28	118.00
IUUC-Mvi-060358	Microbotryum violaceum	29.57	4.00e-09	55.10
IUUC-Mmr-060918	Microcebus murinus	52.04	2.00e-72	264.00
IUUC-Mdo-062638	Monodelphis domestica	52.04	2.00e-70	258.00
IUUC-Mmu-063973	Mus musculus	52.00	1.00e-71	263.00
IUUC-Mac-065274	Musa acuminata	29.29	3.00e-23	102.00
IUUC-Mpu-066013	Mustela putorius furo	52.04	1.00e-72	265.00
IUUC-Mlu-067509	Myotis lucifugus	51.13	2.00e-69	254.00
IUUC-Nle-069673	Nomascus leucogenys	51.13	5.00e-71	259.00
IUUC-Opr-070761	Ochotona princeps	44.10	1.00e-38	152.00
IUUC-Ont-071901	Oreochromis niloticus	44.30	7.00e-55	207.00
IUUC-Oan-072922	Ornithorhynchus anatinus	52.94	4.00e-71	260.00
IUUC-Ocu-074643	Oryctolagus cuniculus	51.97	2.00e-72	265.00
IUUC-Oni-082026	Oryza nivara	25.33	1.00e-08	54.30
IUUC-Oru-084761	Oryza rufipogon	25.33	1.00e-08	54.30
IUUC-Ola-086603	Oryzias latipes	40.43	2.00e-50	191.00
IUUC-Oga-088936	Otolemur garnettii	52.49	1.00e-72	265.00
IUUC-Oar-089460	Ovis aries	52.94	7.00e-73	266.00
IUUC-Ptr-090805	Pan troglodytes	51.58	3.00e-71	261.00
IUUC-Pan-091969	Papio anubis	51.13	5.00e-71	259.00
IUUC-Psi-093823	Pelodiscus sinensis	39.91	8.00e-48	183.00
IUUC-Pma-094366	Petromyzon marinus	45.58	6.00e-56	210.00
IUUC-Pfo-096734	Poecilia formosa	43.42	2.00e-46	178.00
IUUC-Pab-098476	Pongo abelii	51.13	2.00e-70	258.00
IUUC-Pop-099401	Populus trichocarpa	31.12	7.00e-27	114.00
IUUC-Pca-100252	Procavia capensis	45.65	1.00e-22	99.40
IUUC-Ppe-101977	Prunus persica	34.94	3.00e-31	129.00
IUUC-Pva-102204	Pteropus vampyrus	52.04	1.00e-72	265.00
IUUC-Rno-105062	Rattus norvegicus	52.23	1.00e-72	265.00
IUUC-Sha-106968	Sarcophilus harrisii	52.04	3.00e-70	258.00
IUUC-Sly-111640	Solanum lycopersicum	35.93	5.00e-29	121.00
IUUC-Sar-113295	Sorex araneus	52.94	2.00e-71	261.00
IUUC-Ssc-115288	Sus scrofa	52.70	2.00e-72	265.00
IUUC-Tru-117664	Takifugu rubripes	43.35	3.00e-52	197.00
IUUC-Tni-120440	Tetraodon nigroviridis	37.50	3.00e-36	144.00
IUUC-Tca-121467	Theobroma cacao	33.20	1.00e-30	127.00
IUUC-Tbe-128116	Tupaia belangeri	45.34	5.00e-39	154.00
IUUC-Ttr-128622	Tursiops truncatus	44.44	3.00e-56	211.00
IUUC-Uma-129443	Ustilago maydis	32.76	4.00e-18	85.10
IUUC-Vvi-131389	Vitis vinifera	33.60	1.00e-31	130.00
IUUC-Xma-134191	Xiphophorus maculatus	43.86	4.00e-47	181.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence