iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132146

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-protein ligase E3B; HECT-type ubiquitin transferase E3B

Genbank Nucleotide ID

BC124027

Gene Name

ube3b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000018590.3	ENSXETT00000040243.2	ENSXETP00000040243.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-113	378.7	707	1072

Active Site

Position(s)	Description	Evidence
1040	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           ++++k +++v+fv+     E+g+d++Gv++efl++++k++++p l+lf++++++++  +p+p+s++++ ++l+lFef+G++lgka++
   Q: 707  QNAMKGVIRVKFVNdlgvdEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSSGDRL-YPSPTSYIHE-NYLQLFEFVGKMLGKAVY 791
           67899*******************************************999988876.9*******76.****************** PP
   S: 84   dgrlldlplsksfyklllgk.....klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           +g ++d+p++++f+++llg+       s+++l+++d+e+yk+l++ik++ + di++lgl+l++  +e+++g+  ++eL+pgG++ipV
   Q: 792  EGIVVDVPFASFFLSQLLGHhhsifYSSVDELPSLDSEFYKNLTSIKRY-DGDISDLGLTLSY--DEDVMGQLVCHELVPGGKSIPV 875
           ********************777777999********************.7799998777776..5999****************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwe 251
           tneNk +Y++l++++r++++ik+q+ af +Gf+++i +e++++F++ el+ li+G+ +eid++dlkk+t y gg++ ++++i+w+w+
   Q: 876  TNENKISYIHLMAHFRMHTQIKNQTVAFISGFRSIIRPEWIRMFSAPELQRLISGDnAEIDLDDLKKHTVYYGGFHGSHRVIIWLWD 962
           ********************************************************9****************************** PP
   S: 252  vl.eefsseerkafLqFvTgssrlPlgGfaelk........................prlfvirkdasddrlPssnTCfnyLkLPeY 313
           +l ++fssee+++fL+FvT++sr Pl Gfa+lk                        + +f+irk++   rlP+s+TCfn+LkLP+Y
   Q: 963  ILaNDFSSEEKAMFLKFVTSCSRPPLLGFAYLKppfsircvevsddqdtgdtlgsvlRGFFTIRKKEPGGRLPTSSTCFNLLKLPNY 1049
           **99*************************************************************9999****************** PP
   S: 314  sskeilkekLlyAieetkgFels 336
           s+k il+ekL+yAi++++gFels
   Q: 1050 SKKGILREKLRYAISMNTGFELS 1072
           ********************985 PP

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MFGATQVSKA QFLDKARQAR EERKGLKERD RAAIKIQALI RRFLCRCRLQ KEIRQEVDDF 60
LEGTEKGSVK ANALSIFRIS RKLLIIFQIS QDRMRFEKLC RCILNSMEND NEPKVWFVSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGGCCCT ATAAGGTCAG GTATCCTCCA ACCTTAAGAC TTGCAACTTT TGTTTACATT 60
GTGAGATAAT TATTATCGAC ATAAAGGTTA ATGTTCCTTT AAAAAGCCAG TCTATTGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS
IPR027401--Myosin-like_IQ_dom

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT
PF00612--IQ

SMART

SM00119--HECTc
SM00015--IQ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

xtr:780337

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000128	Aegilops tauschii	39.32	7.00e-105	375.00
IUUC-Aml-002107	Ailuropoda melanoleuca	84.14	0.00e+00	1847.00
IUUC-Atr-003017	Amborella trichopoda	38.30	1.00e-109	390.00
IUUC-Apl-003328	Anas platyrhynchos	88.00	0.00e+00	1840.00
IUUC-Aly-005794	Arabidopsis lyrata	39.46	7.00e-110	392.00
IUUC-Ath-007269	Arabidopsis thaliana	39.82	2.00e-112	400.00
IUUC-Bta-013547	Bos taurus	83.96	0.00e+00	1860.00
IUUC-Bdi-014502	Brachypodium distachyon	38.79	4.00e-108	386.00
IUUC-Bol-015093	Brassica oleracea	40.00	3.00e-112	400.00
IUUC-Bra-016722	Brassica rapa	40.36	5.00e-114	405.00
IUUC-Cel-018447	Caenorhabditis elegans	38.98	0.00e+00	687.00
IUUC-Cja-019855	Callithrix jacchus	83.68	0.00e+00	1834.00
IUUC-Cfa-020066	Canis familiaris	83.57	0.00e+00	1824.00
IUUC-Cpo-021504	Cavia porcellus	83.58	0.00e+00	1865.00
IUUC-Csa-023579	Chlorocebus sabaeus	83.86	0.00e+00	1840.00
IUUC-Cho-024430	Choloepus hoffmanni	73.40	0.00e+00	1326.00
IUUC-Cin-025750	Ciona intestinalis	46.17	0.00e+00	951.00
IUUC-Csv-026016	Ciona savignyi	47.38	0.00e+00	1010.00
IUUC-Dre-028271	Danio rerio	82.84	0.00e+00	1786.00
IUUC-Dno-029054	Dasypus novemcinctus	84.70	0.00e+00	1858.00
IUUC-Dor-030938	Dipodomys ordii	77.15	0.00e+00	1657.00
IUUC-Dme-031602	Drosophila melanogaster	47.61	0.00e+00	941.00
IUUC-Ete-033041	Echinops telfairi	68.40	0.00e+00	1216.00
IUUC-Eca-034411	Equus caballus	84.14	0.00e+00	1826.00
IUUC-Eeu-035201	Erinaceus europaeus	81.25	0.00e+00	778.00
IUUC-Fca-036594	Felis catus	83.02	0.00e+00	1806.00
IUUC-Fal-037317	Ficedula albicollis	84.48	0.00e+00	1866.00
IUUC-Gmo-039412	Gadus morhua	78.46	0.00e+00	1759.00
IUUC-Gga-040149	Gallus gallus	88.06	0.00e+00	1889.00
IUUC-Gac-042088	Gasterosteus aculeatus	81.95	0.00e+00	1843.00
IUUC-Gma-043839	Glycine max	40.14	1.00e-112	400.00
IUUC-Ggo-045279	Gorilla gorilla	83.68	0.00e+00	1833.00
IUUC-Hsa-045660	Homo sapiens	83.30	0.00e+00	1828.00
IUUC-Hvu-047102	Hordeum vulgare	39.08	4.00e-104	372.00
IUUC-Itr-048021	Ictidomys tridecemlineatus	75.00	0.00e+00	860.00
IUUC-Lch-050664	Latimeria chalumnae	85.18	0.00e+00	1861.00
IUUC-Lpe-050755	Leersia perrieri	36.75	4.00e-97	349.00
IUUC-Loc-052791	Lepisosteus oculatus	83.64	0.00e+00	1804.00
IUUC-Laf-053902	Loxodonta africana	84.79	0.00e+00	1858.00
IUUC-Mcc-054730	Macaca mulatta	83.77	0.00e+00	1840.00
IUUC-Meu-056527	Macropus eugenii	78.19	0.00e+00	1657.00
IUUC-Mtr-057671	Medicago truncatula	40.14	3.00e-112	399.00
IUUC-Mga-059260	Meleagris gallopavo	87.90	0.00e+00	1889.00
IUUC-Mmr-060804	Microcebus murinus	82.84	0.00e+00	1789.00
IUUC-Mdo-062575	Monodelphis domestica	83.49	0.00e+00	1783.00
IUUC-Mmu-063636	Mus musculus	81.81	0.00e+00	1761.00
IUUC-Mac-064989	Musa acuminata	39.18	6.00e-107	382.00
IUUC-Mpu-066677	Mustela putorius furo	83.25	0.00e+00	1716.00
IUUC-Mlu-067952	Myotis lucifugus	83.77	0.00e+00	1783.00
IUUC-Nle-069153	Nomascus leucogenys	83.68	0.00e+00	1832.00
IUUC-Opr-070554	Ochotona princeps	85.70	0.00e+00	1720.00
IUUC-Ont-071372	Oreochromis niloticus	82.46	0.00e+00	1819.00
IUUC-Oan-073327	Ornithorhynchus anatinus	71.08	0.00e+00	748.00
IUUC-Ocu-074183	Oryctolagus cuniculus	83.02	0.00e+00	1821.00
IUUC-Oba-075213	Oryza barthii	39.02	5.00e-106	379.00
IUUC-Obr-076320	Oryza brachyantha	39.20	1.00e-108	387.00
IUUC-Ogl-077093	Oryza glaberrima	39.20	1.00e-108	387.00
IUUC-Ogu-078947	Oryza glumaepatula	37.79	1.00e-110	394.00
IUUC-Oin-080058	Oryza indica	39.20	7.00e-108	385.00
IUUC-Olo-080742	Oryza longistaminata	38.85	7.00e-107	382.00
IUUC-Ome-081741	Oryza meridionalis	38.69	1.00e-100	360.00
IUUC-Oni-082385	Oryza nivara	37.79	1.00e-110	394.00
IUUC-Opu-083529	Oryza punctata	39.20	2.00e-108	387.00
IUUC-Oru-085128	Oryza rufipogon	37.66	4.00e-95	343.00
IUUC-Osa-085557	Oryza sativa	39.20	1.00e-107	384.00
IUUC-Ola-087337	Oryzias latipes	82.00	0.00e+00	1758.00
IUUC-Oga-088342	Otolemur garnettii	83.60	0.00e+00	1767.00
IUUC-Oar-090234	Ovis aries	83.41	0.00e+00	1834.00
IUUC-Ptr-091661	Pan troglodytes	83.49	0.00e+00	1831.00
IUUC-Pan-092728	Papio anubis	83.60	0.00e+00	1833.00
IUUC-Psi-093251	Pelodiscus sinensis	86.92	0.00e+00	1750.00
IUUC-Pma-094195	Petromyzon marinus	69.32	0.00e+00	1449.00
IUUC-Ppa-095544	Physcomitrella patens	38.03	5.00e-111	395.00
IUUC-Pfo-097472	Poecilia formosa	82.74	0.00e+00	1830.00
IUUC-Pab-098570	Pongo abelii	83.58	0.00e+00	1831.00
IUUC-Pca-100110	Procavia capensis	73.41	0.00e+00	1534.00
IUUC-Ppe-101281	Prunus persica	39.12	4.00e-107	382.00
IUUC-Pva-102887	Pteropus vampyrus	79.78	0.00e+00	1707.00
IUUC-Rno-106028	Rattus norvegicus	79.22	0.00e+00	1664.00
IUUC-Sha-107331	Sarcophilus harrisii	84.06	0.00e+00	1802.00
IUUC-Smo-109488	Selaginella moellendorffii	37.48	5.00e-107	382.00
IUUC-Sit-109811	Setaria italica	38.90	2.00e-107	384.00
IUUC-Sly-111362	Solanum lycopersicum	35.91	1.00e-100	361.00
IUUC-Sar-113287	Sorex araneus	70.07	2.00e-166	579.00
IUUC-Sbi-114433	Sorghum bicolor	39.22	8.00e-109	388.00
IUUC-Ssc-116103	Sus scrofa	84.98	0.00e+00	1837.00
IUUC-Tgu-117275	Taeniopygia guttata	87.13	0.00e+00	1867.00
IUUC-Tru-118681	Takifugu rubripes	81.25	0.00e+00	1832.00
IUUC-Tsy-118985	Tarsius syrichta	73.12	0.00e+00	841.00
IUUC-Tni-120850	Tetraodon nigroviridis	90.23	0.00e+00	771.00
IUUC-Tca-121770	Theobroma cacao	39.54	2.00e-111	397.00
IUUC-Tae-125466	Triticum aestivum	37.03	5.00e-107	382.00
IUUC-Tur-126086	Triticum urartu	39.68	1.00e-104	374.00
IUUC-Tbe-127461	Tupaia belangeri	79.57	0.00e+00	1674.00
IUUC-Ttr-129269	Tursiops truncatus	83.30	0.00e+00	1800.00
IUUC-Vpa-130523	Vicugna pacos	74.83	3.00e-116	412.00
IUUC-Vvi-131524	Vitis vinifera	38.86	5.00e-108	385.00
IUUC-Xma-133526	Xiphophorus maculatus	82.28	0.00e+00	1822.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence