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Tag Content
iUUCD ID IUUC-Mdo-062576
Ensembl Protein ID ENSMODP00000005127.4
UniProt Accession F6R9V6; F6R9V6_MONDO
Protein Name Histone-lysine N-methyltransferase
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMODG00000004162.4 ENSMODT00000005237.4 ENSMODP00000005127.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.60e-14 53.3 860 900
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 860  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WYCNDCR 900
           8*********....*******************....9***8.******8 PP
   
Organism Monodelphis domestica
Protein Sequence
(Fasta)
MNFSIRRNSP SLTQKIVSQL KMKQVPEILG NTNGKTQNCE VNRECSVFLS KAQISTTLPE 60
GVMQKFNGHE ALPFIPAEKL KDLTSRVFNG ESGAQDAKLR FESQEIKGIG TPPHTTPIKN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mdo-062576|E3,PHD|Monodelphis domestica
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTTAGAAT CTTAAAAAAC TTTTGATTTA TTTTTTTAAT TGTAGTGCTG TAATATTGGA 60
AGCATTTGGA CTGAATGAAC TTTAGCATTA GAAGAAATTC TCCATCATTA ACTCAGAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mdo-062576|E3,PHD|Monodelphis domestica
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
KEGG mdo:100022914
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000229 Aegilops tauschii 58.33 4.00e-04 41.60
IUUC-Aml-002181 Ailuropoda melanoleuca 84.26 0.00e+00 2233.00
IUUC-Apl-003677 Anas platyrhynchos 84.99 0.00e+00 2286.00
IUUC-Aca-004278 Anolis carolinensis 82.61 0.00e+00 1501.00
IUUC-Ame-011932 Astyanax mexicanus 72.23 0.00e+00 1057.00
IUUC-Bta-012522 Bos taurus 79.68 0.00e+00 2118.00
IUUC-Bdi-014781 Brachypodium distachyon 30.25 2.00e-12 67.80
IUUC-Bol-016001 Brassica oleracea 33.96 1.00e-15 79.30
IUUC-Bra-017864 Brassica rapa 33.33 1.00e-14 76.60
IUUC-Cja-018908 Callithrix jacchus 82.75 0.00e+00 2160.00
IUUC-Cfa-020894 Canis familiaris 83.36 0.00e+00 2277.00
IUUC-Cpo-021982 Cavia porcellus 81.67 0.00e+00 2198.00
IUUC-Csa-023807 Chlorocebus sabaeus 83.38 0.00e+00 2194.00
IUUC-Cho-024405 Choloepus hoffmanni 64.62 0.00e+00 655.00
IUUC-Csv-026298 Ciona savignyi 38.93 3.00e-57 215.00
IUUC-Dre-027492 Danio rerio 71.95 0.00e+00 1097.00
IUUC-Dno-030020 Dasypus novemcinctus 80.20 0.00e+00 1920.00
IUUC-Dor-031103 Dipodomys ordii 81.85 0.00e+00 1263.00
IUUC-Dme-032193 Drosophila melanogaster 36.13 2.00e-118 420.00
IUUC-Ete-032488 Echinops telfairi 76.40 0.00e+00 1973.00
IUUC-Eca-034066 Equus caballus 85.29 0.00e+00 2312.00
IUUC-Eeu-035199 Erinaceus europaeus 62.93 0.00e+00 675.00
IUUC-Fca-035434 Felis catus 79.16 0.00e+00 1841.00
IUUC-Fal-037113 Ficedula albicollis 86.44 0.00e+00 2356.00
IUUC-Gmo-039686 Gadus morhua 70.41 0.00e+00 1030.00
IUUC-Gga-040273 Gallus gallus 86.35 0.00e+00 2310.00
IUUC-Gac-042123 Gasterosteus aculeatus 69.06 0.00e+00 1078.00
IUUC-Ggo-044643 Gorilla gorilla 83.02 0.00e+00 2208.00
IUUC-Hsa-046380 Homo sapiens 83.20 0.00e+00 2180.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 87.34 0.00e+00 1389.00
IUUC-Lch-050217 Latimeria chalumnae 67.20 0.00e+00 1776.00
IUUC-Lpe-051201 Leersia perrieri 25.87 8.00e-12 65.50
IUUC-Loc-052766 Lepisosteus oculatus 59.43 0.00e+00 1315.00
IUUC-Laf-053780 Loxodonta africana 84.49 0.00e+00 2292.00
IUUC-Mcc-054928 Macaca mulatta 83.53 0.00e+00 2229.00
IUUC-Meu-056184 Macropus eugenii 79.93 0.00e+00 853.00
IUUC-Mga-059576 Meleagris gallopavo 82.93 0.00e+00 2231.00
IUUC-Mmr-061045 Microcebus murinus 83.48 0.00e+00 2273.00
IUUC-Mmu-063640 Mus musculus 81.72 0.00e+00 2176.00
IUUC-Mac-065303 Musa acuminata 28.04 2.00e-11 64.30
IUUC-Mpu-066512 Mustela putorius furo 84.18 0.00e+00 2246.00
IUUC-Mlu-067280 Myotis lucifugus 77.12 0.00e+00 1063.00
IUUC-Nle-069896 Nomascus leucogenys 83.35 0.00e+00 2107.00
IUUC-Ont-072197 Oreochromis niloticus 74.48 0.00e+00 1054.00
IUUC-Oan-072724 Ornithorhynchus anatinus 89.08 0.00e+00 1517.00
IUUC-Ocu-074758 Oryctolagus cuniculus 79.59 0.00e+00 2118.00
IUUC-Ogl-077641 Oryza glaberrima 26.74 8.00e-11 61.20
IUUC-Ogu-078030 Oryza glumaepatula 30.77 2.00e-13 69.70
IUUC-Oin-079557 Oryza indica 26.74 7.00e-11 61.20
IUUC-Olo-080702 Oryza longistaminata 41.47 8.00e-45 176.00
IUUC-Opu-083371 Oryza punctata 41.88 4.00e-46 180.00
IUUC-Osa-085353 Oryza sativa 26.74 7.00e-11 61.60
IUUC-Oga-088702 Otolemur garnettii 83.71 0.00e+00 1965.00
IUUC-Oar-089736 Ovis aries 73.89 0.00e+00 1842.00
IUUC-Ptr-091055 Pan troglodytes 83.05 0.00e+00 2180.00
IUUC-Pan-092752 Papio anubis 90.92 0.00e+00 1369.00
IUUC-Psi-093620 Pelodiscus sinensis 85.36 0.00e+00 2310.00
IUUC-Pfo-097464 Poecilia formosa 65.60 0.00e+00 1068.00
IUUC-Pab-098051 Pongo abelii 83.27 0.00e+00 2214.00
IUUC-Pop-099927 Populus trichocarpa 29.41 4.00e-13 70.50
IUUC-Pca-100273 Procavia capensis 83.89 0.00e+00 2239.00
IUUC-Ppe-101635 Prunus persica 28.02 2.00e-11 64.70
IUUC-Pva-102473 Pteropus vampyrus 72.14 0.00e+00 1786.00
IUUC-Rno-105056 Rattus norvegicus 81.70 0.00e+00 2184.00
IUUC-Sha-107494 Sarcophilus harrisii 97.46 0.00e+00 2536.00
IUUC-Sar-113310 Sorex araneus 81.77 0.00e+00 1724.00
IUUC-Sbi-114581 Sorghum bicolor 31.48 2.00e-09 56.20
IUUC-Ssc-116344 Sus scrofa 76.72 0.00e+00 2075.00
IUUC-Tgu-116786 Taeniopygia guttata 84.99 0.00e+00 2286.00
IUUC-Tru-117638 Takifugu rubripes 49.67 0.00e+00 1220.00
IUUC-Tsy-118937 Tarsius syrichta 88.14 0.00e+00 1457.00
IUUC-Tni-120452 Tetraodon nigroviridis 53.23 0.00e+00 1182.00
IUUC-Tae-125237 Triticum aestivum 28.77 5.00e-07 48.10
IUUC-Tbe-127291 Tupaia belangeri 79.31 0.00e+00 1409.00
IUUC-Ttr-129017 Tursiops truncatus 75.51 0.00e+00 1605.00
IUUC-Xtr-132673 Xenopus tropicalis 68.79 0.00e+00 1786.00
IUUC-Xma-133695 Xiphophorus maculatus 68.11 0.00e+00 1017.00
Created Date 25-Jun-2017

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