iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052685

Ensembl Protein ID

ENSLOCP00000010020.1

UniProt Accession

W5MNR1; W5MNR1_LEPOC

Genbank Protein ID

ENSLOCP00000010020

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01003392

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000008243.1	ENSLOCT00000010032.1	ENSLOCP00000010020.1
ENSLOCG00000008243.1	ENSLOCT00000010042.1	ENSLOCP00000010030.1
ENSLOCG00000008243.1	ENSLOCT00000010057.1	ENSLOCP00000010045.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-85	286.7	4476	4805

Active Site

Position(s)	Description	Evidence
4774	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4476 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakspLHMNMFRFLGVLLGIAIRTGSPL 4562
           4566****************************************9999*******999999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ +  e ++++l f+     +++++ +++  +++  ++t eN+ eYv+
   Q: 4563 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATAEEFEAMTLPFT-----VPNASGQDIQLSSKYSHITLENRAEYVR 4644
           ***************************************998999999999998.....7889999999****************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ p iqwFwev+e+fs++er+
   Q: 4645 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPTAPLIQWFWEVMESFSNTERS 4729
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys  ++l+ekL yAi+ +k++++
   Q: 4730 LFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCRQVLEEKLKYAIHFCKSIDT 4805
           *************.8*************999988888***********************************99875 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MPSPSFSLNA QSRFDSKWLK TDLQRIFSPD GLCELWNELV KDEEITCNGE ESAQPEDSVD 60
CVGSQKKDES NDKEKKEEEE ASTSVHHSII ETWDWGRQPD ESELKECLLV LVDDQQKLAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCTC CGTCTTTCTC CCTGAATGCC CAGTCAAGGT TTGATTCCAA ATGGCTGAAG 60
ACGGACTTGC AGGTAAGCGG GTTTTACAAG ATATTTTGTT TCCTCCCCTA CAGTGTGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	86.28	0.00e+00	6452.00
IUUC-Atr-003065	Amborella trichopoda	34.73	5.00e-51	196.00
IUUC-Apl-003983	Anas platyrhynchos	87.64	0.00e+00	7989.00
IUUC-Aca-004300	Anolis carolinensis	87.10	0.00e+00	7854.00
IUUC-Aly-006441	Arabidopsis lyrata	33.61	3.00e-44	173.00
IUUC-Ame-010621	Astyanax mexicanus	91.38	0.00e+00	7398.00
IUUC-Bta-013067	Bos taurus	84.49	0.00e+00	7658.00
IUUC-Bdi-014093	Brachypodium distachyon	34.02	7.00e-50	192.00
IUUC-Cja-019687	Callithrix jacchus	83.81	0.00e+00	7504.00
IUUC-Cfa-020672	Canis familiaris	84.78	0.00e+00	7720.00
IUUC-Cpo-021819	Cavia porcellus	82.37	0.00e+00	7443.00
IUUC-Csa-023817	Chlorocebus sabaeus	84.91	0.00e+00	7686.00
IUUC-Cho-024387	Choloepus hoffmanni	87.70	0.00e+00	1779.00
IUUC-Cin-025709	Ciona intestinalis	54.70	0.00e+00	2238.00
IUUC-Csv-026336	Ciona savignyi	42.06	0.00e+00	2938.00
IUUC-Dre-027717	Danio rerio	89.02	0.00e+00	7830.00
IUUC-Dno-029296	Dasypus novemcinctus	85.65	0.00e+00	7716.00
IUUC-Dor-030979	Dipodomys ordii	80.55	0.00e+00	2603.00
IUUC-Dme-032171	Drosophila melanogaster	70.83	0.00e+00	1274.00
IUUC-Ete-032687	Echinops telfairi	76.91	0.00e+00	2346.00
IUUC-Eca-034046	Equus caballus	84.06	0.00e+00	7636.00
IUUC-Eeu-034859	Erinaceus europaeus	89.59	0.00e+00	1859.00
IUUC-Fca-036262	Felis catus	85.10	0.00e+00	7727.00
IUUC-Fal-037562	Ficedula albicollis	87.53	0.00e+00	7928.00
IUUC-Gmo-039054	Gadus morhua	90.77	0.00e+00	1144.00
IUUC-Gga-040359	Gallus gallus	87.77	0.00e+00	7952.00
IUUC-Gac-041879	Gasterosteus aculeatus	93.62	0.00e+00	1065.00
IUUC-Ggo-044692	Gorilla gorilla	91.86	0.00e+00	4129.00
IUUC-Hsa-045995	Homo sapiens	84.85	0.00e+00	7717.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	79.65	0.00e+00	2065.00
IUUC-Lch-049808	Latimeria chalumnae	89.68	0.00e+00	3425.00
IUUC-Laf-053372	Loxodonta africana	84.65	0.00e+00	7636.00
IUUC-Mcc-054693	Macaca mulatta	84.91	0.00e+00	7712.00
IUUC-Meu-056660	Macropus eugenii	95.73	0.00e+00	1924.00
IUUC-Mga-059371	Meleagris gallopavo	88.89	0.00e+00	6984.00
IUUC-Mmr-060787	Microcebus murinus	85.04	0.00e+00	7757.00
IUUC-Mdo-062518	Monodelphis domestica	84.44	0.00e+00	7557.00
IUUC-Mmu-063690	Mus musculus	84.32	0.00e+00	7623.00
IUUC-Mpu-066478	Mustela putorius furo	84.33	0.00e+00	7641.00
IUUC-Mlu-067596	Myotis lucifugus	83.43	0.00e+00	4086.00
IUUC-Nle-069445	Nomascus leucogenys	80.48	0.00e+00	1792.00
IUUC-Opr-070990	Ochotona princeps	84.36	0.00e+00	2883.00
IUUC-Ont-072285	Oreochromis niloticus	90.70	0.00e+00	7989.00
IUUC-Oan-072721	Ornithorhynchus anatinus	85.57	0.00e+00	3430.00
IUUC-Ocu-074273	Oryctolagus cuniculus	84.12	0.00e+00	7615.00
IUUC-Oba-075573	Oryza barthii	33.94	7.00e-46	179.00
IUUC-Obr-076107	Oryza brachyantha	34.30	2.00e-50	194.00
IUUC-Ogl-077193	Oryza glaberrima	33.94	6.00e-46	179.00
IUUC-Ogu-078817	Oryza glumaepatula	33.94	7.00e-46	179.00
IUUC-Oin-079609	Oryza indica	33.00	2.00e-49	191.00
IUUC-Olo-080629	Oryza longistaminata	33.94	7.00e-46	179.00
IUUC-Ome-081686	Oryza meridionalis	33.94	3.00e-46	180.00
IUUC-Opu-084137	Oryza punctata	34.20	1.00e-46	181.00
IUUC-Oru-085013	Oryza rufipogon	33.94	7.00e-46	179.00
IUUC-Osa-085597	Oryza sativa	33.94	8.00e-46	179.00
IUUC-Ola-087346	Oryzias latipes	94.67	0.00e+00	1227.00
IUUC-Oga-088742	Otolemur garnettii	84.64	0.00e+00	7605.00
IUUC-Oar-090093	Ovis aries	84.55	0.00e+00	7648.00
IUUC-Ptr-091034	Pan troglodytes	82.11	0.00e+00	5225.00
IUUC-Pan-092783	Papio anubis	83.08	0.00e+00	7522.00
IUUC-Psi-094027	Pelodiscus sinensis	88.66	0.00e+00	7698.00
IUUC-Pfo-096208	Poecilia formosa	88.12	0.00e+00	6561.00
IUUC-Pab-097681	Pongo abelii	76.91	0.00e+00	2106.00
IUUC-Pca-100705	Procavia capensis	90.43	0.00e+00	1117.00
IUUC-Pva-103147	Pteropus vampyrus	74.48	0.00e+00	2106.00
IUUC-Rno-105458	Rattus norvegicus	84.17	0.00e+00	7620.00
IUUC-Sha-106959	Sarcophilus harrisii	79.12	0.00e+00	6710.00
IUUC-Sit-109917	Setaria italica	36.53	2.00e-48	187.00
IUUC-Sly-110961	Solanum lycopersicum	34.78	3.00e-53	203.00
IUUC-Sar-113532	Sorex araneus	80.79	0.00e+00	1744.00
IUUC-Sbi-114352	Sorghum bicolor	32.39	7.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	77.43	0.00e+00	2488.00
IUUC-Tgu-116789	Taeniopygia guttata	87.20	0.00e+00	7952.00
IUUC-Tru-118129	Takifugu rubripes	89.04	0.00e+00	7951.00
IUUC-Tsy-119302	Tarsius syrichta	77.98	0.00e+00	1172.00
IUUC-Tni-120374	Tetraodon nigroviridis	87.17	0.00e+00	7789.00
IUUC-Tca-121094	Theobroma cacao	35.31	4.00e-54	206.00
IUUC-Tae-124157	Triticum aestivum	33.77	2.00e-49	191.00
IUUC-Tbe-128137	Tupaia belangeri	75.08	0.00e+00	1941.00
IUUC-Ttr-128273	Tursiops truncatus	78.78	0.00e+00	2428.00
IUUC-Vpa-130471	Vicugna pacos	78.48	0.00e+00	1397.00
IUUC-Xtr-132185	Xenopus tropicalis	83.54	0.00e+00	7512.00
IUUC-Xma-133233	Xiphophorus maculatus	89.59	0.00e+00	7915.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence