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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046439
UUCD1 version UUC-HoS-00208
Ensembl Protein ID ENSP00000261537.6
UniProt Accession Q86YT6; B0YJ38; Q2TB37; Q68D01; Q6YI51; Q8NBY0; Q8TCB5; Q8TCL7; Q9P2M3; MIB1_HUMAN
Genbank Protein ID AAN75493.1; AAN18023.1; ACA06016.1; AAH22403.1; AAI10582.1; AAI10583.1; CAH18429.1; CAD28502.1; BAA92561.1; BAC11439.1
Protein Name E3 ubiquitin-protein ligase MIB1; DAPK-interacting protein 1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; Zinc finger ZZ type with ankyrin repeat domain protein 2
Genbank Nucleotide ID AY149908; AY147849; EF444995; BC022403; BC110581; BC110582; CR749635; AL713705; AB037744; AK075157
Gene Name MIB1; DIP1; KIAA1323; ZZANK2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101752.11 ENST00000261537.6 ENSP00000261537.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17324930
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 91.76 0.00e+00 1939.00 IUUC-Dre-028261
E3 activity/RING/RING 66.57 0.00e+00 1315.00 IUUC-Dme-031616
E3 activity/RING/RING 99.30 0.00e+00 2031.00 IUUC-Mmu-063520
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
 E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Protein Sequence
(Fasta)
MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY 60
RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT VCYHGDKHHL 120
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Protein Fasta Sequence


>IUUC-Hsa-046439|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTGGGTTCT CCCAGCTAGG TCGCAGTGGG CGATGGGGAT CCCCAAGGGT GGGCCGAGAG 60
CTGACGGATC GGCAGCGCTG GTTAAGGCCC CGCACCTGCA GCCCCAGTGA CCTTGAACGA 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046439|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001370--BIR_rpt
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001568--P:blood vessel development
GO:0006897--P:endocytosis
GO:0001947--P:heart looping
GO:0001701--P:in utero embryonic development
GO:0045665--P:negative regulation of neuron differentiation
GO:0001841--P:neural tube formation
GO:0007219--P:Notch signaling pathway
GO:0045807--P:positive regulation of endocytosis
GO:0001756--P:somitogenesis
KEGG hsa:57534
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001993 Ailuropoda melanoleuca 99.69 0.00e+00 1984.00
IUUC-Atr-002913 Amborella trichopoda 27.54 2.00e-21 99.00
IUUC-Apl-003867 Anas platyrhynchos 99.09 0.00e+00 1999.00
IUUC-Aca-004471 Anolis carolinensis 99.11 0.00e+00 2026.00
IUUC-Aly-006101 Arabidopsis lyrata 28.67 4.00e-18 86.30
IUUC-Ath-007301 Arabidopsis thaliana 29.46 8.00e-20 91.70
IUUC-Ang-009817 Aspergillus niger 36.24 6.00e-31 128.00
IUUC-Ame-011923 Astyanax mexicanus 87.12 0.00e+00 1827.00
IUUC-Bta-012972 Bos taurus 99.60 0.00e+00 2037.00
IUUC-Bol-015345 Brassica oleracea 26.13 2.00e-21 99.40
IUUC-Bra-017946 Brassica rapa 27.10 8.00e-21 97.10
IUUC-Cel-018156 Caenorhabditis elegans 23.08 1.00e-23 105.00
IUUC-Cja-019044 Callithrix jacchus 95.43 0.00e+00 1820.00
IUUC-Cfa-020049 Canis familiaris 97.52 0.00e+00 1978.00
IUUC-Cpo-022228 Cavia porcellus 98.71 0.00e+00 1863.00
IUUC-Csa-023228 Chlorocebus sabaeus 99.90 0.00e+00 2042.00
IUUC-Cho-024456 Choloepus hoffmanni 87.02 0.00e+00 824.00
IUUC-Cin-025506 Ciona intestinalis 71.85 0.00e+00 878.00
IUUC-Csv-026037 Ciona savignyi 65.38 0.00e+00 1206.00
IUUC-Dre-028261 Danio rerio 91.76 0.00e+00 1943.00
IUUC-Dno-029816 Dasypus novemcinctus 99.50 0.00e+00 2034.00
IUUC-Dor-030678 Dipodomys ordii 79.74 0.00e+00 1426.00
IUUC-Dme-031616 Drosophila melanogaster 60.46 0.00e+00 1208.00
IUUC-Ete-032436 Echinops telfairi 93.59 2.00e-131 464.00
IUUC-Eca-033837 Equus caballus 99.89 0.00e+00 1881.00
IUUC-Eeu-034896 Erinaceus europaeus 85.02 0.00e+00 684.00
IUUC-Fca-036568 Felis catus 99.78 0.00e+00 1866.00
IUUC-Fal-037586 Ficedula albicollis 98.81 0.00e+00 2022.00
IUUC-Gmo-038802 Gadus morhua 89.97 0.00e+00 1894.00
IUUC-Gga-040131 Gallus gallus 99.01 0.00e+00 2029.00
IUUC-Gac-042052 Gasterosteus aculeatus 90.60 0.00e+00 1941.00
IUUC-Gma-043595 Glycine max 26.41 3.00e-21 97.80
IUUC-Ggo-044970 Gorilla gorilla 100.00 0.00e+00 2043.00
IUUC-Itr-048363 Ictidomys tridecemlineatus 99.49 0.00e+00 813.00
IUUC-Lch-049434 Latimeria chalumnae 91.08 0.00e+00 1843.00
IUUC-Lpe-051464 Leersia perrieri 26.46 1.00e-15 79.70
IUUC-Loc-052278 Lepisosteus oculatus 90.49 0.00e+00 1885.00
IUUC-Laf-054292 Loxodonta africana 98.49 0.00e+00 1856.00
IUUC-Meu-056752 Macropus eugenii 81.71 1.00e-149 524.00
IUUC-Mpo-057569 Magnaporthe poae 36.90 8.00e-33 135.00
IUUC-Mga-059408 Meleagris gallopavo 98.61 0.00e+00 1877.00
IUUC-Mmr-061628 Microcebus murinus 99.70 0.00e+00 2037.00
IUUC-Mdo-062055 Monodelphis domestica 99.50 0.00e+00 2034.00
IUUC-Mmu-063520 Mus musculus 99.30 0.00e+00 2068.00
IUUC-Mpu-065864 Mustela putorius furo 99.70 0.00e+00 2037.00
IUUC-Mlu-067802 Myotis lucifugus 99.78 0.00e+00 1879.00
IUUC-Nle-069568 Nomascus leucogenys 98.59 0.00e+00 1980.00
IUUC-Opr-071018 Ochotona princeps 78.34 4.00e-172 598.00
IUUC-Ont-072079 Oreochromis niloticus 91.63 0.00e+00 1954.00
IUUC-Oan-073346 Ornithorhynchus anatinus 99.39 0.00e+00 1308.00
IUUC-Ocu-073932 Oryctolagus cuniculus 99.80 0.00e+00 2038.00
IUUC-Oba-075968 Oryza barthii 27.08 1.00e-15 79.70
IUUC-Obr-076548 Oryza brachyantha 26.77 4.00e-20 94.40
IUUC-Ogl-077477 Oryza glaberrima 27.08 2.00e-15 79.70
IUUC-Ogu-079004 Oryza glumaepatula 27.08 2.00e-15 79.30
IUUC-Oin-079705 Oryza indica 27.08 2.00e-15 79.70
IUUC-Olo-080410 Oryza longistaminata 27.08 2.00e-15 79.00
IUUC-Ome-081845 Oryza meridionalis 27.08 5.00e-16 81.30
IUUC-Oni-082055 Oryza nivara 26.63 6.00e-15 77.40
IUUC-Opu-083740 Oryza punctata 26.40 2.00e-16 82.00
IUUC-Oru-085255 Oryza rufipogon 27.08 1.00e-15 79.70
IUUC-Osa-085560 Oryza sativa 29.62 3.00e-18 87.00
IUUC-Ola-087184 Oryzias latipes 91.36 0.00e+00 1929.00
IUUC-Oga-089002 Otolemur garnettii 96.81 0.00e+00 2014.00
IUUC-Oar-089440 Ovis aries 99.57 0.00e+00 1882.00
IUUC-Ptr-090690 Pan troglodytes 99.40 0.00e+00 2022.00
IUUC-Pan-092295 Papio anubis 99.90 0.00e+00 2042.00
IUUC-Psi-093118 Pelodiscus sinensis 99.11 0.00e+00 2016.00
IUUC-Pma-094438 Petromyzon marinus 89.13 0.00e+00 694.00
IUUC-Pfo-096302 Poecilia formosa 87.14 0.00e+00 1832.00
IUUC-Pab-097804 Pongo abelii 100.00 0.00e+00 1107.00
IUUC-Pca-101028 Procavia capensis 90.83 0.00e+00 829.00
IUUC-Pva-102890 Pteropus vampyrus 92.90 0.00e+00 904.00
IUUC-Rno-105470 Rattus norvegicus 98.71 0.00e+00 2028.00
IUUC-Sha-106650 Sarcophilus harrisii 99.18 0.00e+00 1960.00
IUUC-Sja-108012 Schizosaccharomyces japonicus 42.55 8.00e-07 48.10
IUUC-Sly-111367 Solanum lycopersicum 25.74 1.00e-20 96.30
IUUC-Sar-113247 Sorex araneus 86.13 0.00e+00 804.00
IUUC-Ssc-115706 Sus scrofa 99.80 0.00e+00 2038.00
IUUC-Tgu-116863 Taeniopygia guttata 98.81 0.00e+00 2018.00
IUUC-Tru-117733 Takifugu rubripes 90.61 0.00e+00 1925.00
IUUC-Tsy-119313 Tarsius syrichta 99.72 0.00e+00 1390.00
IUUC-Tni-120601 Tetraodon nigroviridis 92.09 0.00e+00 1910.00
IUUC-Tur-126247 Triticum urartu 25.26 5.00e-16 79.70
IUUC-Tbe-127979 Tupaia belangeri 94.57 0.00e+00 1541.00
IUUC-Ttr-128673 Tursiops truncatus 99.80 0.00e+00 2038.00
IUUC-Vda-129784 Verticillium dahliae 35.21 9.00e-32 132.00
IUUC-Vpa-130332 Vicugna pacos 95.80 0.00e+00 1933.00
IUUC-Xtr-132423 Xenopus tropicalis 96.42 0.00e+00 1987.00
Created Date 25-Jun-2017

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