iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046083

Ensembl Protein ID

ENSP00000395574.2

UniProt Accession

Q14241; B2R7Q8; Q8IXH1; ELOA1_HUMAN

Genbank Protein ID

BAG35905.1; CAB40157.1; EAW95070.1; AAA75492.1; AAH02883.1; AAO15305.1

Protein Name

Elongin-A; Elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Transcription elongation factor B polypeptide 3

Genbank Nucleotide ID

AK313079; DA333869; CH471134; L47345; BC002883; AF116729

Gene Name

TCEB3; ELOA; MSTP059

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000011007.12	ENST00000418390.6	ENSP00000395574.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	33.82	3.00e-05	45.80	IUUC-Sce-106376
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	33.82	3.00e-05	45.80	IUUC-Sce-106376

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

Protein Sequence
(Fasta)

MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK KLLKYLKKLS 60
TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK LVPVERNAEP DEQDFEKSNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCCGTCTT GAAGTAGACC CTGGAGAGGT CTTCCAGGCT TGGGCTCAGC ACGCGAGCAC 60
AGGGAGCGGG GGTGCCGGCG GCGGAGGCGC GTACGGCCCG AGCAGCCCCC AGCCCCCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR001810--F-box_dom
IPR010684--RNA_pol_II_trans_fac_SIII_A
IPR003617--TFIIS/CRSP70_N_sub
IPR017923--TFIIS_N

PROSITE

PS50181--FBOX
PS51319--TFIIS_N

Pfam

PF06881--Elongin_A
PF08711--Med26

SMART

SM00509--TFS2N

Gene Ontology

GO:0070449--C:elongin complex
GO:0005615--C:extracellular space
GO:0016021--C:integral component of membrane
GO:0005654--C:nucleoplasm
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

hsa:6924

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001705	Ailuropoda melanoleuca	83.83	0.00e+00	1148.00
IUUC-Apl-003659	Anas platyrhynchos	77.82	5.00e-119	422.00
IUUC-Aca-004513	Anolis carolinensis	54.92	0.00e+00	632.00
IUUC-Ago-007835	Ashbya gossypii	27.27	2.00e-05	43.10
IUUC-Acl-008085	Aspergillus clavatus	26.37	1.00e-06	47.80
IUUC-Afu-008931	Aspergillus fumigatus	28.89	5.00e-07	49.30
IUUC-Ani-009161	Aspergillus nidulans	27.47	2.00e-07	50.10
IUUC-Ang-009875	Aspergillus niger	26.00	1.00e-05	44.30
IUUC-Ame-011668	Astyanax mexicanus	60.87	2.00e-77	283.00
IUUC-Bta-013219	Bos taurus	79.90	0.00e+00	1076.00
IUUC-Bci-014000	Botrytis cinerea	29.89	4.00e-07	49.30
IUUC-Bdi-014527	Brachypodium distachyon	36.62	4.00e-08	51.60
IUUC-Bol-016438	Brassica oleracea	32.26	2.00e-08	53.90
IUUC-Bra-017526	Brassica rapa	32.26	2.00e-08	53.50
IUUC-Cel-018281	Caenorhabditis elegans	32.67	1.00e-14	74.30
IUUC-Cja-018759	Callithrix jacchus	94.70	0.00e+00	1339.00
IUUC-Cfa-020766	Canis familiaris	80.65	0.00e+00	1120.00
IUUC-Cpo-022250	Cavia porcellus	80.54	0.00e+00	1019.00
IUUC-Csa-023293	Chlorocebus sabaeus	98.62	0.00e+00	1467.00
IUUC-Cin-025556	Ciona intestinalis	39.13	4.00e-47	182.00
IUUC-Csv-026153	Ciona savignyi	37.86	8.00e-39	153.00
IUUC-Cgl-026733	Colletotrichum gloeosporioides	27.08	8.00e-04	38.50
IUUC-Cne-026936	Cryptococcus neoformans	26.47	4.00e-05	42.70
IUUC-Dre-027828	Danio rerio	44.47	2.00e-75	277.00
IUUC-Dse-031436	Dothistroma septosporum	30.95	2.00e-04	40.40
IUUC-Dme-031809	Drosophila melanogaster	36.36	5.00e-39	155.00
IUUC-Ete-032677	Echinops telfairi	87.63	2.00e-145	509.00
IUUC-Eca-034045	Equus caballus	70.98	1.00e-96	347.00
IUUC-Eeu-035063	Erinaceus europaeus	86.28	8.00e-177	613.00
IUUC-Fca-036488	Felis catus	83.04	0.00e+00	1136.00
IUUC-Fal-037501	Ficedula albicollis	56.76	0.00e+00	640.00
IUUC-Fso-038123	Fusarium solani	31.33	2.00e-04	40.00
IUUC-Gmo-038614	Gadus morhua	70.56	5.00e-69	255.00
IUUC-Ggr-039793	Gaeumannomyces graminis	36.25	4.00e-08	52.80
IUUC-Gga-040738	Gallus gallus	58.28	0.00e+00	684.00
IUUC-Gac-041381	Gasterosteus aculeatus	52.99	2.00e-93	336.00
IUUC-Gma-042964	Glycine max	30.88	3.00e-04	38.50
IUUC-Ggo-045139	Gorilla gorilla	99.12	0.00e+00	1476.00
IUUC-Itr-048970	Ictidomys tridecemlineatus	84.19	0.00e+00	1119.00
IUUC-Kpa-049376	Komagataella pastoris	37.10	2.00e-05	42.70
IUUC-Lch-050369	Latimeria chalumnae	48.48	3.00e-70	259.00
IUUC-Lpe-050727	Leersia perrieri	32.86	1.00e-06	47.40
IUUC-Loc-052347	Lepisosteus oculatus	63.24	6.00e-57	215.00
IUUC-Lma-053027	Leptosphaeria maculans	23.23	4.60e-01	28.90
IUUC-Laf-053575	Loxodonta africana	84.94	0.00e+00	1197.00
IUUC-Mcc-054823	Macaca mulatta	97.26	0.00e+00	1343.00
IUUC-Meu-056878	Macropus eugenii	42.93	2.00e-108	385.00
IUUC-Mor-056948	Magnaporthe oryzae	30.00	1.00e-06	47.40
IUUC-Mtr-057811	Medicago truncatula	27.96	9.00e-04	37.40
IUUC-Mla-058917	Melampsora laricipopulina	36.62	5.00e-11	62.40
IUUC-Mga-059445	Meleagris gallopavo	77.74	3.00e-120	426.00
IUUC-Mmr-060665	Microcebus murinus	84.37	0.00e+00	1199.00
IUUC-Mdo-062430	Monodelphis domestica	65.24	0.00e+00	805.00
IUUC-Mmu-064173	Mus musculus	81.49	0.00e+00	1063.00
IUUC-Mac-065364	Musa acuminata	33.78	2.00e-04	39.70
IUUC-Mpu-066344	Mustela putorius furo	82.12	0.00e+00	1113.00
IUUC-Mlu-068101	Myotis lucifugus	84.72	0.00e+00	1225.00
IUUC-Nfi-068489	Neosartorya fischeri	28.89	2.00e-07	50.10
IUUC-Opr-070498	Ochotona princeps	48.17	8.00e-44	171.00
IUUC-Ont-071579	Oreochromis niloticus	60.90	1.00e-81	297.00
IUUC-Oan-072862	Ornithorhynchus anatinus	55.75	0.00e+00	657.00
IUUC-Ocu-073882	Oryctolagus cuniculus	74.62	0.00e+00	888.00
IUUC-Oba-075710	Oryza barthii	35.21	2.00e-07	49.70
IUUC-Ogl-077171	Oryza glaberrima	35.21	3.00e-07	49.30
IUUC-Ogu-078827	Oryza glumaepatula	35.21	4.00e-07	48.90
IUUC-Oin-080204	Oryza indica	35.21	2.00e-07	49.30
IUUC-Olo-081049	Oryza longistaminata	35.21	3.00e-07	49.30
IUUC-Ome-081128	Oryza meridionalis	33.33	3.00e-06	44.70
IUUC-Oni-083077	Oryza nivara	35.21	2.00e-07	50.10
IUUC-Opu-083270	Oryza punctata	33.80	1.00e-06	47.00
IUUC-Oru-084299	Oryza rufipogon	33.33	3.00e-06	44.70
IUUC-Osa-085671	Oryza sativa	33.77	1.00e-06	44.70
IUUC-Ola-086456	Oryzias latipes	60.76	5.00e-84	305.00
IUUC-Oga-087918	Otolemur garnettii	87.73	0.00e+00	1258.00
IUUC-Oar-089663	Ovis aries	76.72	0.00e+00	1035.00
IUUC-Ptr-091033	Pan troglodytes	99.05	0.00e+00	1384.00
IUUC-Pan-092277	Papio anubis	96.38	0.00e+00	1461.00
IUUC-Psi-094086	Pelodiscus sinensis	55.72	0.00e+00	673.00
IUUC-Pma-094683	Petromyzon marinus	49.82	2.00e-51	195.00
IUUC-Pno-094930	Phaeosphaeria nodorum	34.38	2.00e-09	56.60
IUUC-Pfo-097334	Poecilia formosa	60.21	2.00e-82	300.00
IUUC-Pab-098345	Pongo abelii	99.10	0.00e+00	1426.00
IUUC-Pop-099683	Populus trichocarpa	31.43	5.00e-04	36.60
IUUC-Pca-100737	Procavia capensis	82.11	0.00e+00	1159.00
IUUC-Pva-102497	Pteropus vampyrus	86.65	0.00e+00	1212.00
IUUC-Pgr-103464	Puccinia graminis	36.62	2.00e-11	61.60
IUUC-Pte-104288	Pyrenophora teres	29.79	2.00e-07	49.30
IUUC-Pyt-104772	Pyrenophora triticirepentis	28.72	5.00e-07	48.10
IUUC-Rno-105177	Rattus norvegicus	82.24	0.00e+00	1079.00
IUUC-Sce-106376	Saccharomyces cerevisiae	31.71	6.00e-07	48.50
IUUC-Sha-106480	Sarcophilus harrisii	67.95	0.00e+00	870.00
IUUC-Sja-107782	Schizosaccharomyces japonicus	25.93	1.00e-11	63.50
IUUC-Spo-108157	Schizosaccharomyces pombe	28.33	6.00e-10	57.40
IUUC-Sit-109960	Setaria italica	25.20	5.00e-05	41.20
IUUC-Sar-113255	Sorex araneus	70.91	0.00e+00	863.00
IUUC-Sbi-114855	Sorghum bicolor	38.03	2.00e-06	46.20
IUUC-Sre-115076	Sporisorium reilianum	37.00	9.00e-17	82.00
IUUC-Ssc-115875	Sus scrofa	84.14	0.00e+00	1229.00
IUUC-Tgu-117066	Taeniopygia guttata	55.44	9.00e-168	583.00
IUUC-Tru-117881	Takifugu rubripes	54.52	7.00e-84	305.00
IUUC-Tsy-119531	Tarsius syrichta	84.48	0.00e+00	1149.00
IUUC-Tni-120325	Tetraodon nigroviridis	59.44	1.00e-90	327.00
IUUC-Tae-122727	Triticum aestivum	31.09	3.00e-08	52.80
IUUC-Tur-126506	Triticum urartu	31.62	7.00e-07	47.80
IUUC-Tbe-127648	Tupaia belangeri	77.97	0.00e+00	1028.00
IUUC-Ttr-129287	Tursiops truncatus	82.59	0.00e+00	1145.00
IUUC-Uma-129543	Ustilago maydis	33.64	4.00e-14	73.20
IUUC-Vpa-130645	Vicugna pacos	83.38	0.00e+00	1122.00
IUUC-Xtr-132709	Xenopus tropicalis	54.56	6.00e-119	421.00
IUUC-Xma-133858	Xiphophorus maculatus	61.59	8.00e-83	301.00
IUUC-Yli-134386	Yarrowia lipolytica	33.77	1.00e-08	53.90
IUUC-Zma-135412	Zea mays	29.47	5.00e-06	44.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence