iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aor-010142

Ensembl Protein ID

BAE61855

UniProt Accession

Q2U9B0; BRE1_ASPOR

Genbank Protein ID

BAE61855.1

Protein Name

E3 ubiquitin-protein ligase bre1; RING-type E3 ubiquitin transferase bre1

Genbank Nucleotide ID

AP007164

Gene Name

bre1; AO090701000102

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AO090701000102	BAE61855	BAE61855

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.20e-06	25.6	708	747

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C +C+  fk+ + +  CgHvf++dC+ +++      +s++ +CP C+
   Q: 708  CTVCRRNFKN-TAIKTCGHVFCKDCVeERL------TSRSRKCPNCN 747
           9*********.99999*********98888......**********7 PP

Organism

Aspergillus oryzae

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MPVAEASPVA SSEPGFVKME DRKRAATSDH NDSAPPLKKQ ATSVNGGSKP HPDADMPWKD 60
DLEVSLGLAG VVGFMSFQGG LRYPSSAEPT TSLTIKDAIW RQMQEYKREK VSLEAKLKDM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCGGTCG CCGAAGCATC CCCCGTCGCA TCCTCCGAGC CCGGTTTCGT CAAGATGGAA 60
GACCGGAAGA GAGCTGCCAC GTCTGATCAC AATGATTCGG CACCACCATT GAAGAAGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08647--BRE1

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001976	Ailuropoda melanoleuca	25.52	1.00e-13	70.10
IUUC-Apl-003407	Anas platyrhynchos	27.51	9.00e-16	77.40
IUUC-Aca-004850	Anolis carolinensis	28.44	1.00e-16	80.50
IUUC-Aly-006469	Arabidopsis lyrata	44.68	2.00e-10	59.30
IUUC-Ath-006615	Arabidopsis thaliana	44.68	3.00e-10	58.90
IUUC-Ago-007988	Ashbya gossypii	30.68	4.00e-34	137.00
IUUC-Acl-008319	Aspergillus clavatus	78.55	0.00e+00	1154.00
IUUC-Afl-008679	Aspergillus flavus	94.75	0.00e+00	1294.00
IUUC-Afu-008884	Aspergillus fumigatus	77.56	0.00e+00	1039.00
IUUC-Ani-009487	Aspergillus nidulans	75.72	0.00e+00	989.00
IUUC-Ang-009601	Aspergillus niger	77.54	0.00e+00	1158.00
IUUC-Ate-010547	Aspergillus terreus	78.01	0.00e+00	1075.00
IUUC-Ame-011916	Astyanax mexicanus	26.19	2.00e-18	86.70
IUUC-Bgr-012245	Blumeria graminis	42.86	2.00e-150	524.00
IUUC-Bta-012357	Bos taurus	26.02	2.00e-14	72.80
IUUC-Bci-013926	Botrytis cinerea	44.86	4.00e-157	546.00
IUUC-Bdi-014799	Brachypodium distachyon	37.68	8.00e-11	60.80
IUUC-Bol-016588	Brassica oleracea	44.68	4.00e-10	58.50
IUUC-Bra-017335	Brassica rapa	44.68	4.00e-10	58.50
IUUC-Cel-018659	Caenorhabditis elegans	22.81	3.00e-14	72.00
IUUC-Cja-019042	Callithrix jacchus	27.06	3.00e-13	68.90
IUUC-Cfa-020320	Canis familiaris	25.52	1.00e-13	70.10
IUUC-Cpo-021617	Cavia porcellus	27.14	1.00e-15	77.40
IUUC-Cre-022940	Chlamydomonas reinhardtii	36.51	3.00e-07	48.50
IUUC-Csa-023509	Chlorocebus sabaeus	25.52	1.00e-13	70.10
IUUC-Cho-024616	Choloepus hoffmanni	25.64	1.00e-12	67.00
IUUC-Cin-025174	Ciona intestinalis	24.80	6.00e-15	74.70
IUUC-Csv-025830	Ciona savignyi	26.25	2.00e-13	69.70
IUUC-Cgl-026569	Colletotrichum gloeosporioides	37.67	1.00e-116	411.00
IUUC-Cne-026878	Cryptococcus neoformans	31.40	6.00e-21	94.40
IUUC-Cme-027134	Cyanidioschyzon merolae	37.50	3.00e-12	65.10
IUUC-Dre-028146	Danio rerio	25.79	1.00e-17	83.60
IUUC-Dno-029537	Dasypus novemcinctus	25.52	2.00e-13	70.10
IUUC-Dor-030250	Dipodomys ordii	25.52	2.00e-13	69.70
IUUC-Dse-031300	Dothistroma septosporum	40.92	2.00e-149	520.00
IUUC-Dme-032034	Drosophila melanogaster	24.88	3.00e-13	69.30
IUUC-Ete-033164	Echinops telfairi	25.86	5.00e-14	71.60
IUUC-Eca-033347	Equus caballus	25.52	2.00e-13	69.70
IUUC-Eeu-034801	Erinaceus europaeus	43.40	9.00e-12	63.90
IUUC-Fca-036024	Felis catus	28.62	8.00e-16	77.40
IUUC-Fal-037622	Ficedula albicollis	25.86	1.00e-13	70.50
IUUC-Fox-038017	Fusarium oxysporum	40.00	9.00e-139	485.00
IUUC-Fso-038414	Fusarium solani	43.31	4.00e-126	443.00
IUUC-Gmo-039446	Gadus morhua	25.68	1.00e-14	73.60
IUUC-Ggr-040117	Gaeumannomyces graminis	39.39	7.00e-129	452.00
IUUC-Gga-040412	Gallus gallus	29.35	1.00e-15	77.40
IUUC-Gac-041303	Gasterosteus aculeatus	29.68	1.00e-16	80.50
IUUC-Gma-042797	Glycine max	23.20	2.00e-13	69.30
IUUC-Ggo-044703	Gorilla gorilla	25.52	1.00e-13	70.10
IUUC-Hsa-046462	Homo sapiens	25.52	1.00e-13	70.10
IUUC-Hvu-047689	Hordeum vulgare	43.75	3.00e-12	65.50
IUUC-Itr-048298	Ictidomys tridecemlineatus	27.47	3.00e-14	72.40
IUUC-Kpa-049345	Komagataella pastoris	24.53	2.00e-32	132.00
IUUC-Lch-049505	Latimeria chalumnae	27.09	7.00e-17	81.30
IUUC-Lpe-051253	Leersia perrieri	36.51	9.00e-11	60.50
IUUC-Loc-052847	Lepisosteus oculatus	43.40	1.00e-11	62.00
IUUC-Lma-053312	Leptosphaeria maculans	41.25	2.00e-156	543.00
IUUC-Laf-054122	Loxodonta africana	25.52	2.00e-13	70.10
IUUC-Mcc-054647	Macaca mulatta	25.52	1.00e-13	70.10
IUUC-Meu-056559	Macropus eugenii	25.64	4.00e-13	68.60
IUUC-Mor-057068	Magnaporthe oryzae	38.21	2.00e-123	434.00
IUUC-Mpo-057568	Magnaporthe poae	39.62	8.00e-132	462.00
IUUC-Mtr-057632	Medicago truncatula	39.66	2.00e-11	62.80
IUUC-Mla-059072	Melampsora laricipopulina	24.06	1.00e-29	123.00
IUUC-Mga-059731	Meleagris gallopavo	29.35	1.00e-14	73.60
IUUC-Mvi-060341	Microbotryum violaceum	31.18	2.00e-22	99.00
IUUC-Mmr-061495	Microcebus murinus	28.62	1.00e-15	77.00
IUUC-Mdo-062599	Monodelphis domestica	25.64	2.00e-13	69.70
IUUC-Mmu-063278	Mus musculus	26.74	1.00e-13	70.10
IUUC-Mac-065103	Musa acuminata	39.66	6.00e-11	61.20
IUUC-Mpu-065910	Mustela putorius furo	25.52	2.00e-13	69.70
IUUC-Mlu-067040	Myotis lucifugus	25.26	5.00e-14	71.60
IUUC-Nfi-068269	Neosartorya fischeri	77.38	0.00e+00	1040.00
IUUC-Ncr-068695	Neurospora crassa	41.04	9.00e-143	498.00
IUUC-Nle-069058	Nomascus leucogenys	25.52	2.00e-13	69.70
IUUC-Opr-071149	Ochotona princeps	43.40	3.00e-12	65.50
IUUC-Ont-071299	Oreochromis niloticus	28.77	3.00e-16	79.30
IUUC-Oan-072996	Ornithorhynchus anatinus	27.51	7.00e-16	77.40
IUUC-Ocu-074773	Oryctolagus cuniculus	25.52	2.00e-13	69.70
IUUC-Oba-075000	Oryza barthii	36.51	6.00e-11	61.20
IUUC-Obr-076532	Oryza brachyantha	36.51	7.00e-11	60.80
IUUC-Ogl-077200	Oryza glaberrima	36.51	6.00e-11	61.20
IUUC-Ogu-078279	Oryza glumaepatula	37.93	6.00e-11	61.20
IUUC-Oin-079097	Oryza indica	36.51	6.00e-11	61.20
IUUC-Olo-080612	Oryza longistaminata	42.55	3.00e-09	55.80
IUUC-Ome-081304	Oryza meridionalis	37.29	5.00e-11	61.20
IUUC-Oni-082162	Oryza nivara	36.51	7.00e-11	60.80
IUUC-Opu-083683	Oryza punctata	37.74	1.00e-09	57.00
IUUC-Oru-084382	Oryza rufipogon	36.51	8.00e-11	60.80
IUUC-Osa-085839	Oryza sativa	37.74	1.00e-09	56.60
IUUC-Ola-086435	Oryzias latipes	29.22	8.00e-17	80.90
IUUC-Olu-087683	Ostreococcus lucimarinus	31.19	5.00e-10	54.70
IUUC-Oga-089016	Otolemur garnettii	27.98	2.00e-15	76.30
IUUC-Oar-089755	Ovis aries	26.02	2.00e-14	73.20
IUUC-Ptr-091602	Pan troglodytes	25.52	1.00e-13	70.10
IUUC-Pan-092263	Papio anubis	25.52	1.00e-13	70.10
IUUC-Psi-093554	Pelodiscus sinensis	25.52	2.00e-13	69.30
IUUC-Pno-095079	Phaeosphaeria nodorum	43.19	1.00e-159	555.00
IUUC-Ppa-095735	Physcomitrella patens	50.00	4.00e-11	62.00
IUUC-Pfo-097527	Poecilia formosa	25.29	8.00e-13	67.80
IUUC-Pab-098598	Pongo abelii	25.52	1.00e-13	70.10
IUUC-Pop-099583	Populus trichocarpa	43.86	6.00e-12	63.20
IUUC-Pca-100544	Procavia capensis	27.52	2.00e-15	76.30
IUUC-Ppe-102065	Prunus persica	41.38	3.00e-11	62.00
IUUC-Pva-102720	Pteropus vampyrus	25.52	1.00e-13	70.50
IUUC-Pgr-103536	Puccinia graminis	27.46	1.00e-20	93.60
IUUC-Ptt-104014	Puccinia triticina	23.83	9.00e-08	50.40
IUUC-Pte-104415	Pyrenophora teres	41.18	2.00e-151	527.00
IUUC-Pyt-104762	Pyrenophora triticirepentis	40.92	2.00e-150	524.00
IUUC-Rno-104996	Rattus norvegicus	26.95	2.00e-13	69.30
IUUC-Sce-106384	Saccharomyces cerevisiae	30.60	1.00e-37	149.00
IUUC-Sha-107000	Sarcophilus harrisii	25.64	2.00e-13	69.30
IUUC-Sja-108010	Schizosaccharomyces japonicus	25.64	9.00e-23	100.00
IUUC-Spo-108304	Schizosaccharomyces pombe	28.32	4.00e-24	104.00
IUUC-Ssl-108546	Sclerotinia sclerotiorum	41.98	4.00e-142	496.00
IUUC-Smo-109550	Selaginella moellendorffii	44.83	4.00e-13	68.20
IUUC-Sit-110382	Setaria italica	42.31	5.00e-11	61.60
IUUC-Sly-111490	Solanum lycopersicum	40.43	8.00e-10	57.40
IUUC-Sar-113349	Sorex araneus	29.44	4.00e-13	68.60
IUUC-Sbi-114734	Sorghum bicolor	38.10	1.00e-10	57.80
IUUC-Sre-115087	Sporisorium reilianum	29.22	1.00e-25	109.00
IUUC-Ssc-115723	Sus scrofa	25.52	1.00e-13	70.10
IUUC-Tgu-116549	Taeniopygia guttata	25.86	2.00e-13	69.70
IUUC-Tru-117867	Takifugu rubripes	29.68	2.00e-17	82.80
IUUC-Tsy-118808	Tarsius syrichta	25.52	4.00e-13	68.20
IUUC-Tni-120802	Tetraodon nigroviridis	29.22	5.00e-17	81.60
IUUC-Tca-121060	Theobroma cacao	46.81	5.00e-10	58.20
IUUC-Tre-122150	Trichoderma reesei	39.31	6.00e-137	479.00
IUUC-Tvi-122431	Trichoderma virens	39.89	6.00e-146	509.00
IUUC-Tae-125415	Triticum aestivum	43.10	4.00e-12	65.10
IUUC-Tur-126160	Triticum urartu	43.14	4.00e-10	58.20
IUUC-Tme-127177	Tuber melanosporum	40.69	4.00e-131	460.00
IUUC-Tbe-127597	Tupaia belangeri	27.52	4.00e-15	75.10
IUUC-Ttr-128266	Tursiops truncatus	25.52	2.00e-13	70.10
IUUC-Uma-129488	Ustilago maydis	27.45	3.00e-27	115.00
IUUC-Vda-129815	Verticillium dahliae	36.55	3.00e-116	410.00
IUUC-Vpa-130237	Vicugna pacos	25.52	1.00e-13	70.50
IUUC-Vvi-131316	Vitis vinifera	42.31	2.00e-10	59.30
IUUC-Xtr-132589	Xenopus tropicalis	26.10	3.00e-15	75.90
IUUC-Xma-133607	Xiphophorus maculatus	28.77	6.00e-17	81.30
IUUC-Yli-134445	Yarrowia lipolytica	29.68	2.00e-63	234.00
IUUC-Zma-135598	Zea mays	36.23	8.00e-11	60.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence