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Tag Content
iUUCD ID IUUC-Cne-026878
Ensembl Protein ID AAW45565
UniProt Accession P0CQ62; Q55N50; Q5KBI0; BRE1_CRYNJ
Genbank Protein ID AAW45565.1
Protein Name E3 ubiquitin-protein ligase BRE1; RING-type E3 ubiquitin transferase BRE1
Genbank Nucleotide ID AE017349
Gene Name BRE1; CNI02470
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CNI02470 AAW45565 AAW45565
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 26.64 1.00e-15 82.80 IUUC-Dme-032034
E3 activity/RING/RING 26.57 2.00e-14 78.20 IUUC-Rno-105165
E3 activity/RING/RING 26.88 3.00e-21 99.00 IUUC-Sce-106384
E3 activity/RING/RING 25.53 8.00e-14 73.90 IUUC-Spo-108304
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Cryptococcus neoformans
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
 E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
Protein Sequence
(Fasta)
MNADLKRVRE NTLDDSPSPS AKRRLNSNAS SPIQPSDDEG MAEWMKIVEV KRKEAIYRQM 60
LEYRRISEHE TKRANDLEAQ RRVLEASFHA VELCWTQIVA AVRDLAGAEN LQLKEEEVLE 120
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Protein Fasta Sequence


>IUUC-Cne-026878|E3,RING|Cryptococcus neoformans
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Nucleotide Sequence
(Fasta)
GTCCACTTTC TCACATTCTG CCAGCTGCTC TCGTCAGCAT ATACCTAGCT GCATCGCTCA 60
AGCGCGCACG CACCCCGTCA AAAATGAACG CAGACCTCAA AAGGGTTCGC GAGAATACAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cne-026878|E3,RING|Cryptococcus neoformans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012284--6PGD_dom_3
IPR013956--E3_ubiquit_lig_BRE1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF08647--BRE1
PF00097--zf-C3HC4
Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination
KEGG cne:CNI02470
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002295 Ailuropoda melanoleuca 26.30 3.00e-17 82.40
IUUC-Apl-003407 Anas platyrhynchos 28.62 4.00e-16 78.60
IUUC-Aca-004850 Anolis carolinensis 27.04 3.00e-16 79.30
IUUC-Aly-006469 Arabidopsis lyrata 49.02 1.00e-13 70.10
IUUC-Ath-006615 Arabidopsis thaliana 49.02 2.00e-13 69.70
IUUC-Ago-007988 Ashbya gossypii 30.22 8.00e-24 103.00
IUUC-Acl-008319 Aspergillus clavatus 30.60 5.00e-20 90.90
IUUC-Afl-008679 Aspergillus flavus 24.31 1.00e-10 60.10
IUUC-Afu-008884 Aspergillus fumigatus 25.05 1.00e-14 73.60
IUUC-Ani-009487 Aspergillus nidulans 22.47 1.00e-12 66.20
IUUC-Ang-009601 Aspergillus niger 29.57 7.00e-21 94.00
IUUC-Aor-010142 Aspergillus oryzae 30.25 2.00e-22 99.00
IUUC-Ate-010547 Aspergillus terreus 30.30 6.00e-21 94.00
IUUC-Ame-011745 Astyanax mexicanus 26.57 1.00e-14 73.90
IUUC-Bgr-012245 Blumeria graminis 28.21 5.00e-24 104.00
IUUC-Bta-013173 Bos taurus 26.30 3.00e-17 82.00
IUUC-Bci-013926 Botrytis cinerea 25.18 2.00e-19 89.40
IUUC-Bdi-014799 Brachypodium distachyon 40.00 2.00e-14 72.80
IUUC-Bol-016588 Brassica oleracea 46.30 5.00e-14 71.20
IUUC-Bra-017335 Brassica rapa 46.30 5.00e-14 71.20
IUUC-Cel-018659 Caenorhabditis elegans 35.19 2.00e-09 55.80
IUUC-Cja-019042 Callithrix jacchus 25.56 2.00e-15 76.30
IUUC-Cfa-020318 Canis familiaris 26.30 3.00e-17 82.40
IUUC-Cpo-021539 Cavia porcellus 26.30 2.00e-17 82.80
IUUC-Cre-022940 Chlamydomonas reinhardtii 35.42 5.00e-07 47.80
IUUC-Csa-024051 Chlorocebus sabaeus 26.30 4.00e-17 82.00
IUUC-Cho-024616 Choloepus hoffmanni 44.44 5.00e-13 68.20
IUUC-Cin-025174 Ciona intestinalis 24.90 2.00e-15 76.30
IUUC-Csv-025830 Ciona savignyi 41.07 3.00e-13 68.90
IUUC-Cgl-026569 Colletotrichum gloeosporioides 27.08 1.00e-13 69.70
IUUC-Cme-027134 Cyanidioschyzon merolae 36.00 8.00e-14 70.10
IUUC-Dre-028171 Danio rerio 28.10 5.00e-19 88.20
IUUC-Dno-028892 Dasypus novemcinctus 26.30 3.00e-17 82.40
IUUC-Dor-030268 Dipodomys ordii 26.30 4.00e-17 82.00
IUUC-Dse-031300 Dothistroma septosporum 29.77 1.00e-19 89.70
IUUC-Dme-032034 Drosophila melanogaster 26.64 9.00e-18 84.30
IUUC-Ete-033164 Echinops telfairi 44.44 3.00e-13 68.90
IUUC-Eca-033436 Equus caballus 26.30 2.00e-17 82.80
IUUC-Eeu-034801 Erinaceus europaeus 44.44 6.00e-13 67.40
IUUC-Fca-035720 Felis catus 26.30 3.00e-17 82.40
IUUC-Fal-037622 Ficedula albicollis 44.44 1.00e-13 70.10
IUUC-Fox-038017 Fusarium oxysporum 28.57 4.00e-17 81.30
IUUC-Fso-038414 Fusarium solani 26.20 4.00e-19 87.80
IUUC-Gmo-039269 Gadus morhua 27.78 3.00e-18 85.90
IUUC-Ggr-040117 Gaeumannomyces graminis 29.24 3.00e-22 98.20
IUUC-Gga-040412 Gallus gallus 28.06 1.00e-16 80.10
IUUC-Gac-041303 Gasterosteus aculeatus 27.41 3.00e-17 82.40
IUUC-Gma-043027 Glycine max 40.00 3.00e-14 72.40
IUUC-Ggo-045426 Gorilla gorilla 26.30 3.00e-17 82.40
IUUC-Hsa-045732 Homo sapiens 26.30 2.00e-17 83.20
IUUC-Hvu-047689 Hordeum vulgare 40.00 7.00e-14 70.90
IUUC-Itr-048724 Ictidomys tridecemlineatus 26.30 3.00e-17 82.40
IUUC-Kpa-049345 Komagataella pastoris 29.58 8.00e-21 93.60
IUUC-Lch-049429 Latimeria chalumnae 27.31 6.00e-15 74.30
IUUC-Lpe-051253 Leersia perrieri 43.64 7.00e-15 74.30
IUUC-Loc-052847 Lepisosteus oculatus 46.30 1.00e-13 68.60
IUUC-Lma-053312 Leptosphaeria maculans 26.12 9.00e-15 73.60
IUUC-Laf-054267 Loxodonta africana 26.30 3.00e-17 82.40
IUUC-Mcc-055240 Macaca mulatta 26.30 4.00e-17 82.00
IUUC-Meu-056750 Macropus eugenii 26.67 2.00e-16 79.30
IUUC-Mor-057068 Magnaporthe oryzae 25.03 1.00e-23 102.00
IUUC-Mpo-057568 Magnaporthe poae 29.77 5.00e-23 100.00
IUUC-Mtr-057632 Medicago truncatula 33.82 3.00e-14 72.00
IUUC-Mla-059072 Melampsora laricipopulina 27.97 4.00e-72 264.00
IUUC-Mga-059731 Meleagris gallopavo 28.78 5.00e-16 78.20
IUUC-Mvi-060341 Microbotryum violaceum 31.27 3.00e-85 308.00
IUUC-Mmr-061177 Microcebus murinus 26.30 3.00e-17 82.40
IUUC-Mdo-062415 Monodelphis domestica 25.93 4.00e-17 82.00
IUUC-Mmu-063981 Mus musculus 26.30 3.00e-17 82.40
IUUC-Mac-065103 Musa acuminata 50.91 9.00e-16 77.00
IUUC-Mpu-066498 Mustela putorius furo 26.30 3.00e-17 82.00
IUUC-Mlu-067242 Myotis lucifugus 26.30 3.00e-17 82.00
IUUC-Nfi-068269 Neosartorya fischeri 24.12 3.00e-15 75.10
IUUC-Ncr-068695 Neurospora crassa 29.01 2.00e-21 95.90
IUUC-Nle-069058 Nomascus leucogenys 44.44 2.00e-13 69.70
IUUC-Opr-071149 Ochotona princeps 44.44 2.00e-13 69.30
IUUC-Ont-071299 Oreochromis niloticus 28.15 2.00e-18 85.90
IUUC-Oan-072996 Ornithorhynchus anatinus 26.55 3.00e-15 75.50
IUUC-Ocu-073799 Oryctolagus cuniculus 26.30 3.00e-17 82.40
IUUC-Oba-075000 Oryza barthii 43.64 1.00e-14 73.90
IUUC-Obr-076532 Oryza brachyantha 45.45 1.00e-15 76.60
IUUC-Ogl-077200 Oryza glaberrima 43.64 1.00e-14 73.90
IUUC-Ogu-078279 Oryza glumaepatula 43.64 9.00e-15 73.60
IUUC-Oin-079097 Oryza indica 43.64 1.00e-14 73.90
IUUC-Olo-080612 Oryza longistaminata 43.14 6.00e-12 64.70
IUUC-Ome-081304 Oryza meridionalis 44.44 6.00e-14 70.90
IUUC-Oni-082162 Oryza nivara 43.64 1.00e-14 73.60
IUUC-Opu-083683 Oryza punctata 43.14 5.00e-12 64.70
IUUC-Oru-084382 Oryza rufipogon 43.64 1.00e-14 73.60
IUUC-Osa-085839 Oryza sativa 43.14 5.00e-12 64.70
IUUC-Ola-086435 Oryzias latipes 27.41 8.00e-18 84.30
IUUC-Olu-087683 Ostreococcus lucimarinus 40.62 3.00e-13 65.50
IUUC-Oga-089016 Otolemur garnettii 26.30 2.00e-17 82.80
IUUC-Oar-089589 Ovis aries 26.30 3.00e-17 82.40
IUUC-Ptr-091602 Pan troglodytes 44.44 2.00e-13 69.70
IUUC-Pan-092502 Papio anubis 26.30 5.00e-17 81.60
IUUC-Psi-093554 Pelodiscus sinensis 44.44 2.00e-13 69.70
IUUC-Pno-095079 Phaeosphaeria nodorum 28.62 2.00e-23 102.00
IUUC-Ppa-095651 Physcomitrella patens 48.15 9.00e-15 73.90
IUUC-Pfo-097527 Poecilia formosa 44.44 6.00e-14 71.20
IUUC-Pab-098619 Pongo abelii 26.30 2.00e-17 83.20
IUUC-Pop-099376 Populus trichocarpa 41.82 1.00e-13 69.70
IUUC-Pca-100544 Procavia capensis 26.30 3.00e-17 82.40
IUUC-Ppe-102065 Prunus persica 43.08 2.00e-14 72.80
IUUC-Pva-102479 Pteropus vampyrus 26.30 5.00e-17 81.60
IUUC-Pgr-103536 Puccinia graminis 30.04 8.00e-81 293.00
IUUC-Ptt-104014 Puccinia triticina 27.14 1.00e-43 169.00
IUUC-Pte-104415 Pyrenophora teres 26.80 4.00e-17 81.60
IUUC-Pyt-104762 Pyrenophora triticirepentis 25.45 7.00e-17 80.50
IUUC-Rno-105165 Rattus norvegicus 26.30 3.00e-17 82.40
IUUC-Sce-106384 Saccharomyces cerevisiae 27.82 3.00e-24 104.00
IUUC-Sha-107602 Sarcophilus harrisii 25.93 3.00e-17 82.40
IUUC-Sja-107993 Schizosaccharomyces japonicus 26.09 2.00e-16 78.60
IUUC-Spo-108304 Schizosaccharomyces pombe 26.34 3.00e-15 75.10
IUUC-Ssl-108546 Sclerotinia sclerotiorum 27.08 2.00e-20 92.40
IUUC-Smo-109550 Selaginella moellendorffii 39.39 2.00e-14 72.80
IUUC-Sit-110382 Setaria italica 23.91 3.00e-16 78.60
IUUC-Sly-111490 Solanum lycopersicum 38.18 8.00e-12 63.90
IUUC-Sar-113349 Sorex araneus 29.90 2.00e-14 73.20
IUUC-Sbi-114734 Sorghum bicolor 24.58 5.00e-15 72.40
IUUC-Sre-115087 Sporisorium reilianum 27.47 2.00e-52 199.00
IUUC-Ssc-115723 Sus scrofa 44.44 2.00e-13 69.70
IUUC-Tgu-116549 Taeniopygia guttata 44.44 2.00e-13 69.30
IUUC-Tru-117867 Takifugu rubripes 27.41 2.00e-18 85.90
IUUC-Tsy-118808 Tarsius syrichta 44.44 3.00e-13 68.90
IUUC-Tni-120802 Tetraodon nigroviridis 27.41 3.00e-18 85.90
IUUC-Tca-121060 Theobroma cacao 41.82 3.00e-12 65.50
IUUC-Tre-122150 Trichoderma reesei 22.85 2.00e-24 105.00
IUUC-Tvi-122431 Trichoderma virens 26.05 1.00e-21 96.70
IUUC-Tae-124308 Triticum aestivum 40.00 1.00e-14 73.60
IUUC-Tur-126160 Triticum urartu 40.74 4.00e-12 65.10
IUUC-Tme-127177 Tuber melanosporum 26.45 6.00e-21 94.00
IUUC-Tbe-127597 Tupaia belangeri 26.30 2.00e-17 82.80
IUUC-Ttr-128303 Tursiops truncatus 26.30 1.00e-15 77.40
IUUC-Uma-129488 Ustilago maydis 27.61 3.00e-53 201.00
IUUC-Vda-129815 Verticillium dahliae 26.92 1.00e-15 76.30
IUUC-Vpa-130237 Vicugna pacos 44.44 2.00e-13 69.70
IUUC-Vvi-131316 Vitis vinifera 41.82 1.00e-12 67.00
IUUC-Xtr-132906 Xenopus tropicalis 24.81 8.00e-15 74.30
IUUC-Xma-133607 Xiphophorus maculatus 27.41 2.00e-18 85.90
IUUC-Yli-134445 Yarrowia lipolytica 31.54 6.00e-22 97.40
IUUC-Zma-135598 Zea mays 45.45 2.00e-15 76.30
Created Date 25-Jun-2017

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