iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	26.92	1.00e-14	76.30	IUUC-Sce-106131

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex (By similarity).

Protein Sequence
(Fasta)

MSGFNFGGTG APAGGFTFGT AKTATTTPAT GFSFSASGTG TGGFNFGTPS QPAATTPSTS 60
LFSLTTQTPT TQTPGFNFGT TPASGGTGFS LGISTPKLSL SNAAATPATA NTGSFGLGSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTTGTCT CCTTGGAGGA AAAGGGGCAG AGGGTCTGTG AATTAGCGCG CAGGCGCAAC 60
GGCGCGCGAG CCGACCTTAA AAGCCCCCAA ATTCTCCGGA AGCACGCCCT CCTCCTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR026010--NSP1/NUP62
IPR007758--Nucleoporin_NSP1_C
IPR033072--NUP62_met

Pfam

PF05064--Nsp1_C

Gene Ontology

GO:0005642--C:annulate lamellae
GO:0005737--C:cytoplasm
GO:0090543--C:Flemming body
GO:0043231--C:intracellular membrane-bounded organelle
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044613--C:nuclear pore central transport channel
GO:0000922--C:spindle pole
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0005543--F:phospholipid binding
GO:0051425--F:PTB domain binding
GO:0030159--F:receptor signaling complex scaffold activity
GO:0042169--F:SH2 domain binding
GO:0017056--F:structural constituent of nuclear pore
GO:0046966--F:thyroid hormone receptor binding
GO:0043130--F:ubiquitin binding
GO:0007569--P:cell aging
GO:0008219--P:cell death
GO:0016477--P:cell migration
GO:0007166--P:cell surface receptor signaling pathway
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043407--P:negative regulation of MAP kinase activity
GO:0043069--P:negative regulation of programmed cell death
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0070208--P:protein heterotrimerization
GO:0006606--P:protein import into nucleus
GO:0042306--P:regulation of protein import into nucleus
GO:0071426--P:ribonucleoprotein complex export from nucleus
GO:0006405--P:RNA export from nucleus
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:18226

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000103	Aegilops tauschii	26.70	1.00e-16	80.90
IUUC-Aml-002215	Ailuropoda melanoleuca	84.62	2.00e-105	375.00
IUUC-Atr-002951	Amborella trichopoda	27.12	2.00e-18	87.40
IUUC-Apl-003795	Anas platyrhynchos	83.04	2.00e-111	396.00
IUUC-Aca-004808	Anolis carolinensis	93.78	2.00e-109	390.00
IUUC-Aly-005471	Arabidopsis lyrata	26.64	8.00e-21	95.50
IUUC-Ath-007120	Arabidopsis thaliana	26.53	2.00e-19	91.30
IUUC-Ago-007770	Ashbya gossypii	27.71	2.00e-17	84.30
IUUC-Acl-008342	Aspergillus clavatus	33.70	5.00e-28	119.00
IUUC-Afl-008407	Aspergillus flavus	32.61	2.00e-27	117.00
IUUC-Ani-009240	Aspergillus nidulans	31.72	7.00e-28	119.00
IUUC-Ang-009754	Aspergillus niger	33.87	3.00e-28	120.00
IUUC-Aor-010138	Aspergillus oryzae	32.61	4.00e-28	119.00
IUUC-Ate-010408	Aspergillus terreus	32.61	7.00e-29	122.00
IUUC-Ame-011356	Astyanax mexicanus	77.59	6.00e-108	384.00
IUUC-Bgr-012171	Blumeria graminis	33.04	6.00e-33	135.00
IUUC-Bci-013631	Botrytis cinerea	35.16	2.00e-32	134.00
IUUC-Bdi-014451	Brachypodium distachyon	28.44	4.00e-17	81.30
IUUC-Bol-015251	Brassica oleracea	26.55	4.00e-19	90.10
IUUC-Bra-017238	Brassica rapa	26.06	8.00e-20	92.40
IUUC-Cja-019404	Callithrix jacchus	73.62	3.00e-128	451.00
IUUC-Cfa-020656	Canis familiaris	85.41	3.00e-106	379.00
IUUC-Cpo-021577	Cavia porcellus	71.95	2.00e-115	409.00
IUUC-Csa-023298	Chlorocebus sabaeus	84.12	1.00e-104	374.00
IUUC-Cin-025543	Ciona intestinalis	58.71	5.00e-54	205.00
IUUC-Csv-026171	Ciona savignyi	56.04	6.00e-53	201.00
IUUC-Cgl-026616	Colletotrichum gloeosporioides	34.43	8.00e-24	103.00
IUUC-Cne-026912	Cryptococcus neoformans	30.85	1.00e-25	111.00
IUUC-Dre-027936	Danio rerio	83.16	4.00e-94	338.00
IUUC-Dno-029425	Dasypus novemcinctus	78.18	8.00e-105	374.00
IUUC-Dor-030759	Dipodomys ordii	87.05	4.00e-79	288.00
IUUC-Dse-031327	Dothistroma septosporum	29.17	2.00e-22	100.00
IUUC-Eca-034163	Equus caballus	92.78	5.00e-102	362.00
IUUC-Fca-035933	Felis catus	75.47	3.00e-123	435.00
IUUC-Fal-036641	Ficedula albicollis	81.30	8.00e-109	387.00
IUUC-Fox-038065	Fusarium oxysporum	35.00	7.00e-30	125.00
IUUC-Fso-038180	Fusarium solani	33.00	2.00e-31	130.00
IUUC-Gmo-038896	Gadus morhua	84.02	7.00e-94	337.00
IUUC-Ggr-040080	Gaeumannomyces graminis	33.33	1.00e-30	127.00
IUUC-Gga-041135	Gallus gallus	82.61	3.00e-110	392.00
IUUC-Gac-041923	Gasterosteus aculeatus	83.25	2.00e-104	372.00
IUUC-Gma-043083	Glycine max	30.22	8.00e-23	102.00
IUUC-Ggo-044765	Gorilla gorilla	84.98	1.00e-106	380.00
IUUC-Hsa-046692	Homo sapiens	72.88	6.00e-118	417.00
IUUC-Itr-048010	Ictidomys tridecemlineatus	74.78	1.00e-132	466.00
IUUC-Kpa-049305	Komagataella pastoris	26.73	2.00e-17	84.70
IUUC-Lch-050204	Latimeria chalumnae	88.82	1.00e-88	320.00
IUUC-Lpe-050941	Leersia perrieri	36.62	5.00e-08	50.80
IUUC-Loc-051832	Lepisosteus oculatus	88.08	8.00e-99	354.00
IUUC-Laf-054586	Loxodonta africana	79.20	1.00e-114	406.00
IUUC-Mcc-054910	Macaca mulatta	84.12	1.00e-104	373.00
IUUC-Meu-056117	Macropus eugenii	94.56	2.00e-79	287.00
IUUC-Mor-057022	Magnaporthe oryzae	35.79	4.00e-32	133.00
IUUC-Mpo-057380	Magnaporthe poae	34.68	1.00e-29	125.00
IUUC-Mtr-057916	Medicago truncatula	30.17	3.00e-18	85.50
IUUC-Mga-059208	Meleagris gallopavo	83.04	2.00e-110	392.00
IUUC-Mvi-060361	Microbotryum violaceum	39.29	9.00e-13	68.90
IUUC-Mmr-061579	Microcebus murinus	85.41	2.00e-106	379.00
IUUC-Mdo-062211	Monodelphis domestica	59.75	8.00e-113	401.00
IUUC-Mac-065316	Musa acuminata	30.36	3.00e-18	87.40
IUUC-Mpu-066778	Mustela putorius furo	73.44	3.00e-121	428.00
IUUC-Mlu-067961	Myotis lucifugus	78.05	2.00e-113	402.00
IUUC-Nfi-068470	Neosartorya fischeri	33.15	6.00e-28	119.00
IUUC-Ncr-068853	Neurospora crassa	34.05	3.00e-28	120.00
IUUC-Nle-069776	Nomascus leucogenys	69.42	3.00e-43	167.00
IUUC-Ont-071804	Oreochromis niloticus	83.25	8.00e-104	370.00
IUUC-Oan-073171	Ornithorhynchus anatinus	83.26	2.00e-111	396.00
IUUC-Ocu-074502	Oryctolagus cuniculus	61.50	7.00e-62	230.00
IUUC-Oba-075227	Oryza barthii	26.44	1.00e-10	59.70
IUUC-Obr-076100	Oryza brachyantha	28.78	1.00e-20	95.10
IUUC-Ogl-077722	Oryza glaberrima	29.38	1.00e-17	83.20
IUUC-Ogu-078656	Oryza glumaepatula	28.57	6.00e-17	80.90
IUUC-Oin-079356	Oryza indica	27.92	1.00e-14	73.60
IUUC-Olo-080776	Oryza longistaminata	30.46	3.00e-19	88.60
IUUC-Ome-081497	Oryza meridionalis	28.64	5.00e-18	84.30
IUUC-Oni-082204	Oryza nivara	28.37	1.00e-17	83.20
IUUC-Opu-083759	Oryza punctata	33.73	9.00e-11	59.70
IUUC-Ola-086898	Oryzias latipes	82.14	2.00e-101	363.00
IUUC-Oga-088255	Otolemur garnettii	74.09	2.00e-116	412.00
IUUC-Oar-089798	Ovis aries	78.34	2.00e-100	359.00
IUUC-Ptr-091608	Pan troglodytes	79.85	4.00e-106	378.00
IUUC-Pan-092757	Papio anubis	82.40	1.00e-101	363.00
IUUC-Psi-093357	Pelodiscus sinensis	83.12	1.00e-111	397.00
IUUC-Pma-094710	Petromyzon marinus	71.79	2.00e-81	296.00
IUUC-Pno-094791	Phaeosphaeria nodorum	26.98	2.00e-24	107.00
IUUC-Ppa-095481	Physcomitrella patens	28.41	2.00e-17	84.30
IUUC-Pfo-097470	Poecilia formosa	76.19	5.00e-104	371.00
IUUC-Pab-098408	Pongo abelii	84.55	6.00e-106	378.00
IUUC-Pop-100081	Populus trichocarpa	29.55	1.00e-18	86.30
IUUC-Pca-100349	Procavia capensis	86.15	3.00e-114	405.00
IUUC-Ppe-101825	Prunus persica	31.07	3.00e-23	103.00
IUUC-Pva-102608	Pteropus vampyrus	59.57	1.00e-76	279.00
IUUC-Pgr-103532	Puccinia graminis	33.00	1.00e-29	124.00
IUUC-Pte-104213	Pyrenophora teres	28.57	7.00e-27	115.00
IUUC-Pyt-104505	Pyrenophora triticirepentis	29.35	3.00e-25	110.00
IUUC-Rno-104985	Rattus norvegicus	95.97	4.00e-131	461.00
IUUC-Sce-106131	Saccharomyces cerevisiae	28.57	8.00e-21	95.90
IUUC-Sha-107579	Sarcophilus harrisii	84.73	7.00e-97	346.00
IUUC-Sja-107816	Schizosaccharomyces japonicus	32.11	1.00e-27	118.00
IUUC-Spo-108243	Schizosaccharomyces pombe	30.64	7.00e-25	108.00
IUUC-Sit-110530	Setaria italica	28.98	2.00e-21	97.40
IUUC-Sly-111305	Solanum lycopersicum	29.55	2.00e-21	97.80
IUUC-Sbi-114353	Sorghum bicolor	29.52	1.00e-17	84.30
IUUC-Sre-115119	Sporisorium reilianum	30.32	2.00e-24	107.00
IUUC-Ssc-116032	Sus scrofa	93.94	6.00e-105	374.00
IUUC-Tgu-117392	Taeniopygia guttata	78.81	9.00e-101	360.00
IUUC-Tru-118364	Takifugu rubripes	82.65	6.00e-102	364.00
IUUC-Tsy-119443	Tarsius syrichta	95.83	1.00e-102	366.00
IUUC-Tni-120115	Tetraodon nigroviridis	82.05	2.00e-101	362.00
IUUC-Tca-120955	Theobroma cacao	30.51	2.00e-22	100.00
IUUC-Tre-122173	Trichoderma reesei	35.56	8.00e-29	122.00
IUUC-Tvi-122527	Trichoderma virens	34.81	5.00e-26	110.00
IUUC-Tae-123047	Triticum aestivum	28.41	1.00e-19	92.00
IUUC-Tur-126776	Triticum urartu	38.46	3.10e-02	33.50
IUUC-Tme-127155	Tuber melanosporum	36.74	1.00e-33	138.00
IUUC-Tbe-127667	Tupaia belangeri	68.18	6.00e-79	286.00
IUUC-Ttr-128589	Tursiops truncatus	74.55	4.00e-127	448.00
IUUC-Vda-129888	Verticillium dahliae	33.88	4.00e-26	113.00
IUUC-Vpa-130367	Vicugna pacos	68.28	3.00e-87	314.00
IUUC-Vvi-131500	Vitis vinifera	30.00	2.00e-23	104.00
IUUC-Xtr-132497	Xenopus tropicalis	85.13	1.00e-103	370.00
IUUC-Xma-133341	Xiphophorus maculatus	76.62	1.00e-105	376.00
IUUC-Yli-134543	Yarrowia lipolytica	37.14	1.00e-32	134.00
IUUC-Zma-135505	Zea mays	28.25	4.00e-21	97.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence