iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118695

UUCD1 version

UUC-TaR-00565

Ensembl Protein ID

ENSTRUP00000027034.1

UniProt Accession

H2TQS7; H2TQS7_TAKRU

Protein Name

Uncharacterized protein

Gene Name

herc1; LOC101075751

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000010716.1	ENSTRUT00000027143.1	ENSTRUP00000027034.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.90e-89	299.8	4579	4913
E3 adaptor/Cullin RING/DCX/DWD	6.00e-15	56.0	3490	3522

Active Site

Position(s)	Description	Evidence
4882	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     eh+  F+flG+l+g+a+++++
   Q: 4579 PSRAWkVKLVGEGADDAGGVFDDTITEICQELETGVVDLLIPSPNATAEVGYNRDRFLLNPsscldEHMLQFKFLGILMGVAIRTKK 4665
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l+ledleevd  ++++lk+i++ ++s i+e +++ ++  ++ + ++++ ++  ++pgG++ip   +N++
   Q: 4666 PLDLHLAPLVWKQLCCIPLQLEDLEEVDLLYVQTLKSILHIEDSGITEDNFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLSFSNRK 4752
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e i++qv+a+reG+++++p  llsl+t+++le+++cG++ei  + lkk  +y++ + e+++ +qwFw++lee+s+
   Q: 4753 EYVERAIEYRLHE-IDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICCDVLKKVVRYRE-VDEQHSLVQWFWQTLEELSN 4837
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4838 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQAVMAERLRYAINNCRSIDM 4913
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v  + + s  +ll++++ Dgt++vW++++
   Q: 3490 HQGRVITCGWcSRkGLLATSGSDGTVRVWNVTK 3522
           888888889*95569***************986 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MALMIPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYSK LLTNKEAVLL PQQVLCLKGP 60
QLPDFERESL SDEQEHYLDA LLGSQLALAK MVCSDSPFAA ALRKRVLVLQ RIFYALSNKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTTAA TGATCCCACC AGTGAAGCTC AAGTGGCTGG AGCACCTCAA CAGCTCATGG 60
ATCACCGAGG ACAGCGAGTC CATAGCCACG CGGGAGGGCG TGTCGGTGCT CTACTCCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	81.16	0.00e+00	7264.00
IUUC-Apl-003461	Anas platyrhynchos	81.15	0.00e+00	7299.00
IUUC-Aca-004452	Anolis carolinensis	78.47	0.00e+00	6751.00
IUUC-Bta-013213	Bos taurus	81.30	0.00e+00	7277.00
IUUC-Bdi-014791	Brachypodium distachyon	34.69	4.00e-53	202.00
IUUC-Bra-017584	Brassica rapa	33.68	2.00e-48	188.00
IUUC-Cja-019298	Callithrix jacchus	81.04	0.00e+00	7260.00
IUUC-Cfa-021213	Canis familiaris	81.00	0.00e+00	7333.00
IUUC-Cpo-021674	Cavia porcellus	79.14	0.00e+00	4922.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.44	7.00e-52	197.00
IUUC-Csa-023341	Chlorocebus sabaeus	80.65	0.00e+00	7236.00
IUUC-Cho-024567	Choloepus hoffmanni	73.68	0.00e+00	1386.00
IUUC-Dre-028289	Danio rerio	80.73	0.00e+00	7227.00
IUUC-Dno-029988	Dasypus novemcinctus	80.77	0.00e+00	7233.00
IUUC-Dor-030636	Dipodomys ordii	82.52	0.00e+00	1888.00
IUUC-Ete-032598	Echinops telfairi	79.95	0.00e+00	1280.00
IUUC-Eca-033754	Equus caballus	80.96	0.00e+00	7271.00
IUUC-Eeu-034702	Erinaceus europaeus	71.21	0.00e+00	1216.00
IUUC-Fca-035900	Felis catus	81.06	0.00e+00	7291.00
IUUC-Fal-037034	Ficedula albicollis	79.01	0.00e+00	6247.00
IUUC-Gmo-039260	Gadus morhua	82.43	0.00e+00	1373.00
IUUC-Gga-040321	Gallus gallus	81.07	0.00e+00	7345.00
IUUC-Ggo-045134	Gorilla gorilla	75.57	0.00e+00	3803.00
IUUC-Hsa-046516	Homo sapiens	80.95	0.00e+00	7240.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	85.14	0.00e+00	2220.00
IUUC-Lch-049903	Latimeria chalumnae	82.10	0.00e+00	7372.00
IUUC-Lpe-051165	Leersia perrieri	33.83	2.00e-51	196.00
IUUC-Loc-052149	Lepisosteus oculatus	83.68	0.00e+00	7367.00
IUUC-Laf-053426	Loxodonta africana	81.20	0.00e+00	7321.00
IUUC-Mcc-055826	Macaca mulatta	80.91	0.00e+00	7288.00
IUUC-Meu-056521	Macropus eugenii	70.44	0.00e+00	1716.00
IUUC-Mga-059567	Meleagris gallopavo	88.38	0.00e+00	1945.00
IUUC-Mmr-061512	Microcebus murinus	80.52	0.00e+00	7176.00
IUUC-Mdo-062177	Monodelphis domestica	78.28	0.00e+00	5036.00
IUUC-Mmu-064373	Mus musculus	81.03	0.00e+00	7269.00
IUUC-Mpu-066148	Mustela putorius furo	80.90	0.00e+00	7257.00
IUUC-Mlu-067680	Myotis lucifugus	80.84	0.00e+00	7236.00
IUUC-Nle-069633	Nomascus leucogenys	80.59	0.00e+00	7186.00
IUUC-Opr-070609	Ochotona princeps	82.09	0.00e+00	1160.00
IUUC-Ont-071249	Oreochromis niloticus	90.01	0.00e+00	8346.00
IUUC-Oan-073157	Ornithorhynchus anatinus	80.59	0.00e+00	7225.00
IUUC-Ocu-074841	Oryctolagus cuniculus	81.01	0.00e+00	7310.00
IUUC-Oba-075262	Oryza barthii	33.50	1.00e-49	190.00
IUUC-Obr-076115	Oryza brachyantha	33.59	3.00e-48	185.00
IUUC-Ogl-077586	Oryza glaberrima	33.50	1.00e-49	190.00
IUUC-Ogu-078796	Oryza glumaepatula	33.25	6.00e-49	188.00
IUUC-Oin-079298	Oryza indica	33.25	5.00e-49	188.00
IUUC-Olo-080768	Oryza longistaminata	34.78	8.00e-54	204.00
IUUC-Ome-081908	Oryza meridionalis	32.91	5.00e-48	184.00
IUUC-Oni-082049	Oryza nivara	33.25	6.00e-49	188.00
IUUC-Opu-083608	Oryza punctata	33.17	1.00e-49	190.00
IUUC-Oru-084712	Oryza rufipogon	33.25	6.00e-49	188.00
IUUC-Osa-086078	Oryza sativa	33.25	6.00e-49	188.00
IUUC-Ola-086889	Oryzias latipes	87.39	0.00e+00	7964.00
IUUC-Oga-088459	Otolemur garnettii	79.89	0.00e+00	7193.00
IUUC-Oar-089888	Ovis aries	81.32	0.00e+00	7247.00
IUUC-Ptr-091114	Pan troglodytes	80.86	0.00e+00	7256.00
IUUC-Pan-092442	Papio anubis	80.79	0.00e+00	7264.00
IUUC-Psi-093833	Pelodiscus sinensis	79.49	0.00e+00	4781.00
IUUC-Pma-094275	Petromyzon marinus	77.76	0.00e+00	1707.00
IUUC-Ppa-095790	Physcomitrella patens	36.17	1.00e-54	206.00
IUUC-Pfo-097262	Poecilia formosa	88.10	0.00e+00	7836.00
IUUC-Pab-097760	Pongo abelii	79.53	0.00e+00	4067.00
IUUC-Pca-100465	Procavia capensis	79.58	0.00e+00	3799.00
IUUC-Ppe-101345	Prunus persica	33.93	7.00e-51	196.00
IUUC-Pva-102950	Pteropus vampyrus	81.22	0.00e+00	3474.00
IUUC-Rno-104892	Rattus norvegicus	80.79	0.00e+00	7229.00
IUUC-Sha-106633	Sarcophilus harrisii	79.94	0.00e+00	7111.00
IUUC-Smo-108827	Selaginella moellendorffii	35.71	1.00e-51	198.00
IUUC-Sit-110415	Setaria italica	34.86	5.00e-54	204.00
IUUC-Sly-111155	Solanum lycopersicum	35.15	2.00e-52	201.00
IUUC-Stu-112166	Solanum tuberosum	31.88	2.00e-47	184.00
IUUC-Sar-113251	Sorex araneus	71.44	0.00e+00	2035.00
IUUC-Ssc-116391	Sus scrofa	80.85	0.00e+00	7294.00
IUUC-Tgu-116554	Taeniopygia guttata	81.07	0.00e+00	7282.00
IUUC-Tsy-119647	Tarsius syrichta	72.55	0.00e+00	4440.00
IUUC-Tni-120707	Tetraodon nigroviridis	94.62	0.00e+00	8645.00
IUUC-Tbe-127346	Tupaia belangeri	75.96	0.00e+00	2187.00
IUUC-Ttr-128542	Tursiops truncatus	74.62	0.00e+00	4671.00
IUUC-Vpa-130611	Vicugna pacos	82.42	0.00e+00	3394.00
IUUC-Xtr-131933	Xenopus tropicalis	78.37	0.00e+00	7037.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence