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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064248
UUCD1 version UUC-MuM-00043
Ensembl Protein ID ENSMUSP00000100059.3
UniProt Accession Q8CCJ3; A2RSP7; B1AXU5; B1AXU6; Q3V145; Q6ZQ50; Q8BT70; Q8C484; Q9D8I8; UFL1_MOUSE
Genbank Protein ID BAB25395.1; BAC25404.1; BAC27976.1; BAC38618.1; BAC98021.1; BAE21308.1; CAM19990.1; CAM19990.1; CAM22171.1; CAM22171.1; CAM19989.1; CAM19989.1; CAM22170.1; CAM22170.1; EDL05527.1; AAI38154.1; AAI32196.1
Protein Name E3 UFM1-protein ligase 1
Genbank Nucleotide ID AK007993; AK013382; AK032663; AK082785; AK129211; AK132697; AL831754; AL935267; AL935267; AL831754; AL831754; AL935267; AL935267; AL831754; CH466538; BC138153; BC132195
Gene Name Ufl1; Kiaa0776
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040359.14 ENSMUST00000102994.9 ENSMUSP00000100059.3
ENSMUSG00000040359.14 ENSMUST00000038705.7 ENSMUSP00000042118.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19690564
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/Other 90.55 0.00e+00 1362.00 IUUC-Hsa-046823
ULD/UDP/UBQ/UBQ_Other 90.55 0.00e+00 1362.00 IUUC-Hsa-046823
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress.
 E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress.
Protein Sequence
(Fasta)
MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIESRVSDI IKSEKHVQMV LGQLIDENYL 120
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Protein Fasta Sequence


>IUUC-Mmu-064248|E3,E3 activity/Other;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGTGCCTG CGGCAGGCTG AAGGCTGACG TGTCTGCCGT TTCCCTGTGT CGGGGCGAGC 60
GGAGCAGTGA TGGCGGACGC CTGGGAGGAG ATCCGGCGGC TGGCGGCTGA CTTCCAGCGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064248|E3,E3 activity/Other;ULD,UBQ_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0436--Ligase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR018611--E3_UFM1_ligase_1
Pfam

PF09743--DUF2042
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016020--C:membrane
GO:0043005--C:neuron projection
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0071568--F:UFM1 transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001649--P:osteoblast differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:0060252--P:positive regulation of glial cell proliferation
GO:0032092--P:positive regulation of protein binding
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0010468--P:regulation of gene expression
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880--P:regulation of protein localization
GO:0034976--P:response to endoplasmic reticulum stress
GO:1902065--P:response to L-glutamate
KEGG mmu:67490
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000068 Aegilops tauschii 30.14 3.00e-42 166.00
IUUC-Aml-001894 Ailuropoda melanoleuca 91.18 0.00e+00 1409.00
IUUC-Atr-003137 Amborella trichopoda 33.51 7.00e-56 211.00
IUUC-Apl-003993 Anas platyrhynchos 73.70 0.00e+00 1084.00
IUUC-Aca-004941 Anolis carolinensis 72.40 0.00e+00 848.00
IUUC-Aly-006023 Arabidopsis lyrata 29.40 7.00e-49 189.00
IUUC-Ath-007249 Arabidopsis thaliana 29.66 3.00e-49 190.00
IUUC-Ame-011084 Astyanax mexicanus 70.72 3.00e-135 474.00
IUUC-Bta-012960 Bos taurus 89.55 0.00e+00 1388.00
IUUC-Bdi-014730 Brachypodium distachyon 28.27 2.00e-70 260.00
IUUC-Bol-016306 Brassica oleracea 30.36 7.00e-48 185.00
IUUC-Bra-016735 Brassica rapa 30.65 3.00e-48 186.00
IUUC-Cel-018267 Caenorhabditis elegans 28.31 2.00e-37 150.00
IUUC-Cja-019432 Callithrix jacchus 89.91 0.00e+00 1373.00
IUUC-Cfa-020879 Canis familiaris 89.53 0.00e+00 1365.00
IUUC-Cpo-021915 Cavia porcellus 84.42 0.00e+00 1271.00
IUUC-Cre-022838 Chlamydomonas reinhardtii 43.18 4.00e-24 103.00
IUUC-Csa-023667 Chlorocebus sabaeus 90.30 0.00e+00 1395.00
IUUC-Cin-025254 Ciona intestinalis 40.30 5.00e-180 624.00
IUUC-Csv-026110 Ciona savignyi 41.24 3.00e-176 612.00
IUUC-Cme-027205 Cyanidioschyzon merolae 31.88 4.50e-01 29.30
IUUC-Dre-028832 Danio rerio 63.14 0.00e+00 914.00
IUUC-Dno-029396 Dasypus novemcinctus 84.65 0.00e+00 1254.00
IUUC-Dor-030872 Dipodomys ordii 77.12 1.00e-164 573.00
IUUC-Dme-031860 Drosophila melanogaster 42.74 3.00e-92 332.00
IUUC-Ete-032382 Echinops telfairi 85.01 0.00e+00 1248.00
IUUC-Eca-034175 Equus caballus 84.40 0.00e+00 1340.00
IUUC-Eeu-035073 Erinaceus europaeus 73.84 3.00e-163 568.00
IUUC-Fca-035655 Felis catus 86.10 0.00e+00 1326.00
IUUC-Fal-037594 Ficedula albicollis 72.46 0.00e+00 919.00
IUUC-Fso-038403 Fusarium solani 37.14 6.80e-02 29.60
IUUC-Gmo-038897 Gadus morhua 60.66 0.00e+00 822.00
IUUC-Gga-040147 Gallus gallus 74.43 0.00e+00 1104.00
IUUC-Gac-042365 Gasterosteus aculeatus 62.06 0.00e+00 951.00
IUUC-Gma-044359 Glycine max 32.64 4.00e-42 166.00
IUUC-Ggo-045085 Gorilla gorilla 90.55 0.00e+00 1377.00
IUUC-Hsa-046823 Homo sapiens 90.55 0.00e+00 1377.00
IUUC-Hvu-047672 Hordeum vulgare 27.73 8.00e-75 275.00
IUUC-Itr-048558 Ictidomys tridecemlineatus 90.29 0.00e+00 1370.00
IUUC-Lch-050099 Latimeria chalumnae 70.85 0.00e+00 1110.00
IUUC-Lpe-051353 Leersia perrieri 31.45 4.00e-52 199.00
IUUC-Loc-052237 Lepisosteus oculatus 72.55 0.00e+00 637.00
IUUC-Laf-053535 Loxodonta africana 86.18 0.00e+00 1301.00
IUUC-Mcc-054991 Macaca mulatta 90.43 0.00e+00 1397.00
IUUC-Meu-055924 Macropus eugenii 77.26 1.00e-95 343.00
IUUC-Mtr-058527 Medicago truncatula 28.28 6.00e-56 212.00
IUUC-Mga-059514 Meleagris gallopavo 74.34 0.00e+00 1095.00
IUUC-Mmr-061625 Microcebus murinus 89.91 0.00e+00 1397.00
IUUC-Mdo-062551 Monodelphis domestica 81.99 0.00e+00 1244.00
IUUC-Mac-065571 Musa acuminata 33.00 2.00e-56 214.00
IUUC-Mpu-065883 Mustela putorius furo 90.05 0.00e+00 1390.00
IUUC-Mlu-067468 Myotis lucifugus 88.41 0.00e+00 1369.00
IUUC-Nfi-068269 Neosartorya fischeri 24.76 8.50e-01 29.30
IUUC-Nle-069831 Nomascus leucogenys 90.55 0.00e+00 1398.00
IUUC-Opr-071153 Ochotona princeps 68.63 0.00e+00 847.00
IUUC-Ont-072677 Oreochromis niloticus 64.66 0.00e+00 972.00
IUUC-Oan-073682 Ornithorhynchus anatinus 75.36 0.00e+00 1078.00
IUUC-Ocu-074268 Oryctolagus cuniculus 90.54 0.00e+00 1410.00
IUUC-Oba-075467 Oryza barthii 28.50 7.00e-76 278.00
IUUC-Obr-076760 Oryza brachyantha 29.08 3.00e-75 276.00
IUUC-Ogl-077088 Oryza glaberrima 28.61 2.00e-76 280.00
IUUC-Ogu-078509 Oryza glumaepatula 28.38 1.00e-76 281.00
IUUC-Oin-079276 Oryza indica 28.68 4.00e-78 286.00
IUUC-Olo-080814 Oryza longistaminata 28.50 4.00e-76 279.00
IUUC-Ome-081647 Oryza meridionalis 28.43 1.00e-74 275.00
IUUC-Oni-082954 Oryza nivara 28.38 1.00e-75 278.00
IUUC-Opu-083580 Oryza punctata 27.49 1.00e-66 248.00
IUUC-Oru-084627 Oryza rufipogon 28.68 4.00e-78 286.00
IUUC-Osa-086096 Oryza sativa 28.68 4.00e-78 286.00
IUUC-Ola-087322 Oryzias latipes 61.64 0.00e+00 970.00
IUUC-Olu-087693 Ostreococcus lucimarinus 25.86 1.00e-18 88.20
IUUC-Oga-088769 Otolemur garnettii 86.02 0.00e+00 1323.00
IUUC-Oar-090007 Ovis aries 89.06 0.00e+00 1379.00
IUUC-Ptr-090760 Pan troglodytes 90.30 0.00e+00 1372.00
IUUC-Pan-092162 Papio anubis 90.68 0.00e+00 1397.00
IUUC-Psi-093045 Pelodiscus sinensis 75.49 0.00e+00 1085.00
IUUC-Ppa-095424 Physcomitrella patens 33.51 4.00e-56 213.00
IUUC-Pfo-096108 Poecilia formosa 62.23 0.00e+00 961.00
IUUC-Pab-098057 Pongo abelii 87.91 0.00e+00 1344.00
IUUC-Pop-099790 Populus trichocarpa 30.81 2.00e-52 201.00
IUUC-Pca-100307 Procavia capensis 83.88 0.00e+00 1276.00
IUUC-Ppe-102029 Prunus persica 30.86 8.00e-53 202.00
IUUC-Pva-102386 Pteropus vampyrus 85.88 0.00e+00 841.00
IUUC-Rno-105550 Rattus norvegicus 95.84 0.00e+00 1401.00
IUUC-Sha-107442 Sarcophilus harrisii 83.00 0.00e+00 1252.00
IUUC-Smo-109447 Selaginella moellendorffii 32.98 4.00e-53 202.00
IUUC-Sit-110568 Setaria italica 31.79 3.00e-50 193.00
IUUC-Sly-111028 Solanum lycopersicum 31.36 1.00e-49 191.00
IUUC-Stu-112317 Solanum tuberosum 30.85 6.00e-48 186.00
IUUC-Sar-113662 Sorex araneus 82.41 0.00e+00 1249.00
IUUC-Sbi-114636 Sorghum bicolor 31.97 5.00e-51 196.00
IUUC-Ssc-116423 Sus scrofa 89.67 0.00e+00 1382.00
IUUC-Tgu-116977 Taeniopygia guttata 72.64 0.00e+00 1099.00
IUUC-Tru-118314 Takifugu rubripes 60.67 0.00e+00 932.00
IUUC-Tsy-119391 Tarsius syrichta 87.26 0.00e+00 1325.00
IUUC-Tni-120594 Tetraodon nigroviridis 62.83 0.00e+00 922.00
IUUC-Tca-121351 Theobroma cacao 27.46 9.00e-64 238.00
IUUC-Tae-122849 Triticum aestivum 28.79 6.00e-23 102.00
IUUC-Tur-126308 Triticum urartu 28.79 8.00e-23 102.00
IUUC-Tbe-127999 Tupaia belangeri 89.30 0.00e+00 1264.00
IUUC-Ttr-129189 Tursiops truncatus 82.35 0.00e+00 1266.00
IUUC-Vpa-130734 Vicugna pacos 84.62 0.00e+00 1283.00
IUUC-Vvi-131695 Vitis vinifera 26.84 3.00e-58 220.00
IUUC-Xtr-132004 Xenopus tropicalis 63.36 0.00e+00 945.00
IUUC-Xma-134108 Xiphophorus maculatus 61.19 0.00e+00 838.00
IUUC-Zma-135513 Zea mays 31.27 2.00e-50 194.00
Created Date 25-Jun-2017

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