iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013362

UUCD1 version

UUC-BoT-01124

Ensembl Protein ID

ENSBTAP00000026801.4

UniProt Accession

Q08DA3; F1N2B1; UBP16_BOVIN

Genbank Protein ID

AAI23862.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

DAAA02000172

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020122.4	ENSBTAT00000026801.4	ENSBTAP00000026801.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-89	300.7	195	824

Active Site

Position(s)	Description	Evidence
204	Nucleophile	ECO:0000255\|HAMAP-Rule:MF_03062}
760	Proton acceptor	ECO:0000255\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 195  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 274
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+prel+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++ ++e     +e++kkk+ +s+++++F+g+l+
   Q: 275  VTPRELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFDNSTEKVDEElknkvKEYEKKKSVPSFVDRIFGGELT 363
           ******************************************9***********9999999999999999******************* PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 364  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdndsylkerndipsgtskhlqkkakkqakkqakn 452
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 453  qrrqqkiqgkvlhlndvyaidhpednecevemslqreadiksnhisqeevapkeycvnqkdlnghekmiesitdnqksteeaamknvsv 541
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 542  dndlevlassatecprnlngaylkegsngevdissgfenlnlnaalqpdeinieildddptpgtkvyevvnedpetafctlanreafnt 630
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lh+kRf  ++++ + +k+nk+++
   Q: 631  decSVQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanmkgerkhiytnAKKQMLISLAPPVLTLHFKRF--QQAGFNLRKVNKHIK 717
           ******************************888888888888889999999*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 718  FPEILDLAPFCTLKCKNVAEehtRVLYSLYGVVEHSGTMRSGHYTAYAKTrtasthlsnlvlhgdipqdfemesTKGQWFHISDTHVQA 806
           *************9999988777899************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 807  VPTTKVLS---SQAYLLFYER 824
           ********...********98 PP

Organism

Bos taurus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRNSQEQH ALKHYMKPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGCAGGC TGCCCGGCCC GAGGGCCCAT TAGGGGATGC AGCAATGGGC GCTGTCGCCG 60
TGGGTGAGTT CCGCTCCCAC TGCCTTCGCA GTCACCACTC GCATGACTTC CTGCGCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016578--P:histone deubiquitination
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:519992

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	28.90	3.00e-29	124.00
IUUC-Aml-001931	Ailuropoda melanoleuca	90.92	0.00e+00	1410.00
IUUC-Atr-003015	Amborella trichopoda	32.46	6.00e-36	146.00
IUUC-Apl-004145	Anas platyrhynchos	61.91	0.00e+00	905.00
IUUC-Aca-004314	Anolis carolinensis	59.86	0.00e+00	897.00
IUUC-Aly-006422	Arabidopsis lyrata	30.54	5.00e-31	130.00
IUUC-Ath-006732	Arabidopsis thaliana	35.21	3.00e-35	144.00
IUUC-Ame-011659	Astyanax mexicanus	49.32	8.00e-111	394.00
IUUC-Bdi-014465	Brachypodium distachyon	30.28	2.00e-29	124.00
IUUC-Bol-015941	Brassica oleracea	30.57	4.00e-33	136.00
IUUC-Bra-016751	Brassica rapa	30.64	2.00e-31	131.00
IUUC-Cja-019177	Callithrix jacchus	90.93	0.00e+00	1440.00
IUUC-Cfa-020051	Canis familiaris	91.53	0.00e+00	1431.00
IUUC-Cpo-021886	Cavia porcellus	80.96	0.00e+00	1298.00
IUUC-Csa-024103	Chlorocebus sabaeus	91.41	0.00e+00	1452.00
IUUC-Cho-024315	Choloepus hoffmanni	76.57	3.00e-128	452.00
IUUC-Cin-025775	Ciona intestinalis	48.94	1.00e-38	151.00
IUUC-Csv-026075	Ciona savignyi	50.95	3.00e-57	216.00
IUUC-Cme-027348	Cyanidioschyzon merolae	38.51	1.00e-19	91.70
IUUC-Dre-028388	Danio rerio	48.30	0.00e+00	648.00
IUUC-Dno-029409	Dasypus novemcinctus	88.50	0.00e+00	1411.00
IUUC-Dor-030443	Dipodomys ordii	77.56	0.00e+00	639.00
IUUC-Ete-032807	Echinops telfairi	84.45	0.00e+00	686.00
IUUC-Eca-033479	Equus caballus	91.77	0.00e+00	1457.00
IUUC-Eeu-034835	Erinaceus europaeus	83.64	0.00e+00	667.00
IUUC-Fca-036320	Felis catus	91.89	0.00e+00	1474.00
IUUC-Fal-037029	Ficedula albicollis	60.14	0.00e+00	858.00
IUUC-Gmo-039480	Gadus morhua	53.09	1.00e-115	410.00
IUUC-Gga-040527	Gallus gallus	63.01	0.00e+00	912.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.26	1.00e-114	407.00
IUUC-Gma-044402	Glycine max	28.32	6.00e-33	136.00
IUUC-Ggo-045598	Gorilla gorilla	90.81	0.00e+00	1439.00
IUUC-Hsa-046598	Homo sapiens	90.69	0.00e+00	1431.00
IUUC-Hvu-047146	Hordeum vulgare	30.67	4.00e-29	124.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	90.81	0.00e+00	1437.00
IUUC-Lch-050536	Latimeria chalumnae	56.31	2.00e-128	453.00
IUUC-Lpe-050703	Leersia perrieri	29.41	4.00e-28	120.00
IUUC-Loc-051814	Lepisosteus oculatus	57.00	5.00e-129	455.00
IUUC-Laf-053732	Loxodonta africana	86.51	0.00e+00	1405.00
IUUC-Mcc-054661	Macaca mulatta	91.66	0.00e+00	1453.00
IUUC-Meu-055967	Macropus eugenii	73.35	8.00e-156	544.00
IUUC-Mtr-057945	Medicago truncatula	30.91	2.00e-33	137.00
IUUC-Mga-059551	Meleagris gallopavo	62.90	0.00e+00	922.00
IUUC-Mvi-060391	Microbotryum violaceum	32.14	6.00e-19	89.70
IUUC-Mmr-061747	Microcebus murinus	92.18	0.00e+00	1425.00
IUUC-Mdo-062220	Monodelphis domestica	68.44	0.00e+00	1041.00
IUUC-Mmu-063582	Mus musculus	81.18	0.00e+00	1240.00
IUUC-Mpu-066339	Mustela putorius furo	90.68	0.00e+00	1451.00
IUUC-Mlu-067511	Myotis lucifugus	86.34	0.00e+00	1346.00
IUUC-Nle-069252	Nomascus leucogenys	91.17	0.00e+00	1449.00
IUUC-Opr-070969	Ochotona princeps	85.09	0.00e+00	1302.00
IUUC-Ont-071786	Oreochromis niloticus	50.95	3.00e-117	416.00
IUUC-Ocu-074704	Oryctolagus cuniculus	89.86	0.00e+00	1392.00
IUUC-Oba-075094	Oryza barthii	29.97	2.00e-29	124.00
IUUC-Obr-076743	Oryza brachyantha	30.34	3.00e-30	127.00
IUUC-Ogl-077739	Oryza glaberrima	29.97	2.00e-29	125.00
IUUC-Ogu-078851	Oryza glumaepatula	29.97	2.00e-29	124.00
IUUC-Oin-079402	Oryza indica	29.97	2.00e-29	124.00
IUUC-Olo-080431	Oryza longistaminata	29.97	2.00e-29	124.00
IUUC-Ome-081580	Oryza meridionalis	29.97	3.00e-29	124.00
IUUC-Oni-082644	Oryza nivara	29.97	2.00e-29	124.00
IUUC-Opu-083452	Oryza punctata	29.72	3.00e-29	124.00
IUUC-Oru-084546	Oryza rufipogon	29.97	2.00e-29	124.00
IUUC-Osa-085858	Oryza sativa	29.97	2.00e-29	124.00
IUUC-Oga-088713	Otolemur garnettii	89.72	0.00e+00	1420.00
IUUC-Oar-089887	Ovis aries	98.43	0.00e+00	1535.00
IUUC-Ptr-091670	Pan troglodytes	90.93	0.00e+00	1444.00
IUUC-Pan-092293	Papio anubis	91.66	0.00e+00	1453.00
IUUC-Psi-093101	Pelodiscus sinensis	66.31	0.00e+00	926.00
IUUC-Ppa-095825	Physcomitrella patens	38.17	1.00e-33	139.00
IUUC-Pfo-097202	Poecilia formosa	46.41	0.00e+00	644.00
IUUC-Pab-098773	Pongo abelii	90.23	0.00e+00	1117.00
IUUC-Pop-099136	Populus trichocarpa	29.56	2.00e-39	157.00
IUUC-Pca-101069	Procavia capensis	71.38	0.00e+00	874.00
IUUC-Ppe-101794	Prunus persica	31.44	7.00e-36	145.00
IUUC-Pva-103092	Pteropus vampyrus	85.87	0.00e+00	681.00
IUUC-Rno-105237	Rattus norvegicus	81.88	0.00e+00	1261.00
IUUC-Sha-106889	Sarcophilus harrisii	72.31	0.00e+00	1105.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	28.14	5.00e-11	63.20
IUUC-Sit-110283	Setaria italica	30.61	1.00e-29	125.00
IUUC-Sly-111487	Solanum lycopersicum	29.52	5.00e-38	153.00
IUUC-Stu-112820	Solanum tuberosum	29.41	1.00e-36	148.00
IUUC-Sar-113530	Sorex araneus	82.49	0.00e+00	1309.00
IUUC-Sbi-113785	Sorghum bicolor	28.86	2.00e-23	105.00
IUUC-Ssc-116091	Sus scrofa	92.06	0.00e+00	1419.00
IUUC-Tgu-117478	Taeniopygia guttata	59.48	0.00e+00	866.00
IUUC-Tru-118640	Takifugu rubripes	53.04	1.00e-119	423.00
IUUC-Tsy-119042	Tarsius syrichta	77.06	0.00e+00	902.00
IUUC-Tni-120015	Tetraodon nigroviridis	46.07	8.00e-180	624.00
IUUC-Tca-121701	Theobroma cacao	29.26	8.00e-38	152.00
IUUC-Tae-125305	Triticum aestivum	28.83	5.00e-27	116.00
IUUC-Tur-126788	Triticum urartu	28.53	3.00e-27	117.00
IUUC-Tbe-127309	Tupaia belangeri	77.05	0.00e+00	1105.00
IUUC-Ttr-128271	Tursiops truncatus	92.87	0.00e+00	1472.00
IUUC-Vpa-130674	Vicugna pacos	92.15	0.00e+00	1342.00
IUUC-Xtr-131869	Xenopus tropicalis	51.64	0.00e+00	794.00
IUUC-Xma-134195	Xiphophorus maculatus	46.59	0.00e+00	644.00
IUUC-Zma-135157	Zea mays	30.03	3.00e-26	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence