iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021766

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02044781

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000001068.3	ENSCPOT00000001079.2	ENSCPOP00000000965.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-118	395.9	576	905

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQSNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGR RKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAGAG CGATGGAGCA GCTGAACCGC CTCACGCGCT CGCTCCGCCG CGCGCGCACT 60
GTGGAGTTGC CCGAGGGTGA GCGGCACCAG GGCCGGGCCG GGTCAGGGTC CAGAGGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	96.93	0.00e+00	1844.00
IUUC-Atr-002582	Amborella trichopoda	43.64	2.00e-99	358.00
IUUC-Apl-003400	Anas platyrhynchos	87.72	0.00e+00	1154.00
IUUC-Aca-005375	Anolis carolinensis	90.23	0.00e+00	1722.00
IUUC-Aly-006157	Arabidopsis lyrata	44.55	2.00e-100	362.00
IUUC-Ath-007160	Arabidopsis thaliana	42.99	8.00e-95	343.00
IUUC-Afu-009022	Aspergillus fumigatus	42.66	1.00e-95	347.00
IUUC-Ani-009412	Aspergillus nidulans	42.79	1.00e-97	353.00
IUUC-Ate-010253	Aspergillus terreus	42.79	4.00e-96	348.00
IUUC-Ame-011847	Astyanax mexicanus	84.55	0.00e+00	1641.00
IUUC-Bta-012831	Bos taurus	96.63	0.00e+00	1803.00
IUUC-Bdi-014884	Brachypodium distachyon	43.21	1.00e-97	353.00
IUUC-Bol-016533	Brassica oleracea	52.55	3.00e-78	284.00
IUUC-Bra-016726	Brassica rapa	44.55	7.00e-101	363.00
IUUC-Cja-019160	Callithrix jacchus	97.58	0.00e+00	1857.00
IUUC-Cfa-020346	Canis familiaris	97.03	0.00e+00	1850.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	43.35	6.00e-99	353.00
IUUC-Csa-023768	Chlorocebus sabaeus	97.36	0.00e+00	1857.00
IUUC-Cho-024688	Choloepus hoffmanni	93.36	0.00e+00	1173.00
IUUC-Cin-025417	Ciona intestinalis	50.42	1.00e-138	487.00
IUUC-Csv-025993	Ciona savignyi	43.42	0.00e+00	758.00
IUUC-Cme-027267	Cyanidioschyzon merolae	41.90	2.00e-87	317.00
IUUC-Dre-027819	Danio rerio	85.64	0.00e+00	1629.00
IUUC-Dno-029027	Dasypus novemcinctus	96.61	0.00e+00	1836.00
IUUC-Dor-030327	Dipodomys ordii	89.24	0.00e+00	1615.00
IUUC-Ete-032966	Echinops telfairi	89.56	0.00e+00	1689.00
IUUC-Eca-034339	Equus caballus	97.14	0.00e+00	1852.00
IUUC-Eeu-034544	Erinaceus europaeus	69.35	0.00e+00	682.00
IUUC-Fca-035617	Felis catus	97.22	0.00e+00	1323.00
IUUC-Fal-036687	Ficedula albicollis	90.34	0.00e+00	1750.00
IUUC-Gmo-039508	Gadus morhua	87.93	0.00e+00	829.00
IUUC-Gga-040845	Gallus gallus	90.76	0.00e+00	1775.00
IUUC-Gac-041894	Gasterosteus aculeatus	84.82	0.00e+00	1575.00
IUUC-Gma-044216	Glycine max	44.32	3.00e-101	365.00
IUUC-Ggo-044465	Gorilla gorilla	93.64	0.00e+00	1777.00
IUUC-Hsa-045731	Homo sapiens	97.47	0.00e+00	1859.00
IUUC-Hvu-047697	Hordeum vulgare	42.99	9.00e-97	350.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	97.69	0.00e+00	1857.00
IUUC-Lch-050436	Latimeria chalumnae	89.18	0.00e+00	1692.00
IUUC-Lpe-051550	Leersia perrieri	43.44	7.00e-99	357.00
IUUC-Loc-052287	Lepisosteus oculatus	84.65	0.00e+00	1656.00
IUUC-Laf-053846	Loxodonta africana	97.47	0.00e+00	1854.00
IUUC-Mcc-055845	Macaca mulatta	97.36	0.00e+00	1857.00
IUUC-Meu-056060	Macropus eugenii	96.25	0.00e+00	699.00
IUUC-Mtr-057633	Medicago truncatula	44.55	7.00e-102	367.00
IUUC-Mga-059935	Meleagris gallopavo	93.22	0.00e+00	1753.00
IUUC-Mmr-060960	Microcebus murinus	97.80	0.00e+00	1865.00
IUUC-Mdo-061851	Monodelphis domestica	92.46	0.00e+00	1813.00
IUUC-Mmu-063657	Mus musculus	96.26	0.00e+00	1842.00
IUUC-Mac-065229	Musa acuminata	43.64	3.00e-99	358.00
IUUC-Mpu-066161	Mustela putorius furo	98.49	0.00e+00	827.00
IUUC-Mlu-067354	Myotis lucifugus	95.37	0.00e+00	1777.00
IUUC-Nfi-068278	Neosartorya fischeri	42.66	6.00e-96	347.00
IUUC-Nle-069112	Nomascus leucogenys	97.36	0.00e+00	1857.00
IUUC-Opr-070686	Ochotona princeps	88.61	0.00e+00	810.00
IUUC-Ont-072398	Oreochromis niloticus	84.31	0.00e+00	1578.00
IUUC-Oan-073194	Ornithorhynchus anatinus	94.41	0.00e+00	1728.00
IUUC-Ocu-074397	Oryctolagus cuniculus	85.56	0.00e+00	1566.00
IUUC-Oba-075757	Oryza barthii	43.21	5.00e-98	354.00
IUUC-Obr-076553	Oryza brachyantha	43.67	9.00e-99	357.00
IUUC-Ogl-077520	Oryza glaberrima	43.21	6.00e-98	354.00
IUUC-Ogu-078278	Oryza glumaepatula	43.21	6.00e-98	353.00
IUUC-Oin-079767	Oryza indica	43.21	7.00e-98	353.00
IUUC-Olo-080380	Oryza longistaminata	43.05	2.00e-96	348.00
IUUC-Ome-081925	Oryza meridionalis	43.05	1.00e-96	349.00
IUUC-Oni-082619	Oryza nivara	43.21	5.00e-98	354.00
IUUC-Opu-083684	Oryza punctata	43.05	1.00e-96	349.00
IUUC-Oru-084501	Oryza rufipogon	43.21	6.00e-98	354.00
IUUC-Osa-086251	Oryza sativa	43.05	7.00e-98	351.00
IUUC-Ola-086777	Oryzias latipes	80.93	0.00e+00	1563.00
IUUC-Oga-088684	Otolemur garnettii	97.58	0.00e+00	1857.00
IUUC-Oar-089428	Ovis aries	96.54	0.00e+00	1812.00
IUUC-Ptr-090529	Pan troglodytes	97.36	0.00e+00	1857.00
IUUC-Pan-091702	Papio anubis	97.25	0.00e+00	1856.00
IUUC-Psi-093969	Pelodiscus sinensis	90.42	0.00e+00	1703.00
IUUC-Ppa-095834	Physcomitrella patens	43.74	2.00e-97	352.00
IUUC-Pfo-097364	Poecilia formosa	85.75	0.00e+00	1604.00
IUUC-Pab-098574	Pongo abelii	97.47	0.00e+00	1859.00
IUUC-Pop-099468	Populus trichocarpa	44.55	3.00e-101	365.00
IUUC-Pca-100525	Procavia capensis	85.75	2.00e-177	615.00
IUUC-Ppe-101641	Prunus persica	44.09	4.00e-100	361.00
IUUC-Pva-102365	Pteropus vampyrus	85.48	0.00e+00	1580.00
IUUC-Pgr-103465	Puccinia graminis	40.25	2.00e-98	355.00
IUUC-Ptt-103813	Puccinia triticina	37.71	8.00e-88	320.00
IUUC-Rno-105153	Rattus norvegicus	96.26	0.00e+00	1846.00
IUUC-Sha-107319	Sarcophilus harrisii	92.46	0.00e+00	1805.00
IUUC-Smo-109640	Selaginella moellendorffii	43.51	4.00e-99	358.00
IUUC-Sit-110598	Setaria italica	43.89	3.00e-98	355.00
IUUC-Sly-111706	Solanum lycopersicum	44.77	4.00e-101	364.00
IUUC-Stu-112894	Solanum tuberosum	34.76	5.00e-54	206.00
IUUC-Sar-113449	Sorex araneus	80.44	1.00e-175	610.00
IUUC-Sbi-114042	Sorghum bicolor	44.19	9.00e-99	357.00
IUUC-Sre-114958	Sporisorium reilianum	45.43	6.00e-109	387.00
IUUC-Ssc-115865	Sus scrofa	97.25	0.00e+00	1855.00
IUUC-Tgu-117225	Taeniopygia guttata	90.55	0.00e+00	1770.00
IUUC-Tru-118026	Takifugu rubripes	81.95	0.00e+00	1560.00
IUUC-Tsy-119407	Tarsius syrichta	84.38	0.00e+00	1556.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.44	0.00e+00	1263.00
IUUC-Tca-121479	Theobroma cacao	44.32	3.00e-102	368.00
IUUC-Tae-125214	Triticum aestivum	42.48	2.00e-96	348.00
IUUC-Tbe-127708	Tupaia belangeri	87.01	0.00e+00	866.00
IUUC-Ttr-128667	Tursiops truncatus	97.14	0.00e+00	1854.00
IUUC-Uma-129355	Ustilago maydis	46.10	1.00e-109	390.00
IUUC-Vpa-130200	Vicugna pacos	96.94	0.00e+00	1792.00
IUUC-Vvi-131078	Vitis vinifera	44.09	3.00e-101	365.00
IUUC-Xtr-132176	Xenopus tropicalis	86.97	0.00e+00	1695.00
IUUC-Xma-133936	Xiphophorus maculatus	82.29	0.00e+00	940.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence