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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018157
Ensembl Protein ID B0207.4
UniProt Accession O01427; AIR2_CAEEL
Genbank Protein ID AAC70945.1; CCD61317.1
Protein Name Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase aurora-B
Genbank Nucleotide ID AF071207; FO080115
Gene Name air-2; stu-7; B0207.4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000099 B0207.4 B0207.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 61.23 1.00e-99 360.00 IUUC-Hsa-046968
Active Site
Position(s) Description Evidence
153 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027}
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116, PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-680'(PubMed:15854913). Required for the recruitment of bub-1 to the ring-shaped domain between chromosomes during meiotic anaphase I (PubMed:20729837).
 Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation (PubMed:9852156, PubMed:10354474, PubMed:10975519, PubMed:11050384, PubMed:11050385, PubMed:10983970, PubMed:12015116, PubMed:11940606). Phosphorylates tlk-1 at 'Ser-634', which enhances its activity (PubMed:15916946). Phosphorylates zen-4 at 'Ser-680'(PubMed:15854913). Required for the recruitment of bub-1 to the ring-shaped domain between chromosomes during meiotic anaphase I (PubMed:20729837).
Protein Sequence
(Fasta)
MENKPPVINL PEKETVNTPQ KGGKFTINDF EIGRPLGKGK FGSVYLARTK TGHFHVAIKV 60
LFKSQLISGG VEHQLEREIE IQSHLNHPNI IKLYTYFWDA KKIYLVLEYA PGGEMYKQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018157|E3,E3 activity/Other|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTCCGACATG GAGAATAAGC CACCTGTAAT CAACCTTCCA GAGAAGGAAA CTGTGAATAC 60
TCCACAGAAG GGAGGGTAAG AAATCAAGGT TTTAAAAGTT TATAAATTAT TCTTGATTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018157|E3,E3 activity/Other|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0418--Kinase
KW-0469--Meiosis
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR030616--Aur
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0032133--C:chromosome passenger complex
GO:0000793--C:condensed chromosome
GO:0000794--C:condensed nuclear chromosome
GO:0000780--C:condensed nuclear chromosome, centromeric region
GO:0005737--C:cytoplasm
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:0005876--C:spindle microtubule
GO:0051233--C:spindle midzone
GO:0031616--C:spindle pole centrosome
GO:0005524--F:ATP binding
GO:0051117--F:ATPase binding
GO:0035174--F:histone serine kinase activity
GO:0019894--F:kinesin binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0030261--P:chromosome condensation
GO:0007059--P:chromosome segregation
GO:0045184--P:establishment of protein localization
GO:0051257--P:meiotic spindle midzone assembly
GO:0051256--P:mitotic spindle midzone assembly
GO:0007275--P:multicellular organism development
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0031991--P:regulation of actomyosin contractile ring contraction
KEGG cel:CELE_B0207.4
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000930 Aegilops tauschii 54.24 1.00e-84 304.00
IUUC-Aml-001426 Ailuropoda melanoleuca 63.26 6.00e-102 362.00
IUUC-Atr-002453 Amborella trichopoda 57.53 1.00e-87 314.00
IUUC-Apl-003626 Anas platyrhynchos 63.04 1.00e-99 355.00
IUUC-Aca-004602 Anolis carolinensis 62.21 5.00e-100 356.00
IUUC-Aly-005878 Arabidopsis lyrata 57.92 8.00e-89 318.00
IUUC-Ath-007117 Arabidopsis thaliana 58.30 9.00e-89 318.00
IUUC-Acl-008199 Aspergillus clavatus 55.56 3.00e-79 287.00
IUUC-Afl-008419 Aspergillus flavus 55.17 1.00e-79 288.00
IUUC-Afu-008751 Aspergillus fumigatus 55.94 3.00e-79 287.00
IUUC-Ani-009181 Aspergillus nidulans 54.02 3.00e-82 297.00
IUUC-Ang-009787 Aspergillus niger 54.79 5.00e-79 286.00
IUUC-Aor-009980 Aspergillus oryzae 55.17 1.00e-79 288.00
IUUC-Ate-010286 Aspergillus terreus 54.41 2.00e-78 284.00
IUUC-Ame-010849 Astyanax mexicanus 58.59 4.00e-94 337.00
IUUC-Bgr-012110 Blumeria graminis 55.64 6.00e-81 293.00
IUUC-Bta-013474 Bos taurus 61.35 5.00e-103 366.00
IUUC-Bci-013756 Botrytis cinerea 54.92 1.00e-82 298.00
IUUC-Bdi-014257 Brachypodium distachyon 55.35 4.00e-86 309.00
IUUC-Bol-016310 Brassica oleracea 57.31 4.00e-87 313.00
IUUC-Bra-017438 Brassica rapa 55.72 8.00e-88 315.00
IUUC-Cja-019282 Callithrix jacchus 57.09 2.00e-101 361.00
IUUC-Cfa-020162 Canis familiaris 63.64 3.00e-102 363.00
IUUC-Cpo-021764 Cavia porcellus 61.34 5.00e-101 359.00
IUUC-Cre-022827 Chlamydomonas reinhardtii 56.51 9.00e-90 321.00
IUUC-Csa-023694 Chlorocebus sabaeus 57.43 3.00e-101 360.00
IUUC-Cho-024350 Choloepus hoffmanni 62.24 2.00e-72 263.00
IUUC-Cin-025542 Ciona intestinalis 61.63 4.00e-99 352.00
IUUC-Csv-025873 Ciona savignyi 59.17 7.00e-102 362.00
IUUC-Cgl-026632 Colletotrichum gloeosporioides 50.54 6.00e-74 269.00
IUUC-Cne-026928 Cryptococcus neoformans 59.48 1.00e-89 322.00
IUUC-Cme-027336 Cyanidioschyzon merolae 59.41 2.00e-96 345.00
IUUC-Dre-028198 Danio rerio 60.16 8.00e-96 342.00
IUUC-Dno-029928 Dasypus novemcinctus 63.81 7.00e-101 359.00
IUUC-Dor-030238 Dipodomys ordii 53.68 2.00e-85 308.00
IUUC-Dse-031266 Dothistroma septosporum 56.86 5.00e-84 303.00
IUUC-Dme-032007 Drosophila melanogaster 53.88 8.00e-83 299.00
IUUC-Ete-032911 Echinops telfairi 45.60 1.00e-61 228.00
IUUC-Eca-033749 Equus caballus 62.50 4.00e-101 360.00
IUUC-Eeu-035170 Erinaceus europaeus 56.21 5.00e-97 346.00
IUUC-Fca-035498 Felis catus 62.88 3.00e-102 363.00
IUUC-Fal-037397 Ficedula albicollis 62.26 4.00e-98 350.00
IUUC-Fox-037747 Fusarium oxysporum 54.15 2.00e-84 304.00
IUUC-Fso-038429 Fusarium solani 51.50 1.00e-83 302.00
IUUC-Gmo-039378 Gadus morhua 57.46 1.00e-93 335.00
IUUC-Ggr-039939 Gaeumannomyces graminis 53.55 2.00e-86 311.00
IUUC-Gga-040187 Gallus gallus 62.65 8.00e-99 352.00
IUUC-Gac-042223 Gasterosteus aculeatus 56.25 3.00e-95 340.00
IUUC-Gma-042870 Glycine max 58.36 1.00e-85 308.00
IUUC-Ggo-045617 Gorilla gorilla 61.23 2.00e-101 360.00
IUUC-Hsa-046968 Homo sapiens 61.23 3.00e-101 360.00
IUUC-Hvu-047072 Hordeum vulgare 50.00 4.00e-67 246.00
IUUC-Itr-048233 Ictidomys tridecemlineatus 50.35 9.00e-78 282.00
IUUC-Kpa-049093 Komagataella pastoris 51.10 2.00e-70 258.00
IUUC-Lch-050346 Latimeria chalumnae 60.15 3.00e-98 350.00
IUUC-Lpe-051466 Leersia perrieri 56.65 7.00e-87 312.00
IUUC-Lma-053006 Leptosphaeria maculans 56.16 2.00e-84 304.00
IUUC-Laf-053422 Loxodonta africana 59.29 3.00e-100 357.00
IUUC-Mcc-055245 Macaca mulatta 61.23 4.00e-101 360.00
IUUC-Mor-056952 Magnaporthe oryzae 54.21 4.00e-84 303.00
IUUC-Mpo-057605 Magnaporthe poae 54.26 6.00e-87 313.00
IUUC-Mtr-057726 Medicago truncatula 57.99 2.00e-91 327.00
IUUC-Mla-059174 Melampsora laricipopulina 58.11 1.00e-87 315.00
IUUC-Mga-059562 Meleagris gallopavo 58.96 8.00e-73 266.00
IUUC-Mvi-060305 Microbotryum violaceum 59.30 2.00e-85 308.00
IUUC-Mmr-061588 Microcebus murinus 61.62 5.00e-101 359.00
IUUC-Mdo-061914 Monodelphis domestica 60.21 1.00e-102 364.00
IUUC-Mmu-063288 Mus musculus 61.83 4.00e-99 353.00
IUUC-Mac-064969 Musa acuminata 58.30 3.00e-88 316.00
IUUC-Mpu-066855 Mustela putorius furo 63.85 7.00e-102 362.00
IUUC-Mlu-068046 Myotis lucifugus 62.88 1.00e-102 365.00
IUUC-Nfi-068527 Neosartorya fischeri 55.94 2.00e-79 288.00
IUUC-Ncr-068678 Neurospora crassa 55.48 3.00e-86 310.00
IUUC-Nle-069848 Nomascus leucogenys 57.43 1.00e-100 358.00
IUUC-Opr-070589 Ochotona princeps 63.26 3.00e-102 363.00
IUUC-Ont-071733 Oreochromis niloticus 58.30 1.00e-88 318.00
IUUC-Oan-073399 Ornithorhynchus anatinus 59.57 1.00e-100 358.00
IUUC-Ocu-074063 Oryctolagus cuniculus 59.23 1.00e-100 358.00
IUUC-Oba-075264 Oryza barthii 56.65 1.00e-85 308.00
IUUC-Obr-076048 Oryza brachyantha 56.65 3.00e-86 310.00
IUUC-Ogl-077637 Oryza glaberrima 57.03 8.00e-86 308.00
IUUC-Ogu-078830 Oryza glumaepatula 57.03 3.00e-86 310.00
IUUC-Oin-079150 Oryza indica 57.03 3.00e-86 310.00
IUUC-Olo-080398 Oryza longistaminata 51.68 3.00e-70 256.00
IUUC-Ome-081544 Oryza meridionalis 50.97 2.00e-75 274.00
IUUC-Oni-082250 Oryza nivara 57.03 3.00e-86 310.00
IUUC-Opu-083638 Oryza punctata 57.03 4.00e-86 309.00
IUUC-Oru-084981 Oryza rufipogon 57.03 3.00e-86 310.00
IUUC-Osa-085961 Oryza sativa 57.03 3.00e-86 310.00
IUUC-Olu-087880 Ostreococcus lucimarinus 59.69 1.00e-93 335.00
IUUC-Oga-088891 Otolemur garnettii 62.03 9.00e-101 358.00
IUUC-Oar-090021 Ovis aries 61.70 2.00e-103 367.00
IUUC-Ptr-091458 Pan troglodytes 61.23 3.00e-101 360.00
IUUC-Pan-092546 Papio anubis 57.43 3.00e-101 360.00
IUUC-Psi-093280 Pelodiscus sinensis 61.98 1.00e-99 355.00
IUUC-Pma-094298 Petromyzon marinus 58.49 4.00e-88 316.00
IUUC-Pno-094847 Phaeosphaeria nodorum 51.74 7.00e-81 292.00
IUUC-Ppa-095855 Physcomitrella patens 57.92 2.00e-88 317.00
IUUC-Pfo-096428 Poecilia formosa 60.08 9.00e-90 322.00
IUUC-Pab-098696 Pongo abelii 57.43 2.00e-101 361.00
IUUC-Pop-099405 Populus trichocarpa 59.85 8.00e-91 325.00
IUUC-Pca-100740 Procavia capensis 63.04 3.00e-100 357.00
IUUC-Ppe-101854 Prunus persica 59.85 9.00e-91 325.00
IUUC-Pva-103212 Pteropus vampyrus 63.26 2.00e-101 361.00
IUUC-Pgr-103474 Puccinia graminis 58.05 8.00e-89 319.00
IUUC-Ptt-103933 Puccinia triticina 45.56 2.00e-55 208.00
IUUC-Pte-104089 Pyrenophora teres 54.68 3.00e-82 297.00
IUUC-Pyt-104555 Pyrenophora triticirepentis 54.68 3.00e-82 297.00
IUUC-Rno-105057 Rattus norvegicus 62.21 2.00e-99 354.00
IUUC-Sha-107137 Sarcophilus harrisii 62.88 9.00e-103 365.00
IUUC-Sja-107767 Schizosaccharomyces japonicus 54.34 2.00e-85 307.00
IUUC-Spo-108078 Schizosaccharomyces pombe 56.20 3.00e-89 320.00
IUUC-Smo-109288 Selaginella moellendorffii 57.09 6.00e-87 312.00
IUUC-Sit-110246 Setaria italica 57.92 1.00e-86 311.00
IUUC-Sly-111379 Solanum lycopersicum 59.46 1.00e-90 325.00
IUUC-Stu-112777 Solanum tuberosum 58.69 8.00e-90 322.00
IUUC-Sar-113569 Sorex araneus 30.38 1.00e-26 114.00
IUUC-Sbi-114325 Sorghum bicolor 57.53 2.00e-86 310.00
IUUC-Sre-115203 Sporisorium reilianum 51.57 3.00e-71 261.00
IUUC-Ssc-115361 Sus scrofa 61.96 4.00e-102 363.00
IUUC-Tgu-116967 Taeniopygia guttata 62.65 1.00e-98 352.00
IUUC-Tru-117570 Takifugu rubripes 57.92 5.00e-94 336.00
IUUC-Tsy-119280 Tarsius syrichta 56.54 2.00e-73 268.00
IUUC-Tni-120721 Tetraodon nigroviridis 55.00 6.00e-94 336.00
IUUC-Tca-121494 Theobroma cacao 59.07 3.00e-89 320.00
IUUC-Tre-121869 Trichoderma reesei 54.68 4.00e-82 296.00
IUUC-Tvi-122510 Trichoderma virens 53.17 3.00e-83 300.00
IUUC-Tae-123071 Triticum aestivum 54.24 1.00e-84 304.00
IUUC-Tur-126240 Triticum urartu 54.24 4.00e-84 303.00
IUUC-Tme-126921 Tuber melanosporum 56.98 7.00e-84 302.00
IUUC-Tbe-127872 Tupaia belangeri 55.76 1.00e-87 315.00
IUUC-Ttr-129134 Tursiops truncatus 61.96 3.00e-102 363.00
IUUC-Uma-129412 Ustilago maydis 56.33 2.00e-68 251.00
IUUC-Vda-130003 Verticillium dahliae 55.02 4.00e-84 303.00
IUUC-Vvi-131272 Vitis vinifera 57.72 8.00e-91 325.00
IUUC-Xtr-132019 Xenopus tropicalis 60.00 6.00e-100 356.00
IUUC-Xma-134203 Xiphophorus maculatus 60.47 2.00e-96 344.00
IUUC-Yli-134503 Yarrowia lipolytica 48.20 2.00e-77 281.00
IUUC-Zma-135232 Zea mays 57.14 2.00e-86 310.00
Created Date 25-Jun-2017

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