iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.30e-06	26.2	263	314
E3 activity/RING/RING	8.00e-09	35.9	266	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 5    eflCpIslelM..rdPvvlpsGitydrssIekwlasggktcPvtrqplteedl 55
            ++CpI ++    r+Pv +++G+++ r++Ie  ++  +k cP+++++lt +++
   Q: 263  LYKCPICMDSVskREPVSTKCGHVFCRECIETAIRATHK-CPICNKKLTARQF 314
           578999888653479************************.********99875 PP

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+++  k++p+++ CgHvf+++C++         + + +CP+C+
   Q: 266  CPICMDSVsKREPVSTKCGHVFCRECIETA------IRATHKCPICN 306
           ******998888***************888......999999****7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSDSTIFRFN SSILDQSADS NVSSSSSNSS VSDSSVDSHS SIESNSGHNT SVESQSSAES 60
DSSADSHSSL ERPSPVERDL SVESDSSSAT NTSESSVGEA SNQLQSPQSN NPLNMANLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATTTATAT ACATTTCTTA TAATTATTTT GTTATCAAAG AATTTCGCCG AAACGGAAAT 60
TTTATTTTTA ATAAATTATT GATTTTTATT GAATTACAAG TGTCATTCTA AACAGCATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0034399--C:nuclear periphery
GO:0005634--C:nucleus
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0001103--F:RNA polymerase II repressing transcription factor binding
GO:0032183--F:SUMO binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0000724--P:double-strand break repair via homologous recombination
GO:0022008--P:neurogenesis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045995--P:regulation of embryonic development
GO:0070201--P:regulation of establishment of protein localization
GO:0043393--P:regulation of protein binding
GO:0007530--P:sex determination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000620	Aegilops tauschii	46.43	2.00e-13	68.90
IUUC-Aml-002206	Ailuropoda melanoleuca	42.37	4.00e-11	60.10
IUUC-Atr-002771	Amborella trichopoda	52.54	3.00e-15	74.30
IUUC-Apl-004120	Anas platyrhynchos	52.54	2.00e-14	70.90
IUUC-Aca-004236	Anolis carolinensis	41.43	1.00e-12	65.50
IUUC-Aly-006041	Arabidopsis lyrata	37.62	3.00e-14	70.50
IUUC-Ath-007007	Arabidopsis thaliana	50.00	1.00e-13	68.90
IUUC-Ame-011555	Astyanax mexicanus	49.15	9.00e-14	68.90
IUUC-Bta-012913	Bos taurus	40.68	2.00e-11	60.80
IUUC-Bdi-014655	Brachypodium distachyon	46.43	1.00e-13	69.30
IUUC-Bol-015811	Brassica oleracea	37.61	2.00e-16	77.80
IUUC-Bra-017153	Brassica rapa	39.62	7.00e-15	72.80
IUUC-Cja-019151	Callithrix jacchus	44.07	2.00e-11	61.20
IUUC-Cfa-020868	Canis familiaris	44.07	1.00e-11	61.60
IUUC-Cpo-022249	Cavia porcellus	42.37	4.00e-11	60.10
IUUC-Csa-024125	Chlorocebus sabaeus	42.37	3.00e-11	60.50
IUUC-Csv-026318	Ciona savignyi	43.48	9.00e-13	65.90
IUUC-Dre-028145	Danio rerio	49.15	3.00e-13	67.00
IUUC-Dno-029605	Dasypus novemcinctus	42.37	3.00e-11	60.50
IUUC-Dor-030898	Dipodomys ordii	42.37	3.00e-11	61.20
IUUC-Ete-032694	Echinops telfairi	42.37	2.00e-11	61.20
IUUC-Eca-033443	Equus caballus	42.37	4.00e-11	60.50
IUUC-Eeu-034603	Erinaceus europaeus	42.37	4.00e-11	59.30
IUUC-Fca-035507	Felis catus	42.37	4.00e-11	60.10
IUUC-Fal-037382	Ficedula albicollis	52.54	8.00e-14	69.30
IUUC-Gmo-038960	Gadus morhua	52.17	4.00e-11	59.30
IUUC-Gga-040493	Gallus gallus	52.54	3.00e-14	70.90
IUUC-Gac-042194	Gasterosteus aculeatus	34.31	2.00e-14	71.20
IUUC-Gma-043026	Glycine max	47.62	8.00e-15	72.80
IUUC-Ggo-044726	Gorilla gorilla	42.37	4.00e-11	60.50
IUUC-Hsa-046212	Homo sapiens	42.37	4.00e-11	60.50
IUUC-Hvu-047630	Hordeum vulgare	34.92	3.00e-15	74.30
IUUC-Itr-047892	Ictidomys tridecemlineatus	42.37	4.00e-11	60.10
IUUC-Lpe-050920	Leersia perrieri	48.21	1.00e-13	69.30
IUUC-Loc-051907	Lepisosteus oculatus	49.15	5.00e-13	66.20
IUUC-Laf-054487	Loxodonta africana	29.61	4.00e-11	60.10
IUUC-Mcc-055689	Macaca mulatta	42.37	4.00e-11	60.10
IUUC-Meu-056654	Macropus eugenii	50.85	5.00e-13	66.60
IUUC-Mtr-058638	Medicago truncatula	47.37	3.00e-14	70.90
IUUC-Mga-059303	Meleagris gallopavo	52.54	2.00e-14	70.90
IUUC-Mmr-061355	Microcebus murinus	42.37	4.00e-11	60.50
IUUC-Mdo-062968	Monodelphis domestica	50.85	2.00e-13	68.20
IUUC-Mmu-064421	Mus musculus	42.37	2.00e-11	60.80
IUUC-Mac-064624	Musa acuminata	48.33	9.00e-16	76.30
IUUC-Mpu-066522	Mustela putorius furo	42.37	4.00e-11	60.10
IUUC-Mlu-067065	Myotis lucifugus	42.37	2.00e-11	60.80
IUUC-Nle-069768	Nomascus leucogenys	40.68	3.00e-11	60.50
IUUC-Opr-071141	Ochotona princeps	42.37	1.00e-11	62.00
IUUC-Ocu-074030	Oryctolagus cuniculus	42.37	2.00e-11	60.80
IUUC-Oba-075460	Oryza barthii	50.00	1.00e-15	75.90
IUUC-Obr-076406	Oryza brachyantha	44.62	7.00e-16	77.00
IUUC-Ogl-077094	Oryza glaberrima	50.00	9.00e-16	76.30
IUUC-Ogu-078677	Oryza glumaepatula	50.00	1.00e-15	75.90
IUUC-Oin-079992	Oryza indica	50.00	9.00e-16	76.30
IUUC-Olo-080257	Oryza longistaminata	51.67	7.00e-16	76.60
IUUC-Ome-081943	Oryza meridionalis	50.00	1.00e-15	76.60
IUUC-Oni-082671	Oryza nivara	50.00	1.00e-15	75.90
IUUC-Opu-083644	Oryza punctata	51.67	7.00e-16	76.60
IUUC-Oru-084650	Oryza rufipogon	50.00	1.00e-15	75.90
IUUC-Osa-086110	Oryza sativa	50.00	1.00e-15	75.90
IUUC-Ola-086970	Oryzias latipes	45.16	5.00e-14	69.70
IUUC-Olu-087634	Ostreococcus lucimarinus	40.74	1.00e-08	51.60
IUUC-Oga-088242	Otolemur garnettii	42.37	3.00e-11	60.80
IUUC-Oar-089469	Ovis aries	42.37	1.00e-11	62.40
IUUC-Ptr-091254	Pan troglodytes	44.07	4.00e-12	63.50
IUUC-Pan-092919	Papio anubis	42.37	4.00e-11	60.50
IUUC-Psi-093929	Pelodiscus sinensis	49.15	2.00e-13	67.80
IUUC-Pma-094118	Petromyzon marinus	46.27	1.00e-12	63.50
IUUC-Ppa-095567	Physcomitrella patens	49.21	2.00e-15	75.10
IUUC-Pfo-097412	Poecilia formosa	46.77	2.00e-14	71.20
IUUC-Pab-098424	Pongo abelii	42.37	4.00e-11	60.10
IUUC-Pop-099835	Populus trichocarpa	52.63	1.00e-14	72.40
IUUC-Ppe-102052	Prunus persica	50.00	3.00e-14	71.20
IUUC-Pgr-103282	Puccinia graminis	32.86	3.00e-07	47.80
IUUC-Ptt-103843	Puccinia triticina	40.91	1.00e-05	43.10
IUUC-Rno-105460	Rattus norvegicus	42.37	4.00e-11	60.50
IUUC-Sha-107487	Sarcophilus harrisii	50.85	2.00e-13	68.20
IUUC-Sja-107944	Schizosaccharomyces japonicus	37.88	2.00e-08	52.00
IUUC-Smo-109339	Selaginella moellendorffii	46.30	4.00e-10	57.00
IUUC-Sit-109959	Setaria italica	48.21	2.00e-05	42.40
IUUC-Stu-112694	Solanum tuberosum	45.12	2.00e-16	77.80
IUUC-Sar-113601	Sorex araneus	42.37	5.00e-11	60.10
IUUC-Sbi-114398	Sorghum bicolor	50.00	3.00e-06	44.70
IUUC-Ssc-115911	Sus scrofa	42.37	4.00e-11	60.10
IUUC-Tgu-117264	Taeniopygia guttata	52.54	8.00e-14	68.90
IUUC-Tru-117663	Takifugu rubripes	36.50	6.00e-15	72.40
IUUC-Tsy-118883	Tarsius syrichta	42.37	2.00e-11	60.10
IUUC-Tni-120136	Tetraodon nigroviridis	42.37	9.00e-10	57.40
IUUC-Tca-121320	Theobroma cacao	46.43	2.00e-08	51.60
IUUC-Tae-124872	Triticum aestivum	35.71	2.00e-15	75.50
IUUC-Tur-126408	Triticum urartu	35.71	2.00e-15	75.10
IUUC-Ttr-128950	Tursiops truncatus	42.37	3.00e-11	60.80
IUUC-Vvi-130833	Vitis vinifera	51.79	2.00e-15	75.50
IUUC-Xtr-132879	Xenopus tropicalis	49.15	2.00e-12	64.30
IUUC-Xma-133319	Xiphophorus maculatus	46.77	4.00e-14	69.30

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence