iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-72	243.9	164	468

Active Site

Position(s)	Description	Evidence
172	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
428	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           Gl N gNtC++ SvLQc +++ +l + l +  + + +n     ++k +++++l++ +e  + s+   ++  ++ + l  +++ f  ++q+Da+Efl+ 
   Q: 164  GLYNSGNTCFIASVLQCFTHTVPLIDSLRSfMYGNPCNC---GNEKFCVMQALRDHIELALRSSGYGINIDRFRDNLTYFSSDFMINHQEDAHEFLQS 258
           9*****************************655566655...5689**************9************************************* PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           +ld+le+ +                   ++++  +  ++  ++++++F+g l s++ c +c++vs+++ep l  sl++++ +     +l ++Lesft 
   Q: 259  FLDKLERCC----LD-------------PKNQLGSVSSQDLNIVDNVFGGGLMSTLCCCNCNSVSNTFEPSLGWSLEIEDVN-----TLWKALESFTC 334
           *********....22.............2223456778899****************************************9.....9********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssG 293
            e+le+  ++ c++ck+k++ ek+l+++klP+v ++hLkRf  ++++   eki++++efpleLdlspf++s+ +  +++++Y L+a v H G  +  G
   Q: 335  VEKLED--QLTCDNCKEKVTKEKQLRFDKLPPVATFHLKRF--TNDGVTMEKIFDHIEFPLELDLSPFMSSNHD-PEVSTRYHLYAFVEHIGiRATFG 427
           ****95..8********************************..77778999********************665.557******************** PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HY +yv++  + W +fdDskVt ++ee+vl+   + aY+lfY r
   Q: 428  HYSSYVRSAPETWHNFDDSKVTRISEERVLS---RPAYILFYAR 468
           ********999********************...********87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MAEFSDPPPS NLSSSHKLTK PNQTLDESSP TAPIRDLVTN SLSLSSPIRQ IQALSPAKPD 60
GSSSSPPDKT LNFNPEENRD VNPDESSSSP SDKTLIAPPA QISPVSNNNH LRITNTSDSY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTATTTTA TCTGTGGAAA AGGTCAAAAG AAACCCTAAA TCCCCAAATA AATGGCGGCT 60
TGATTTTCCC TCCCAATTCA AACCTTCTTC TCCACTCCAA TTCTCATCTT CCCTCCAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G46740

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000766	Aegilops tauschii	43.40	8.00e-76	277.00
IUUC-Atr-002708	Amborella trichopoda	45.54	6.00e-81	294.00
IUUC-Aly-005458	Arabidopsis lyrata	82.21	0.00e+00	1125.00
IUUC-Bdi-014605	Brachypodium distachyon	48.35	1.00e-62	233.00
IUUC-Bol-015756	Brassica oleracea	58.13	0.00e+00	775.00
IUUC-Bra-017084	Brassica rapa	56.87	0.00e+00	743.00
IUUC-Hvu-047714	Hordeum vulgare	47.62	4.00e-87	315.00
IUUC-Lpe-051429	Leersia perrieri	48.08	2.00e-60	226.00
IUUC-Oba-075717	Oryza barthii	44.08	1.00e-75	277.00
IUUC-Ogl-077443	Oryza glaberrima	46.13	6.00e-61	228.00
IUUC-Ogu-078191	Oryza glumaepatula	45.09	1.00e-71	263.00
IUUC-Oin-079634	Oryza indica	44.08	1.00e-71	263.00
IUUC-Ome-081886	Oryza meridionalis	46.48	6.00e-57	214.00
IUUC-Oni-082505	Oryza nivara	44.90	6.00e-73	268.00
IUUC-Opu-083445	Oryza punctata	46.48	2.00e-57	216.00
IUUC-Oru-085176	Oryza rufipogon	46.13	5.00e-57	215.00
IUUC-Pop-098814	Populus trichocarpa	54.47	2.00e-100	359.00
IUUC-Ppe-101932	Prunus persica	48.69	2.00e-104	372.00
IUUC-Sbi-114738	Sorghum bicolor	40.19	7.00e-58	216.00
IUUC-Tca-120971	Theobroma cacao	55.04	5.00e-105	374.00
IUUC-Tae-125005	Triticum aestivum	45.80	2.00e-87	316.00
IUUC-Tur-126591	Triticum urartu	47.06	9.00e-62	230.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence