iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	14657406; 18552232

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	5.60e-35	120.1	256	328
E3 activity/RING/RING	0.0018	19.6	262	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           +p++f+CpIsle+MrdPv+++sG+ty+r++Iekw++ g++tcP+t+q lt+++l+Pn++lr+li +wce+n++
   Q: 256  IPDDFRCPISLEMMRDPVIVSSGQTYERTCIEKWIEGGHSTCPKTQQALTSTTLTPNYVLRSLIAQWCEANDI 328
           89********************************************************************987 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCP 43
           C+i le+++d p++++ g ++ ++C++kw      + ++ +CP
   Q: 262  CPISLEMMRD-PVIVSSGQTYERTCIEKW-----IEGGHSTCP 298
           ********99.999***************.....688899998 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Functions as an E3 ubiquitin ligase.

Protein Sequence
(Fasta)

MEEEKASAAQ SLIDVVNEIA AISDYRITVK KLCYNLARRL KLLVPMFEEI RESNEPISED 60
TLKTLMNLKE AMCSAKDYLK FCSQGSKIYL VMEREQVTSK LMEVSVKLEQ SLSQIPYEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATAATATA ATATATTAAT GTAAAAAATA AAACAAACAC AATCGTAACC GGTCCCGCGG 60
CTTCGTGGTC GAATTTACCT TTGTTCCGGT TTAGTTCTTA AGCCGAGAGA ATCGTACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000225--Armadillo
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50176--ARM_REPEAT
PS51698--U_BOX

Pfam

PF00514--Arm
PF04564--U-box

SMART

SM00185--ARM
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0070696--F:transmembrane receptor protein serine/threonine kinase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042742--P:defense response to bacterium
GO:0043066--P:negative regulation of apoptotic process
GO:0016567--P:protein ubiquitination
GO:2000028--P:regulation of photoperiodism, flowering

KEGG

ath:AT3G46510

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000439	Aegilops tauschii	62.87	0.00e+00	658.00
IUUC-Aly-005681	Arabidopsis lyrata	97.88	0.00e+00	1281.00
IUUC-Bdi-014829	Brachypodium distachyon	59.21	0.00e+00	682.00
IUUC-Bol-015254	Brassica oleracea	91.98	0.00e+00	1189.00
IUUC-Bra-017857	Brassica rapa	91.68	0.00e+00	1177.00
IUUC-Gma-043064	Glycine max	69.67	0.00e+00	912.00
IUUC-Hvu-047052	Hordeum vulgare	59.89	4.00e-180	623.00
IUUC-Lch-050378	Latimeria chalumnae	31.65	4.00e-10	60.50
IUUC-Lpe-051284	Leersia perrieri	57.97	0.00e+00	672.00
IUUC-Mtr-058332	Medicago truncatula	67.63	0.00e+00	878.00
IUUC-Mac-065438	Musa acuminata	58.14	0.00e+00	687.00
IUUC-Oba-075184	Oryza barthii	58.14	0.00e+00	690.00
IUUC-Obr-076590	Oryza brachyantha	57.56	0.00e+00	676.00
IUUC-Ogl-077386	Oryza glaberrima	58.14	0.00e+00	690.00
IUUC-Ogu-078326	Oryza glumaepatula	58.14	0.00e+00	691.00
IUUC-Oin-079687	Oryza indica	58.14	0.00e+00	689.00
IUUC-Olo-081001	Oryza longistaminata	58.14	0.00e+00	690.00
IUUC-Ome-081417	Oryza meridionalis	57.78	0.00e+00	697.00
IUUC-Oni-082379	Oryza nivara	58.14	0.00e+00	689.00
IUUC-Opu-083774	Oryza punctata	57.05	0.00e+00	687.00
IUUC-Oru-084885	Oryza rufipogon	57.98	0.00e+00	688.00
IUUC-Osa-085946	Oryza sativa	57.65	0.00e+00	682.00
IUUC-Ppa-095383	Physcomitrella patens	51.13	2.00e-178	618.00
IUUC-Pop-098809	Populus trichocarpa	72.31	0.00e+00	934.00
IUUC-Ppe-102057	Prunus persica	70.02	0.00e+00	786.00
IUUC-Spo-108349	Schizosaccharomyces pombe	28.03	2.00e-14	73.20
IUUC-Smo-109443	Selaginella moellendorffii	51.83	4.00e-163	567.00
IUUC-Sit-110392	Setaria italica	63.75	0.00e+00	669.00
IUUC-Sly-111594	Solanum lycopersicum	70.43	0.00e+00	896.00
IUUC-Stu-112876	Solanum tuberosum	68.43	0.00e+00	882.00
IUUC-Sbi-113843	Sorghum bicolor	56.13	0.00e+00	651.00
IUUC-Tca-121745	Theobroma cacao	69.89	0.00e+00	891.00
IUUC-Tae-124662	Triticum aestivum	59.04	0.00e+00	679.00
IUUC-Tur-126448	Triticum urartu	61.90	0.00e+00	674.00
IUUC-Vvi-131752	Vitis vinifera	72.99	0.00e+00	888.00
IUUC-Xtr-132376	Xenopus tropicalis	29.18	2.00e-12	68.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence