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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018331
UUCD1 version UUC-CaE-00011
Ensembl Protein ID F35D6.1a
UniProt Accession P17221; Q95ZU3; FEM1_CAEEL
Genbank Protein ID AAA28055.1; CCD61590.1; CCD61591.1
Protein Name Sex-determining protein fem-1; Feminization of XX and XO animals protein 1
Genbank Nucleotide ID J03172; FO080146; FO080146
Gene Name fem-1; isx-1; F35D6.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00001411 F35D6.1a F35D6.1a
WBGene00001411 F35D6.1b F35D6.1b
Annotation
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Other E3 adaptor/Cullin RING/Other 17609115; 24076122
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1.
 Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1.
Protein Sequence
(Fasta)
MTPNGHHFRT VIYNAAAVGN LQRIKVFTIN SRNDRQWIID CFNSDQDGRY PLVIAARNGH 60
ANVVEYLLEI GADPSVRGVV EFDNENIQGT PPLWAASAAG HIEIVKLLIE KANADVNQAT 120
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Protein Fasta Sequence


>IUUC-Cel-018331|E3,Cullin RING/Other|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
CTTTTCTTTT TCTTCTCGAA TTTCTGCAAT TTCTATTAAA ATTCCGCCAG TTTTTTTTTG 60
GAAAAATTGG CGGTATGACA CCAAATGGAC ATCATTTTCG AACAGTAATT TATAATGCTG 120
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Nucleotide Fasta Sequence


>IUUC-Cel-018331|E3,Cullin RING/Other|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF12796--Ank_2
SMART

SM00248--ANK
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0019100--P:male germ-line sex determination
GO:0019102--P:male somatic sex determination
GO:0042006--P:masculinization of hermaphroditic germ-line
GO:0016567--P:protein ubiquitination
GO:0010468--P:regulation of gene expression
GO:1905936--P:regulation of germ cell proliferation
GO:0036369--P:transcription factor catabolic process
KEGG cel:CELE_F35D6.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000539 Aegilops tauschii 31.39 9.00e-10 56.20
IUUC-Aml-002342 Ailuropoda melanoleuca 43.72 4.00e-88 317.00
IUUC-Atr-002541 Amborella trichopoda 27.88 2.00e-09 55.50
IUUC-Apl-003985 Anas platyrhynchos 32.94 4.00e-61 227.00
IUUC-Aca-005021 Anolis carolinensis 35.45 3.00e-91 327.00
IUUC-Ath-006849 Arabidopsis thaliana 29.29 2.00e-09 55.80
IUUC-Ang-009817 Aspergillus niger 33.17 8.00e-15 73.60
IUUC-Ame-011230 Astyanax mexicanus 35.44 2.00e-92 331.00
IUUC-Bta-013387 Bos taurus 43.72 4.00e-88 317.00
IUUC-Bdi-014410 Brachypodium distachyon 29.63 3.00e-09 55.10
IUUC-Bol-016502 Brassica oleracea 29.49 2.00e-09 56.20
IUUC-Bra-017756 Brassica rapa 29.91 5.00e-10 57.80
IUUC-Cja-019699 Callithrix jacchus 43.72 3.00e-88 317.00
IUUC-Cfa-020538 Canis familiaris 43.72 4.00e-88 317.00
IUUC-Cpo-021778 Cavia porcellus 38.77 2.00e-61 228.00
IUUC-Csa-023288 Chlorocebus sabaeus 43.72 3.00e-88 317.00
IUUC-Cho-024656 Choloepus hoffmanni 40.87 1.00e-47 182.00
IUUC-Cin-025401 Ciona intestinalis 43.16 2.00e-81 295.00
IUUC-Csv-025937 Ciona savignyi 42.08 4.00e-79 287.00
IUUC-Cme-027144 Cyanidioschyzon merolae 37.88 3.00e-15 76.60
IUUC-Dre-028359 Danio rerio 37.53 4.00e-61 228.00
IUUC-Dno-029410 Dasypus novemcinctus 43.72 4.00e-88 317.00
IUUC-Dor-030434 Dipodomys ordii 44.09 1.00e-88 319.00
IUUC-Dme-031725 Drosophila melanogaster 43.46 3.00e-86 311.00
IUUC-Ete-033142 Echinops telfairi 43.72 3.00e-88 317.00
IUUC-Eca-033604 Equus caballus 43.72 2.00e-88 318.00
IUUC-Eeu-035045 Erinaceus europaeus 43.46 7.00e-88 316.00
IUUC-Fca-035992 Felis catus 43.72 6.00e-88 317.00
IUUC-Fal-037002 Ficedula albicollis 36.33 5.00e-89 320.00
IUUC-Fox-037717 Fusarium oxysporum 41.41 8.00e-06 45.40
IUUC-Gmo-038702 Gadus morhua 36.82 4.00e-93 334.00
IUUC-Ggr-039803 Gaeumannomyces graminis 41.24 4.00e-15 73.20
IUUC-Gga-040317 Gallus gallus 44.03 7.00e-87 313.00
IUUC-Gac-041410 Gasterosteus aculeatus 35.55 8.00e-92 330.00
IUUC-Gma-043652 Glycine max 32.13 2.00e-10 59.30
IUUC-Ggo-045522 Gorilla gorilla 43.72 3.00e-88 317.00
IUUC-Hsa-046796 Homo sapiens 43.72 3.00e-88 317.00
IUUC-Hvu-047098 Hordeum vulgare 31.92 2.00e-09 56.20
IUUC-Itr-048316 Ictidomys tridecemlineatus 43.72 4.00e-88 317.00
IUUC-Kpa-049236 Komagataella pastoris 41.38 3.00e-04 38.90
IUUC-Lch-050179 Latimeria chalumnae 38.43 8.00e-94 336.00
IUUC-Lpe-050794 Leersia perrieri 32.98 2.00e-11 62.40
IUUC-Loc-051857 Lepisosteus oculatus 36.84 1.00e-94 338.00
IUUC-Laf-053354 Loxodonta africana 43.72 3.00e-88 318.00
IUUC-Mcc-055364 Macaca mulatta 43.72 3.00e-88 317.00
IUUC-Meu-055961 Macropus eugenii 46.22 9.00e-88 316.00
IUUC-Mpo-057569 Magnaporthe poae 33.50 1.00e-16 80.50
IUUC-Mtr-058135 Medicago truncatula 28.48 1.00e-10 59.70
IUUC-Mla-058995 Melampsora laricipopulina 34.65 9.00e-09 50.80
IUUC-Mga-059954 Meleagris gallopavo 52.60 8.00e-54 203.00
IUUC-Mvi-060501 Microbotryum violaceum 29.67 3.00e-17 83.20
IUUC-Mmr-061523 Microcebus murinus 38.77 2.00e-61 228.00
IUUC-Mdo-062747 Monodelphis domestica 46.49 2.00e-87 315.00
IUUC-Mmu-064254 Mus musculus 43.04 8.00e-86 310.00
IUUC-Mac-065606 Musa acuminata 27.71 5.00e-10 57.80
IUUC-Mpu-065985 Mustela putorius furo 43.72 4.00e-88 317.00
IUUC-Mlu-067989 Myotis lucifugus 42.78 1.00e-85 309.00
IUUC-Nfi-068574 Neosartorya fischeri 29.33 7.00e-09 54.70
IUUC-Nle-069932 Nomascus leucogenys 43.72 3.00e-88 317.00
IUUC-Opr-070186 Ochotona princeps 43.72 3.00e-88 317.00
IUUC-Ont-072533 Oreochromis niloticus 35.29 8.00e-92 330.00
IUUC-Oan-073603 Ornithorhynchus anatinus 37.63 2.00e-48 185.00
IUUC-Ocu-074213 Oryctolagus cuniculus 43.72 4.00e-88 317.00
IUUC-Oba-075304 Oryza barthii 31.92 3.00e-10 58.90
IUUC-Obr-076187 Oryza brachyantha 33.51 4.00e-12 64.70
IUUC-Ogl-077822 Oryza glaberrima 32.98 3.00e-11 62.00
IUUC-Ogu-078020 Oryza glumaepatula 32.98 3.00e-11 62.00
IUUC-Oin-079995 Oryza indica 32.98 2.00e-11 62.00
IUUC-Olo-080305 Oryza longistaminata 31.92 2.00e-10 59.30
IUUC-Ome-081528 Oryza meridionalis 32.98 3.00e-11 62.00
IUUC-Oni-082930 Oryza nivara 32.98 3.00e-11 62.00
IUUC-Opu-083946 Oryza punctata 32.98 1.00e-11 62.80
IUUC-Oru-084572 Oryza rufipogon 32.98 2.00e-11 62.00
IUUC-Osa-085743 Oryza sativa 32.98 3.00e-11 62.00
IUUC-Ola-086744 Oryzias latipes 35.68 4.00e-96 344.00
IUUC-Olu-087673 Ostreococcus lucimarinus 30.73 9.00e-16 77.00
IUUC-Oga-088031 Otolemur garnettii 43.72 2.00e-88 318.00
IUUC-Oar-089759 Ovis aries 43.72 4.00e-88 317.00
IUUC-Ptr-091472 Pan troglodytes 43.72 3.00e-88 317.00
IUUC-Pan-092660 Papio anubis 43.72 2.00e-88 318.00
IUUC-Psi-093528 Pelodiscus sinensis 46.65 2.00e-87 315.00
IUUC-Pma-094411 Petromyzon marinus 44.88 3.00e-89 321.00
IUUC-Pno-094944 Phaeosphaeria nodorum 32.24 7.00e-19 87.80
IUUC-Pfo-096936 Poecilia formosa 45.09 6.00e-91 327.00
IUUC-Pab-098073 Pongo abelii 43.72 3.00e-88 317.00
IUUC-Pop-099715 Populus trichocarpa 31.25 4.00e-11 61.20
IUUC-Pca-100953 Procavia capensis 40.23 2.00e-59 222.00
IUUC-Ppe-101736 Prunus persica 28.46 3.00e-12 65.10
IUUC-Pva-102915 Pteropus vampyrus 38.46 5.00e-77 280.00
IUUC-Rno-104915 Rattus norvegicus 46.20 8.00e-86 310.00
IUUC-Sha-106623 Sarcophilus harrisii 46.49 2.00e-87 315.00
IUUC-Sja-107861 Schizosaccharomyces japonicus 37.50 2.00e-13 66.60
IUUC-Smo-109510 Selaginella moellendorffii 31.39 2.00e-10 58.90
IUUC-Sit-109748 Setaria italica 31.41 5.00e-10 58.20
IUUC-Sly-111372 Solanum lycopersicum 29.09 8.00e-12 63.50
IUUC-Stu-112634 Solanum tuberosum 29.09 8.00e-12 63.50
IUUC-Sar-113422 Sorex araneus 44.41 2.00e-86 311.00
IUUC-Sbi-114785 Sorghum bicolor 31.92 6.00e-10 57.80
IUUC-Ssc-116086 Sus scrofa 38.34 1.00e-67 249.00
IUUC-Tgu-117192 Taeniopygia guttata 36.33 7.00e-89 320.00
IUUC-Tru-118533 Takifugu rubripes 34.02 1.00e-89 323.00
IUUC-Tsy-119026 Tarsius syrichta 48.07 2.00e-42 165.00
IUUC-Tni-119869 Tetraodon nigroviridis 34.68 3.00e-92 331.00
IUUC-Tca-121216 Theobroma cacao 32.32 7.00e-11 60.50
IUUC-Tae-123509 Triticum aestivum 31.25 9.00e-10 56.60
IUUC-Tur-126367 Triticum urartu 28.91 1.00e-07 48.90
IUUC-Tbe-127905 Tupaia belangeri 38.77 5.00e-61 227.00
IUUC-Ttr-128277 Tursiops truncatus 42.71 4.00e-64 237.00
IUUC-Vda-129784 Verticillium dahliae 33.16 2.00e-19 90.10
IUUC-Vpa-130370 Vicugna pacos 43.72 4.00e-88 317.00
IUUC-Vvi-130914 Vitis vinifera 27.27 6.00e-09 53.90
IUUC-Xtr-132661 Xenopus tropicalis 34.87 3.00e-92 331.00
IUUC-Xma-133950 Xiphophorus maculatus 35.47 5.00e-91 327.00
IUUC-Yli-134395 Yarrowia lipolytica 34.62 2.00e-03 36.20
Created Date 25-Jun-2017

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