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Tag Content
UUCD2 ID IUUC-Bta-012644
UUCD1 version UUC-BoT-00970
Ensembl Protein ID ENSBTAP00000018478.3
UniProt Accession Q3ZCF6; APC11_BOVIN
Genbank Protein ID AAI02427.1
Protein Name Anaphase-promoting complex subunit 11; Cyclosome subunit 11
Genbank Nucleotide ID BC102426
Gene Name ANAPC11
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000001937.3 ENSBTAT00000018478.3 ENSBTAP00000018478.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 48.28 2.00e-17 83.60 IUUC-Cel-018191
E3 adaptor/Cullin RING/APC_C/APC_C 97.62 2.00e-43 171.00 IUUC-Hsa-046268
E3 adaptor/Cullin RING/APC_C/APC_C 43.14 3.00e-19 87.80 IUUC-Sce-106149
E3 activity/RING/RING 51.85 3.00e-21 94.40 IUUC-Spo-108296
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
 Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity).
Protein Sequence
(Fasta)
MRVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI 60
LKWLNAQQVQ QHCPMCRQEW KFKE 84
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Protein Fasta Sequence


>IUUC-Bta-012644|E3,RING;E3,APC_C|Bos taurus
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Nucleotide Sequence
(Fasta)
GGGAGTGAGT GCGGCCCGTG CGGCCCGTGC GGCCCACGCC TGGGTTGTTT CCGGGGTGAC 60
CTCGTAGGGA GCGGGCTTGG GTCTCCATCT ACTCAGCCCC GTCAGCCCTT TCGGAAGTAG 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012644|E3,RING;E3,APC_C|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024991--Apc11
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF12861--zf-ANAPC11
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
KEGG bta:616275
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000514 Aegilops tauschii 39.29 1.00e-06 48.50
IUUC-Aml-002323 Ailuropoda melanoleuca 98.81 2.00e-45 172.00
IUUC-Aly-006393 Arabidopsis lyrata 69.51 1.00e-33 134.00
IUUC-Ath-006698 Arabidopsis thaliana 69.51 1.00e-33 134.00
IUUC-Ago-007824 Ashbya gossypii 43.43 2.00e-19 88.20
IUUC-Acl-008180 Aspergillus clavatus 56.25 1.00e-23 101.00
IUUC-Afl-008622 Aspergillus flavus 56.25 7.00e-24 101.00
IUUC-Afu-008844 Aspergillus fumigatus 55.00 3.00e-23 99.40
IUUC-Ani-009260 Aspergillus nidulans 55.00 2.00e-23 100.00
IUUC-Ang-009794 Aspergillus niger 56.96 3.00e-27 116.00
IUUC-Ame-011274 Astyanax mexicanus 91.67 5.00e-39 151.00
IUUC-Bgr-012017 Blumeria graminis 49.37 2.00e-18 83.60
IUUC-Bci-013779 Botrytis cinerea 51.76 1.00e-23 100.00
IUUC-Bdi-014975 Brachypodium distachyon 67.47 4.00e-32 128.00
IUUC-Bol-016184 Brassica oleracea 71.43 2.00e-32 129.00
IUUC-Bra-016983 Brassica rapa 66.67 8.00e-34 135.00
IUUC-Cel-018191 Caenorhabditis elegans 48.28 3.00e-18 83.60
IUUC-Cja-019909 Callithrix jacchus 97.62 6.00e-45 171.00
IUUC-Cfa-020306 Canis familiaris 98.81 2.00e-45 172.00
IUUC-Cpo-021773 Cavia porcellus 98.81 2.00e-45 172.00
IUUC-Cre-022961 Chlamydomonas reinhardtii 55.42 3.00e-24 102.00
IUUC-Csa-024274 Chlorocebus sabaeus 97.62 6.00e-45 171.00
IUUC-Cgl-026398 Colletotrichum gloeosporioides 52.38 4.00e-23 99.00
IUUC-Cne-027036 Cryptococcus neoformans 44.23 3.00e-22 96.70
IUUC-Cme-027263 Cyanidioschyzon merolae 57.14 6.00e-27 111.00
IUUC-Dre-027617 Danio rerio 91.67 2.00e-39 152.00
IUUC-Dse-031304 Dothistroma septosporum 56.79 1.00e-23 100.00
IUUC-Dme-031897 Drosophila melanogaster 72.29 2.00e-34 136.00
IUUC-Fca-036297 Felis catus 98.81 3.00e-46 176.00
IUUC-Fal-037228 Ficedula albicollis 90.48 3.00e-43 165.00
IUUC-Fox-037929 Fusarium oxysporum 58.62 1.00e-15 73.60
IUUC-Fso-038194 Fusarium solani 55.70 4.00e-22 95.50
IUUC-Gmo-039638 Gadus morhua 95.74 2.00e-19 86.30
IUUC-Gga-040897 Gallus gallus 91.67 2.00e-43 166.00
IUUC-Gac-041644 Gasterosteus aculeatus 95.74 2.00e-19 86.30
IUUC-Gma-043111 Glycine max 69.14 2.00e-33 133.00
IUUC-Hsa-046268 Homo sapiens 97.62 6.00e-45 171.00
IUUC-Hvu-047356 Hordeum vulgare 66.27 1.00e-31 127.00
IUUC-Itr-048453 Ictidomys tridecemlineatus 98.81 2.00e-45 172.00
IUUC-Kpa-049388 Komagataella pastoris 41.28 1.00e-18 85.10
IUUC-Lch-049838 Latimeria chalumnae 90.48 1.00e-42 163.00
IUUC-Lpe-050878 Leersia perrieri 71.43 2.00e-25 106.00
IUUC-Lma-053166 Leptosphaeria maculans 52.38 7.00e-24 101.00
IUUC-Laf-054221 Loxodonta africana 98.81 2.00e-45 172.00
IUUC-Mor-056930 Magnaporthe oryzae 55.29 2.00e-24 103.00
IUUC-Mtr-058104 Medicago truncatula 72.37 1.00e-32 130.00
IUUC-Mla-059079 Melampsora laricipopulina 46.73 4.00e-24 102.00
IUUC-Mvi-060446 Microbotryum violaceum 67.24 9.00e-23 99.40
IUUC-Mmu-064301 Mus musculus 98.81 2.00e-45 172.00
IUUC-Mac-064936 Musa acuminata 71.08 4.00e-34 135.00
IUUC-Mpu-066041 Mustela putorius furo 98.81 2.00e-45 172.00
IUUC-Mlu-067360 Myotis lucifugus 100.00 8.00e-46 174.00
IUUC-Ncr-068931 Neurospora crassa 54.88 1.00e-23 100.00
IUUC-Ont-072502 Oreochromis niloticus 92.77 3.00e-39 152.00
IUUC-Ocu-074751 Oryctolagus cuniculus 88.10 2.00e-40 155.00
IUUC-Oba-075026 Oryza barthii 69.88 7.00e-33 130.00
IUUC-Obr-076888 Oryza brachyantha 68.67 1.00e-32 131.00
IUUC-Ogl-077846 Oryza glaberrima 69.88 8.00e-33 130.00
IUUC-Ogu-078433 Oryza glumaepatula 68.67 2.00e-33 134.00
IUUC-Oin-079264 Oryza indica 69.88 8.00e-33 130.00
IUUC-Ome-081297 Oryza meridionalis 73.02 4.00e-26 110.00
IUUC-Oni-082739 Oryza nivara 69.88 2.00e-33 134.00
IUUC-Opu-083502 Oryza punctata 73.02 2.00e-25 106.00
IUUC-Oru-084838 Oryza rufipogon 69.88 3.00e-33 133.00
IUUC-Osa-085826 Oryza sativa 69.88 8.00e-33 130.00
IUUC-Ola-087572 Oryzias latipes 92.86 2.00e-39 152.00
IUUC-Olu-087765 Ostreococcus lucimarinus 52.94 9.00e-24 100.00
IUUC-Oga-088853 Otolemur garnettii 96.43 1.00e-44 169.00
IUUC-Oar-089687 Ovis aries 98.81 2.00e-45 172.00
IUUC-Ptr-091674 Pan troglodytes 97.62 6.00e-45 171.00
IUUC-Psi-093124 Pelodiscus sinensis 95.24 2.00e-44 169.00
IUUC-Pno-094852 Phaeosphaeria nodorum 52.38 8.00e-24 101.00
IUUC-Ppa-095866 Physcomitrella patens 67.11 4.00e-30 122.00
IUUC-Pfo-096410 Poecilia formosa 90.48 1.00e-38 150.00
IUUC-Pop-099204 Populus trichocarpa 67.05 2.00e-33 133.00
IUUC-Ppe-101903 Prunus persica 68.67 8.00e-33 130.00
IUUC-Pte-104160 Pyrenophora teres 51.19 9.00e-23 97.80
IUUC-Rno-104979 Rattus norvegicus 98.81 2.00e-45 172.00
IUUC-Sce-106149 Saccharomyces cerevisiae 43.14 3.00e-19 87.80
IUUC-Sja-107930 Schizosaccharomyces japonicus 54.12 2.00e-24 103.00
IUUC-Spo-108296 Schizosaccharomyces pombe 51.85 1.00e-21 94.40
IUUC-Ssl-108464 Sclerotinia sclerotiorum 46.25 7.00e-15 71.60
IUUC-Smo-109289 Selaginella moellendorffii 67.11 2.00e-30 122.00
IUUC-Sit-109777 Setaria italica 67.47 4.00e-32 128.00
IUUC-Stu-112287 Solanum tuberosum 71.43 4.00e-33 132.00
IUUC-Sbi-113803 Sorghum bicolor 67.47 4.00e-32 128.00
IUUC-Sre-115018 Sporisorium reilianum 54.65 6.00e-22 95.10
IUUC-Ssc-116403 Sus scrofa 92.77 5.00e-42 161.00
IUUC-Tgu-117375 Taeniopygia guttata 90.48 3.00e-43 165.00
IUUC-Tru-118064 Takifugu rubripes 90.00 4.00e-36 142.00
IUUC-Tni-120387 Tetraodon nigroviridis 90.48 8.00e-39 150.00
IUUC-Tca-121186 Theobroma cacao 73.21 6.00e-23 98.20
IUUC-Tre-122153 Trichoderma reesei 55.00 2.00e-23 99.80
IUUC-Tvi-122412 Trichoderma virens 51.76 1.00e-23 100.00
IUUC-Tae-125184 Triticum aestivum 67.47 5.00e-32 128.00
IUUC-Tur-126516 Triticum urartu 66.27 4.00e-32 129.00
IUUC-Tme-127121 Tuber melanosporum 51.81 4.00e-24 102.00
IUUC-Uma-129529 Ustilago maydis 56.10 3.00e-21 92.80
IUUC-Vvi-131191 Vitis vinifera 72.37 5.00e-33 132.00
IUUC-Xma-133275 Xiphophorus maculatus 89.29 4.00e-38 148.00
IUUC-Yli-134369 Yarrowia lipolytica 59.76 8.00e-26 108.00
IUUC-Zma-134869 Zea mays 67.47 8.00e-32 127.00
Created Date 25-Jun-2017

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