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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046045
UUCD1 version UUC-HoS-00129
Ensembl Protein ID ENSP00000428334.1
UniProt Accession Q15369; E5RGD9; Q567Q6; ELOC_HUMAN
Genbank Protein ID AAA67650.1; AAH13809.1; AAH93065.1; AAI00029.1; AAI00284.1
Protein Name Elongin-C; Elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C; SIII p15; Transcription elongation factor B polypeptide 1
Genbank Nucleotide ID L34587; BX649138; BC093065; BC100028; BC100283
Gene Name ELOC; TCEB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000154582.16 ENST00000602840.5 ENSP00000473408.1
ENSG00000154582.16 ENST00000518127.5 ENSP00000428334.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/Elon-B_C Elon-B_C 17361105; 9606976
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/ECS/Elon-B_C 75.45 8.00e-47 181.00 IUUC-Cel-018375
Organism Homo sapiens
Functional Description
(View)

Functional Description


     The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
 The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
Protein Sequence
(Fasta)
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV 60
NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC 112
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046045|E3,Elon-B_C|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGACGGAAG TGAGCGACAC ACTCTGCGTC CTCGCCTCAC CAGGTACGGA TCTCCCGCGC 60
GTCGCCGAAA GCGGCTCTGA CCCAGCGGAA GTAATTCTTT CGACTGCCCC GGAACCCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046045|E3,Elon-B_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR001232--SKP1-like
IPR011333--SKP1/BTB/POZ
IPR016073--Skp1_comp_POZ
Pfam

PF03931--Skp1_POZ
SMART

SM00512--Skp1
Gene Ontology

GO:0005829--C:cytosol
GO:0070449--C:elongin complex
GO:0005654--C:nucleoplasm
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016032--P:viral process
KEGG hsa:6921
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000253 Aegilops tauschii 50.00 3.00e-23 100.00
IUUC-Aml-001991 Ailuropoda melanoleuca 96.43 3.00e-60 222.00
IUUC-Atr-002833 Amborella trichopoda 47.83 3.00e-19 86.30
IUUC-Apl-003237 Anas platyrhynchos 100.00 2.00e-62 230.00
IUUC-Aca-004654 Anolis carolinensis 99.11 2.00e-63 233.00
IUUC-Aly-006231 Arabidopsis lyrata 45.65 3.00e-20 89.40
IUUC-Ath-006923 Arabidopsis thaliana 45.65 3.00e-20 89.40
IUUC-Ago-007903 Ashbya gossypii 41.05 2.00e-12 63.90
IUUC-Acl-008323 Aspergillus clavatus 46.81 2.00e-18 83.60
IUUC-Afl-008628 Aspergillus flavus 45.36 2.00e-18 84.00
IUUC-Afu-009082 Aspergillus fumigatus 45.74 4.00e-18 82.80
IUUC-Aor-010001 Aspergillus oryzae 45.36 2.00e-18 84.00
IUUC-Ate-010513 Aspergillus terreus 44.68 1.00e-17 81.30
IUUC-Ame-011398 Astyanax mexicanus 99.11 8.00e-63 231.00
IUUC-Bgr-012303 Blumeria graminis 43.00 4.00e-16 75.90
IUUC-Bta-012534 Bos taurus 100.00 8.00e-64 234.00
IUUC-Bci-013677 Botrytis cinerea 45.74 2.00e-17 80.10
IUUC-Bdi-014321 Brachypodium distachyon 51.61 4.00e-23 99.80
IUUC-Bol-016090 Brassica oleracea 46.74 8.00e-21 91.30
IUUC-Bra-017868 Brassica rapa 46.74 2.00e-20 90.10
IUUC-Cel-018375 Caenorhabditis elegans 75.45 1.00e-47 181.00
IUUC-Cja-019366 Callithrix jacchus 100.00 8.00e-64 234.00
IUUC-Cfa-020174 Canis familiaris 100.00 8.00e-64 234.00
IUUC-Cpo-021699 Cavia porcellus 99.11 2.00e-63 233.00
IUUC-Cre-022777 Chlamydomonas reinhardtii 61.70 5.00e-28 115.00
IUUC-Csa-023190 Chlorocebus sabaeus 100.00 8.00e-64 234.00
IUUC-Cho-024745 Choloepus hoffmanni 100.00 8.00e-64 234.00
IUUC-Cin-025306 Ciona intestinalis 83.78 9.00e-54 201.00
IUUC-Csv-025946 Ciona savignyi 83.78 7.00e-54 201.00
IUUC-Cgl-026396 Colletotrichum gloeosporioides 47.31 5.00e-18 82.40
IUUC-Cne-027000 Cryptococcus neoformans 41.90 9.00e-14 68.60
IUUC-Cme-027340 Cyanidioschyzon merolae 31.96 2.00e-08 50.40
IUUC-Dre-028790 Danio rerio 99.11 3.00e-63 232.00
IUUC-Dno-029818 Dasypus novemcinctus 98.21 5.00e-62 228.00
IUUC-Dor-030819 Dipodomys ordii 100.00 8.00e-64 234.00
IUUC-Dse-031361 Dothistroma septosporum 42.55 8.00e-16 74.70
IUUC-Dme-031930 Drosophila melanogaster 93.52 2.00e-58 216.00
IUUC-Ete-032591 Echinops telfairi 100.00 9.00e-33 130.00
IUUC-Eca-034061 Equus caballus 100.00 8.00e-64 234.00
IUUC-Eeu-034521 Erinaceus europaeus 96.30 7.00e-59 218.00
IUUC-Fca-036134 Felis catus 100.00 8.00e-64 234.00
IUUC-Fal-036748 Ficedula albicollis 99.12 2.00e-62 230.00
IUUC-Fox-037851 Fusarium oxysporum 46.24 3.00e-17 80.90
IUUC-Fso-038264 Fusarium solani 45.16 3.00e-17 79.70
IUUC-Gmo-038954 Gadus morhua 100.00 2.00e-62 230.00
IUUC-Ggr-040012 Gaeumannomyces graminis 40.59 2.00e-17 80.50
IUUC-Gga-040980 Gallus gallus 100.00 8.00e-64 234.00
IUUC-Gac-041521 Gasterosteus aculeatus 99.11 2.00e-63 233.00
IUUC-Gma-043602 Glycine max 46.23 1.00e-21 95.50
IUUC-Ggo-045234 Gorilla gorilla 93.75 2.00e-50 190.00
IUUC-Itr-048702 Ictidomys tridecemlineatus 100.00 8.00e-64 234.00
IUUC-Lch-049778 Latimeria chalumnae 99.11 3.00e-63 232.00
IUUC-Lpe-051659 Leersia perrieri 47.57 2.00e-22 97.40
IUUC-Loc-052233 Lepisosteus oculatus 100.00 5.00e-50 188.00
IUUC-Lma-053309 Leptosphaeria maculans 42.71 1.00e-15 74.30
IUUC-Laf-053786 Loxodonta africana 99.11 2.00e-63 233.00
IUUC-Mcc-055335 Macaca mulatta 99.11 2.00e-63 233.00
IUUC-Meu-056860 Macropus eugenii 92.73 5.00e-51 192.00
IUUC-Mor-057180 Magnaporthe oryzae 42.42 2.00e-17 80.10
IUUC-Mpo-057363 Magnaporthe poae 40.20 3.00e-16 76.60
IUUC-Mtr-058082 Medicago truncatula 53.26 3.00e-23 99.40
IUUC-Mga-059423 Meleagris gallopavo 100.00 8.00e-64 234.00
IUUC-Mvi-060554 Microbotryum violaceum 44.00 7.00e-15 73.20
IUUC-Mmr-061580 Microcebus murinus 99.11 2.00e-63 233.00
IUUC-Mdo-062202 Monodelphis domestica 84.21 3.00e-60 223.00
IUUC-Mmu-063628 Mus musculus 100.00 1.00e-60 224.00
IUUC-Mac-064490 Musa acuminata 48.65 1.00e-14 70.90
IUUC-Mpu-066346 Mustela putorius furo 100.00 8.00e-64 234.00
IUUC-Mlu-067018 Myotis lucifugus 99.11 2.00e-63 233.00
IUUC-Nfi-068602 Neosartorya fischeri 45.74 4.00e-18 82.80
IUUC-Ncr-068827 Neurospora crassa 35.71 8.00e-12 62.00
IUUC-Nle-069159 Nomascus leucogenys 100.00 8.00e-64 234.00
IUUC-Opr-071223 Ochotona princeps 100.00 9.00e-33 130.00
IUUC-Ont-071271 Oreochromis niloticus 99.11 2.00e-63 233.00
IUUC-Oan-073669 Ornithorhynchus anatinus 100.00 5.00e-24 102.00
IUUC-Ocu-074728 Oryctolagus cuniculus 99.11 5.00e-63 232.00
IUUC-Oba-075100 Oryza barthii 48.42 5.00e-22 96.30
IUUC-Ogu-078673 Oryza glumaepatula 48.42 9.00e-22 96.30
IUUC-Oin-080039 Oryza indica 42.65 9.00e-14 68.60
IUUC-Olo-080570 Oryza longistaminata 35.37 2.00e-10 58.50
IUUC-Ome-081403 Oryza meridionalis 48.42 5.00e-22 96.30
IUUC-Oni-082578 Oryza nivara 48.42 5.00e-22 96.30
IUUC-Opu-083635 Oryza punctata 46.23 1.00e-21 95.50
IUUC-Oru-085035 Oryza rufipogon 48.42 5.00e-22 96.30
IUUC-Osa-085821 Oryza sativa 48.42 5.00e-22 96.30
IUUC-Ola-086971 Oryzias latipes 98.21 6.00e-63 231.00
IUUC-Olu-087763 Ostreococcus lucimarinus 40.00 2.00e-13 67.80
IUUC-Oga-088648 Otolemur garnettii 100.00 2.00e-62 230.00
IUUC-Oar-089700 Ovis aries 99.10 3.00e-62 231.00
IUUC-Ptr-091070 Pan troglodytes 63.39 2.00e-32 130.00
IUUC-Pan-091801 Papio anubis 100.00 8.00e-64 234.00
IUUC-Psi-093227 Pelodiscus sinensis 100.00 8.00e-64 234.00
IUUC-Pma-094234 Petromyzon marinus 97.30 5.00e-62 228.00
IUUC-Ppa-095747 Physcomitrella patens 47.83 2.00e-19 89.40
IUUC-Pfo-096185 Poecilia formosa 98.21 4.00e-63 232.00
IUUC-Pab-098417 Pongo abelii 100.00 8.00e-64 234.00
IUUC-Pop-099607 Populus trichocarpa 51.09 3.00e-23 99.80
IUUC-Ppe-101921 Prunus persica 48.91 2.00e-21 93.20
IUUC-Pva-102930 Pteropus vampyrus 100.00 8.00e-64 234.00
IUUC-Pgr-103471 Puccinia graminis 31.07 2.00e-07 47.80
IUUC-Ptt-103936 Puccinia triticina 30.77 8.00e-06 43.10
IUUC-Pte-104395 Pyrenophora teres 42.55 1.00e-15 74.70
IUUC-Pyt-104631 Pyrenophora triticirepentis 41.49 1.00e-15 74.30
IUUC-Rno-105140 Rattus norvegicus 100.00 8.00e-64 234.00
IUUC-Sce-106143 Saccharomyces cerevisiae 39.58 1.00e-09 54.30
IUUC-Sha-106705 Sarcophilus harrisii 100.00 8.00e-64 234.00
IUUC-Sja-107988 Schizosaccharomyces japonicus 51.06 4.00e-21 92.00
IUUC-Spo-108165 Schizosaccharomyces pombe 47.87 2.00e-18 83.60
IUUC-Ssl-108453 Sclerotinia sclerotiorum 50.00 2.00e-19 87.40
IUUC-Smo-109012 Selaginella moellendorffii 50.00 4.00e-20 89.00
IUUC-Sit-110266 Setaria italica 52.69 2.00e-16 77.40
IUUC-Sly-111805 Solanum lycopersicum 47.69 1.00e-14 70.50
IUUC-Stu-112888 Solanum tuberosum 50.00 3.00e-21 92.80
IUUC-Sbi-114820 Sorghum bicolor 51.61 2.00e-24 103.00
IUUC-Sre-115154 Sporisorium reilianum 42.59 3.00e-15 73.20
IUUC-Ssc-115310 Sus scrofa 100.00 8.00e-64 234.00
IUUC-Tgu-117102 Taeniopygia guttata 100.00 2.00e-62 230.00
IUUC-Tru-117654 Takifugu rubripes 98.20 3.00e-62 229.00
IUUC-Tsy-119381 Tarsius syrichta 100.00 2.00e-62 230.00
IUUC-Tca-121163 Theobroma cacao 48.91 1.00e-21 94.00
IUUC-Tre-121943 Trichoderma reesei 43.88 3.00e-17 79.70
IUUC-Tvi-122667 Trichoderma virens 44.90 1.00e-17 81.30
IUUC-Tae-122895 Triticum aestivum 50.00 3.00e-23 100.00
IUUC-Tur-126150 Triticum urartu 50.00 3.00e-23 100.00
IUUC-Tme-127140 Tuber melanosporum 43.48 5.00e-18 82.40
IUUC-Tbe-127857 Tupaia belangeri 100.00 2.00e-62 230.00
IUUC-Ttr-128270 Tursiops truncatus 100.00 8.00e-64 234.00
IUUC-Uma-129350 Ustilago maydis 44.00 2.00e-15 73.90
IUUC-Vda-129668 Verticillium dahliae 41.84 8.00e-17 78.60
IUUC-Vpa-130824 Vicugna pacos 100.00 8.00e-64 234.00
IUUC-Vvi-131018 Vitis vinifera 48.91 6.00e-22 95.10
IUUC-Xtr-132564 Xenopus tropicalis 100.00 8.00e-64 234.00
IUUC-Xma-133957 Xiphophorus maculatus 97.32 1.00e-62 230.00
IUUC-Yli-134430 Yarrowia lipolytica 47.00 1.00e-23 101.00
IUUC-Zma-134683 Zea mays 52.13 1.00e-24 104.00
Created Date 25-Jun-2017

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