iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048430

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01102991

Gene Name

Huwe1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000005546.2	ENSSTOT00000005649.2	ENSSTOP00000005055.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-122	409.0	1377	1711

Active Site

Position(s)	Description	Evidence
1679	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 1377 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 1462
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 1463 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 1546
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 1547 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 1632
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 1633 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 1711
           *********************99998999999988899***************************************97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MHDCVSVVKV PIVNHLEFLR DEELEERREK RRKQLAEEET KITDKGKEDK ENRDQSAQCT 60
ASKTNDSTEQ NLSDGTPMPD SYPTTPSSTD AATSESKETL GTLQPSQQQP ALPPPPSLGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCTTCAAT AGCCTGACCT GAGGGGTTAG TGCTCCAGAG GAACCAGTGG ACCAACTTGG 60
TCAGGAAGGT TCAGAAGGCT GTTGGAGCCG TGTTGGGATT TCCCACCAGG ATGAGTATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR025527--DUF4414
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	41.03	1.00e-106	382.00
IUUC-Aml-001684	Ailuropoda melanoleuca	99.14	0.00e+00	1487.00
IUUC-Atr-003044	Amborella trichopoda	52.69	6.00e-126	447.00
IUUC-Apl-003729	Anas platyrhynchos	93.54	0.00e+00	697.00
IUUC-Aca-005263	Anolis carolinensis	95.85	0.00e+00	1526.00
IUUC-Aly-006083	Arabidopsis lyrata	51.77	4.00e-126	447.00
IUUC-Ath-007472	Arabidopsis thaliana	51.77	3.00e-126	447.00
IUUC-Ago-008005	Ashbya gossypii	46.53	1.00e-131	465.00
IUUC-Acl-008254	Aspergillus clavatus	46.46	2.00e-134	475.00
IUUC-Afl-008712	Aspergillus flavus	45.57	4.00e-136	479.00
IUUC-Afu-009022	Aspergillus fumigatus	46.27	6.00e-134	473.00
IUUC-Ani-009412	Aspergillus nidulans	46.83	1.00e-135	479.00
IUUC-Ang-009771	Aspergillus niger	46.46	6.00e-135	476.00
IUUC-Aor-010186	Aspergillus oryzae	44.74	9.00e-127	448.00
IUUC-Ate-010253	Aspergillus terreus	46.99	7.00e-135	476.00
IUUC-Ame-011067	Astyanax mexicanus	91.88	0.00e+00	1055.00
IUUC-Bgr-012043	Blumeria graminis	46.62	2.00e-139	491.00
IUUC-Bta-012813	Bos taurus	98.65	0.00e+00	1488.00
IUUC-Bci-013995	Botrytis cinerea	45.97	9.00e-138	486.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	4.00e-127	451.00
IUUC-Bol-016533	Brassica oleracea	58.33	6.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	44.29	4.00e-123	437.00
IUUC-Cel-018179	Caenorhabditis elegans	61.52	0.00e+00	647.00
IUUC-Cja-018741	Callithrix jacchus	98.97	0.00e+00	1113.00
IUUC-Cfa-020083	Canis familiaris	96.20	0.00e+00	1427.00
IUUC-Cpo-021923	Cavia porcellus	90.80	0.00e+00	1348.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	49.19	1.00e-119	422.00
IUUC-Csa-023853	Chlorocebus sabaeus	99.27	0.00e+00	1494.00
IUUC-Cho-024718	Choloepus hoffmanni	100.00	0.00e+00	815.00
IUUC-Cin-025627	Ciona intestinalis	71.48	0.00e+00	815.00
IUUC-Csv-025872	Ciona savignyi	76.85	0.00e+00	726.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	53.11	1.00e-136	482.00
IUUC-Cne-027095	Cryptococcus neoformans	41.70	2.00e-105	378.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.00	6.00e-116	412.00
IUUC-Dre-028525	Danio rerio	83.01	0.00e+00	1274.00
IUUC-Dno-029680	Dasypus novemcinctus	98.90	0.00e+00	1481.00
IUUC-Dor-030902	Dipodomys ordii	87.23	0.00e+00	1142.00
IUUC-Dse-031197	Dothistroma septosporum	47.12	1.00e-138	489.00
IUUC-Dme-032122	Drosophila melanogaster	68.19	0.00e+00	793.00
IUUC-Ete-032690	Echinops telfairi	90.45	0.00e+00	1242.00
IUUC-Eca-033915	Equus caballus	97.67	0.00e+00	1456.00
IUUC-Eeu-034963	Erinaceus europaeus	97.92	0.00e+00	1502.00
IUUC-Fca-035824	Felis catus	98.77	0.00e+00	1489.00
IUUC-Fox-037756	Fusarium oxysporum	53.53	4.00e-137	484.00
IUUC-Fso-038464	Fusarium solani	54.48	5.00e-137	484.00
IUUC-Gmo-039073	Gadus morhua	90.05	0.00e+00	1388.00
IUUC-Ggr-039946	Gaeumannomyces graminis	46.18	2.00e-134	475.00
IUUC-Gga-040309	Gallus gallus	98.38	0.00e+00	659.00
IUUC-Gac-042430	Gasterosteus aculeatus	90.11	0.00e+00	1385.00
IUUC-Gma-043129	Glycine max	47.50	6.00e-126	447.00
IUUC-Hsa-046879	Homo sapiens	99.15	0.00e+00	1492.00
IUUC-Hvu-047697	Hordeum vulgare	44.99	9.00e-128	452.00
IUUC-Kpa-049228	Komagataella pastoris	48.40	6.00e-141	496.00
IUUC-Lch-050252	Latimeria chalumnae	93.17	0.00e+00	1427.00
IUUC-Lpe-051550	Leersia perrieri	51.99	5.00e-127	450.00
IUUC-Loc-052472	Lepisosteus oculatus	94.23	0.00e+00	1074.00
IUUC-Lma-053159	Leptosphaeria maculans	45.95	1.00e-136	482.00
IUUC-Laf-054154	Loxodonta africana	99.27	0.00e+00	1496.00
IUUC-Mcc-055085	Macaca mulatta	97.44	0.00e+00	1516.00
IUUC-Meu-056727	Macropus eugenii	78.71	0.00e+00	796.00
IUUC-Mor-057201	Magnaporthe oryzae	46.49	3.00e-135	478.00
IUUC-Mpo-057597	Magnaporthe poae	46.11	3.00e-133	471.00
IUUC-Mtr-058088	Medicago truncatula	52.69	2.00e-126	448.00
IUUC-Mla-058888	Melampsora laricipopulina	49.12	6.00e-116	410.00
IUUC-Mvi-060320	Microbotryum violaceum	43.55	2.00e-123	438.00
IUUC-Mmr-060820	Microcebus murinus	99.27	0.00e+00	1493.00
IUUC-Mdo-062930	Monodelphis domestica	95.49	0.00e+00	1513.00
IUUC-Mmu-063601	Mus musculus	98.78	0.00e+00	1533.00
IUUC-Mac-065557	Musa acuminata	52.09	6.00e-119	423.00
IUUC-Mpu-066653	Mustela putorius furo	98.90	0.00e+00	1489.00
IUUC-Mlu-067418	Myotis lucifugus	97.43	0.00e+00	1546.00
IUUC-Nfi-068278	Neosartorya fischeri	46.08	2.00e-134	475.00
IUUC-Ncr-068813	Neurospora crassa	46.68	2.00e-136	482.00
IUUC-Nle-069418	Nomascus leucogenys	99.27	0.00e+00	1494.00
IUUC-Opr-070187	Ochotona princeps	84.36	0.00e+00	884.00
IUUC-Ont-071300	Oreochromis niloticus	89.54	0.00e+00	1394.00
IUUC-Oan-073046	Ornithorhynchus anatinus	96.79	0.00e+00	1509.00
IUUC-Ocu-074178	Oryctolagus cuniculus	94.87	0.00e+00	1507.00
IUUC-Oba-075757	Oryza barthii	51.76	5.00e-127	450.00
IUUC-Obr-076553	Oryza brachyantha	45.17	5.00e-126	447.00
IUUC-Ogl-077520	Oryza glaberrima	51.76	4.00e-127	450.00
IUUC-Ogu-078278	Oryza glumaepatula	51.76	5.00e-127	450.00
IUUC-Oin-079767	Oryza indica	51.76	5.00e-127	450.00
IUUC-Olo-080380	Oryza longistaminata	51.28	3.00e-125	444.00
IUUC-Ome-081925	Oryza meridionalis	51.28	3.00e-125	444.00
IUUC-Oni-082619	Oryza nivara	51.76	4.00e-127	450.00
IUUC-Opu-083684	Oryza punctata	51.28	3.00e-125	444.00
IUUC-Oru-084501	Oryza rufipogon	51.76	5.00e-127	450.00
IUUC-Osa-086251	Oryza sativa	51.76	2.00e-125	443.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.50	6.00e-114	403.00
IUUC-Oga-088903	Otolemur garnettii	98.90	0.00e+00	1489.00
IUUC-Oar-090210	Ovis aries	98.78	0.00e+00	1489.00
IUUC-Ptr-090502	Pan troglodytes	97.06	0.00e+00	1104.00
IUUC-Pan-092368	Papio anubis	99.24	0.00e+00	1420.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.76	1.00e-134	476.00
IUUC-Ppa-095657	Physcomitrella patens	51.36	3.00e-125	444.00
IUUC-Pfo-096232	Poecilia formosa	72.51	0.00e+00	1919.00
IUUC-Pab-098583	Pongo abelii	98.78	0.00e+00	1500.00
IUUC-Pop-099613	Populus trichocarpa	53.16	4.00e-128	453.00
IUUC-Pca-100310	Procavia capensis	93.52	0.00e+00	999.00
IUUC-Ppe-102109	Prunus persica	52.46	1.00e-126	449.00
IUUC-Pva-102116	Pteropus vampyrus	94.74	0.00e+00	1399.00
IUUC-Pgr-103465	Puccinia graminis	43.29	2.00e-127	452.00
IUUC-Ptt-103813	Puccinia triticina	41.21	4.00e-115	410.00
IUUC-Pte-104018	Pyrenophora teres	45.83	3.00e-133	471.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	45.79	3.00e-133	471.00
IUUC-Rno-105889	Rattus norvegicus	93.00	0.00e+00	931.00
IUUC-Sce-106449	Saccharomyces cerevisiae	45.11	1.00e-126	449.00
IUUC-Sha-106961	Sarcophilus harrisii	95.49	0.00e+00	1521.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.54	3.00e-128	454.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.24	1.00e-130	462.00
IUUC-Smo-109640	Selaginella moellendorffii	50.99	1.00e-130	462.00
IUUC-Sit-110598	Setaria italica	52.46	1.00e-127	452.00
IUUC-Sly-111285	Solanum lycopersicum	51.67	1.00e-127	452.00
IUUC-Stu-112582	Solanum tuberosum	32.35	6.00e-57	215.00
IUUC-Sar-113291	Sorex araneus	86.92	0.00e+00	1429.00
IUUC-Sbi-114042	Sorghum bicolor	52.46	6.00e-128	453.00
IUUC-Sre-114958	Sporisorium reilianum	56.50	4.00e-139	488.00
IUUC-Ssc-115754	Sus scrofa	99.02	0.00e+00	1488.00
IUUC-Tru-118570	Takifugu rubripes	90.47	0.00e+00	1387.00
IUUC-Tsy-119159	Tarsius syrichta	93.91	0.00e+00	1169.00
IUUC-Tni-120836	Tetraodon nigroviridis	88.10	0.00e+00	1348.00
IUUC-Tca-121479	Theobroma cacao	51.29	1.00e-124	442.00
IUUC-Tre-121909	Trichoderma reesei	53.41	4.00e-133	471.00
IUUC-Tvi-122370	Trichoderma virens	53.18	3.00e-133	471.00
IUUC-Tae-125214	Triticum aestivum	51.04	1.00e-125	444.00
IUUC-Tme-127172	Tuber melanosporum	46.99	2.00e-139	491.00
IUUC-Tbe-127506	Tupaia belangeri	95.92	0.00e+00	1115.00
IUUC-Ttr-129253	Tursiops truncatus	96.70	0.00e+00	1458.00
IUUC-Uma-129355	Ustilago maydis	49.06	4.00e-141	494.00
IUUC-Vda-129886	Verticillium dahliae	47.44	6.00e-139	490.00
IUUC-Vpa-130708	Vicugna pacos	99.65	0.00e+00	1107.00
IUUC-Vvi-131170	Vitis vinifera	51.00	4.00e-127	449.00
IUUC-Xtr-132123	Xenopus tropicalis	89.18	0.00e+00	1345.00
IUUC-Xma-133869	Xiphophorus maculatus	86.09	0.00e+00	1377.00
IUUC-Yli-134657	Yarrowia lipolytica	45.44	5.00e-130	460.00
IUUC-Zma-135570	Zea mays	44.58	3.00e-128	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence