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Tag Content
iUUCD ID IUUC-Oga-088560
Ensembl Protein ID ENSOGAP00000015079.2
UniProt Accession H0XG86; H0XG86_OTOGA
Genbank Protein ID ENSOGAP00000015079
Protein Name Presenilin
Genbank Nucleotide ID AAQR03147993
Gene Name PSEN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOGAG00000016839.2 ENSOGAT00000016845.2 ENSOGAP00000015079.2
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/CUE 3.20e-08 33.4 278 316
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP
   
Organism Otolemur garnettii
Functional Description
(View)

Functional Description


     Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Protein Sequence
(Fasta)
MLMFMASDSE EEVYDERTSL MSAESPTPRS CQEGRQGPED GENTAQWRIQ DGEEDGDEDP 60
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oga-088560|UBD,CUE|Otolemur garnettii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCTCATGT TCATGGCCTC TGACAGTGAG GAAGAAGTGT ACGACGAGCG GACGTCCCTG 60
ATGTCAGCCG AGAGCCCCAC ACCACGCTCC TGCCAGGAGG GCAGGCAGGG CCCGGAGGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oga-088560|UBD,CUE|Otolemur garnettii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2
SMART

SM00730--PSN
Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 56.79 3.00e-15 77.00
IUUC-Aml-002356 Ailuropoda melanoleuca 87.80 1.00e-176 612.00
IUUC-Atr-003039 Amborella trichopoda 31.42 5.00e-19 89.00
IUUC-Apl-003959 Anas platyrhynchos 76.60 9.00e-162 563.00
IUUC-Aca-005160 Anolis carolinensis 75.74 5.00e-160 556.00
IUUC-Aly-005455 Arabidopsis lyrata 60.49 6.00e-17 82.00
IUUC-Ath-006730 Arabidopsis thaliana 31.16 4.00e-17 82.80
IUUC-Ang-009768 Aspergillus niger 51.85 9.80e-02 32.00
IUUC-Ame-010686 Astyanax mexicanus 79.07 2.00e-147 515.00
IUUC-Bta-013097 Bos taurus 94.47 0.00e+00 709.00
IUUC-Bdi-014196 Brachypodium distachyon 38.32 1.00e-18 87.80
IUUC-Bol-015841 Brassica oleracea 61.73 3.00e-17 83.20
IUUC-Bra-017580 Brassica rapa 57.47 3.00e-17 82.80
IUUC-Cel-018553 Caenorhabditis elegans 48.80 6.00e-92 330.00
IUUC-Cja-018824 Callithrix jacchus 94.68 0.00e+00 726.00
IUUC-Cfa-020253 Canis familiaris 94.24 0.00e+00 723.00
IUUC-Cpo-021401 Cavia porcellus 93.57 0.00e+00 718.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 33.89 4.00e-30 126.00
IUUC-Csa-023369 Chlorocebus sabaeus 96.67 0.00e+00 751.00
IUUC-Cho-024735 Choloepus hoffmanni 61.39 2.00e-115 409.00
IUUC-Cin-025780 Ciona intestinalis 60.84 7.00e-117 414.00
IUUC-Csv-025967 Ciona savignyi 60.14 3.00e-118 418.00
IUUC-Dre-028526 Danio rerio 69.80 9.00e-145 506.00
IUUC-Dno-029758 Dasypus novemcinctus 70.13 3.00e-124 438.00
IUUC-Dor-031127 Dipodomys ordii 89.80 0.00e+00 671.00
IUUC-Dme-031929 Drosophila melanogaster 64.91 7.00e-83 301.00
IUUC-Ete-033081 Echinops telfairi 82.46 5.00e-91 328.00
IUUC-Eca-034387 Equus caballus 94.90 0.00e+00 686.00
IUUC-Eeu-034846 Erinaceus europaeus 79.30 3.00e-146 511.00
IUUC-Fca-035396 Felis catus 93.78 0.00e+00 735.00
IUUC-Fal-037457 Ficedula albicollis 76.03 5.00e-160 557.00
IUUC-Gmo-038550 Gadus morhua 82.76 2.00e-105 375.00
IUUC-Gga-040706 Gallus gallus 76.64 4.00e-156 544.00
IUUC-Gac-042511 Gasterosteus aculeatus 65.57 1.00e-130 459.00
IUUC-Gma-043822 Glycine max 36.84 5.00e-22 98.60
IUUC-Ggo-045338 Gorilla gorilla 96.90 0.00e+00 752.00
IUUC-Hsa-046455 Homo sapiens 96.90 0.00e+00 752.00
IUUC-Hvu-047141 Hordeum vulgare 58.02 5.00e-16 79.00
IUUC-Itr-048731 Ictidomys tridecemlineatus 95.57 0.00e+00 737.00
IUUC-Lch-049638 Latimeria chalumnae 67.88 2.00e-142 498.00
IUUC-Lpe-051132 Leersia perrieri 36.96 2.00e-17 83.60
IUUC-Loc-052427 Lepisosteus oculatus 74.78 6.00e-156 543.00
IUUC-Laf-053758 Loxodonta africana 89.38 0.00e+00 718.00
IUUC-Mcc-054755 Macaca mulatta 96.67 0.00e+00 749.00
IUUC-Meu-056004 Macropus eugenii 75.21 7.00e-91 327.00
IUUC-Mtr-058392 Medicago truncatula 32.98 3.00e-29 122.00
IUUC-Mga-059466 Meleagris gallopavo 71.97 5.00e-128 451.00
IUUC-Mmr-060890 Microcebus murinus 96.01 0.00e+00 742.00
IUUC-Mdo-062197 Monodelphis domestica 80.26 1.00e-174 605.00
IUUC-Mmu-063823 Mus musculus 94.68 0.00e+00 735.00
IUUC-Mac-064858 Musa acuminata 43.35 1.00e-21 97.10
IUUC-Mpu-066181 Mustela putorius furo 94.24 0.00e+00 725.00
IUUC-Mlu-067079 Myotis lucifugus 69.47 1.00e-131 462.00
IUUC-Nle-069596 Nomascus leucogenys 96.48 0.00e+00 701.00
IUUC-Opr-070344 Ochotona princeps 94.01 0.00e+00 741.00
IUUC-Ont-071867 Oreochromis niloticus 70.98 6.00e-135 473.00
IUUC-Oan-073378 Ornithorhynchus anatinus 74.82 3.00e-153 534.00
IUUC-Ocu-074652 Oryctolagus cuniculus 93.79 0.00e+00 697.00
IUUC-Oba-075256 Oryza barthii 48.76 2.00e-16 79.70
IUUC-Obr-076302 Oryza brachyantha 36.23 9.00e-17 81.60
IUUC-Ogl-077097 Oryza glaberrima 36.23 2.00e-16 80.10
IUUC-Ogu-078570 Oryza glumaepatula 36.23 2.00e-16 80.10
IUUC-Oin-079244 Oryza indica 36.96 1.00e-16 80.90
IUUC-Olo-080484 Oryza longistaminata 48.76 1.00e-16 80.10
IUUC-Ome-081814 Oryza meridionalis 35.75 8.00e-17 81.60
IUUC-Oni-082057 Oryza nivara 36.96 1.00e-16 80.90
IUUC-Opu-084176 Oryza punctata 36.96 2.00e-16 80.10
IUUC-Oru-084618 Oryza rufipogon 36.96 1.00e-16 80.90
IUUC-Osa-085602 Oryza sativa 36.31 6.00e-17 82.00
IUUC-Ola-086707 Oryzias latipes 71.48 1.00e-107 382.00
IUUC-Olu-087811 Ostreococcus lucimarinus 37.54 3.00e-45 175.00
IUUC-Oar-089200 Ovis aries 94.03 0.00e+00 688.00
IUUC-Ptr-090569 Pan troglodytes 96.67 0.00e+00 749.00
IUUC-Pan-091742 Papio anubis 96.67 0.00e+00 749.00
IUUC-Psi-093297 Pelodiscus sinensis 73.63 2.00e-130 458.00
IUUC-Pma-094612 Petromyzon marinus 76.52 4.00e-126 444.00
IUUC-Ppa-095431 Physcomitrella patens 32.43 9.00e-29 121.00
IUUC-Pfo-097396 Poecilia formosa 66.34 1.00e-126 446.00
IUUC-Pab-098531 Pongo abelii 96.67 0.00e+00 751.00
IUUC-Pop-099661 Populus trichocarpa 32.53 1.00e-31 130.00
IUUC-Pca-101120 Procavia capensis 91.80 0.00e+00 706.00
IUUC-Ppe-101495 Prunus persica 32.43 1.00e-20 94.40
IUUC-Pva-102934 Pteropus vampyrus 84.92 0.00e+00 677.00
IUUC-Rno-106052 Rattus norvegicus 93.57 0.00e+00 741.00
IUUC-Sha-106876 Sarcophilus harrisii 79.74 4.00e-173 600.00
IUUC-Smo-109325 Selaginella moellendorffii 35.26 1.00e-30 127.00
IUUC-Sit-110624 Setaria italica 58.02 1.00e-15 77.80
IUUC-Stu-112433 Solanum tuberosum 33.33 1.00e-17 84.30
IUUC-Sar-113169 Sorex araneus 63.81 6.00e-96 344.00
IUUC-Sbi-114305 Sorghum bicolor 47.83 4.00e-16 79.30
IUUC-Ssc-115380 Sus scrofa 96.23 0.00e+00 763.00
IUUC-Tgu-117280 Taeniopygia guttata 76.67 1.00e-160 559.00
IUUC-Tru-117732 Takifugu rubripes 68.26 4.00e-120 424.00
IUUC-Tsy-119624 Tarsius syrichta 59.87 9.00e-122 430.00
IUUC-Tni-119852 Tetraodon nigroviridis 63.84 6.00e-112 397.00
IUUC-Tca-121865 Theobroma cacao 34.25 5.00e-19 88.60
IUUC-Tae-125925 Triticum aestivum 58.02 5.00e-16 79.00
IUUC-Tur-126237 Triticum urartu 58.02 5.00e-16 78.60
IUUC-Tbe-127632 Tupaia belangeri 95.92 5.00e-179 620.00
IUUC-Ttr-129008 Tursiops truncatus 93.79 0.00e+00 716.00
IUUC-Vpa-130625 Vicugna pacos 57.72 7.00e-95 340.00
IUUC-Vvi-131312 Vitis vinifera 37.65 5.00e-19 88.60
IUUC-Xtr-132756 Xenopus tropicalis 71.18 1.00e-159 556.00
IUUC-Xma-133377 Xiphophorus maculatus 67.51 1.00e-124 439.00
Created Date 25-Jun-2017

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