iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007978

Ensembl Protein ID

AAS51357

UniProt Accession

Q75BY9; ATG5_ASHGO

Genbank Protein ID

AAS51357.2

Protein Name

Autophagy protein 5

Genbank Nucleotide ID

AE016816

Gene Name

ATG5; ACR131C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ACR131C	AAS51357	AAS51357

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	31.72	4.00e-39	156.00	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ashbya gossypii

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MGVVNELRQR TWSGMLNVEV VLNPKLVVQG MPDEQVRCHL RIPRESYLVL HLPFVLNKLR 60
GVLRQEVKDA FHGWWFGMED VLVHWNHPVG TLYDSLVGLR PQERAAQFQA NTLTMWTLTL 120

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Nucleotide Sequence
(Fasta)

ATGGGCGTGG TCAATGAGCT GCGGCAACGA ACATGGTCGG GCATGTTGAA TGTGGAAGTT 60
GTTTTGAACC CGAAGCTGGT AGTGCAAGGC ATGCCTGATG AGCAAGTCAG GTGCCACCTA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0008047--F:enzyme activator activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0034727--P:piecemeal microautophagy of nucleus

KEGG

ago:AGOS_ACR131C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	22.54	7.00e-08	50.40
IUUC-Aml-002403	Ailuropoda melanoleuca	26.77	6.00e-11	58.90
IUUC-Atr-002645	Amborella trichopoda	25.00	1.00e-11	62.00
IUUC-Apl-003611	Anas platyrhynchos	26.19	2.00e-11	60.10
IUUC-Aca-004411	Anolis carolinensis	27.06	1.00e-11	61.20
IUUC-Aly-005636	Arabidopsis lyrata	23.73	2.00e-05	41.20
IUUC-Ath-006959	Arabidopsis thaliana	23.73	3.00e-05	40.40
IUUC-Acl-008328	Aspergillus clavatus	24.60	1.00e-12	64.30
IUUC-Afl-008638	Aspergillus flavus	23.15	3.00e-14	70.10
IUUC-Afu-009042	Aspergillus fumigatus	23.66	1.00e-13	68.60
IUUC-Ani-009364	Aspergillus nidulans	26.19	7.00e-15	72.40
IUUC-Aor-009889	Aspergillus oryzae	23.15	3.00e-14	70.10
IUUC-Ate-010511	Aspergillus terreus	27.37	2.00e-05	38.50
IUUC-Bgr-012153	Blumeria graminis	25.77	6.00e-09	52.40
IUUC-Bta-012360	Bos taurus	35.71	3.00e-04	35.80
IUUC-Bci-013723	Botrytis cinerea	21.83	5.00e-06	42.40
IUUC-Bdi-014520	Brachypodium distachyon	21.90	4.00e-07	46.60
IUUC-Bol-016053	Brassica oleracea	21.83	5.00e-07	46.20
IUUC-Bra-017072	Brassica rapa	21.13	2.00e-07	47.40
IUUC-Cja-019569	Callithrix jacchus	28.06	7.00e-11	58.90
IUUC-Cfa-020473	Canis familiaris	28.06	8.00e-11	58.50
IUUC-Cpo-021421	Cavia porcellus	26.59	2.00e-10	57.00
IUUC-Cre-022862	Chlamydomonas reinhardtii	27.27	4.40e-02	29.30
IUUC-Csa-024197	Chlorocebus sabaeus	28.06	6.00e-11	58.90
IUUC-Cho-024521	Choloepus hoffmanni	27.56	9.00e-12	61.60
IUUC-Cin-025119	Ciona intestinalis	20.32	4.00e-03	33.10
IUUC-Csv-026192	Ciona savignyi	20.56	7.00e-06	42.00
IUUC-Cgl-026686	Colletotrichum gloeosporioides	25.00	1.00e-08	51.20
IUUC-Cme-027158	Cyanidioschyzon merolae	39.29	5.40e-01	25.40
IUUC-Dre-028466	Danio rerio	22.57	4.00e-10	56.20
IUUC-Dse-031228	Dothistroma septosporum	27.02	6.00e-25	105.00
IUUC-Dme-031703	Drosophila melanogaster	24.22	2.00e-09	53.50
IUUC-Ete-032482	Echinops telfairi	27.09	5.00e-10	55.80
IUUC-Eca-034036	Equus caballus	28.85	2.00e-11	60.50
IUUC-Eeu-035235	Erinaceus europaeus	35.71	5.00e-04	35.80
IUUC-Fca-036263	Felis catus	28.06	1.00e-10	58.20
IUUC-Fal-037064	Ficedula albicollis	26.98	6.00e-12	62.00
IUUC-Fox-037813	Fusarium oxysporum	25.10	6.00e-09	52.00
IUUC-Fso-038139	Fusarium solani	26.17	8.00e-07	45.10
IUUC-Gmo-039509	Gadus morhua	25.85	9.00e-07	44.70
IUUC-Ggr-040111	Gaeumannomyces graminis	24.69	8.00e-08	48.90
IUUC-Gga-040517	Gallus gallus	26.98	6.00e-12	62.40
IUUC-Gac-042270	Gasterosteus aculeatus	23.58	1.00e-07	48.10
IUUC-Gma-044400	Glycine max	23.94	4.00e-08	49.70
IUUC-Ggo-045048	Gorilla gorilla	28.06	5.00e-11	59.30
IUUC-Hsa-046744	Homo sapiens	28.06	5.00e-11	58.90
IUUC-Kpa-049174	Komagataella pastoris	28.86	7.00e-35	138.00
IUUC-Lch-049475	Latimeria chalumnae	27.17	9.00e-12	61.60
IUUC-Lpe-051283	Leersia perrieri	22.54	4.00e-07	48.10
IUUC-Loc-052446	Lepisosteus oculatus	24.80	3.00e-11	60.10
IUUC-Lma-053278	Leptosphaeria maculans	24.20	9.00e-16	75.10
IUUC-Laf-054020	Loxodonta africana	27.84	6.00e-11	58.90
IUUC-Mcc-055176	Macaca mulatta	28.06	5.00e-11	58.90
IUUC-Mor-057164	Magnaporthe oryzae	25.38	8.00e-08	48.90
IUUC-Mpo-057428	Magnaporthe poae	25.15	9.00e-09	51.60
IUUC-Mtr-058424	Medicago truncatula	22.54	2.00e-07	47.40
IUUC-Mla-058872	Melampsora laricipopulina	21.63	3.00e-08	50.80
IUUC-Mga-059859	Meleagris gallopavo	26.98	6.00e-12	62.40
IUUC-Mmr-061482	Microcebus murinus	28.06	8.00e-11	58.50
IUUC-Mdo-062371	Monodelphis domestica	27.67	3.00e-12	63.50
IUUC-Mmu-063139	Mus musculus	27.38	9.00e-11	58.20
IUUC-Mac-065332	Musa acuminata	23.45	6.00e-06	42.70
IUUC-Mpu-066783	Mustela putorius furo	27.67	3.00e-10	56.60
IUUC-Mlu-068165	Myotis lucifugus	26.77	2.00e-10	57.00
IUUC-Nfi-068578	Neosartorya fischeri	23.90	3.00e-13	67.00
IUUC-Ncr-068636	Neurospora crassa	25.43	2.00e-08	51.60
IUUC-Nle-069740	Nomascus leucogenys	28.06	6.00e-11	58.90
IUUC-Opr-070802	Ochotona princeps	35.71	6.00e-04	35.80
IUUC-Ont-072222	Oreochromis niloticus	24.32	1.00e-11	61.60
IUUC-Oan-072760	Ornithorhynchus anatinus	25.86	1.00e-06	44.70
IUUC-Ocu-074844	Oryctolagus cuniculus	32.17	4.00e-06	42.40
IUUC-Oba-075834	Oryza barthii	21.83	2.00e-07	47.80
IUUC-Obr-076230	Oryza brachyantha	24.07	4.00e-05	40.00
IUUC-Ogl-077554	Oryza glaberrima	21.83	2.00e-07	47.80
IUUC-Ogu-078687	Oryza glumaepatula	22.54	1.00e-07	48.50
IUUC-Oin-079677	Oryza indica	22.34	8.00e-09	52.40
IUUC-Olo-081078	Oryza longistaminata	24.67	6.00e-08	50.10
IUUC-Ome-081548	Oryza meridionalis	24.67	9.00e-08	50.10
IUUC-Oni-082050	Oryza nivara	22.54	1.00e-07	48.50
IUUC-Opu-083609	Oryza punctata	22.54	9.00e-08	48.90
IUUC-Oru-085057	Oryza rufipogon	22.54	1.00e-07	48.50
IUUC-Osa-085917	Oryza sativa	22.54	1.00e-07	48.50
IUUC-Ola-087032	Oryzias latipes	27.40	4.00e-13	66.20
IUUC-Oga-088468	Otolemur garnettii	27.56	2.00e-12	64.30
IUUC-Oar-089751	Ovis aries	28.06	1.00e-10	57.80
IUUC-Ptr-091064	Pan troglodytes	28.06	5.00e-11	58.90
IUUC-Pan-092505	Papio anubis	27.84	6.00e-11	58.90
IUUC-Psi-093086	Pelodiscus sinensis	26.17	5.00e-10	55.80
IUUC-Pno-094825	Phaeosphaeria nodorum	27.34	6.00e-20	89.00
IUUC-Ppa-095419	Physcomitrella patens	24.49	7.00e-11	59.30
IUUC-Pfo-096224	Poecilia formosa	25.42	6.00e-13	65.90
IUUC-Pab-098501	Pongo abelii	28.06	6.00e-11	58.90
IUUC-Pop-099243	Populus trichocarpa	24.67	4.00e-05	40.00
IUUC-Ppe-101255	Prunus persica	23.21	9.00e-08	48.90
IUUC-Pva-102828	Pteropus vampyrus	26.98	2.00e-10	57.40
IUUC-Pgr-103672	Puccinia graminis	22.01	3.00e-07	47.00
IUUC-Ptt-104013	Puccinia triticina	23.24	4.00e-06	43.10
IUUC-Pyt-104615	Pyrenophora triticirepentis	26.17	4.00e-17	79.70
IUUC-Rno-106089	Rattus norvegicus	28.97	2.00e-11	60.10
IUUC-Sce-106216	Saccharomyces cerevisiae	32.66	1.00e-40	157.00
IUUC-Sha-106484	Sarcophilus harrisii	28.06	2.00e-12	63.50
IUUC-Sja-107699	Schizosaccharomyces japonicus	25.52	5.00e-18	82.40
IUUC-Spo-108177	Schizosaccharomyces pombe	29.84	3.00e-22	96.30
IUUC-Ssl-108475	Sclerotinia sclerotiorum	23.55	9.00e-08	48.50
IUUC-Smo-109473	Selaginella moellendorffii	22.87	5.00e-07	46.20
IUUC-Sit-110736	Setaria italica	24.00	9.00e-07	45.40
IUUC-Sly-111657	Solanum lycopersicum	23.61	1.00e-06	45.10
IUUC-Sar-113050	Sorex araneus	23.26	4.00e-04	35.80
IUUC-Sbi-114258	Sorghum bicolor	24.00	2.00e-07	48.10
IUUC-Sre-114902	Sporisorium reilianum	23.21	1.00e-09	55.80
IUUC-Ssc-116166	Sus scrofa	25.79	2.00e-08	50.80
IUUC-Tgu-116814	Taeniopygia guttata	26.98	8.00e-12	62.00
IUUC-Tru-118172	Takifugu rubripes	25.34	1.00e-11	61.20
IUUC-Tsy-119010	Tarsius syrichta	23.12	2.00e-05	40.40
IUUC-Tni-120397	Tetraodon nigroviridis	23.96	7.00e-07	44.70
IUUC-Tca-121283	Theobroma cacao	21.39	4.00e-05	40.40
IUUC-Tvi-122545	Trichoderma virens	22.56	4.00e-07	46.20
IUUC-Tae-122685	Triticum aestivum	24.03	7.00e-09	52.40
IUUC-Tur-126407	Triticum urartu	22.88	2.00e-08	51.20
IUUC-Tme-126913	Tuber melanosporum	29.12	3.00e-24	103.00
IUUC-Tbe-127738	Tupaia belangeri	27.67	2.00e-07	46.60
IUUC-Ttr-128528	Tursiops truncatus	26.59	7.00e-11	58.50
IUUC-Uma-129625	Ustilago maydis	22.27	1.00e-07	48.90
IUUC-Vda-129906	Verticillium dahliae	29.61	3.00e-10	56.60
IUUC-Vpa-130223	Vicugna pacos	26.48	2.00e-06	44.30
IUUC-Vvi-131617	Vitis vinifera	25.81	2.00e-07	48.10
IUUC-Xtr-132288	Xenopus tropicalis	26.77	1.00e-10	57.80
IUUC-Xma-134214	Xiphophorus maculatus	24.31	9.00e-07	44.70
IUUC-Yli-134377	Yarrowia lipolytica	30.10	2.00e-17	80.50
IUUC-Zma-135108	Zea mays	24.00	2.00e-07	48.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence