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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Spo-108247
Ensembl Protein ID SPAC1565.08.1:pep
UniProt Accession Q9P3A7; O14221; CDC48_SCHPO
Genbank Protein ID CAB99275.1
Protein Name Cell division cycle protein 48
Genbank Nucleotide ID CU329670
Gene Name cdc48; SPAC1565.08; SPAC6F12.01
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPAC1565.08 SPAC1565.08.1 SPAC1565.08.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 70.59 0.00e+00 1075.00 IUUC-Hsa-046162
UBD/Other/Other 75.76 0.00e+00 1177.00 IUUC-Sce-106244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.
 Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel.
Protein Sequence
(Fasta)
MNAPSTMTDK KPEVEHLQGE NPPKDTYSAE DTATAILRKK RKPNSLVVDD ATNDDNSVIT 60
LSSNTMETLQ LFRGDTVVVK GKRRKDTVLI VLTDEEMEDG VARINRVVRN NLRVRLGDIV 120
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Protein Fasta Sequence


>IUUC-Spo-108247|UBD,UBD/Other/Other|Schizosaccharomyces pombe
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGAATAGA TAAATTAAAT TTGGCAATTT ATACAATACG TGTTTTCTAG AGATGCGTTA 60
AATAAAAACA ATCTAGCGAA AATAATGGAA ATTGGTAGTA ACGACCTTGC GAGGCAGCTA 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108247|UBD,UBD/Other/Other|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR003593--AAA+_ATPase
IPR005938--AAA_ATPase_CDC48
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR004201--Cdc48_dom2
IPR029067--CDC48_domain_2-like
IPR003338--CDC4_N-term_subdom
IPR027417--P-loop_NTPase
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF02933--CDC48_2
PF02359--CDC48_N
SMART

SM00382--AAA
SM01072--CDC48_2
SM01073--CDC48_N
Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000836--C:Hrd1p ubiquitin ligase complex
GO:1990023--C:mitotic spindle midzone
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:1990112--C:RQC complex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0061166--P:establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site
GO:0051306--P:mitotic sister chromatid separation
GO:0051228--P:mitotic spindle disassembly
GO:0016485--P:protein processing
GO:0015031--P:protein transport
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG spo:SPAC1565.08
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000524 Aegilops tauschii 68.57 0.00e+00 1070.00
IUUC-Aml-001849 Ailuropoda melanoleuca 72.32 0.00e+00 1107.00
IUUC-Atr-002619 Amborella trichopoda 68.73 0.00e+00 1115.00
IUUC-Apl-004070 Anas platyrhynchos 72.40 0.00e+00 1102.00
IUUC-Aca-004847 Anolis carolinensis 72.19 0.00e+00 1103.00
IUUC-Aly-005406 Arabidopsis lyrata 69.97 0.00e+00 1110.00
IUUC-Ath-006796 Arabidopsis thaliana 70.12 0.00e+00 1122.00
IUUC-Ago-008001 Ashbya gossypii 77.11 0.00e+00 1134.00
IUUC-Acl-008066 Aspergillus clavatus 79.37 0.00e+00 1216.00
IUUC-Afl-008505 Aspergillus flavus 77.29 0.00e+00 1237.00
IUUC-Afu-008840 Aspergillus fumigatus 80.03 0.00e+00 1236.00
IUUC-Ani-009368 Aspergillus nidulans 78.26 0.00e+00 1236.00
IUUC-Ang-009724 Aspergillus niger 79.92 0.00e+00 1244.00
IUUC-Aor-010204 Aspergillus oryzae 77.29 0.00e+00 1237.00
IUUC-Ate-010370 Aspergillus terreus 79.42 0.00e+00 1234.00
IUUC-Ame-011388 Astyanax mexicanus 72.02 0.00e+00 1087.00
IUUC-Bgr-012223 Blumeria graminis 77.14 0.00e+00 1237.00
IUUC-Bta-013188 Bos taurus 72.32 0.00e+00 1108.00
IUUC-Bci-013831 Botrytis cinerea 77.76 0.00e+00 1212.00
IUUC-Bdi-014967 Brachypodium distachyon 69.78 0.00e+00 1116.00
IUUC-Bol-016113 Brassica oleracea 70.89 0.00e+00 1130.00
IUUC-Bra-017796 Brassica rapa 70.76 0.00e+00 1128.00
IUUC-Cel-018243 Caenorhabditis elegans 67.59 0.00e+00 1056.00
IUUC-Cja-019904 Callithrix jacchus 72.06 0.00e+00 1093.00
IUUC-Cfa-020304 Canis familiaris 72.32 0.00e+00 1106.00
IUUC-Cpo-021518 Cavia porcellus 72.02 0.00e+00 1105.00
IUUC-Cre-022719 Chlamydomonas reinhardtii 68.90 0.00e+00 1093.00
IUUC-Csa-023444 Chlorocebus sabaeus 72.45 0.00e+00 1104.00
IUUC-Cho-024482 Choloepus hoffmanni 71.54 0.00e+00 1079.00
IUUC-Cin-025517 Ciona intestinalis 70.14 0.00e+00 1090.00
IUUC-Csv-026060 Ciona savignyi 69.99 0.00e+00 1122.00
IUUC-Cgl-026690 Colletotrichum gloeosporioides 78.99 0.00e+00 1245.00
IUUC-Cne-026910 Cryptococcus neoformans 70.35 0.00e+00 1154.00
IUUC-Cme-027145 Cyanidioschyzon merolae 67.57 0.00e+00 1090.00
IUUC-Dre-028487 Danio rerio 72.02 0.00e+00 1088.00
IUUC-Dno-029257 Dasypus novemcinctus 72.45 0.00e+00 1104.00
IUUC-Dor-030473 Dipodomys ordii 71.06 0.00e+00 1065.00
IUUC-Dse-031319 Dothistroma septosporum 76.94 0.00e+00 1202.00
IUUC-Dme-032203 Drosophila melanogaster 67.95 0.00e+00 1070.00
IUUC-Eca-033311 Equus caballus 71.54 0.00e+00 1100.00
IUUC-Eeu-035293 Erinaceus europaeus 75.90 7.00e-175 605.00
IUUC-Fca-036097 Felis catus 73.35 0.00e+00 1062.00
IUUC-Fal-037292 Ficedula albicollis 72.58 0.00e+00 1106.00
IUUC-Fox-037827 Fusarium oxysporum 79.92 0.00e+00 1244.00
IUUC-Fso-038226 Fusarium solani 79.30 0.00e+00 1248.00
IUUC-Gmo-039157 Gadus morhua 67.15 0.00e+00 991.00
IUUC-Ggr-039951 Gaeumannomyces graminis 78.33 0.00e+00 1226.00
IUUC-Gga-041183 Gallus gallus 72.58 0.00e+00 1106.00
IUUC-Gac-042039 Gasterosteus aculeatus 71.63 0.00e+00 1074.00
IUUC-Gma-044090 Glycine max 66.63 0.00e+00 1098.00
IUUC-Ggo-045568 Gorilla gorilla 72.45 0.00e+00 1104.00
IUUC-Hsa-046162 Homo sapiens 72.45 0.00e+00 1104.00
IUUC-Hvu-047107 Hordeum vulgare 72.17 0.00e+00 914.00
IUUC-Itr-047885 Ictidomys tridecemlineatus 72.27 0.00e+00 1100.00
IUUC-Kpa-049220 Komagataella pastoris 74.58 0.00e+00 1216.00
IUUC-Lch-050657 Latimeria chalumnae 72.03 0.00e+00 987.00
IUUC-Lpe-051083 Leersia perrieri 69.76 0.00e+00 1115.00
IUUC-Loc-052064 Lepisosteus oculatus 72.55 0.00e+00 1087.00
IUUC-Lma-053323 Leptosphaeria maculans 79.35 0.00e+00 1221.00
IUUC-Laf-054574 Loxodonta africana 72.45 0.00e+00 1105.00
IUUC-Mcc-055448 Macaca mulatta 72.45 0.00e+00 1104.00
IUUC-Meu-056316 Macropus eugenii 67.62 0.00e+00 1002.00
IUUC-Mor-057057 Magnaporthe oryzae 79.30 0.00e+00 1227.00
IUUC-Mpo-057406 Magnaporthe poae 79.37 0.00e+00 1215.00
IUUC-Mtr-057648 Medicago truncatula 70.29 0.00e+00 1132.00
IUUC-Mla-059156 Melampsora laricipopulina 73.57 0.00e+00 1193.00
IUUC-Mga-060004 Meleagris gallopavo 69.96 0.00e+00 954.00
IUUC-Mvi-060488 Microbotryum violaceum 72.97 0.00e+00 1169.00
IUUC-Mmr-061027 Microcebus murinus 72.02 0.00e+00 1103.00
IUUC-Mdo-062159 Monodelphis domestica 72.58 0.00e+00 1107.00
IUUC-Mmu-063633 Mus musculus 72.45 0.00e+00 1104.00
IUUC-Mac-064919 Musa acuminata 69.27 0.00e+00 1118.00
IUUC-Mpu-066078 Mustela putorius furo 72.32 0.00e+00 1108.00
IUUC-Mlu-067757 Myotis lucifugus 72.32 0.00e+00 1104.00
IUUC-Nfi-068533 Neosartorya fischeri 79.87 0.00e+00 1229.00
IUUC-Ncr-068775 Neurospora crassa 79.27 0.00e+00 1192.00
IUUC-Nle-069424 Nomascus leucogenys 72.45 0.00e+00 1105.00
IUUC-Opr-071147 Ochotona princeps 71.88 0.00e+00 1088.00
IUUC-Ont-071351 Oreochromis niloticus 72.15 0.00e+00 1065.00
IUUC-Oan-073335 Ornithorhynchus anatinus 70.92 0.00e+00 1109.00
IUUC-Ocu-074072 Oryctolagus cuniculus 72.45 0.00e+00 1104.00
IUUC-Oba-075914 Oryza barthii 70.38 0.00e+00 1124.00
IUUC-Obr-076224 Oryza brachyantha 71.17 0.00e+00 1108.00
IUUC-Ogl-077282 Oryza glaberrima 69.94 0.00e+00 1134.00
IUUC-Ogu-078174 Oryza glumaepatula 70.38 0.00e+00 1124.00
IUUC-Oin-079103 Oryza indica 70.38 0.00e+00 1124.00
IUUC-Olo-080675 Oryza longistaminata 70.25 0.00e+00 1122.00
IUUC-Ome-081959 Oryza meridionalis 69.94 0.00e+00 1134.00
IUUC-Oni-082078 Oryza nivara 70.38 0.00e+00 1123.00
IUUC-Opu-083806 Oryza punctata 70.41 0.00e+00 1127.00
IUUC-Oru-084634 Oryza rufipogon 70.38 0.00e+00 1124.00
IUUC-Osa-085960 Oryza sativa 70.38 0.00e+00 1124.00
IUUC-Ola-086382 Oryzias latipes 71.88 0.00e+00 1063.00
IUUC-Olu-087839 Ostreococcus lucimarinus 68.06 0.00e+00 1078.00
IUUC-Oga-088037 Otolemur garnettii 71.93 0.00e+00 1102.00
IUUC-Oar-089684 Ovis aries 72.32 0.00e+00 1107.00
IUUC-Ptr-091378 Pan troglodytes 72.45 0.00e+00 1104.00
IUUC-Pan-092849 Papio anubis 72.45 0.00e+00 1104.00
IUUC-Psi-093725 Pelodiscus sinensis 71.17 0.00e+00 1058.00
IUUC-Pma-094537 Petromyzon marinus 68.22 2.00e-161 559.00
IUUC-Pno-094915 Phaeosphaeria nodorum 83.59 0.00e+00 1174.00
IUUC-Ppa-095632 Physcomitrella patens 68.30 0.00e+00 1085.00
IUUC-Pfo-097440 Poecilia formosa 72.02 0.00e+00 1063.00
IUUC-Pab-098469 Pongo abelii 72.45 0.00e+00 1104.00
IUUC-Pop-100047 Populus trichocarpa 69.40 0.00e+00 1109.00
IUUC-Pca-100399 Procavia capensis 68.02 0.00e+00 1009.00
IUUC-Ppe-101767 Prunus persica 68.01 0.00e+00 1130.00
IUUC-Pva-102426 Pteropus vampyrus 71.93 0.00e+00 1083.00
IUUC-Pgr-103599 Puccinia graminis 73.32 0.00e+00 1184.00
IUUC-Ptt-103740 Puccinia triticina 73.17 0.00e+00 1186.00
IUUC-Pte-104030 Pyrenophora teres 76.93 0.00e+00 1220.00
IUUC-Pyt-104541 Pyrenophora triticirepentis 76.00 0.00e+00 1219.00
IUUC-Rno-105144 Rattus norvegicus 72.45 0.00e+00 1105.00
IUUC-Sce-106244 Saccharomyces cerevisiae 77.45 0.00e+00 1154.00
IUUC-Sha-106589 Sarcophilus harrisii 72.58 0.00e+00 1108.00
IUUC-Sja-107673 Schizosaccharomyces japonicus 91.41 0.00e+00 1436.00
IUUC-Ssl-108642 Sclerotinia sclerotiorum 78.02 0.00e+00 1216.00
IUUC-Smo-108877 Selaginella moellendorffii 70.27 0.00e+00 1117.00
IUUC-Sit-110368 Setaria italica 70.25 0.00e+00 1109.00
IUUC-Sly-111151 Solanum lycopersicum 69.23 0.00e+00 1100.00
IUUC-Stu-111959 Solanum tuberosum 69.88 0.00e+00 1122.00
IUUC-Sar-113021 Sorex araneus 72.45 0.00e+00 1104.00
IUUC-Sbi-114457 Sorghum bicolor 69.21 0.00e+00 1110.00
IUUC-Sre-115052 Sporisorium reilianum 74.68 0.00e+00 1191.00
IUUC-Ssc-116293 Sus scrofa 72.14 0.00e+00 1102.00
IUUC-Tgu-116544 Taeniopygia guttata 69.88 0.00e+00 1030.00
IUUC-Tru-117991 Takifugu rubripes 73.86 0.00e+00 789.00
IUUC-Tsy-119131 Tarsius syrichta 75.87 2.00e-167 580.00
IUUC-Tni-120192 Tetraodon nigroviridis 72.38 0.00e+00 1067.00
IUUC-Tca-121502 Theobroma cacao 68.92 0.00e+00 1085.00
IUUC-Tre-122189 Trichoderma reesei 77.55 0.00e+00 1238.00
IUUC-Tvi-122310 Trichoderma virens 77.46 0.00e+00 1221.00
IUUC-Tae-124332 Triticum aestivum 69.28 0.00e+00 1078.00
IUUC-Tur-126733 Triticum urartu 69.02 0.00e+00 1068.00
IUUC-Tme-127147 Tuber melanosporum 78.86 0.00e+00 1189.00
IUUC-Tbe-127255 Tupaia belangeri 67.49 0.00e+00 1035.00
IUUC-Ttr-128876 Tursiops truncatus 72.06 0.00e+00 1097.00
IUUC-Uma-129448 Ustilago maydis 73.37 0.00e+00 1170.00
IUUC-Vda-129800 Verticillium dahliae 77.24 0.00e+00 1216.00
IUUC-Vpa-130573 Vicugna pacos 76.07 0.00e+00 669.00
IUUC-Vvi-131622 Vitis vinifera 69.25 0.00e+00 1115.00
IUUC-Xtr-132458 Xenopus tropicalis 73.02 0.00e+00 1061.00
IUUC-Xma-134045 Xiphophorus maculatus 72.02 0.00e+00 1063.00
IUUC-Yli-134382 Yarrowia lipolytica 77.79 0.00e+00 1238.00
IUUC-Zma-134817 Zea mays 69.47 0.00e+00 1131.00
Created Date 25-Jun-2017

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