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Tag Content
UUCD2 ID IUUC-Dre-028092
UUCD1 version UUC-DaR-01198
Ensembl Protein ID ENSDARP00000055311.6
UniProt Accession Q5U3S7; NOSIP_DANRE
Genbank Protein ID AAH85409.1
Protein Name Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP
Genbank Nucleotide ID BC085409
Gene Name nosip; zgc:101669
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000037958.7 ENSDART00000055312.7 ENSDARP00000055311.6
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.10e-14 55.2 40 95
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.......tcPvtrqpl 50
           + ++ +C++sl++ rdPv +++G+ y++++I +++ ++++          + +q l
   Q: 40   IKDFDCCSLSLQPCRDPVLTEDGYLYEKEAILQYILHQKTeiakkmkAYEKQKQAL 95
           567889*****************************888874444443444455555 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).
 E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face (By similarity). Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity (By similarity).
Protein Sequence
(Fasta)
MTRHGKNCTA GAVYTYHEKR KDTAASGYGT QSVRLGKDAI KDFDCCSLSL QPCRDPVLTE 60
DGYLYEKEAI LQYILHQKTE IAKKMKAYEK QKQALKSEGQ LESKSEERER AEKFKQRENN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028092|E3,U-box|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGAGAATG TCAACTTTTA TTTTGAAGTT TTTTTATGAC GAACCAGGAA AAGGAGCAAA 60
GGATCTTTTC CGGTTTACGA CCATAGGAGG TAAACAGAAA CATCTGTGCT TATTACTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028092|E3,U-box|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF15906--zf-NOSIP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination
GO:0050999--P:regulation of nitric-oxide synthase activity
KEGG dre:492793
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000769 Aegilops tauschii 46.51 1.00e-14 75.10
IUUC-Aml-002069 Ailuropoda melanoleuca 62.10 3.00e-114 404.00
IUUC-Atr-002661 Amborella trichopoda 31.10 1.00e-27 117.00
IUUC-Aca-004630 Anolis carolinensis 66.12 4.00e-116 410.00
IUUC-Aly-006316 Arabidopsis lyrata 31.58 5.00e-32 131.00
IUUC-Ath-007000 Arabidopsis thaliana 31.25 1.00e-31 130.00
IUUC-Acl-008175 Aspergillus clavatus 31.15 1.00e-05 44.30
IUUC-Afl-008440 Aspergillus flavus 26.05 1.00e-10 60.80
IUUC-Afu-009012 Aspergillus fumigatus 28.80 2.00e-06 46.60
IUUC-Ani-009153 Aspergillus nidulans 32.09 5.00e-04 39.30
IUUC-Ang-009556 Aspergillus niger 24.61 2.00e-11 63.50
IUUC-Aor-009892 Aspergillus oryzae 32.74 7.00e-07 48.50
IUUC-Ate-010473 Aspergillus terreus 29.36 9.00e-05 42.70
IUUC-Ame-011874 Astyanax mexicanus 83.12 2.00e-133 468.00
IUUC-Bgr-012090 Blumeria graminis 24.38 1.00e-04 40.80
IUUC-Bta-012956 Bos taurus 65.46 1.00e-118 419.00
IUUC-Bci-013897 Botrytis cinerea 38.75 2.00e-09 56.60
IUUC-Bdi-014968 Brachypodium distachyon 32.66 1.00e-34 140.00
IUUC-Bol-015578 Brassica oleracea 31.58 6.00e-35 141.00
IUUC-Bra-017234 Brassica rapa 31.58 6.00e-35 141.00
IUUC-Cel-018637 Caenorhabditis elegans 40.49 4.00e-56 211.00
IUUC-Cja-019632 Callithrix jacchus 65.26 2.00e-118 418.00
IUUC-Cfa-020192 Canis familiaris 64.47 3.00e-117 414.00
IUUC-Cpo-021939 Cavia porcellus 65.46 9.00e-117 412.00
IUUC-Cre-023005 Chlamydomonas reinhardtii 33.33 5.00e-36 144.00
IUUC-Csa-023802 Chlorocebus sabaeus 64.29 5.00e-118 417.00
IUUC-Cho-024637 Choloepus hoffmanni 54.09 7.00e-42 163.00
IUUC-Cin-025180 Ciona intestinalis 51.15 8.00e-84 303.00
IUUC-Csv-026206 Ciona savignyi 57.64 3.00e-46 177.00
IUUC-Cgl-026696 Colletotrichum gloeosporioides 24.25 1.00e-13 70.90
IUUC-Cne-026827 Cryptococcus neoformans 27.07 7.00e-09 55.10
IUUC-Dno-029501 Dasypus novemcinctus 60.33 5.00e-102 364.00
IUUC-Dor-030542 Dipodomys ordii 65.46 3.00e-119 421.00
IUUC-Dse-031188 Dothistroma septosporum 23.82 2.00e-12 67.00
IUUC-Dme-031734 Drosophila melanogaster 49.68 7.00e-84 303.00
IUUC-Eca-033577 Equus caballus 65.13 1.00e-118 419.00
IUUC-Fca-035761 Felis catus 65.46 1.00e-118 419.00
IUUC-Fox-037703 Fusarium oxysporum 35.80 7.00e-08 51.60
IUUC-Fso-038208 Fusarium solani 25.35 1.00e-11 63.90
IUUC-Gmo-038523 Gadus morhua 70.83 4.00e-70 257.00
IUUC-Ggr-040087 Gaeumannomyces graminis 37.18 3.00e-08 52.80
IUUC-Gac-042621 Gasterosteus aculeatus 75.16 3.00e-126 444.00
IUUC-Gma-042698 Glycine max 33.78 1.00e-34 140.00
IUUC-Ggo-045357 Gorilla gorilla 65.26 4.00e-118 417.00
IUUC-Hsa-046195 Homo sapiens 65.26 4.00e-118 417.00
IUUC-Hvu-047174 Hordeum vulgare 32.66 3.00e-33 135.00
IUUC-Itr-048487 Ictidomys tridecemlineatus 65.79 4.00e-118 417.00
IUUC-Lch-050569 Latimeria chalumnae 68.49 1.00e-111 396.00
IUUC-Lpe-050992 Leersia perrieri 35.78 6.00e-21 95.10
IUUC-Loc-052522 Lepisosteus oculatus 74.92 1.00e-120 425.00
IUUC-Lma-053254 Leptosphaeria maculans 25.42 2.00e-08 53.90
IUUC-Laf-053397 Loxodonta africana 64.80 5.00e-117 413.00
IUUC-Mcc-054681 Macaca mulatta 64.61 4.00e-118 418.00
IUUC-Meu-056723 Macropus eugenii 64.82 1.00e-116 412.00
IUUC-Mor-056961 Magnaporthe oryzae 35.40 1.00e-09 57.40
IUUC-Mtr-058063 Medicago truncatula 33.11 6.00e-36 144.00
IUUC-Mla-059004 Melampsora laricipopulina 26.75 5.00e-20 92.00
IUUC-Mvi-060460 Microbotryum violaceum 28.40 3.00e-23 102.00
IUUC-Mmr-060847 Microcebus murinus 65.46 7.00e-119 419.00
IUUC-Mdo-062480 Monodelphis domestica 66.23 6.00e-117 413.00
IUUC-Mmu-063809 Mus musculus 64.50 5.00e-117 414.00
IUUC-Mac-064870 Musa acuminata 32.78 2.00e-35 143.00
IUUC-Mpu-066322 Mustela putorius furo 65.58 2.00e-118 418.00
IUUC-Mlu-067556 Myotis lucifugus 64.47 6.00e-118 416.00
IUUC-Nfi-068440 Neosartorya fischeri 28.80 3.00e-06 46.60
IUUC-Ncr-068898 Neurospora crassa 35.90 4.00e-07 49.30
IUUC-Nle-070049 Nomascus leucogenys 65.26 2.00e-118 418.00
IUUC-Opr-070972 Ochotona princeps 64.47 9.00e-118 416.00
IUUC-Ont-071682 Oreochromis niloticus 80.46 7.00e-136 476.00
IUUC-Oan-073296 Ornithorhynchus anatinus 86.44 3.00e-28 117.00
IUUC-Ocu-074218 Oryctolagus cuniculus 63.60 7.00e-103 366.00
IUUC-Oba-075284 Oryza barthii 33.00 2.00e-32 132.00
IUUC-Obr-076651 Oryza brachyantha 31.99 1.00e-34 140.00
IUUC-Ogl-077899 Oryza glaberrima 33.00 2.00e-32 132.00
IUUC-Ogu-078477 Oryza glumaepatula 33.00 2.00e-32 132.00
IUUC-Oin-080011 Oryza indica 33.00 2.00e-32 132.00
IUUC-Olo-080545 Oryza longistaminata 33.33 3.00e-24 106.00
IUUC-Ome-081543 Oryza meridionalis 33.00 2.00e-32 132.00
IUUC-Oni-082955 Oryza nivara 33.00 2.00e-32 132.00
IUUC-Opu-083565 Oryza punctata 32.66 2.00e-32 132.00
IUUC-Oru-084474 Oryza rufipogon 33.00 2.00e-32 132.00
IUUC-Osa-085913 Oryza sativa 33.00 2.00e-32 132.00
IUUC-Ola-086851 Oryzias latipes 76.64 6.00e-136 476.00
IUUC-Olu-087724 Ostreococcus lucimarinus 31.07 3.00e-11 62.80
IUUC-Oga-087970 Otolemur garnettii 65.25 4.00e-117 414.00
IUUC-Oar-089756 Ovis aries 63.49 2.00e-111 395.00
IUUC-Ptr-091485 Pan troglodytes 64.61 5.00e-115 407.00
IUUC-Pan-091832 Papio anubis 64.61 2.00e-118 419.00
IUUC-Pma-094551 Petromyzon marinus 60.91 1.00e-102 365.00
IUUC-Pno-094830 Phaeosphaeria nodorum 30.39 5.00e-06 45.10
IUUC-Ppa-095255 Physcomitrella patens 31.10 7.00e-29 120.00
IUUC-Pfo-096373 Poecilia formosa 80.07 2.00e-140 491.00
IUUC-Pab-098247 Pongo abelii 65.26 4.00e-118 417.00
IUUC-Pop-099186 Populus trichocarpa 33.33 6.00e-34 137.00
IUUC-Pca-100677 Procavia capensis 59.71 1.00e-91 329.00
IUUC-Ppe-101403 Prunus persica 30.43 3.00e-31 129.00
IUUC-Pva-103000 Pteropus vampyrus 65.46 3.00e-119 421.00
IUUC-Pgr-103663 Puccinia graminis 29.72 2.00e-27 117.00
IUUC-Ptt-103712 Puccinia triticina 33.85 7.00e-08 51.20
IUUC-Pte-104287 Pyrenophora teres 31.63 6.00e-07 48.50
IUUC-Pyt-104579 Pyrenophora triticirepentis 31.25 5.00e-07 48.90
IUUC-Rno-106069 Rattus norvegicus 64.50 3.00e-117 414.00
IUUC-Sha-106553 Sarcophilus harrisii 64.80 4.00e-116 410.00
IUUC-Smo-108874 Selaginella moellendorffii 34.22 3.00e-38 152.00
IUUC-Sit-110307 Setaria italica 33.00 1.00e-30 127.00
IUUC-Sly-111094 Solanum lycopersicum 32.78 6.00e-35 141.00
IUUC-Stu-112363 Solanum tuberosum 32.78 5.00e-35 141.00
IUUC-Sar-113480 Sorex araneus 63.82 5.00e-113 400.00
IUUC-Sbi-113939 Sorghum bicolor 33.33 4.00e-33 135.00
IUUC-Ssc-115644 Sus scrofa 64.61 2.00e-118 418.00
IUUC-Tru-118781 Takifugu rubripes 76.22 1.00e-134 472.00
IUUC-Tni-119672 Tetraodon nigroviridis 75.86 3.00e-36 142.00
IUUC-Tca-121795 Theobroma cacao 32.11 7.00e-35 140.00
IUUC-Tre-122037 Trichoderma reesei 32.47 1.00e-06 47.80
IUUC-Tvi-122524 Trichoderma virens 25.00 1.00e-13 70.90
IUUC-Tae-122828 Triticum aestivum 33.00 2.00e-33 136.00
IUUC-Tur-126387 Triticum urartu 32.82 8.00e-26 111.00
IUUC-Tme-127111 Tuber melanosporum 36.90 8.00e-08 51.20
IUUC-Ttr-128227 Tursiops truncatus 65.26 6.00e-118 417.00
IUUC-Vda-129924 Verticillium dahliae 24.65 1.00e-15 77.40
IUUC-Vpa-130802 Vicugna pacos 69.66 3.00e-34 138.00
IUUC-Vvi-131105 Vitis vinifera 33.00 6.00e-34 137.00
IUUC-Xtr-132830 Xenopus tropicalis 64.89 2.00e-117 415.00
IUUC-Xma-133618 Xiphophorus maculatus 80.26 6.00e-134 469.00
IUUC-Zma-135389 Zea mays 33.33 1.00e-32 133.00
Created Date 25-Jun-2017

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