iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-38	129.9	53	88
UBD/Beta-Prp	7.20e-52	176.8	46	269

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH ++++++++ +d +llvs+s Dg++ vWD+ t +
   Q: 53   GHLAKIYAMHWaTDsKLLVSASQDGKLIVWDTYTTN 88
           899*********888****************87765 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
            + r+l gh a+++a+ +  d+k+lv++s+D+ + vwd  t   vh++   ++ v+++++ psg++++ G+ d++  ++ l++++   +
   Q: 46   RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDTYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYSLKSREGNVK 134
           45689****************************************************************************99987777 PP
   S: 132  ...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrt 217
               ls h+g  +c ++ + +n +v++s D+t+ lWd++tg+  + + g ht++  sl+++++ k ++sg++d + klwd+++g+c +t
   Q: 135  vsrELSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVFVG-HTGDCMSLAVSPDYKLFISGACDASAKLWDVREGTCRQT 221
           778***************9.566899**********************9.*************************************** PP
   S: 218  lnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           ++gh++ ++ + f+pn+e + +gs+D s r++dlr ++ l+++++  +s+
   Q: 222  FTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELTAYSH--ESI 269
           ***************************************999988..445 PP

Organism

Rattus norvegicus

Functional Description
(View)

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with RASD2 (By similarity).

Protein Sequence
(Fasta)

MGEMEQLKQE AEQLKKQIAD ARKACADITL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA 60
MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTGACAGG CAGGCATCAC AGCTGAGACC GTGAGGAGGC GCCTGGGAAG CGGAAACCTG 60
GGAGAAATCC AGCTAGAGCC CAAGTAAGAA GGAGCTGGCC CTCTGGGATT GGGGGCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0044297--C:cell body
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0043005--C:neuron projection
GO:0004871--F:signal transducer activity
GO:0030507--F:spectrin binding

KEGG

rno:60449

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000161	Aegilops tauschii	49.63	2.00e-75	275.00
IUUC-Aml-002370	Ailuropoda melanoleuca	98.24	0.00e+00	697.00
IUUC-Atr-002610	Amborella trichopoda	49.35	1.00e-86	313.00
IUUC-Apl-004079	Anas platyrhynchos	93.53	0.00e+00	674.00
IUUC-Aca-004539	Anolis carolinensis	90.00	0.00e+00	652.00
IUUC-Aly-006025	Arabidopsis lyrata	50.64	7.00e-84	303.00
IUUC-Ath-006617	Arabidopsis thaliana	51.29	1.00e-83	303.00
IUUC-Bta-012810	Bos taurus	97.65	0.00e+00	693.00
IUUC-Bci-013621	Botrytis cinerea	66.08	3.00e-131	461.00
IUUC-Bdi-014785	Brachypodium distachyon	49.68	9.00e-87	313.00
IUUC-Bol-015759	Brassica oleracea	51.44	1.00e-81	298.00
IUUC-Bra-017618	Brassica rapa	50.96	3.00e-84	305.00
IUUC-Cja-019894	Callithrix jacchus	96.76	0.00e+00	687.00
IUUC-Cfa-020140	Canis familiaris	97.65	0.00e+00	691.00
IUUC-Cpo-021908	Cavia porcellus	98.24	0.00e+00	697.00
IUUC-Csa-023321	Chlorocebus sabaeus	96.47	0.00e+00	685.00
IUUC-Dno-029783	Dasypus novemcinctus	96.14	0.00e+00	628.00
IUUC-Dse-031388	Dothistroma septosporum	66.67	2.00e-137	481.00
IUUC-Ete-032435	Echinops telfairi	90.00	3.00e-179	620.00
IUUC-Eca-034169	Equus caballus	98.82	0.00e+00	697.00
IUUC-Eeu-034631	Erinaceus europaeus	91.23	1.00e-165	575.00
IUUC-Fca-035392	Felis catus	98.24	0.00e+00	695.00
IUUC-Fal-036902	Ficedula albicollis	92.06	0.00e+00	667.00
IUUC-Gga-040655	Gallus gallus	92.08	0.00e+00	659.00
IUUC-Ggo-045346	Gorilla gorilla	96.47	0.00e+00	685.00
IUUC-Hsa-046203	Homo sapiens	96.47	0.00e+00	685.00
IUUC-Hvu-047596	Hordeum vulgare	49.68	2.00e-85	309.00
IUUC-Itr-048501	Ictidomys tridecemlineatus	97.94	0.00e+00	694.00
IUUC-Lpe-051040	Leersia perrieri	49.36	4.00e-87	314.00
IUUC-Loc-052327	Lepisosteus oculatus	86.76	0.00e+00	634.00
IUUC-Laf-053616	Loxodonta africana	97.35	0.00e+00	693.00
IUUC-Mcc-055798	Macaca mulatta	96.47	0.00e+00	685.00
IUUC-Meu-056021	Macropus eugenii	94.88	4.00e-169	586.00
IUUC-Mtr-058752	Medicago truncatula	48.23	1.00e-85	309.00
IUUC-Mga-059516	Meleagris gallopavo	93.53	0.00e+00	674.00
IUUC-Mmr-061701	Microcebus murinus	98.24	0.00e+00	694.00
IUUC-Mdo-061879	Monodelphis domestica	93.82	0.00e+00	670.00
IUUC-Mmu-063132	Mus musculus	98.82	0.00e+00	697.00
IUUC-Mac-064871	Musa acuminata	49.36	3.00e-84	305.00
IUUC-Mpu-066365	Mustela putorius furo	97.94	0.00e+00	696.00
IUUC-Mlu-067628	Myotis lucifugus	97.06	0.00e+00	686.00
IUUC-Nle-069015	Nomascus leucogenys	95.00	0.00e+00	669.00
IUUC-Opr-070261	Ochotona princeps	98.53	0.00e+00	698.00
IUUC-Ocu-074255	Oryctolagus cuniculus	98.82	0.00e+00	699.00
IUUC-Oba-075818	Oryza barthii	47.69	4.00e-84	305.00
IUUC-Obr-076229	Oryza brachyantha	49.04	4.00e-84	305.00
IUUC-Ogl-077730	Oryza glaberrima	49.68	2.00e-87	315.00
IUUC-Ogu-078583	Oryza glumaepatula	49.23	4.00e-69	254.00
IUUC-Oin-079661	Oryza indica	49.04	3.00e-84	305.00
IUUC-Olo-080225	Oryza longistaminata	49.23	4.00e-69	254.00
IUUC-Oni-082161	Oryza nivara	49.36	4.00e-87	314.00
IUUC-Opu-084072	Oryza punctata	49.68	2.00e-87	315.00
IUUC-Oru-084316	Oryza rufipogon	49.04	3.00e-84	305.00
IUUC-Osa-085380	Oryza sativa	49.04	3.00e-84	305.00
IUUC-Oga-088685	Otolemur garnettii	98.53	0.00e+00	698.00
IUUC-Oar-089373	Ovis aries	94.43	0.00e+00	658.00
IUUC-Ptr-090627	Pan troglodytes	93.82	0.00e+00	665.00
IUUC-Pan-092347	Papio anubis	96.46	0.00e+00	683.00
IUUC-Psi-092965	Pelodiscus sinensis	92.94	0.00e+00	671.00
IUUC-Ppa-095726	Physcomitrella patens	45.30	2.00e-75	275.00
IUUC-Pab-098335	Pongo abelii	95.88	0.00e+00	682.00
IUUC-Pop-099370	Populus trichocarpa	49.68	2.00e-87	315.00
IUUC-Ppe-102016	Prunus persica	48.06	1.00e-84	306.00
IUUC-Pva-102666	Pteropus vampyrus	98.53	0.00e+00	695.00
IUUC-Sha-107128	Sarcophilus harrisii	94.41	0.00e+00	671.00
IUUC-Spo-108352	Schizosaccharomyces pombe	43.33	1.00e-68	253.00
IUUC-Ssl-108539	Sclerotinia sclerotiorum	66.28	5.00e-131	460.00
IUUC-Smo-109652	Selaginella moellendorffii	43.70	9.00e-74	270.00
IUUC-Sit-110441	Setaria italica	49.36	7.00e-87	313.00
IUUC-Sly-111784	Solanum lycopersicum	50.00	3.00e-85	308.00
IUUC-Stu-112400	Solanum tuberosum	50.00	4.00e-85	308.00
IUUC-Sbi-114038	Sorghum bicolor	48.72	1.00e-85	310.00
IUUC-Ssc-115886	Sus scrofa	98.24	0.00e+00	695.00
IUUC-Tgu-116461	Taeniopygia guttata	92.65	0.00e+00	671.00
IUUC-Tca-121224	Theobroma cacao	50.00	2.00e-87	315.00
IUUC-Tae-125653	Triticum aestivum	50.00	1.00e-85	310.00
IUUC-Tur-126755	Triticum urartu	49.52	2.00e-86	314.00
IUUC-Tbe-127694	Tupaia belangeri	81.76	6.00e-149	520.00
IUUC-Vvi-131162	Vitis vinifera	50.00	5.00e-87	314.00
IUUC-Xtr-132928	Xenopus tropicalis	88.24	5.00e-179	619.00
IUUC-Yli-134396	Yarrowia lipolytica	32.21	4.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence