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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063492
UUCD1 version UUC-MuM-00543
Ensembl Protein ID ENSMUSP00000041145.8
UniProt Accession Q6ZPR6; B9EHE9; Q3V3X0; Q8BVL7; IBTK_MOUSE
Genbank Protein ID EDL26483.1; AAI37799.1; BAE20460.1; BAC36779.1; BAC98163.1
Protein Name Inhibitor of Bruton tyrosine kinase
Genbank Nucleotide ID CH466522; BC137798; AK030895; AK077387; AK129353
Gene Name Ibtk; Kiaa1417
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035941.15 ENSMUST00000039213.14 ENSMUSP00000041145.8
ENSMUSG00000035941.15 ENSMUST00000187521.6 ENSMUSP00000139424.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 4.50e-26 92.1 566 643
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmelees.............ksklmveikdvqpevfrallkFlYtgklde 67
           Dv+++vg+++f+ahk++La +S++F++lfl++ ++                    +++ v p+ f+ ll+F+Yt++ d+
   Q: 566  DVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLeltdvyqkdedaaG-CHLFVVEKVHPDLFEYLLQFMYTDTCDL 643
           9****************************998886668999999998642.33445556****************9987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).
 Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).
Protein Sequence
(Fasta)
MDAATPDCTS KCRSLKHALD VLSVVTKGSE SQIKSFLARY CYNAATVKDA FGRNAGHLAS 60
SCGKKGVLDW LIEKGVDLLV KDKESGWTAL HRSVFYGHID CVWSLLKHGV SLYMQDKEGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063492|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTCTAGCTC AGGTTTCCCC GAACCCGGTC CCGGCGCCGA CAGTCGCGGC TGTCGCTTTC 60
CGTGCAGCCG TCCCCGGAGC TGACTCGGGC GTCCCGGCTC CTGGCTCCCT TCGTTGTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063492|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR011333--SKP1/BTB/POZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
PS50012--RCC1_3
Pfam

PF12796--Ank_2
PF00651--BTB
PF00415--RCC1
SMART

SM00248--ANK
SM00225--BTB
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0019901--F:protein kinase binding
GO:0030292--F:protein tyrosine kinase inhibitor activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:0051209--P:release of sequestered calcium ion into cytosol
KEGG mmu:108837
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000696 Aegilops tauschii 32.26 3.00e-36 147.00
IUUC-Aml-001765 Ailuropoda melanoleuca 84.59 0.00e+00 2249.00
IUUC-Apl-003868 Anas platyrhynchos 70.39 0.00e+00 1912.00
IUUC-Aca-004897 Anolis carolinensis 65.10 0.00e+00 1656.00
IUUC-Ath-007268 Arabidopsis thaliana 30.79 5.00e-30 127.00
IUUC-Ago-007942 Ashbya gossypii 24.40 2.00e-10 62.00
IUUC-Acl-008353 Aspergillus clavatus 25.00 9.00e-24 106.00
IUUC-Afl-008409 Aspergillus flavus 25.74 4.00e-27 118.00
IUUC-Afu-008944 Aspergillus fumigatus 25.00 6.00e-26 114.00
IUUC-Ani-009309 Aspergillus nidulans 25.95 2.00e-25 112.00
IUUC-Ang-009872 Aspergillus niger 27.73 1.00e-30 129.00
IUUC-Aor-010054 Aspergillus oryzae 25.74 3.00e-27 118.00
IUUC-Ate-010319 Aspergillus terreus 23.53 7.00e-07 50.80
IUUC-Ame-010972 Astyanax mexicanus 56.75 0.00e+00 1419.00
IUUC-Bgr-012036 Blumeria graminis 25.06 1.00e-20 96.70
IUUC-Bta-012491 Bos taurus 83.97 0.00e+00 2261.00
IUUC-Bci-013874 Botrytis cinerea 26.42 3.00e-27 118.00
IUUC-Bdi-014094 Brachypodium distachyon 31.28 7.00e-37 149.00
IUUC-Cja-019928 Callithrix jacchus 84.80 0.00e+00 2311.00
IUUC-Cfa-021191 Canis familiaris 85.08 0.00e+00 2321.00
IUUC-Cpo-021893 Cavia porcellus 79.98 0.00e+00 1376.00
IUUC-Csa-023410 Chlorocebus sabaeus 85.38 0.00e+00 2315.00
IUUC-Cho-024939 Choloepus hoffmanni 75.78 0.00e+00 1786.00
IUUC-Cin-025713 Ciona intestinalis 34.14 4.00e-140 492.00
IUUC-Cgl-026577 Colletotrichum gloeosporioides 23.86 4.00e-16 81.30
IUUC-Cne-026961 Cryptococcus neoformans 31.33 2.00e-17 85.50
IUUC-Cme-027274 Cyanidioschyzon merolae 30.61 9.00e-10 59.70
IUUC-Dre-027465 Danio rerio 54.53 0.00e+00 1360.00
IUUC-Dno-029885 Dasypus novemcinctus 84.27 0.00e+00 2308.00
IUUC-Dor-030105 Dipodomys ordii 84.99 0.00e+00 900.00
IUUC-Dse-031213 Dothistroma septosporum 27.29 6.00e-32 133.00
IUUC-Dme-031915 Drosophila melanogaster 29.10 5.00e-63 236.00
IUUC-Ete-033002 Echinops telfairi 72.14 0.00e+00 1830.00
IUUC-Eca-034271 Equus caballus 84.64 0.00e+00 2310.00
IUUC-Eeu-034921 Erinaceus europaeus 75.98 0.00e+00 2011.00
IUUC-Fca-036135 Felis catus 82.87 0.00e+00 2292.00
IUUC-Fal-036815 Ficedula albicollis 70.56 0.00e+00 1798.00
IUUC-Fox-037821 Fusarium oxysporum 26.89 2.00e-21 99.00
IUUC-Fso-038316 Fusarium solani 27.74 7.00e-24 107.00
IUUC-Gmo-038841 Gadus morhua 56.10 0.00e+00 1395.00
IUUC-Ggr-040105 Gaeumannomyces graminis 27.95 2.00e-22 102.00
IUUC-Gga-040756 Gallus gallus 70.68 0.00e+00 1853.00
IUUC-Gac-041957 Gasterosteus aculeatus 56.70 0.00e+00 1421.00
IUUC-Ggo-044737 Gorilla gorilla 82.87 0.00e+00 2227.00
IUUC-Hsa-046756 Homo sapiens 85.82 0.00e+00 2326.00
IUUC-Itr-048204 Ictidomys tridecemlineatus 84.49 0.00e+00 2279.00
IUUC-Lch-050082 Latimeria chalumnae 72.22 4.00e-78 283.00
IUUC-Lpe-050709 Leersia perrieri 32.80 6.00e-38 153.00
IUUC-Loc-052669 Lepisosteus oculatus 61.80 0.00e+00 1604.00
IUUC-Lma-053227 Leptosphaeria maculans 27.42 6.00e-30 127.00
IUUC-Laf-053898 Loxodonta africana 84.64 0.00e+00 2254.00
IUUC-Mcc-055614 Macaca mulatta 85.30 0.00e+00 2308.00
IUUC-Meu-056803 Macropus eugenii 57.07 0.00e+00 944.00
IUUC-Mor-056973 Magnaporthe oryzae 25.08 6.00e-27 117.00
IUUC-Mpo-057627 Magnaporthe poae 28.21 2.00e-22 102.00
IUUC-Mla-058948 Melampsora laricipopulina 27.55 4.00e-27 118.00
IUUC-Mga-059344 Meleagris gallopavo 69.74 0.00e+00 1809.00
IUUC-Mvi-060265 Microbotryum violaceum 24.74 9.00e-25 110.00
IUUC-Mmr-061025 Microcebus murinus 85.75 0.00e+00 2291.00
IUUC-Mdo-061884 Monodelphis domestica 74.04 0.00e+00 1967.00
IUUC-Mpu-065714 Mustela putorius furo 84.49 0.00e+00 2278.00
IUUC-Mlu-068229 Myotis lucifugus 82.88 0.00e+00 2208.00
IUUC-Nfi-068585 Neosartorya fischeri 25.40 5.00e-27 117.00
IUUC-Ncr-068789 Neurospora crassa 28.85 2.00e-19 92.40
IUUC-Nle-070017 Nomascus leucogenys 85.60 0.00e+00 2325.00
IUUC-Opr-070430 Ochotona princeps 76.02 0.00e+00 1562.00
IUUC-Ont-071686 Oreochromis niloticus 58.48 0.00e+00 1496.00
IUUC-Oan-073539 Ornithorhynchus anatinus 73.56 0.00e+00 1784.00
IUUC-Ocu-074076 Oryctolagus cuniculus 84.71 0.00e+00 2268.00
IUUC-Oba-075204 Oryza barthii 32.70 1.00e-37 152.00
IUUC-Obr-076797 Oryza brachyantha 32.64 6.00e-37 149.00
IUUC-Ogl-077619 Oryza glaberrima 33.05 6.00e-38 153.00
IUUC-Ogu-078961 Oryza glumaepatula 32.64 2.00e-37 151.00
IUUC-Oin-079261 Oryza indica 32.64 2.00e-37 151.00
IUUC-Olo-080829 Oryza longistaminata 32.54 1.00e-37 152.00
IUUC-Ome-081599 Oryza meridionalis 32.43 4.00e-37 150.00
IUUC-Oni-082029 Oryza nivara 32.64 5.00e-37 150.00
IUUC-Opu-083657 Oryza punctata 33.94 1.00e-36 148.00
IUUC-Oru-084765 Oryza rufipogon 32.64 2.00e-37 151.00
IUUC-Osa-086136 Oryza sativa 32.01 9.00e-37 148.00
IUUC-Ola-087419 Oryzias latipes 59.52 0.00e+00 1506.00
IUUC-Oga-088885 Otolemur garnettii 82.87 0.00e+00 2194.00
IUUC-Oar-090361 Ovis aries 83.90 0.00e+00 2241.00
IUUC-Ptr-091424 Pan troglodytes 85.75 0.00e+00 2327.00
IUUC-Pan-092557 Papio anubis 85.02 0.00e+00 2271.00
IUUC-Psi-093980 Pelodiscus sinensis 71.82 0.00e+00 1884.00
IUUC-Pno-094989 Phaeosphaeria nodorum 26.56 4.00e-35 144.00
IUUC-Ppa-095929 Physcomitrella patens 33.84 3.00e-35 144.00
IUUC-Pfo-096296 Poecilia formosa 55.79 0.00e+00 1438.00
IUUC-Pab-097552 Pongo abelii 85.60 0.00e+00 2323.00
IUUC-Pop-099124 Populus trichocarpa 30.56 1.00e-34 142.00
IUUC-Pca-100417 Procavia capensis 78.32 0.00e+00 855.00
IUUC-Ppe-101574 Prunus persica 31.09 6.00e-32 133.00
IUUC-Pva-102906 Pteropus vampyrus 79.47 0.00e+00 2113.00
IUUC-Pgr-103405 Puccinia graminis 28.46 7.00e-31 130.00
IUUC-Ptt-103743 Puccinia triticina 27.95 2.00e-30 129.00
IUUC-Pte-104407 Pyrenophora teres 27.82 1.00e-31 132.00
IUUC-Pyt-104646 Pyrenophora triticirepentis 27.82 2.00e-31 132.00
IUUC-Rno-105118 Rattus norvegicus 91.57 0.00e+00 2394.00
IUUC-Sha-106797 Sarcophilus harrisii 73.44 0.00e+00 1924.00
IUUC-Sja-107740 Schizosaccharomyces japonicus 28.17 3.00e-37 151.00
IUUC-Spo-108090 Schizosaccharomyces pombe 31.64 8.00e-34 139.00
IUUC-Ssl-108513 Sclerotinia sclerotiorum 24.88 2.00e-21 98.60
IUUC-Sit-110676 Setaria italica 32.08 3.00e-37 150.00
IUUC-Sar-113437 Sorex araneus 75.35 0.00e+00 1951.00
IUUC-Sbi-114124 Sorghum bicolor 30.75 6.00e-33 136.00
IUUC-Sre-114999 Sporisorium reilianum 28.46 1.00e-26 116.00
IUUC-Ssc-116088 Sus scrofa 84.34 0.00e+00 2175.00
IUUC-Tgu-116854 Taeniopygia guttata 70.42 0.00e+00 1846.00
IUUC-Tru-117552 Takifugu rubripes 56.54 0.00e+00 1435.00
IUUC-Tsy-118821 Tarsius syrichta 79.95 0.00e+00 1900.00
IUUC-Tni-119891 Tetraodon nigroviridis 56.10 0.00e+00 1453.00
IUUC-Tca-121015 Theobroma cacao 31.38 3.00e-36 147.00
IUUC-Tre-122202 Trichoderma reesei 23.96 3.00e-26 115.00
IUUC-Tvi-122439 Trichoderma virens 27.39 6.00e-25 110.00
IUUC-Tae-123606 Triticum aestivum 32.79 3.00e-37 150.00
IUUC-Tur-126077 Triticum urartu 32.83 2.00e-35 145.00
IUUC-Tme-127029 Tuber melanosporum 30.04 3.00e-29 125.00
IUUC-Tbe-127811 Tupaia belangeri 76.57 0.00e+00 789.00
IUUC-Ttr-128664 Tursiops truncatus 79.34 0.00e+00 1910.00
IUUC-Uma-129427 Ustilago maydis 27.27 5.00e-25 111.00
IUUC-Vda-129791 Verticillium dahliae 28.03 2.00e-18 89.00
IUUC-Vpa-130558 Vicugna pacos 77.18 0.00e+00 2011.00
IUUC-Vvi-131602 Vitis vinifera 29.55 2.00e-33 138.00
IUUC-Xtr-131965 Xenopus tropicalis 61.96 0.00e+00 1554.00
IUUC-Xma-133569 Xiphophorus maculatus 56.42 0.00e+00 1432.00
IUUC-Yli-134409 Yarrowia lipolytica 31.34 2.00e-21 98.60
IUUC-Zma-135450 Zea mays 31.85 9.00e-37 149.00
Created Date 25-Jun-2017

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