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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046652
Ensembl Protein ID ENSP00000394466.2
UniProt Accession O60784; B4DEL9; B4DNA1; Q5TIJ6; Q86X74; TOM1_HUMAN
Genbank Protein ID CAA07362.1; CAG30481.1; BAG57130.1; BAG60163.1; CAI21633.1; CAI21633.1; CAI17951.1; CAI17951.1; EAW60055.1; AAH46151.1
Protein Name Target of Myb protein 1
Genbank Nucleotide ID AJ006973; CR456595; AK293694; AK297827; AL008635; Z82244; Z82244; AL008635; CH471095; BC046151
Gene Name TOM1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100284.20 ENST00000456128.5 ENSP00000393714.1
ENSG00000100284.20 ENST00000449058.6 ENSP00000394466.2
ENSG00000100284.20 ENST00000404284.6 ENSP00000385906.2
ENSG00000100284.20 ENST00000439512.5 ENSP00000394944.1
ENSG00000100284.20 ENST00000424387.5 ENSP00000397492.1
ENSG00000100284.20 ENST00000395736.7 ENSP00000379085.3
ENSG00000100284.20 ENST00000449508.1 ENSP00000390429.1
ENSG00000100284.20 ENST00000411850.5 ENSP00000413697.1
ENSG00000100284.20 ENST00000425375.5 ENSP00000394924.1
ENSG00000100284.20 ENST00000382034.9 ENSP00000371465.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRecords
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/GAT GAT 23781020
UBD/Alpha-Helix/VHS VHS 14563850; 16199040
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 3.50e-51 174.3 20 152
UBD/Alpha-Helix/GAT 2.50e-28 100.3 215 302
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkri.nnknphvalraLtlLdscvsnCgkkfhvevaskdllee..lrell.knenep 88
           at+ +++sedw+l++eicd+i+et+eg+kdalra++kri +nkn+h++++aLt+L++cv+nCg++fhv+vas+d++e+  +r++l kn++++
   Q: 20   ATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIvGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESvlVRTILpKNNPPT 111
           68999*********************************99**************************************999*********** PP
   S: 89   kvieKlkalivsWadelknepalslivaliktlkeeGlefp 129
            v++K+++li+sWad+++++p+l+++v+++++l+++Glefp
   Q: 112  IVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFP 152
           ****************************************8 PP
   

   UBD/Alpha-Helix/GAT
   S: 39   ekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkllklieeeedndellaellkanDelnqvlnkykqlk 127
           e+i+kl+sele+v++nv++++eml+el+p+++ep+d ellqel++tc+a+++++l+li +   n++l++ell +nD+ln+v++++++++
   Q: 215  EQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCRAMQQRVLELIPQ-IANEQLTEELLIVNDNLNNVFLRHERFE 302
           89**********************************************************.*************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with ZFYVE16; interaction is required to target it to endosomes.
 Interacts with ZFYVE16; interaction is required to target it to endosomes.
Protein Sequence
(Fasta)
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA LRAVKKRIVG 60
NKNFHEVMLA LTVLETCVKN CGHRFHVLVA SQDFVESVLV RTILPKNNPP TIVHDKVLNL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046652|UBD,GAT;UBD,VHS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCTTTTTGCC ATCCTGGGCG CTAGAGGGAA TTGCGCTGCA ATTCATTAAA TTGCCTCTCA 60
GTCTCAACAG ATGACAAACC CCTTGCCCTT GCCTCTGATT TAAGGTAAGA TAATTTGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046652|UBD,GAT;UBD,VHS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR014645--TOM1
IPR002014--VHS_dom
PROSITE

PS50909--GAT
PS50179--VHS
Pfam

PF03127--GAT
PF00790--VHS
SMART

SM00288--VHS
Gene Ontology

GO:0035577--C:azurophil granule membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0035579--C:specific granule membrane
GO:0030276--F:clathrin binding
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0006886--P:intracellular protein transport
GO:0043312--P:neutrophil degranulation
GO:0015031--P:protein transport
KEGG hsa:10043
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001372 Ailuropoda melanoleuca 90.22 0.00e+00 884.00
IUUC-Apl-004197 Anas platyrhynchos 73.81 0.00e+00 687.00
IUUC-Aca-005277 Anolis carolinensis 72.07 0.00e+00 656.00
IUUC-Bta-013410 Bos taurus 92.48 0.00e+00 902.00
IUUC-Cja-018944 Callithrix jacchus 92.79 0.00e+00 893.00
IUUC-Cfa-021024 Canis familiaris 91.46 0.00e+00 879.00
IUUC-Cpo-021418 Cavia porcellus 83.77 0.00e+00 815.00
IUUC-Csa-023653 Chlorocebus sabaeus 94.71 0.00e+00 943.00
IUUC-Cin-025779 Ciona intestinalis 42.38 2.00e-71 262.00
IUUC-Cne-026931 Cryptococcus neoformans 25.82 6.00e-15 75.90
IUUC-Dno-029610 Dasypus novemcinctus 89.00 0.00e+00 712.00
IUUC-Dor-030925 Dipodomys ordii 77.85 0.00e+00 743.00
IUUC-Eca-034207 Equus caballus 93.09 0.00e+00 888.00
IUUC-Eeu-035025 Erinaceus europaeus 73.00 3.00e-122 432.00
IUUC-Fca-036407 Felis catus 91.72 0.00e+00 817.00
IUUC-Fal-036809 Ficedula albicollis 73.96 0.00e+00 690.00
IUUC-Gga-040357 Gallus gallus 73.27 0.00e+00 726.00
IUUC-Gma-043377 Glycine max 31.36 8.00e-33 135.00
IUUC-Ggo-044454 Gorilla gorilla 97.60 0.00e+00 954.00
IUUC-Itr-049028 Ictidomys tridecemlineatus 86.82 0.00e+00 877.00
IUUC-Lch-049918 Latimeria chalumnae 61.52 1.00e-156 546.00
IUUC-Laf-054231 Loxodonta africana 88.86 0.00e+00 682.00
IUUC-Mcc-055475 Macaca mulatta 98.37 0.00e+00 957.00
IUUC-Meu-056002 Macropus eugenii 65.89 4.00e-155 541.00
IUUC-Mla-058817 Melampsora laricipopulina 25.65 5.00e-19 89.00
IUUC-Mga-059199 Meleagris gallopavo 69.73 0.00e+00 668.00
IUUC-Mvi-060415 Microbotryum violaceum 24.72 2.00e-15 77.80
IUUC-Mmr-061193 Microcebus murinus 93.51 0.00e+00 860.00
IUUC-Mdo-062456 Monodelphis domestica 80.79 0.00e+00 726.00
IUUC-Mmu-063746 Mus musculus 89.43 0.00e+00 888.00
IUUC-Mpu-066772 Mustela putorius furo 90.87 0.00e+00 884.00
IUUC-Mlu-067475 Myotis lucifugus 84.75 0.00e+00 684.00
IUUC-Nle-068998 Nomascus leucogenys 96.21 0.00e+00 935.00
IUUC-Oan-073103 Ornithorhynchus anatinus 75.10 0.00e+00 736.00
IUUC-Ocu-073922 Oryctolagus cuniculus 84.93 0.00e+00 789.00
IUUC-Olo-080980 Oryza longistaminata 31.79 2.00e-30 127.00
IUUC-Olu-087840 Ostreococcus lucimarinus 24.63 4.00e-16 79.70
IUUC-Oga-089050 Otolemur garnettii 81.71 0.00e+00 768.00
IUUC-Oar-090246 Ovis aries 88.13 0.00e+00 845.00
IUUC-Ptr-090714 Pan troglodytes 99.39 0.00e+00 959.00
IUUC-Pan-092875 Papio anubis 98.37 0.00e+00 957.00
IUUC-Psi-094051 Pelodiscus sinensis 72.88 0.00e+00 707.00
IUUC-Pab-098291 Pongo abelii 99.13 0.00e+00 893.00
IUUC-Pca-100907 Procavia capensis 82.32 0.00e+00 743.00
IUUC-Pva-102610 Pteropus vampyrus 83.33 0.00e+00 800.00
IUUC-Pgr-103677 Puccinia graminis 27.22 1.00e-20 94.40
IUUC-Rno-105809 Rattus norvegicus 88.82 0.00e+00 877.00
IUUC-Sha-107255 Sarcophilus harrisii 83.18 0.00e+00 719.00
IUUC-Ssl-108413 Sclerotinia sclerotiorum 39.04 7.00e-22 96.30
IUUC-Sre-115232 Sporisorium reilianum 25.58 2.00e-19 90.50
IUUC-Tgu-117517 Taeniopygia guttata 75.00 0.00e+00 730.00
IUUC-Tni-120701 Tetraodon nigroviridis 54.01 4.00e-144 504.00
IUUC-Ttr-128710 Tursiops truncatus 83.77 0.00e+00 771.00
IUUC-Uma-129380 Ustilago maydis 26.63 4.00e-15 76.60
IUUC-Vpa-130381 Vicugna pacos 71.88 6.00e-107 380.00
Created Date 25-Jun-2017

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