iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007157

Ensembl Protein ID

AT1G16190.1

UniProt Accession

Q84L32; Q9S9L8; Q9SA20; RD23A_ARATH

Genbank Protein ID

BAC76391.1; AAD34676.1; AAF18513.1; AEE29418.1

Protein Name

Probable ubiquitin receptor RAD23a; Putative DNA repair protein RAD23-2; RAD23-like protein 2

Genbank Nucleotide ID

AB109195; AC006341; AC010924; CP002684

Gene Name

RAD23A; RAD23; RAD23-2; At1g16190; F3O9.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G16190	AT1G16190.1	AT1G16190.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	20086187
ULD/UDP/UFD/MUB	MUB	20086187; 25320573

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.10e-24	86.7	146	187
ULD/UDP/UBQ/UBQ_PIM	1.80e-22	79.9	1	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMG...FdreealqaLraannnleaAveyLldg 41
            e++++q++eMG   +d+e++ +aLraa+nn+e+Av+yL++g
   Q: 146  IEQMVQQIMEMGggsWDKETVTRALRAAYNNPERAVDYLYSG 187
           59*************************************986 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           mkltvktlkg++fe++v + dt+ ++K++i+++++   +p+ qq LI++Gk+LkD+ttL e+++ ++ +++++++ksk
   Q: 1    MKLTVKTLKGSHFEIRVLPTDTIMAVKKNIEDSQSkdnYPCGQQLLIHNGKVLKDETTLVENKVTEEGFLVVMLSKSK 78
           99*******************************99999*************************************997 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity).

Protein Sequence
(Fasta)

MKLTVKTLKG SHFEIRVLPT DTIMAVKKNI EDSQSKDNYP CGQQLLIHNG KVLKDETTLV 60
ENKVTEEGFL VVMLSKSKTA SSAGPSSTQP TSTTTSTISS TTLAAPSTTQ SIAVPASNST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTGTTGAC AGCGACTGTT TGATAAAGTC GGCATTGTTG TACAGTGATT GAAAATCAAA 60
AAGCTCTTTT AGGTCACTCT CTATTTTTCG CTCCCTCGCC GGACTTTGCT GACGCCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0006289--P:nucleotide-excision repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G16190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000088	Aegilops tauschii	51.51	2.00e-87	315.00
IUUC-Aly-005694	Arabidopsis lyrata	90.22	0.00e+00	628.00
IUUC-Afl-008605	Aspergillus flavus	37.60	4.00e-31	128.00
IUUC-Aor-010032	Aspergillus oryzae	37.60	5.00e-31	127.00
IUUC-Ame-011342	Astyanax mexicanus	35.33	6.00e-37	147.00
IUUC-Bci-013933	Botrytis cinerea	34.69	1.00e-34	139.00
IUUC-Bol-015272	Brassica oleracea	86.68	3.00e-167	580.00
IUUC-Bra-016970	Brassica rapa	83.42	5.00e-167	579.00
IUUC-Cho-024814	Choloepus hoffmanni	41.67	8.00e-19	87.00
IUUC-Cin-025741	Ciona intestinalis	29.82	2.00e-23	102.00
IUUC-Csv-025823	Ciona savignyi	32.41	3.00e-27	114.00
IUUC-Dno-030017	Dasypus novemcinctus	32.98	1.00e-39	156.00
IUUC-Dor-030358	Dipodomys ordii	40.91	4.00e-35	141.00
IUUC-Eca-034243	Equus caballus	38.31	3.00e-33	135.00
IUUC-Fal-037148	Ficedula albicollis	39.29	7.00e-34	137.00
IUUC-Fso-038107	Fusarium solani	49.60	3.00e-20	92.00
IUUC-Gmo-038528	Gadus morhua	34.75	3.00e-47	181.00
IUUC-Lch-049719	Latimeria chalumnae	34.55	1.00e-47	182.00
IUUC-Lpe-051168	Leersia perrieri	61.29	8.00e-113	399.00
IUUC-Lma-053328	Leptosphaeria maculans	39.47	3.00e-09	52.00
IUUC-Laf-054589	Loxodonta africana	34.01	8.00e-46	176.00
IUUC-Mga-060060	Meleagris gallopavo	29.03	2.00e-03	35.80
IUUC-Mvi-060220	Microbotryum violaceum	49.21	2.00e-25	110.00
IUUC-Mlu-067787	Myotis lucifugus	35.13	3.00e-47	181.00
IUUC-Oba-074972	Oryza barthii	61.83	1.00e-114	405.00
IUUC-Obr-076909	Oryza brachyantha	63.13	6.00e-119	419.00
IUUC-Oin-079203	Oryza indica	64.44	3.00e-121	427.00
IUUC-Olo-080559	Oryza longistaminata	64.61	1.00e-120	425.00
IUUC-Oni-082812	Oryza nivara	61.83	6.00e-115	406.00
IUUC-Opu-083963	Oryza punctata	60.75	6.00e-110	389.00
IUUC-Oru-084942	Oryza rufipogon	60.57	2.00e-103	368.00
IUUC-Osa-085951	Oryza sativa	64.44	3.00e-121	427.00
IUUC-Olu-087843	Ostreococcus lucimarinus	38.24	2.00e-48	185.00
IUUC-Pop-099726	Populus trichocarpa	66.05	2.00e-123	434.00
IUUC-Pca-100348	Procavia capensis	34.02	6.00e-45	174.00
IUUC-Sce-106214	Saccharomyces cerevisiae	32.85	1.00e-13	70.10
IUUC-Spo-108298	Schizosaccharomyces pombe	35.40	5.00e-46	177.00
IUUC-Sit-109813	Setaria italica	58.49	3.00e-104	371.00
IUUC-Sly-111349	Solanum lycopersicum	68.90	8.00e-130	456.00
IUUC-Stu-112306	Solanum tuberosum	66.93	3.00e-121	427.00
IUUC-Tsy-118836	Tarsius syrichta	41.67	4.00e-18	85.10
IUUC-Tca-121594	Theobroma cacao	64.83	3.00e-128	451.00
IUUC-Tre-121911	Trichoderma reesei	33.94	3.00e-32	131.00
IUUC-Tvi-122617	Trichoderma virens	35.62	1.00e-37	149.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence