iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008328

Ensembl Protein ID

CADACLAP00008623

UniProt Accession

A1CE93; ATG5_ASPCL

Genbank Protein ID

EAW11192.1

Protein Name

Autophagy protein 5

Genbank Nucleotide ID

DS027052

Gene Name

ACLA_088830; atg5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00008833	CADACLAT00008833	CADACLAP00008623

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	24.19	1.00e-07	52.00	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus clavatus

Functional Description
(View)

Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate acts as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).

Protein Sequence
(Fasta)

MENQASLNSI QKTISCPRIS YLPSLLPRLR SFFASSLIEP KSQPHEGWFS FEGVPLKWHL 60
PIGLLYDLYA GADPASKGSR PDESEQIISS VGDTLPWRLT LHFSDWPDEE LVRLDADGMV 120

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Nucleotide Sequence
(Fasta)

ATGGAGAATC AAGCCTCCCT CAACAGTATC CAGAAGACTG TATGGGATGG AAAACTACCA 60
TTGCAGATAA CGCTTGCTTC ATCTGAAAGT CGAACATTCG ACCAGACAGA TCCATATCTG 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

act:ACLA_088830

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	27.80	5.00e-22	98.20
IUUC-Aml-002403	Ailuropoda melanoleuca	24.73	2.00e-19	87.40
IUUC-Atr-002645	Amborella trichopoda	30.24	2.00e-21	94.70
IUUC-Apl-003611	Anas platyrhynchos	24.64	3.00e-24	103.00
IUUC-Aca-004411	Anolis carolinensis	25.89	6.00e-22	95.90
IUUC-Aly-005636	Arabidopsis lyrata	34.84	8.00e-19	85.90
IUUC-Ath-006959	Arabidopsis thaliana	34.84	1.00e-18	85.10
IUUC-Ago-007978	Ashbya gossypii	24.31	2.00e-13	67.80
IUUC-Afl-008638	Aspergillus flavus	72.84	3.00e-114	402.00
IUUC-Afu-009042	Aspergillus fumigatus	78.50	1.00e-138	483.00
IUUC-Ani-009364	Aspergillus nidulans	69.10	4.00e-105	372.00
IUUC-Aor-009889	Aspergillus oryzae	72.53	5.00e-116	408.00
IUUC-Ate-010511	Aspergillus terreus	74.34	1.00e-45	172.00
IUUC-Ame-011644	Astyanax mexicanus	35.71	3.00e-04	34.30
IUUC-Bgr-012153	Blumeria graminis	36.46	2.00e-35	140.00
IUUC-Bta-012360	Bos taurus	31.25	2.00e-15	73.20
IUUC-Bci-013723	Botrytis cinerea	40.07	5.00e-48	182.00
IUUC-Bdi-014520	Brachypodium distachyon	27.27	2.00e-20	91.70
IUUC-Bol-016053	Brassica oleracea	34.19	1.00e-20	92.00
IUUC-Bra-017072	Brassica rapa	33.55	4.00e-21	93.60
IUUC-Cel-018529	Caenorhabditis elegans	21.71	2.00e-12	64.70
IUUC-Cja-019569	Callithrix jacchus	24.55	4.00e-20	90.10
IUUC-Cfa-020473	Canis familiaris	24.91	1.00e-20	91.30
IUUC-Cpo-021421	Cavia porcellus	24.91	2.00e-20	90.90
IUUC-Cre-022862	Chlamydomonas reinhardtii	32.41	3.00e-12	63.20
IUUC-Csa-024197	Chlorocebus sabaeus	24.55	5.00e-20	89.70
IUUC-Cho-024521	Choloepus hoffmanni	23.83	1.00e-17	81.60
IUUC-Cin-025119	Ciona intestinalis	23.74	2.00e-19	87.40
IUUC-Csv-026192	Ciona savignyi	26.35	1.00e-21	95.10
IUUC-Cgl-026686	Colletotrichum gloeosporioides	41.70	2.00e-36	144.00
IUUC-Dre-028466	Danio rerio	24.46	6.00e-22	95.90
IUUC-Dse-031228	Dothistroma septosporum	46.67	8.00e-76	275.00
IUUC-Dme-031703	Drosophila melanogaster	31.03	8.00e-20	89.00
IUUC-Ete-032482	Echinops telfairi	23.83	1.00e-19	87.80
IUUC-Eca-034036	Equus caballus	24.91	1.00e-20	91.70
IUUC-Eeu-035235	Erinaceus europaeus	31.03	3.00e-15	73.90
IUUC-Fca-036263	Felis catus	24.91	2.00e-20	90.90
IUUC-Fal-037064	Ficedula albicollis	25.00	1.00e-24	104.00
IUUC-Fox-037813	Fusarium oxysporum	39.07	5.00e-41	159.00
IUUC-Fso-038139	Fusarium solani	39.02	2.00e-40	157.00
IUUC-Gmo-039509	Gadus morhua	28.22	4.00e-21	92.80
IUUC-Ggr-040111	Gaeumannomyces graminis	42.29	4.00e-40	156.00
IUUC-Gga-040517	Gallus gallus	24.64	5.00e-24	102.00
IUUC-Gac-042270	Gasterosteus aculeatus	29.70	2.00e-20	90.90
IUUC-Gma-044400	Glycine max	32.05	3.00e-18	83.60
IUUC-Ggo-045048	Gorilla gorilla	24.55	3.00e-20	90.50
IUUC-Hsa-046744	Homo sapiens	24.55	3.00e-20	90.10
IUUC-Kpa-049174	Komagataella pastoris	26.06	3.00e-25	107.00
IUUC-Lch-049475	Latimeria chalumnae	26.81	1.00e-23	101.00
IUUC-Lpe-051283	Leersia perrieri	29.28	2.00e-23	103.00
IUUC-Loc-052446	Lepisosteus oculatus	25.72	4.00e-24	103.00
IUUC-Lma-053278	Leptosphaeria maculans	48.11	3.00e-70	256.00
IUUC-Laf-054020	Loxodonta africana	24.38	7.00e-19	85.90
IUUC-Mcc-055176	Macaca mulatta	24.55	3.00e-20	90.10
IUUC-Mor-057164	Magnaporthe oryzae	39.46	5.00e-42	162.00
IUUC-Mpo-057428	Magnaporthe poae	41.50	4.00e-39	152.00
IUUC-Mtr-058424	Medicago truncatula	33.97	6.00e-20	89.40
IUUC-Mla-058872	Melampsora laricipopulina	26.75	1.00e-23	102.00
IUUC-Mga-059859	Meleagris gallopavo	24.64	5.00e-24	102.00
IUUC-Mmr-061482	Microcebus murinus	24.28	3.00e-20	90.10
IUUC-Mdo-062371	Monodelphis domestica	24.91	8.00e-23	99.00
IUUC-Mmu-063139	Mus musculus	23.83	1.00e-19	88.60
IUUC-Mac-065332	Musa acuminata	33.95	4.00e-21	94.00
IUUC-Mpu-066783	Mustela putorius furo	24.55	6.00e-20	89.40
IUUC-Mlu-068165	Myotis lucifugus	24.73	2.00e-18	84.30
IUUC-Nfi-068578	Neosartorya fischeri	78.82	8.00e-140	487.00
IUUC-Ncr-068636	Neurospora crassa	39.73	5.00e-41	159.00
IUUC-Nle-069740	Nomascus leucogenys	24.55	4.00e-20	89.70
IUUC-Opr-070802	Ochotona princeps	31.03	9.00e-15	72.00
IUUC-Ont-072222	Oreochromis niloticus	25.00	3.00e-23	100.00
IUUC-Oan-072760	Ornithorhynchus anatinus	31.25	4.00e-21	92.80
IUUC-Ocu-074844	Oryctolagus cuniculus	20.42	6.00e-07	45.40
IUUC-Oba-075834	Oryza barthii	28.79	1.00e-23	102.00
IUUC-Obr-076230	Oryza brachyantha	25.91	2.00e-14	70.90
IUUC-Ogl-077554	Oryza glaberrima	28.46	2.00e-23	101.00
IUUC-Ogu-078687	Oryza glumaepatula	27.99	4.00e-23	100.00
IUUC-Oin-079677	Oryza indica	29.88	7.00e-25	106.00
IUUC-Olo-081078	Oryza longistaminata	29.10	3.00e-24	104.00
IUUC-Ome-081548	Oryza meridionalis	29.50	1.00e-23	103.00
IUUC-Oni-082050	Oryza nivara	28.79	9.00e-24	102.00
IUUC-Opu-083609	Oryza punctata	28.46	6.00e-24	103.00
IUUC-Oru-085057	Oryza rufipogon	28.79	7.00e-24	102.00
IUUC-Osa-085917	Oryza sativa	28.84	5.00e-24	103.00
IUUC-Ola-087032	Oryzias latipes	24.64	1.00e-21	95.10
IUUC-Olu-087877	Ostreococcus lucimarinus	23.95	8.30e-02	27.70
IUUC-Oga-088468	Otolemur garnettii	24.82	6.00e-22	95.90
IUUC-Oar-089751	Ovis aries	24.64	2.00e-20	90.90
IUUC-Ptr-091064	Pan troglodytes	24.55	3.00e-20	90.10
IUUC-Pan-092505	Papio anubis	24.38	5.00e-19	86.30
IUUC-Psi-093086	Pelodiscus sinensis	26.35	7.00e-23	99.00
IUUC-Pno-094825	Phaeosphaeria nodorum	45.00	5.00e-66	242.00
IUUC-Ppa-095419	Physcomitrella patens	34.16	4.00e-21	94.00
IUUC-Pfo-096224	Poecilia formosa	25.00	1.00e-25	107.00
IUUC-Pab-098501	Pongo abelii	24.55	3.00e-20	90.10
IUUC-Pop-099243	Populus trichocarpa	36.54	8.00e-20	89.40
IUUC-Ppe-101255	Prunus persica	34.62	7.00e-20	89.70
IUUC-Pva-102828	Pteropus vampyrus	24.55	7.00e-20	89.00
IUUC-Pgr-103672	Puccinia graminis	25.88	6.00e-17	79.70
IUUC-Ptt-104013	Puccinia triticina	26.33	2.00e-17	81.30
IUUC-Pyt-104615	Pyrenophora triticirepentis	44.75	7.00e-62	228.00
IUUC-Rno-106089	Rattus norvegicus	23.10	1.00e-17	81.60
IUUC-Sce-106216	Saccharomyces cerevisiae	23.93	3.00e-10	57.40
IUUC-Sha-106484	Sarcophilus harrisii	25.63	2.00e-23	100.00
IUUC-Sja-107699	Schizosaccharomyces japonicus	31.05	2.00e-36	144.00
IUUC-Spo-108177	Schizosaccharomyces pombe	27.56	6.00e-28	115.00
IUUC-Ssl-108475	Sclerotinia sclerotiorum	38.23	3.00e-45	172.00
IUUC-Smo-109473	Selaginella moellendorffii	31.51	7.00e-18	82.80
IUUC-Sit-110736	Setaria italica	33.54	4.00e-21	93.60
IUUC-Sly-111657	Solanum lycopersicum	36.88	5.00e-23	100.00
IUUC-Sar-113050	Sorex araneus	31.25	1.00e-18	84.30
IUUC-Sbi-114258	Sorghum bicolor	27.38	4.00e-22	97.10
IUUC-Sre-114902	Sporisorium reilianum	29.21	3.00e-18	84.70
IUUC-Ssc-116166	Sus scrofa	23.27	4.00e-16	76.60
IUUC-Tgu-116814	Taeniopygia guttata	24.64	3.00e-24	103.00
IUUC-Tru-118172	Takifugu rubripes	23.19	8.00e-22	95.50
IUUC-Tsy-119010	Tarsius syrichta	30.68	1.00e-19	88.20
IUUC-Tni-120397	Tetraodon nigroviridis	29.14	8.00e-20	88.20
IUUC-Tca-121283	Theobroma cacao	33.97	1.00e-20	92.40
IUUC-Tvi-122545	Trichoderma virens	37.68	2.00e-35	140.00
IUUC-Tae-122685	Triticum aestivum	28.09	2.00e-22	97.40
IUUC-Tur-126407	Triticum urartu	28.83	1.00e-22	99.00
IUUC-Tme-126913	Tuber melanosporum	40.78	3.00e-59	219.00
IUUC-Tbe-127738	Tupaia belangeri	23.40	6.00e-13	65.50
IUUC-Ttr-128528	Tursiops truncatus	24.64	3.00e-20	90.50
IUUC-Uma-129625	Ustilago maydis	31.91	1.00e-18	86.30
IUUC-Vda-129906	Verticillium dahliae	39.13	3.00e-40	156.00
IUUC-Vpa-130223	Vicugna pacos	24.00	2.00e-18	84.00
IUUC-Vvi-131617	Vitis vinifera	34.13	3.00e-18	84.00
IUUC-Xtr-132288	Xenopus tropicalis	26.45	2.00e-24	104.00
IUUC-Xma-134214	Xiphophorus maculatus	30.29	1.00e-22	97.40
IUUC-Yli-134377	Yarrowia lipolytica	30.67	6.00e-19	85.90
IUUC-Zma-135108	Zea mays	34.78	7.00e-22	96.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence