iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132481

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6

Genbank Nucleotide ID

AAMC01083154

Gene Name

herc6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000000342.3	ENSXETT00000000722.3	ENSXETP00000000722.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-80	269.1	708	1028

Active Site

Position(s)	Description	Evidence
998	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +lkk l vef+gE+ +d   vt+ef+  l++ + npd+g+f +s+     ++p+        e+ k+F+f G+++g+a++++ ++ l
   Q: 708  NLKKDLLVEFQGESTTDSAAVTKEFFLVLLESMVNPDYGMFSCSDPLLPIWFPSTPLV----EKKKYFYF-GIICGLAVYNQIVIYL 789
           68999************************************************99887....68899987.**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           p++ +++k+llgkk +ledl+e++p++ +++k +++ + s + e +++  f+ s     + k+ +L+p+G +++V+n Nk+++v++ 
   Q: 790  PFPLALFKKLLGKKATLEDLKELQPTMGRTMKDLLDAE-STVVE-SMETYFCFSW----DNKSIDLIPNGGSVQVNNLNKKDFVNKC 870
           ***********************************994.44444.5899999655....679999********************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           ++y++++++   +e+f++Gf++v+++e++s F++ el  l+ G++e+d++ ++k+t+y g +t+d+p+i++Fw+v++++s  ++k f
   Q: 871  IDYIFNTSVMVPFEEFKRGFYKVCDKEIISFFQPDELMALVAGTTEYDWNIFEKTTMYLGKFTPDHPTIRMFWKVFHALSLVNKKGF 957
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPl..gGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           L F+Tg+++lP+  +G ++++   + i+     ++++lP+++TCf++L LPeYs+ + lk+kL++Ai ++kg+e
   Q: 958  LMFLTGNDKLPIftRGGDNIR---MKISSfgVPDETHLPEAQTCFHMLFLPEYSNIKSLKQKLMLAIAHNKGYE 1028
           ***********9999999999...44555556889************************************997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MYCWGDNCFG QLALLQGEKE VVHFKENDYF QSQECVQKVS CGEKHTLYLL EDGTLLSCGQ 60
NPYGQLGRKS NNSSIEQISS LEAQTIVDIS CGTNHSVAVS DEGSIYSWGD GSEGQLGTGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTGCT GGGGTGACAA CTGCTTTGGG CAGCTAGCTT TATTGCAAGG GGAAAAAGAA 60
GTGGTGCATT TTAAAGAAAA TGATTATTTT CAAAGCCAGG AATGTGTTCA GAAAGTGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	42.46	0.00e+00	714.00
IUUC-Aca-004663	Anolis carolinensis	45.65	0.00e+00	855.00
IUUC-Bta-013080	Bos taurus	42.81	0.00e+00	754.00
IUUC-Cja-018891	Callithrix jacchus	42.18	0.00e+00	737.00
IUUC-Cfa-020763	Canis familiaris	42.76	0.00e+00	719.00
IUUC-Cpo-022346	Cavia porcellus	43.41	0.00e+00	797.00
IUUC-Csa-023049	Chlorocebus sabaeus	42.79	0.00e+00	822.00
IUUC-Dno-029093	Dasypus novemcinctus	43.13	0.00e+00	779.00
IUUC-Eca-034098	Equus caballus	45.57	0.00e+00	804.00
IUUC-Eeu-035028	Erinaceus europaeus	38.40	1.00e-92	334.00
IUUC-Fca-036283	Felis catus	43.72	0.00e+00	741.00
IUUC-Ggo-045553	Gorilla gorilla	41.93	0.00e+00	762.00
IUUC-Hsa-046396	Homo sapiens	42.83	0.00e+00	782.00
IUUC-Loc-052736	Lepisosteus oculatus	41.55	0.00e+00	767.00
IUUC-Laf-054433	Loxodonta africana	42.05	0.00e+00	806.00
IUUC-Mcc-055014	Macaca mulatta	40.32	0.00e+00	757.00
IUUC-Mdo-061839	Monodelphis domestica	42.36	0.00e+00	721.00
IUUC-Mmu-064378	Mus musculus	41.50	0.00e+00	739.00
IUUC-Mpu-066293	Mustela putorius furo	42.74	0.00e+00	700.00
IUUC-Mlu-067407	Myotis lucifugus	42.56	0.00e+00	763.00
IUUC-Nle-069978	Nomascus leucogenys	41.92	0.00e+00	798.00
IUUC-Olu-087836	Ostreococcus lucimarinus	30.24	1.00e-31	130.00
IUUC-Oga-088780	Otolemur garnettii	39.92	0.00e+00	713.00
IUUC-Oar-090307	Ovis aries	44.12	0.00e+00	776.00
IUUC-Ptr-091567	Pan troglodytes	43.03	0.00e+00	792.00
IUUC-Pan-091802	Papio anubis	39.81	0.00e+00	730.00
IUUC-Pca-100320	Procavia capensis	35.23	2.00e-164	573.00
IUUC-Pva-102382	Pteropus vampyrus	41.66	0.00e+00	720.00
IUUC-Rno-105768	Rattus norvegicus	39.42	0.00e+00	705.00
IUUC-Sha-106525	Sarcophilus harrisii	42.20	0.00e+00	792.00
IUUC-Sar-113014	Sorex araneus	40.92	4.00e-97	349.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence