iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000055483.19	ENST00000587010.5	ENSP00000465679.1
ENSG00000055483.19	ENST00000588130.5	ENSP00000464746.1
ENSG00000055483.19	ENST00000589225.5	ENSP00000467280.1
ENSG00000055483.19	ENST00000587379.1	ENSP00000464886.1
ENSG00000055483.19	ENST00000592231.5	ENSP00000465698.1
ENSG00000055483.19	ENST00000586066.3	ENSP00000466567.1
ENSG00000055483.19	ENST00000589424.5	ENSP00000466187.1
ENSG00000055483.19	ENST00000590546.6	ENSP00000467682.1
ENSG00000055483.19	ENST00000591942.6	ENSP00000475654.1
ENSG00000055483.19	ENST00000449938.6	ENSP00000401119.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	15809067; 14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	1.30e-79	269.6	123	421

Active Site

Position(s)	Description	Evidence
131	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
382	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           Gl+NlgNtC++N+++QcL+ +p+l+++ll+ ++ ++++     + + ++l+ +q+ + +   ++ +a++p ++++ lkk+a++f+  +q+Da
   Q: 123  GLHNLGNTCFLNATIQCLTYTPPLANYLLSkEHARSCH-----QGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDA 209
           9*****************************33333333.....456788899999999999******************************* PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           +Efl++ +d++++++                  l+  a+ + +++ ++l++++F+g l+s++kc  c++vs +++p ld+ l++++      
   Q: 210  HEFLRYTIDAMQKAC------------------LNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAA---- 279
           ***************..................344556788999*******************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            ++  +Le f+k++ l gen+y c kckkk+ a+k++++++ ++vL+l LkRf    ++ s  ki+k v +p+ L+++p++++++ +   ++
   Q: 280  -NIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRF----ANFSGGKITKDVGYPEFLNIRPYMSQNNGD---PV 363
           .9***************************************************....668899********************6654...9* PP
   S: 277  kYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
            Y L+av+vHsG s++ GHY++yvk ++g+W++++Ds V++++ + vl+   ++aYvlfY 
   Q: 364  MYGLYAVLVHSGySCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLN---QQAYVLFYL 421
           *************************************************...********6 PP

Organism

Homo sapiens

Functional Description
(View)

May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).

Protein Sequence
(Fasta)

MPIVDKLKEA LKPGRKDSAD DGELGKLLAS SAKKVLLQKI EFEPASKSFS YQLEALKSKY 60
VLLNPKTEGA SRHKSGDDPP ARRQGSEHTY ESCGDGVPAP QKVLFPTERL SLRWERVFRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAATTCCGA AGAGCCATTT CCTCGGCAGC CCCAGGCTTT GGCCGATCGC TCCCAGATCC 60
CTCCCTCCCC AAACTGCAGG TGCTCCGCGT GTGGGAGTCA CGGATGGCCC CAGAGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:1903146--P:regulation of mitophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:57602

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002092	Ailuropoda melanoleuca	74.16	0.00e+00	1367.00
IUUC-Aca-005360	Anolis carolinensis	65.72	0.00e+00	905.00
IUUC-Bta-013047	Bos taurus	71.24	0.00e+00	1264.00
IUUC-Bdi-014036	Brachypodium distachyon	44.62	1.00e-83	304.00
IUUC-Cja-019203	Callithrix jacchus	88.80	0.00e+00	1671.00
IUUC-Cfa-020586	Canis familiaris	74.53	0.00e+00	1358.00
IUUC-Cpo-021804	Cavia porcellus	70.68	0.00e+00	1292.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	47.98	2.00e-52	199.00
IUUC-Csa-023137	Chlorocebus sabaeus	95.19	0.00e+00	1877.00
IUUC-Cin-025230	Ciona intestinalis	53.03	2.00e-97	349.00
IUUC-Cne-027049	Cryptococcus neoformans	34.17	5.00e-39	155.00
IUUC-Cme-027339	Cyanidioschyzon merolae	36.12	5.00e-62	232.00
IUUC-Dre-028587	Danio rerio	73.76	0.00e+00	805.00
IUUC-Dno-029149	Dasypus novemcinctus	68.58	0.00e+00	1276.00
IUUC-Dor-030836	Dipodomys ordii	70.40	0.00e+00	1011.00
IUUC-Dme-032119	Drosophila melanogaster	34.17	2.00e-70	260.00
IUUC-Ete-032567	Echinops telfairi	71.00	0.00e+00	895.00
IUUC-Eca-033600	Equus caballus	76.46	0.00e+00	1408.00
IUUC-Eeu-035206	Erinaceus europaeus	59.65	7.00e-139	488.00
IUUC-Fca-036392	Felis catus	59.55	0.00e+00	627.00
IUUC-Fal-036852	Ficedula albicollis	66.97	1.00e-158	554.00
IUUC-Gmo-039033	Gadus morhua	71.27	0.00e+00	795.00
IUUC-Gga-040664	Gallus gallus	76.41	0.00e+00	761.00
IUUC-Gac-042176	Gasterosteus aculeatus	61.76	0.00e+00	805.00
IUUC-Ggo-045437	Gorilla gorilla	98.04	0.00e+00	1900.00
IUUC-Hvu-047714	Hordeum vulgare	39.45	2.00e-66	247.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	73.03	0.00e+00	1360.00
IUUC-Lch-050120	Latimeria chalumnae	59.91	0.00e+00	754.00
IUUC-Lpe-051574	Leersia perrieri	36.04	2.00e-79	291.00
IUUC-Loc-052796	Lepisosteus oculatus	63.84	0.00e+00	782.00
IUUC-Laf-054243	Loxodonta africana	71.53	0.00e+00	1314.00
IUUC-Mcc-055762	Macaca mulatta	94.75	0.00e+00	1833.00
IUUC-Meu-056697	Macropus eugenii	68.18	0.00e+00	1285.00
IUUC-Mtr-058537	Medicago truncatula	44.38	4.00e-85	309.00
IUUC-Mla-059049	Melampsora laricipopulina	42.20	1.00e-59	224.00
IUUC-Mga-059359	Meleagris gallopavo	80.23	5.00e-159	555.00
IUUC-Mmr-060966	Microcebus murinus	78.23	0.00e+00	1399.00
IUUC-Mdo-062733	Monodelphis domestica	65.73	0.00e+00	1212.00
IUUC-Mmu-064331	Mus musculus	70.98	0.00e+00	1348.00
IUUC-Mac-065039	Musa acuminata	40.35	1.00e-88	321.00
IUUC-Mpu-065759	Mustela putorius furo	72.74	0.00e+00	1279.00
IUUC-Mlu-067371	Myotis lucifugus	67.20	0.00e+00	1186.00
IUUC-Nle-070087	Nomascus leucogenys	96.35	0.00e+00	1855.00
IUUC-Opr-070729	Ochotona princeps	67.63	0.00e+00	1025.00
IUUC-Ont-071346	Oreochromis niloticus	75.05	0.00e+00	798.00
IUUC-Oan-072931	Ornithorhynchus anatinus	71.22	0.00e+00	881.00
IUUC-Ocu-074823	Oryctolagus cuniculus	65.07	0.00e+00	1128.00
IUUC-Oba-075866	Oryza barthii	44.13	4.00e-82	299.00
IUUC-Obr-076408	Oryza brachyantha	37.39	3.00e-83	303.00
IUUC-Ogl-077559	Oryza glaberrima	44.94	4.00e-83	303.00
IUUC-Ogu-078064	Oryza glumaepatula	44.30	7.00e-83	302.00
IUUC-Oin-079471	Oryza indica	44.94	2.00e-83	304.00
IUUC-Olo-080231	Oryza longistaminata	43.04	1.00e-75	278.00
IUUC-Ome-081746	Oryza meridionalis	45.10	3.00e-82	300.00
IUUC-Oni-082339	Oryza nivara	40.93	8.00e-83	302.00
IUUC-Opu-083194	Oryza punctata	40.64	8.00e-83	303.00
IUUC-Oru-085083	Oryza rufipogon	44.30	8.00e-83	302.00
IUUC-Osa-085395	Oryza sativa	44.94	2.00e-83	304.00
IUUC-Ola-087255	Oryzias latipes	71.23	0.00e+00	811.00
IUUC-Olu-087773	Ostreococcus lucimarinus	44.44	3.00e-71	261.00
IUUC-Oga-088818	Otolemur garnettii	79.04	0.00e+00	1267.00
IUUC-Oar-089410	Ovis aries	69.12	0.00e+00	1246.00
IUUC-Ptr-090680	Pan troglodytes	97.06	0.00e+00	1637.00
IUUC-Pan-092482	Papio anubis	95.01	0.00e+00	1864.00
IUUC-Ppa-095853	Physcomitrella patens	47.45	6.00e-92	332.00
IUUC-Pfo-096807	Poecilia formosa	59.54	0.00e+00	822.00
IUUC-Pab-098724	Pongo abelii	97.06	0.00e+00	1918.00
IUUC-Pop-099693	Populus trichocarpa	41.35	2.00e-82	300.00
IUUC-Pca-100117	Procavia capensis	78.30	2.00e-156	547.00
IUUC-Pva-102883	Pteropus vampyrus	62.35	0.00e+00	1002.00
IUUC-Pgr-103270	Puccinia graminis	46.25	1.00e-69	257.00
IUUC-Ptt-103887	Puccinia triticina	44.95	1.00e-69	258.00
IUUC-Rno-105340	Rattus norvegicus	73.04	0.00e+00	1146.00
IUUC-Sha-107019	Sarcophilus harrisii	66.49	0.00e+00	1251.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	42.61	2.00e-76	280.00
IUUC-Spo-108119	Schizosaccharomyces pombe	44.29	2.00e-84	306.00
IUUC-Sit-110536	Setaria italica	39.70	5.00e-79	290.00
IUUC-Sly-111722	Solanum lycopersicum	39.81	2.00e-79	290.00
IUUC-Stu-112912	Solanum tuberosum	39.66	1.00e-80	295.00
IUUC-Sbi-114477	Sorghum bicolor	44.62	1.00e-84	308.00
IUUC-Sre-114924	Sporisorium reilianum	40.65	2.00e-66	247.00
IUUC-Ssc-116022	Sus scrofa	84.54	0.00e+00	884.00
IUUC-Tgu-116976	Taeniopygia guttata	70.53	8.00e-160	556.00
IUUC-Tru-118391	Takifugu rubripes	63.33	0.00e+00	825.00
IUUC-Tsy-119253	Tarsius syrichta	67.17	0.00e+00	938.00
IUUC-Tni-120064	Tetraodon nigroviridis	76.72	0.00e+00	786.00
IUUC-Tae-125259	Triticum aestivum	47.00	1.00e-86	315.00
IUUC-Tur-126014	Triticum urartu	46.41	7.00e-83	302.00
IUUC-Tbe-127377	Tupaia belangeri	63.88	0.00e+00	813.00
IUUC-Ttr-129259	Tursiops truncatus	65.28	0.00e+00	1074.00
IUUC-Uma-129416	Ustilago maydis	43.20	3.00e-68	253.00
IUUC-Vpa-130568	Vicugna pacos	67.52	9.00e-45	175.00
IUUC-Xtr-132944	Xenopus tropicalis	77.96	0.00e+00	682.00
IUUC-Xma-133735	Xiphophorus maculatus	73.27	0.00e+00	816.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence