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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063771
Ensembl Protein ID ENSMUSP00000100025.4
UniProt Accession P70297; STAM1_MOUSE
Genbank Protein ID AAC52840.1; AAH44666.1; AAH55326.1
Protein Name Signal transducing adapter molecule 1
Genbank Nucleotide ID U43900; BC044666; BC055326
Gene Name Stam; Stam1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026718.17 ENSMUST00000102960.10 ENSMUSP00000100025.4
ENSMUSG00000026718.17 ENSMUST00000028050.13 ENSMUSP00000028050.7
ENSMUSG00000026718.17 ENSMUST00000193636.5 ENSMUSP00000141207.1
ENSMUSG00000026718.17 ENSMUST00000138989.1 ENSMUSP00000121228.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDABioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 15713877
UBD/Alpha-Helix/VHS VHS 15713877
Classification
Family E-value Score Start End
UBD/SH3 5.90e-17 62.5 213 265
UBD/Alpha-Helix/VHS 4.50e-55 186.4 16 143
UBD/Alpha-Helix/UIM 0.0015 19.5 171 189
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +kv++ yd+ea++d+eLt+k+G++++v+  ++ d +W+kg  e+++  GlfP+nFv+
   Q: 213  RKVRAVYDFEAAEDNELTFKAGEIITVL--DDSDPNWWKG--ETHQGVGLFPSNFVT 265
           689*************************..99********..9************97 PP
   

   UBD/Alpha-Helix/VHS
   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           atsel+t+edw lil+icd+++++++g+kd+lr++++r+n+k+phva++aLtlL++cvsnCgk+fh+ev+s+d+++e++++l n+ +pk
   Q: 16   ATSELNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL-NKGHPK 103
           799*******************************************************************************.9***** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v+eKlkal+v+W+de+kn+p+lsli+a+ik+lke+G++fp
   Q: 104  VCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFP 143
           ***************************************8 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+e+L++A++lSl+E+++
   Q: 171  KEEEDLAKAIELSLKEQRQ 189
           69**************987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
 Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Protein Sequence
(Fasta)
MPLFATNPFD QDVEKATSEL NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH 60
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063771|UBD,UIM;UBD,VHS;UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTGTTCCGC TTCTCGGCTG TTGCCGCCGC CGCCGCCTCT GTTGCTGGGG TGGGTGAGAG 60
GAGGGGCTGA GAGGGACCCT GCACTGGCAG GCAGGCGCCC TTGCTGTGTT TGTACCTGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063771|UBD,UIM;UBD,VHS;UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom
PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS
Pfam

PF00018--SH3_1
PF02809--UIM
PF00790--VHS
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00288--VHS
Gene Ontology

GO:0031901--C:early endosome membrane
GO:0006886--P:intracellular protein transport
GO:1903543--P:positive regulation of exosomal secretion
GO:1903551--P:regulation of extracellular exosome assembly
KEGG mmu:20844
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002392 Ailuropoda melanoleuca 90.87 0.00e+00 919.00
IUUC-Apl-003463 Anas platyrhynchos 83.43 0.00e+00 871.00
IUUC-Aca-005116 Anolis carolinensis 79.02 0.00e+00 850.00
IUUC-Ame-011220 Astyanax mexicanus 72.40 0.00e+00 750.00
IUUC-Bta-013368 Bos taurus 88.55 0.00e+00 892.00
IUUC-Cel-018461 Caenorhabditis elegans 33.25 2.00e-51 196.00
IUUC-Cja-019133 Callithrix jacchus 88.93 0.00e+00 896.00
IUUC-Cfa-020800 Canis familiaris 90.49 0.00e+00 917.00
IUUC-Cpo-021685 Cavia porcellus 88.76 0.00e+00 919.00
IUUC-Csa-023325 Chlorocebus sabaeus 89.73 0.00e+00 910.00
IUUC-Cho-024556 Choloepus hoffmanni 86.15 0.00e+00 789.00
IUUC-Cin-025766 Ciona intestinalis 38.35 8.00e-52 196.00
IUUC-Csv-026035 Ciona savignyi 40.52 9.00e-48 183.00
IUUC-Dre-028379 Danio rerio 69.93 0.00e+00 758.00
IUUC-Dno-029288 Dasypus novemcinctus 82.85 0.00e+00 860.00
IUUC-Dor-030515 Dipodomys ordii 82.89 0.00e+00 780.00
IUUC-Dme-031987 Drosophila melanogaster 44.93 3.00e-98 353.00
IUUC-Ete-032804 Echinops telfairi 74.24 0.00e+00 674.00
IUUC-Eca-033520 Equus caballus 90.06 0.00e+00 862.00
IUUC-Eeu-034820 Erinaceus europaeus 86.31 0.00e+00 825.00
IUUC-Fca-035914 Felis catus 90.61 0.00e+00 919.00
IUUC-Fal-037355 Ficedula albicollis 87.23 0.00e+00 830.00
IUUC-Fso-038126 Fusarium solani 28.25 2.00e-41 164.00
IUUC-Gmo-039628 Gadus morhua 82.99 0.00e+00 684.00
IUUC-Gga-041110 Gallus gallus 81.90 0.00e+00 905.00
IUUC-Gac-042301 Gasterosteus aculeatus 81.19 0.00e+00 739.00
IUUC-Ggo-044963 Gorilla gorilla 89.92 0.00e+00 910.00
IUUC-Hsa-046159 Homo sapiens 89.73 0.00e+00 910.00
IUUC-Itr-048016 Ictidomys tridecemlineatus 86.84 0.00e+00 646.00
IUUC-Kpa-049200 Komagataella pastoris 25.36 4.00e-27 115.00
IUUC-Lch-050447 Latimeria chalumnae 76.91 0.00e+00 810.00
IUUC-Loc-052761 Lepisosteus oculatus 75.71 0.00e+00 774.00
IUUC-Lma-053287 Leptosphaeria maculans 28.28 2.00e-36 147.00
IUUC-Laf-053662 Loxodonta africana 87.90 0.00e+00 890.00
IUUC-Mcc-055110 Macaca mulatta 89.73 0.00e+00 910.00
IUUC-Meu-056371 Macropus eugenii 70.60 0.00e+00 693.00
IUUC-Mga-060117 Meleagris gallopavo 81.49 0.00e+00 864.00
IUUC-Mmr-061413 Microcebus murinus 90.87 0.00e+00 890.00
IUUC-Mdo-061951 Monodelphis domestica 87.18 0.00e+00 914.00
IUUC-Mpu-066335 Mustela putorius furo 85.04 0.00e+00 822.00
IUUC-Mlu-067740 Myotis lucifugus 89.88 0.00e+00 877.00
IUUC-Nle-069083 Nomascus leucogenys 89.73 0.00e+00 909.00
IUUC-Opr-071162 Ochotona princeps 76.31 8.00e-146 510.00
IUUC-Ont-072360 Oreochromis niloticus 78.19 0.00e+00 757.00
IUUC-Oan-073093 Ornithorhynchus anatinus 82.08 0.00e+00 825.00
IUUC-Ocu-074641 Oryctolagus cuniculus 90.29 0.00e+00 882.00
IUUC-Ola-087487 Oryzias latipes 78.03 0.00e+00 715.00
IUUC-Oga-088551 Otolemur garnettii 89.60 0.00e+00 955.00
IUUC-Oar-089972 Ovis aries 88.55 0.00e+00 892.00
IUUC-Ptr-090672 Pan troglodytes 89.92 0.00e+00 910.00
IUUC-Pan-092407 Papio anubis 93.35 0.00e+00 877.00
IUUC-Psi-092953 Pelodiscus sinensis 81.24 0.00e+00 859.00
IUUC-Pma-094312 Petromyzon marinus 71.15 1.00e-160 558.00
IUUC-Pfo-096030 Poecilia formosa 82.34 0.00e+00 735.00
IUUC-Pab-097691 Pongo abelii 89.92 0.00e+00 911.00
IUUC-Pca-100396 Procavia capensis 78.11 0.00e+00 641.00
IUUC-Pva-103120 Pteropus vampyrus 91.44 0.00e+00 902.00
IUUC-Pgr-103679 Puccinia graminis 39.84 3.00e-20 93.60
IUUC-Ptt-103709 Puccinia triticina 39.84 1.00e-20 94.70
IUUC-Pte-104251 Pyrenophora teres 29.50 3.00e-38 153.00
IUUC-Pyt-104694 Pyrenophora triticirepentis 29.68 1.00e-38 154.00
IUUC-Rno-105982 Rattus norvegicus 94.00 0.00e+00 968.00
IUUC-Sha-106927 Sarcophilus harrisii 85.22 0.00e+00 934.00
IUUC-Sar-113551 Sorex araneus 92.52 0.00e+00 857.00
IUUC-Ssc-115322 Sus scrofa 94.22 0.00e+00 798.00
IUUC-Tgu-116550 Taeniopygia guttata 83.27 0.00e+00 895.00
IUUC-Tru-118646 Takifugu rubripes 81.74 0.00e+00 719.00
IUUC-Tsy-118874 Tarsius syrichta 89.73 0.00e+00 896.00
IUUC-Tni-120235 Tetraodon nigroviridis 81.69 0.00e+00 719.00
IUUC-Tvi-122365 Trichoderma virens 28.93 1.00e-40 161.00
IUUC-Tme-127104 Tuber melanosporum 27.66 8.00e-36 145.00
IUUC-Tbe-127233 Tupaia belangeri 87.69 2.00e-162 565.00
IUUC-Ttr-129298 Tursiops truncatus 83.78 0.00e+00 824.00
IUUC-Vpa-130071 Vicugna pacos 81.37 0.00e+00 795.00
IUUC-Xtr-131863 Xenopus tropicalis 78.39 0.00e+00 788.00
IUUC-Xma-132992 Xiphophorus maculatus 81.38 0.00e+00 746.00
Created Date 25-Jun-2017

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