iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004936

UUCD1 version

UUC-AnC-00988

Ensembl Protein ID

ENSACAP00000004050.2

UniProt Accession

H9G8L0; H9G8L0_ANOCA

Protein Name

Uncharacterized protein

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000003991.3	ENSACAT00000030072.1	ENSACAP00000022655.1
ENSACAG00000003991.3	ENSACAT00000004144.3	ENSACAP00000004050.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-109	364.8	737	1067

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw ++ +++sp++++ +++k++ +f g
   Q: 737  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnYYQVDINRSNFLGHKGEVAEEFGIIMKALWAGQYRYISPKDFKMTIGKINDQFAG 823
           7******************************6677799************************************************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeed...kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++ +ee++d   + ++ d a+ k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 824  YSQQDSQELLLFLMDDLHEDLNKADNRKRYKEENNDdldDPKAADLAWHKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 910
           *********************9965555555555540114455566***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lq+c++ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 911  YLSLPLASTSKC---TLQECFRLFSKEEKLTDNNRFYCSHCKTRRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 992
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ld+s++++ p+++   +k+Y+L+av +H+G+l++GHY+ay+kn +++ W++fdD++V+e++ ++v++   s aY+lfY+
   Q: 993  EsLDVSQYVIGPKSN---SKRYNLFAVSNHYGGLDGGHYTAYCKNATKQrWYKFDDHEVSEISTSSVKS---SAAYILFYT 1067
           ***********9988...69*************************88778*******************...********8 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MPAVASVPKD LYLCTSLKDL NKKTEIKPEK TSTKSYVQSA LKIFKSSEVV RYILHKLRAY 60
LISTATAAFY SILNQKGLFE VLVQDYFHSL LGPTNVKKAI EEAERLSESL KLRYEEAEVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACACGG TAAGCAGAAT TTTAAAATTT TCCTCCTCCT CAAGACACAG GCATTTTGGG 60
AAATTTAAAT GTTTAACCAT TTGAGAAATC AATAAAGTCA ATAAAACAAA AATCAGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	66.67	0.00e+00	1315.00
IUUC-Apl-003226	Anas platyrhynchos	68.27	0.00e+00	1332.00
IUUC-Ago-007959	Ashbya gossypii	34.99	2.00e-53	204.00
IUUC-Acl-008102	Aspergillus clavatus	31.87	1.00e-54	208.00
IUUC-Afl-008604	Aspergillus flavus	30.22	7.00e-52	198.00
IUUC-Afu-009001	Aspergillus fumigatus	31.39	3.00e-54	207.00
IUUC-Ani-009291	Aspergillus nidulans	30.22	4.00e-52	200.00
IUUC-Ang-009844	Aspergillus niger	31.11	2.00e-52	201.00
IUUC-Aor-010098	Aspergillus oryzae	30.22	4.00e-51	196.00
IUUC-Ate-010585	Aspergillus terreus	31.22	4.00e-52	200.00
IUUC-Ame-010960	Astyanax mexicanus	76.11	1.00e-83	301.00
IUUC-Bta-013008	Bos taurus	82.28	0.00e+00	901.00
IUUC-Bol-015281	Brassica oleracea	38.51	7.00e-53	201.00
IUUC-Bra-017228	Brassica rapa	39.70	2.00e-54	206.00
IUUC-Cel-018482	Caenorhabditis elegans	33.72	1.00e-52	201.00
IUUC-Cja-019173	Callithrix jacchus	78.52	0.00e+00	894.00
IUUC-Cfa-021243	Canis familiaris	66.73	0.00e+00	1326.00
IUUC-Cpo-021522	Cavia porcellus	67.91	0.00e+00	1332.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	2.00e-85	308.00
IUUC-Csa-023616	Chlorocebus sabaeus	78.99	0.00e+00	888.00
IUUC-Cho-024381	Choloepus hoffmanni	59.00	0.00e+00	1112.00
IUUC-Cin-025287	Ciona intestinalis	50.38	3.00e-100	360.00
IUUC-Csv-026253	Ciona savignyi	49.25	2.00e-88	320.00
IUUC-Cne-026821	Cryptococcus neoformans	40.17	5.00e-75	276.00
IUUC-Dre-028440	Danio rerio	58.49	0.00e+00	743.00
IUUC-Dno-029039	Dasypus novemcinctus	65.86	0.00e+00	1338.00
IUUC-Dor-031043	Dipodomys ordii	87.50	9.00e-126	444.00
IUUC-Dse-031463	Dothistroma septosporum	27.91	2.00e-43	171.00
IUUC-Dme-032089	Drosophila melanogaster	45.67	6.00e-87	315.00
IUUC-Ete-033040	Echinops telfairi	60.58	0.00e+00	1103.00
IUUC-Eca-033449	Equus caballus	66.49	0.00e+00	1326.00
IUUC-Eeu-034693	Erinaceus europaeus	87.07	5.00e-119	422.00
IUUC-Fca-035794	Felis catus	88.84	0.00e+00	845.00
IUUC-Fal-037322	Ficedula albicollis	81.47	0.00e+00	880.00
IUUC-Gmo-038584	Gadus morhua	67.34	0.00e+00	682.00
IUUC-Gga-041188	Gallus gallus	89.88	0.00e+00	894.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.40	0.00e+00	753.00
IUUC-Ggo-045565	Gorilla gorilla	79.34	0.00e+00	896.00
IUUC-Hsa-046438	Homo sapiens	79.51	0.00e+00	896.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	68.99	0.00e+00	1342.00
IUUC-Kpa-049321	Komagataella pastoris	33.33	3.00e-51	196.00
IUUC-Lch-050485	Latimeria chalumnae	81.68	0.00e+00	868.00
IUUC-Loc-052769	Lepisosteus oculatus	76.81	0.00e+00	764.00
IUUC-Lma-053021	Leptosphaeria maculans	31.72	3.00e-56	213.00
IUUC-Laf-053432	Loxodonta africana	63.41	0.00e+00	1283.00
IUUC-Mcc-055823	Macaca mulatta	79.17	0.00e+00	893.00
IUUC-Meu-056099	Macropus eugenii	90.71	2.00e-153	536.00
IUUC-Mla-059089	Melampsora laricipopulina	39.88	1.00e-69	258.00
IUUC-Mga-059739	Meleagris gallopavo	83.70	0.00e+00	891.00
IUUC-Mvi-060559	Microbotryum violaceum	40.67	1.00e-79	291.00
IUUC-Mmr-061158	Microcebus murinus	66.34	0.00e+00	1313.00
IUUC-Mdo-061801	Monodelphis domestica	80.50	0.00e+00	890.00
IUUC-Mmu-063665	Mus musculus	65.21	0.00e+00	1277.00
IUUC-Mpu-066738	Mustela putorius furo	78.66	0.00e+00	894.00
IUUC-Mlu-067307	Myotis lucifugus	76.71	0.00e+00	896.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	2.00e-54	207.00
IUUC-Nle-069314	Nomascus leucogenys	78.99	0.00e+00	892.00
IUUC-Opr-070378	Ochotona princeps	73.02	5.00e-137	482.00
IUUC-Ont-071545	Oreochromis niloticus	75.50	0.00e+00	758.00
IUUC-Oan-073537	Ornithorhynchus anatinus	87.50	0.00e+00	880.00
IUUC-Ocu-074193	Oryctolagus cuniculus	68.33	0.00e+00	1350.00
IUUC-Ola-086622	Oryzias latipes	56.64	0.00e+00	1012.00
IUUC-Oga-088271	Otolemur garnettii	79.34	0.00e+00	905.00
IUUC-Oar-090431	Ovis aries	82.10	0.00e+00	902.00
IUUC-Ptr-091339	Pan troglodytes	65.81	0.00e+00	1342.00
IUUC-Pan-092266	Papio anubis	86.45	9.00e-169	585.00
IUUC-Psi-093187	Pelodiscus sinensis	82.13	1.00e-139	490.00
IUUC-Pma-094626	Petromyzon marinus	56.87	2.00e-143	501.00
IUUC-Pfo-096463	Poecilia formosa	75.30	0.00e+00	764.00
IUUC-Pab-097645	Pongo abelii	79.23	0.00e+00	891.00
IUUC-Pva-103222	Pteropus vampyrus	87.40	0.00e+00	694.00
IUUC-Pgr-103408	Puccinia graminis	37.39	1.00e-56	215.00
IUUC-Ptt-103699	Puccinia triticina	44.76	4.00e-65	243.00
IUUC-Pte-104348	Pyrenophora teres	28.53	1.00e-42	168.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	30.49	6.00e-55	209.00
IUUC-Rno-105510	Rattus norvegicus	67.09	0.00e+00	1308.00
IUUC-Sha-106879	Sarcophilus harrisii	79.90	0.00e+00	887.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	35.48	1.00e-52	200.00
IUUC-Sar-113019	Sorex araneus	62.68	0.00e+00	1239.00
IUUC-Sre-115031	Sporisorium reilianum	36.49	3.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	67.94	0.00e+00	1344.00
IUUC-Tgu-117062	Taeniopygia guttata	88.06	0.00e+00	882.00
IUUC-Tru-117908	Takifugu rubripes	76.28	0.00e+00	749.00
IUUC-Tsy-118867	Tarsius syrichta	71.88	0.00e+00	784.00
IUUC-Tni-120206	Tetraodon nigroviridis	54.01	0.00e+00	985.00
IUUC-Tme-127144	Tuber melanosporum	39.07	1.00e-79	291.00
IUUC-Tbe-127877	Tupaia belangeri	87.58	1.00e-76	281.00
IUUC-Ttr-128580	Tursiops truncatus	78.09	0.00e+00	885.00
IUUC-Uma-129340	Ustilago maydis	35.02	2.00e-72	267.00
IUUC-Vpa-130541	Vicugna pacos	65.60	0.00e+00	1293.00
IUUC-Xtr-132161	Xenopus tropicalis	75.90	0.00e+00	799.00
IUUC-Xma-134271	Xiphophorus maculatus	74.90	0.00e+00	759.00
IUUC-Yli-134561	Yarrowia lipolytica	36.36	6.00e-61	229.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence