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Tag Content
UUCD2 ID IUUC-Bta-013008
UUCD1 version UUC-BoT-01110
Ensembl Protein ID ENSBTAP00000033723.4
UniProt Accession Q0IIM6; F1N3U9; Q0IIM6_BOVIN
Genbank Protein ID AAI22572.1
Protein Name Ubiquitin specific peptidase 8
Genbank Nucleotide ID DAAA02029069
Gene Name USP8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000011916.5 ENSBTAT00000033814.4 ENSBTAP00000033723.4
ENSBTAG00000011916.5 ENSBTAT00000015809.4 ENSBTAP00000015809.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.10e-109 366.9 744 1074
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n+p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 744  TGLRNLGNTCYMNSILQCLCNTPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 830
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 831  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 917
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 918  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 999
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1000 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISISSVKS---SAAYILFYT 1074
           ***********9988...69*************************88888*******************...********8 PP
   
Organism Bos taurus
Protein Sequence
(Fasta)
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFM QQQDHFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013008|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGATTCTTCC TCGAGTTGGT GGGAGATGGG CCTTTGGCGA GGAGGCCGGC GTTAGTGAAG 60
TGCGCCGGGC TCCAAGGTGA GTGCGGGGCT GGGTCCTGGC CTTTGATCCT TGGGAATCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013008|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer
SMART

SM00450--RHOD
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:538743
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001661 Ailuropoda melanoleuca 89.73 0.00e+00 1840.00
IUUC-Apl-003226 Anas platyrhynchos 69.31 0.00e+00 1421.00
IUUC-Aca-004936 Anolis carolinensis 67.92 0.00e+00 1298.00
IUUC-Ago-007959 Ashbya gossypii 36.16 3.00e-56 213.00
IUUC-Acl-008102 Aspergillus clavatus 31.87 2.00e-53 204.00
IUUC-Afl-008604 Aspergillus flavus 31.59 5.00e-52 199.00
IUUC-Afu-009001 Aspergillus fumigatus 31.67 1.00e-52 201.00
IUUC-Ani-009291 Aspergillus nidulans 30.77 7.00e-52 199.00
IUUC-Ang-009844 Aspergillus niger 32.50 4.00e-52 199.00
IUUC-Aor-010098 Aspergillus oryzae 31.59 2.00e-51 197.00
IUUC-Ate-010585 Aspergillus terreus 31.49 1.00e-51 198.00
IUUC-Ame-010960 Astyanax mexicanus 76.67 5.00e-85 306.00
IUUC-Bol-015281 Brassica oleracea 38.51 5.00e-51 195.00
IUUC-Bra-017228 Brassica rapa 39.40 1.00e-52 200.00
IUUC-Cel-018482 Caenorhabditis elegans 34.11 3.00e-54 206.00
IUUC-Cja-019173 Callithrix jacchus 87.03 0.00e+00 1800.00
IUUC-Cfa-021243 Canis familiaris 90.15 0.00e+00 1858.00
IUUC-Cpo-021522 Cavia porcellus 86.56 0.00e+00 1758.00
IUUC-Cre-022582 Chlamydomonas reinhardtii 44.06 1.00e-84 306.00
IUUC-Csa-023616 Chlorocebus sabaeus 87.43 0.00e+00 1531.00
IUUC-Cho-024381 Choloepus hoffmanni 77.37 0.00e+00 1540.00
IUUC-Cin-025287 Ciona intestinalis 50.13 3.00e-100 360.00
IUUC-Csv-026253 Ciona savignyi 47.92 2.00e-89 323.00
IUUC-Cne-026821 Cryptococcus neoformans 40.17 2.00e-76 281.00
IUUC-Dre-028440 Danio rerio 67.95 0.00e+00 759.00
IUUC-Dno-029039 Dasypus novemcinctus 86.14 0.00e+00 1825.00
IUUC-Dor-031043 Dipodomys ordii 95.69 3.00e-139 489.00
IUUC-Dse-031463 Dothistroma septosporum 28.34 1.00e-44 175.00
IUUC-Dme-032089 Drosophila melanogaster 44.50 6.00e-89 322.00
IUUC-Ete-033040 Echinops telfairi 77.52 0.00e+00 1473.00
IUUC-Eca-033449 Equus caballus 89.88 0.00e+00 1873.00
IUUC-Eeu-034693 Erinaceus europaeus 97.41 2.00e-133 470.00
IUUC-Fca-035794 Felis catus 98.11 0.00e+00 931.00
IUUC-Fal-037322 Ficedula albicollis 78.61 0.00e+00 875.00
IUUC-Gmo-038584 Gadus morhua 66.87 0.00e+00 682.00
IUUC-Gga-041188 Gallus gallus 82.38 0.00e+00 902.00
IUUC-Gac-041850 Gasterosteus aculeatus 74.75 0.00e+00 754.00
IUUC-Ggo-045565 Gorilla gorilla 87.57 0.00e+00 1823.00
IUUC-Hsa-046438 Homo sapiens 87.48 0.00e+00 1822.00
IUUC-Itr-048883 Ictidomys tridecemlineatus 90.82 0.00e+00 1828.00
IUUC-Kpa-049321 Komagataella pastoris 33.51 5.00e-51 196.00
IUUC-Lch-050485 Latimeria chalumnae 83.30 0.00e+00 880.00
IUUC-Loc-052769 Lepisosteus oculatus 77.50 0.00e+00 772.00
IUUC-Lma-053021 Leptosphaeria maculans 32.53 9.00e-57 215.00
IUUC-Laf-053432 Loxodonta africana 81.02 0.00e+00 1697.00
IUUC-Mcc-055823 Macaca mulatta 87.21 0.00e+00 1813.00
IUUC-Meu-056099 Macropus eugenii 97.40 4.00e-165 575.00
IUUC-Mla-059089 Melampsora laricipopulina 40.18 3.00e-72 267.00
IUUC-Mga-059739 Meleagris gallopavo 81.49 0.00e+00 894.00
IUUC-Mvi-060559 Microbotryum violaceum 39.83 1.00e-78 288.00
IUUC-Mmr-061158 Microcebus murinus 87.26 0.00e+00 1779.00
IUUC-Mdo-061801 Monodelphis domestica 86.61 0.00e+00 960.00
IUUC-Mmu-063665 Mus musculus 83.55 0.00e+00 1677.00
IUUC-Mpu-066738 Mustela putorius furo 89.16 0.00e+00 1811.00
IUUC-Mlu-067307 Myotis lucifugus 86.51 0.00e+00 1774.00
IUUC-Nfi-068410 Neosartorya fischeri 31.94 5.00e-53 203.00
IUUC-Nle-069314 Nomascus leucogenys 87.22 0.00e+00 1811.00
IUUC-Opr-070378 Ochotona princeps 79.68 0.00e+00 1197.00
IUUC-Ont-071545 Oreochromis niloticus 73.99 0.00e+00 771.00
IUUC-Oan-073537 Ornithorhynchus anatinus 74.36 0.00e+00 1478.00
IUUC-Ocu-074193 Oryctolagus cuniculus 89.99 0.00e+00 1831.00
IUUC-Ola-086622 Oryzias latipes 58.76 0.00e+00 1079.00
IUUC-Oga-088271 Otolemur garnettii 85.87 0.00e+00 1780.00
IUUC-Oar-090431 Ovis aries 98.35 0.00e+00 1951.00
IUUC-Ptr-091339 Pan troglodytes 88.55 0.00e+00 1869.00
IUUC-Pan-091783 Papio anubis 80.62 0.00e+00 884.00
IUUC-Psi-093187 Pelodiscus sinensis 62.79 2.00e-151 529.00
IUUC-Pma-094626 Petromyzon marinus 58.47 3.00e-145 508.00
IUUC-Pno-094986 Phaeosphaeria nodorum 30.21 9.00e-40 159.00
IUUC-Pfo-096463 Poecilia formosa 76.02 0.00e+00 765.00
IUUC-Pab-097645 Pongo abelii 87.03 0.00e+00 1818.00
IUUC-Pva-103222 Pteropus vampyrus 84.00 0.00e+00 897.00
IUUC-Pgr-103408 Puccinia graminis 35.92 4.00e-57 217.00
IUUC-Ptt-103699 Puccinia triticina 46.15 8.00e-69 255.00
IUUC-Pte-104348 Pyrenophora teres 28.83 5.00e-42 166.00
IUUC-Pyt-104711 Pyrenophora triticirepentis 30.23 1.00e-52 201.00
IUUC-Rno-105510 Rattus norvegicus 82.92 0.00e+00 1697.00
IUUC-Sce-106166 Saccharomyces cerevisiae 35.81 7.00e-53 202.00
IUUC-Sha-106879 Sarcophilus harrisii 85.34 0.00e+00 946.00
IUUC-Sja-107836 Schizosaccharomyces japonicus 36.29 8.00e-50 191.00
IUUC-Sar-113019 Sorex araneus 82.05 0.00e+00 1708.00
IUUC-Sre-115031 Sporisorium reilianum 37.33 2.00e-70 260.00
IUUC-Ssc-116334 Sus scrofa 93.11 0.00e+00 1906.00
IUUC-Tgu-117062 Taeniopygia guttata 78.51 0.00e+00 876.00
IUUC-Tru-117908 Takifugu rubripes 57.71 0.00e+00 1161.00
IUUC-Tsy-118867 Tarsius syrichta 81.18 0.00e+00 1011.00
IUUC-Tni-120206 Tetraodon nigroviridis 74.65 0.00e+00 738.00
IUUC-Tme-127144 Tuber melanosporum 40.28 5.00e-80 293.00
IUUC-Tbe-127877 Tupaia belangeri 85.31 2.00e-86 314.00
IUUC-Ttr-128580 Tursiops truncatus 89.73 0.00e+00 1165.00
IUUC-Uma-129340 Ustilago maydis 36.52 8.00e-73 269.00
IUUC-Vpa-130541 Vicugna pacos 89.25 0.00e+00 1841.00
IUUC-Xtr-132161 Xenopus tropicalis 58.58 0.00e+00 1197.00
IUUC-Xma-134271 Xiphophorus maculatus 73.22 0.00e+00 764.00
IUUC-Yli-134561 Yarrowia lipolytica 36.19 2.00e-60 228.00
Created Date 25-Jun-2017

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