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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018707
UUCD1 version UUC-CaE-00217
Ensembl Protein ID W10C6.1
UniProt Accession O18191; APC1_CAEEL
Genbank Protein ID CAB16467.2
Protein Name Anaphase-promoting complex subunit 1; Metaphase-to-anaphase transition protein 2
Genbank Nucleotide ID Z99269
Gene Name mat-2; apc-1; evl-22; pod-3; W10C6.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003133 W10C6.1 W10C6.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBasemicroRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 28.09 2.00e-77 289.00 IUUC-Hsa-045774
E3 adaptor/Cullin RING/APC_C/APC_C 23.41 3.00e-17 86.70 IUUC-Sce-106246
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076, PubMed:11861581). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
 Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11861581). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (PubMed:11861581). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells (PubMed:11134076, PubMed:11861581). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).
Protein Sequence
(Fasta)
MRKYVLFFIS GNNDSQIWAT TPNTPRVIAR GGLERNIHTR TLARMVNEDA PGTSTPAAQS 60
RLQTTASPFH RTHLTQMCRR GDTNASLLRD FTRMIRDTPR NFSKNTQHGN DRDFGDLERD 120
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Protein Fasta Sequence


>IUUC-Cel-018707|E3,APC_C|Caenorhabditis elegans
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Nucleotide Sequence
(Fasta)
ATGAGAAAGT ATGTACTTTT TTTTATTTCA GGCAACAATG ACTCTCAAAT ATGGGCAACT 60
ACTCCGAATA CGCCACGAGT TATTGCGAGA GGAGGTCTCG AACGGAATAT ACATACTAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018707|E3,APC_C|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0498--Mitosis
KW-0532--Neurotransmitter transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR024990--Apc1
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0051301--P:cell division
GO:0051295--P:establishment of meiotic spindle localization
GO:0044785--P:metaphase/anaphase transition of meiotic cell cycle
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0006836--P:neurotransmitter transport
GO:0009949--P:polarity specification of anterior/posterior axis
GO:0016567--P:protein ubiquitination
KEGG cel:CELE_W10C6.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000342 Aegilops tauschii 30.61 5.70e-01 28.50
IUUC-Aml-002294 Ailuropoda melanoleuca 28.22 4.00e-76 279.00
IUUC-Atr-002881 Amborella trichopoda 24.53 2.00e-44 173.00
IUUC-Apl-003588 Anas platyrhynchos 27.96 2.00e-73 270.00
IUUC-Aca-005361 Anolis carolinensis 26.63 9.00e-74 271.00
IUUC-Aly-005680 Arabidopsis lyrata 24.01 1.00e-45 178.00
IUUC-Ath-007479 Arabidopsis thaliana 26.65 3.00e-59 223.00
IUUC-Ago-007943 Ashbya gossypii 25.64 9.00e-17 82.00
IUUC-Acl-008141 Aspergillus clavatus 27.45 1.00e-58 221.00
IUUC-Afl-008487 Aspergillus flavus 27.14 4.00e-27 116.00
IUUC-Afu-008897 Aspergillus fumigatus 26.87 3.00e-59 223.00
IUUC-Ani-009232 Aspergillus nidulans 31.67 4.00e-25 110.00
IUUC-Ang-009699 Aspergillus niger 26.45 1.00e-23 105.00
IUUC-Aor-009943 Aspergillus oryzae 26.07 5.00e-27 116.00
IUUC-Ate-010554 Aspergillus terreus 25.72 8.00e-28 119.00
IUUC-Ame-011373 Astyanax mexicanus 28.34 4.00e-82 299.00
IUUC-Bgr-011994 Blumeria graminis 23.77 5.00e-47 182.00
IUUC-Bta-013227 Bos taurus 26.91 8.00e-72 265.00
IUUC-Bci-013591 Botrytis cinerea 23.59 1.00e-48 188.00
IUUC-Bdi-015048 Brachypodium distachyon 25.81 3.00e-37 149.00
IUUC-Bol-016448 Brassica oleracea 26.75 5.00e-59 222.00
IUUC-Bra-017688 Brassica rapa 26.51 2.00e-42 167.00
IUUC-Cja-019608 Callithrix jacchus 26.73 8.00e-74 271.00
IUUC-Cfa-021133 Canis familiaris 27.06 3.00e-76 280.00
IUUC-Cpo-022097 Cavia porcellus 27.16 6.00e-75 275.00
IUUC-Cre-022722 Chlamydomonas reinhardtii 34.85 9.00e-10 58.20
IUUC-Csa-024077 Chlorocebus sabaeus 28.22 1.00e-76 281.00
IUUC-Cho-024372 Choloepus hoffmanni 32.20 6.00e-26 112.00
IUUC-Cin-025169 Ciona intestinalis 26.11 4.00e-36 144.00
IUUC-Csv-026053 Ciona savignyi 28.24 8.00e-14 71.20
IUUC-Cgl-026415 Colletotrichum gloeosporioides 25.70 6.00e-54 206.00
IUUC-Cne-026772 Cryptococcus neoformans 26.30 2.00e-44 174.00
IUUC-Cme-027221 Cyanidioschyzon merolae 25.00 1.10e-02 36.20
IUUC-Dre-028168 Danio rerio 28.17 2.00e-82 300.00
IUUC-Dno-029251 Dasypus novemcinctus 27.63 8.00e-75 274.00
IUUC-Dor-031058 Dipodomys ordii 31.70 4.00e-36 146.00
IUUC-Dse-031374 Dothistroma septosporum 22.27 2.00e-27 116.00
IUUC-Dme-031637 Drosophila melanogaster 28.09 4.00e-77 283.00
IUUC-Ete-032785 Echinops telfairi 25.84 2.00e-64 241.00
IUUC-Eca-034301 Equus caballus 28.22 6.00e-76 278.00
IUUC-Eeu-034448 Erinaceus europaeus 23.82 3.00e-44 173.00
IUUC-Fca-036327 Felis catus 27.22 2.00e-76 280.00
IUUC-Fal-037242 Ficedula albicollis 28.30 2.00e-70 260.00
IUUC-Fox-037815 Fusarium oxysporum 27.25 3.00e-25 110.00
IUUC-Fso-038155 Fusarium solani 24.87 4.00e-56 213.00
IUUC-Gmo-039055 Gadus morhua 26.77 5.00e-68 252.00
IUUC-Ggr-039950 Gaeumannomyces graminis 25.25 7.00e-49 189.00
IUUC-Gga-040699 Gallus gallus 27.89 7.00e-77 281.00
IUUC-Gac-041384 Gasterosteus aculeatus 27.89 4.00e-71 263.00
IUUC-Gma-043887 Glycine max 25.31 1.00e-58 221.00
IUUC-Hsa-045774 Homo sapiens 27.11 6.00e-76 278.00
IUUC-Hvu-047197 Hordeum vulgare 27.35 3.00e-36 145.00
IUUC-Itr-048307 Ictidomys tridecemlineatus 27.96 3.00e-76 279.00
IUUC-Kpa-049213 Komagataella pastoris 25.28 5.00e-55 209.00
IUUC-Lch-050625 Latimeria chalumnae 27.58 6.00e-82 298.00
IUUC-Lpe-050901 Leersia perrieri 24.83 6.00e-44 172.00
IUUC-Loc-052539 Lepisosteus oculatus 28.77 6.00e-82 297.00
IUUC-Lma-052970 Leptosphaeria maculans 24.31 4.00e-41 163.00
IUUC-Laf-054144 Loxodonta africana 27.46 9.00e-77 281.00
IUUC-Mcc-054940 Macaca mulatta 28.22 1.00e-76 281.00
IUUC-Mor-057218 Magnaporthe oryzae 24.75 1.00e-51 198.00
IUUC-Mtr-058775 Medicago truncatula 25.95 3.00e-58 220.00
IUUC-Mla-059122 Melampsora laricipopulina 25.07 2.00e-48 187.00
IUUC-Mga-059663 Meleagris gallopavo 27.89 1.00e-76 281.00
IUUC-Mvi-060259 Microbotryum violaceum 25.78 1.00e-37 151.00
IUUC-Mmr-060620 Microcebus murinus 28.14 1.00e-75 278.00
IUUC-Mdo-062149 Monodelphis domestica 26.98 1.00e-70 261.00
IUUC-Mmu-063698 Mus musculus 27.26 1.00e-76 281.00
IUUC-Mac-065285 Musa acuminata 24.50 3.00e-35 142.00
IUUC-Mpu-066489 Mustela putorius furo 28.22 2.00e-76 280.00
IUUC-Mlu-067969 Myotis lucifugus 28.27 2.00e-75 277.00
IUUC-Nfi-068325 Neosartorya fischeri 27.25 1.00e-58 221.00
IUUC-Ncr-068817 Neurospora crassa 24.00 1.00e-52 201.00
IUUC-Nle-069961 Nomascus leucogenys 27.06 2.00e-76 280.00
IUUC-Opr-071086 Ochotona princeps 30.73 1.00e-39 158.00
IUUC-Ont-071831 Oreochromis niloticus 27.05 2.00e-75 276.00
IUUC-Oan-073375 Ornithorhynchus anatinus 26.63 6.00e-16 77.40
IUUC-Ocu-073892 Oryctolagus cuniculus 27.22 4.00e-76 279.00
IUUC-Oba-075880 Oryza barthii 29.32 2.00e-19 90.90
IUUC-Obr-076384 Oryza brachyantha 25.00 1.00e-20 94.70
IUUC-Ogl-077165 Oryza glaberrima 25.25 6.00e-22 98.60
IUUC-Ogu-078764 Oryza glumaepatula 23.06 3.00e-13 70.50
IUUC-Oin-079711 Oryza indica 25.25 6.00e-22 99.40
IUUC-Olo-080715 Oryza longistaminata 24.83 4.00e-25 109.00
IUUC-Ome-081131 Oryza meridionalis 29.32 2.00e-19 91.30
IUUC-Oni-082223 Oryza nivara 23.06 3.00e-13 70.50
IUUC-Opu-083985 Oryza punctata 25.25 1.00e-22 101.00
IUUC-Oru-085031 Oryza rufipogon 23.06 3.00e-13 70.50
IUUC-Osa-085599 Oryza sativa 25.25 5.00e-22 98.60
IUUC-Ola-087375 Oryzias latipes 29.44 9.00e-71 261.00
IUUC-Olu-087875 Ostreococcus lucimarinus 27.34 1.00e-63 237.00
IUUC-Oga-088815 Otolemur garnettii 27.05 2.00e-77 284.00
IUUC-Oar-090326 Ovis aries 26.91 6.00e-72 265.00
IUUC-Ptr-091143 Pan troglodytes 27.22 2.00e-76 280.00
IUUC-Pan-091945 Papio anubis 28.22 1.00e-76 281.00
IUUC-Psi-092955 Pelodiscus sinensis 29.66 2.00e-41 164.00
IUUC-Pma-094473 Petromyzon marinus 27.00 3.00e-69 256.00
IUUC-Pno-094991 Phaeosphaeria nodorum 24.89 2.00e-44 172.00
IUUC-Ppa-095617 Physcomitrella patens 23.62 2.00e-22 100.00
IUUC-Pfo-096119 Poecilia formosa 28.14 5.00e-77 282.00
IUUC-Pab-098265 Pongo abelii 27.22 3.00e-75 276.00
IUUC-Pop-099429 Populus trichocarpa 25.53 2.00e-52 200.00
IUUC-Pca-100116 Procavia capensis 28.36 9.00e-20 92.40
IUUC-Ppe-102034 Prunus persica 25.41 2.00e-53 202.00
IUUC-Pva-102425 Pteropus vampyrus 26.58 2.00e-54 207.00
IUUC-Pgr-103486 Puccinia graminis 25.07 8.00e-41 162.00
IUUC-Pte-104231 Pyrenophora teres 28.53 6.00e-17 82.80
IUUC-Pyt-104725 Pyrenophora triticirepentis 25.17 1.00e-42 168.00
IUUC-Rno-106106 Rattus norvegicus 27.38 5.00e-77 282.00
IUUC-Sce-106246 Saccharomyces cerevisiae 23.24 5.00e-12 66.60
IUUC-Sha-107371 Sarcophilus harrisii 27.29 1.00e-64 241.00
IUUC-Sja-107837 Schizosaccharomyces japonicus 25.92 1.00e-18 87.80
IUUC-Spo-108151 Schizosaccharomyces pombe 27.39 2.00e-36 147.00
IUUC-Smo-109131 Selaginella moellendorffii 25.00 5.00e-23 102.00
IUUC-Sit-109833 Setaria italica 25.74 6.00e-27 114.00
IUUC-Sly-111174 Solanum lycopersicum 24.59 1.00e-45 176.00
IUUC-Sar-113322 Sorex araneus 28.74 1.00e-26 114.00
IUUC-Sre-115207 Sporisorium reilianum 25.46 8.00e-50 192.00
IUUC-Ssc-115572 Sus scrofa 27.13 9.00e-76 278.00
IUUC-Tgu-117040 Taeniopygia guttata 28.57 5.00e-76 279.00
IUUC-Tru-118159 Takifugu rubripes 27.69 1.00e-80 294.00
IUUC-Tsy-119288 Tarsius syrichta 25.23 1.00e-42 168.00
IUUC-Tni-119889 Tetraodon nigroviridis 27.89 8.00e-25 108.00
IUUC-Tca-120982 Theobroma cacao 26.87 2.00e-51 197.00
IUUC-Tre-122017 Trichoderma reesei 23.93 5.00e-55 209.00
IUUC-Tvi-122340 Trichoderma virens 24.60 7.00e-58 218.00
IUUC-Tae-122989 Triticum aestivum 25.10 8.00e-52 198.00
IUUC-Tme-127169 Tuber melanosporum 25.17 1.00e-44 174.00
IUUC-Ttr-128376 Tursiops truncatus 27.70 8.00e-67 248.00
IUUC-Uma-129513 Ustilago maydis 25.11 4.00e-43 170.00
IUUC-Vda-129898 Verticillium dahliae 29.23 2.00e-25 110.00
IUUC-Vpa-130495 Vicugna pacos 27.76 4.00e-71 263.00
IUUC-Vvi-131656 Vitis vinifera 25.76 2.00e-46 179.00
IUUC-Xtr-132770 Xenopus tropicalis 27.97 2.00e-73 270.00
IUUC-Xma-133490 Xiphophorus maculatus 30.03 4.00e-69 255.00
IUUC-Yli-134525 Yarrowia lipolytica 26.35 3.00e-53 202.00
IUUC-Zma-134774 Zea mays 25.95 6.00e-27 115.00
Created Date 25-Jun-2017

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