iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005338

UUCD1 version

UUC-AnC-00665

Ensembl Protein ID

ENSACAP00000009140.3

UniProt Accession

G1KIS2; G1KIS2_ANOCA

Protein Name

Uncharacterized protein

Gene Name

itch

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000009222.3	ENSACAT00000009333.3	ENSACAP00000009140.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-136	455.3	598	929

Active Site

Position(s)	Description	Evidence
898	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+ 
   Q: 598  LDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDTG 685
           5899*******************************************************9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +s++fyk++l+k++ l+dle+vdpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G+n+ Vt+eNkeeY++lv+e+
   Q: 686  FSQPFYKRILNKPVGLKDLESVDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGSNVLVTEENKEEYIRLVAEW 771
           **********************************99...9************************************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++++++e+r ++LqFvT
   Q: 772  RLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSKQIVWFWQFVKDIDNEKRMRLLQFVT 859
           *******************************************************99.******************************* PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           g++rlP+gGf +l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 860  GTCRLPVGGFSDLMasngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 929
           ********************************************************************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MGRVVLCPPS SFRFSCACAR AARLWRVAAS GWTWTGCHLR RGAVASRAGS CTPFCGMAGN 60
GSRSESFSGL TMKSQLQITV ISAKLKENKN KWFGPSPYVE VTVDGQSKKT EKCNNTNSPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTGAGTGTG TTTCTTGTAA AAGCAGTCAT GCAGTATACC TAGAGGACAT ATTTTTGGTG 60
CTTGGTGTAA ACAACCTGAA CGGAATTTTC ACAAAATAAG TTCCTTAGGC CATTTTAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	81.62	0.00e+00	1410.00
IUUC-Apl-003752	Anas platyrhynchos	86.61	0.00e+00	1477.00
IUUC-Ago-007742	Ashbya gossypii	48.71	4.00e-161	561.00
IUUC-Acl-008273	Aspergillus clavatus	47.47	6.00e-155	541.00
IUUC-Afl-008713	Aspergillus flavus	46.97	8.00e-153	534.00
IUUC-Afu-009103	Aspergillus fumigatus	47.98	3.00e-156	545.00
IUUC-Ani-009259	Aspergillus nidulans	46.99	6.00e-154	538.00
IUUC-Ang-009738	Aspergillus niger	46.99	8.00e-153	534.00
IUUC-Aor-010053	Aspergillus oryzae	52.00	4.00e-94	337.00
IUUC-Ate-010529	Aspergillus terreus	47.55	1.00e-154	540.00
IUUC-Ame-010601	Astyanax mexicanus	85.55	0.00e+00	1099.00
IUUC-Bgr-012148	Blumeria graminis	45.69	7.00e-150	524.00
IUUC-Bta-012782	Bos taurus	82.12	0.00e+00	1407.00
IUUC-Bci-013785	Botrytis cinerea	46.14	6.00e-152	531.00
IUUC-Cja-018899	Callithrix jacchus	79.42	0.00e+00	1391.00
IUUC-Cfa-020648	Canis familiaris	81.43	0.00e+00	1378.00
IUUC-Cpo-022073	Cavia porcellus	82.57	0.00e+00	1443.00
IUUC-Csa-023252	Chlorocebus sabaeus	80.41	0.00e+00	1428.00
IUUC-Cho-024695	Choloepus hoffmanni	76.39	0.00e+00	1384.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.51	3.00e-155	542.00
IUUC-Cne-026849	Cryptococcus neoformans	48.47	2.00e-159	555.00
IUUC-Dre-028451	Danio rerio	71.70	0.00e+00	1285.00
IUUC-Dno-029884	Dasypus novemcinctus	80.80	0.00e+00	1438.00
IUUC-Dse-031241	Dothistroma septosporum	47.80	9.00e-156	543.00
IUUC-Eca-033793	Equus caballus	81.56	0.00e+00	1423.00
IUUC-Eeu-034716	Erinaceus europaeus	90.39	0.00e+00	870.00
IUUC-Fca-035605	Felis catus	82.06	0.00e+00	1439.00
IUUC-Fal-037126	Ficedula albicollis	86.35	0.00e+00	1474.00
IUUC-Fox-037774	Fusarium oxysporum	47.03	2.00e-154	539.00
IUUC-Fso-038393	Fusarium solani	46.70	3.00e-153	535.00
IUUC-Gmo-038596	Gadus morhua	79.93	0.00e+00	993.00
IUUC-Ggr-040107	Gaeumannomyces graminis	46.92	1.00e-153	536.00
IUUC-Gga-040832	Gallus gallus	86.12	0.00e+00	1494.00
IUUC-Gac-041520	Gasterosteus aculeatus	87.86	0.00e+00	1100.00
IUUC-Ggo-044535	Gorilla gorilla	79.48	0.00e+00	1399.00
IUUC-Hsa-046564	Homo sapiens	77.15	0.00e+00	1414.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	82.43	0.00e+00	1401.00
IUUC-Kpa-049273	Komagataella pastoris	48.71	2.00e-161	562.00
IUUC-Lch-050454	Latimeria chalumnae	78.43	0.00e+00	1366.00
IUUC-Loc-052647	Lepisosteus oculatus	72.73	0.00e+00	1333.00
IUUC-Laf-054383	Loxodonta africana	83.05	0.00e+00	1445.00
IUUC-Mcc-055532	Macaca mulatta	80.30	0.00e+00	1429.00
IUUC-Mor-057097	Magnaporthe oryzae	37.42	8.00e-155	540.00
IUUC-Mla-058996	Melampsora laricipopulina	51.87	3.00e-147	515.00
IUUC-Mga-059661	Meleagris gallopavo	86.92	0.00e+00	1484.00
IUUC-Mvi-060395	Microbotryum violaceum	51.45	4.00e-148	518.00
IUUC-Mmr-061135	Microcebus murinus	82.69	0.00e+00	1453.00
IUUC-Mdo-062505	Monodelphis domestica	84.61	0.00e+00	1447.00
IUUC-Mmu-063375	Mus musculus	82.46	0.00e+00	1431.00
IUUC-Mpu-066203	Mustela putorius furo	82.01	0.00e+00	1414.00
IUUC-Mlu-067837	Myotis lucifugus	79.86	0.00e+00	1430.00
IUUC-Nfi-068427	Neosartorya fischeri	47.98	5.00e-156	544.00
IUUC-Ncr-068918	Neurospora crassa	47.75	2.00e-152	532.00
IUUC-Nle-069244	Nomascus leucogenys	82.05	0.00e+00	1413.00
IUUC-Opr-070585	Ochotona princeps	78.24	0.00e+00	1391.00
IUUC-Ont-071798	Oreochromis niloticus	85.55	0.00e+00	1127.00
IUUC-Ocu-074298	Oryctolagus cuniculus	82.73	0.00e+00	1434.00
IUUC-Ola-086526	Oryzias latipes	85.69	0.00e+00	1103.00
IUUC-Oga-088167	Otolemur garnettii	75.43	0.00e+00	1310.00
IUUC-Oar-090316	Ovis aries	67.71	0.00e+00	1050.00
IUUC-Ptr-090819	Pan troglodytes	76.47	0.00e+00	1375.00
IUUC-Pan-092454	Papio anubis	80.16	0.00e+00	1433.00
IUUC-Psi-093319	Pelodiscus sinensis	85.76	0.00e+00	1469.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.50	1.00e-151	530.00
IUUC-Pfo-097346	Poecilia formosa	82.92	0.00e+00	1092.00
IUUC-Pab-097580	Pongo abelii	72.47	0.00e+00	1259.00
IUUC-Pca-100923	Procavia capensis	67.65	0.00e+00	1174.00
IUUC-Pva-103209	Pteropus vampyrus	80.16	0.00e+00	1363.00
IUUC-Pgr-103620	Puccinia graminis	51.45	1.00e-145	509.00
IUUC-Ptt-103806	Puccinia triticina	50.61	8.00e-118	417.00
IUUC-Pte-104016	Pyrenophora teres	46.75	2.00e-152	532.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	46.75	2.00e-152	532.00
IUUC-Rno-104924	Rattus norvegicus	81.78	0.00e+00	1435.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.63	1.00e-161	563.00
IUUC-Sha-107175	Sarcophilus harrisii	84.49	0.00e+00	1461.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.64	5.00e-152	531.00
IUUC-Sar-113761	Sorex araneus	95.81	0.00e+00	1174.00
IUUC-Tgu-116632	Taeniopygia guttata	78.96	0.00e+00	1322.00
IUUC-Tru-118442	Takifugu rubripes	88.37	0.00e+00	1111.00
IUUC-Tsy-119198	Tarsius syrichta	75.14	0.00e+00	1305.00
IUUC-Tni-120168	Tetraodon nigroviridis	71.82	0.00e+00	1222.00
IUUC-Tre-122203	Trichoderma reesei	46.36	2.00e-150	526.00
IUUC-Tvi-122595	Trichoderma virens	45.88	2.00e-150	526.00
IUUC-Tbe-127756	Tupaia belangeri	65.26	0.00e+00	1096.00
IUUC-Ttr-128504	Tursiops truncatus	73.49	0.00e+00	984.00
IUUC-Vda-129753	Verticillium dahliae	47.10	2.00e-154	539.00
IUUC-Vpa-130103	Vicugna pacos	68.91	0.00e+00	1189.00
IUUC-Xtr-132885	Xenopus tropicalis	73.70	0.00e+00	1372.00
IUUC-Xma-133796	Xiphophorus maculatus	71.80	0.00e+00	1290.00
IUUC-Yli-134668	Yarrowia lipolytica	46.33	6.00e-156	544.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence