iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.30e-07	31.9	11	74
E3 activity/RING/RING	1.70e-09	39.1	16	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk.tcPvtrqplteedlvPnltlrrli 65
            ee  CpI +e+ +dPv++ +G+ +  ++I +  ++++k +cP+++ ++ ++++ Pn+ l +l 
   Q: 11   QEEVTCPICMEILQDPVTIDCGHNFCLQCISQVGKTSEKiQCPLCKLSVNKNTFRPNKLLASLA 74
           58899*************************9987777778******************997765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e ++d p++ +CgH f+++C+ ++     ++s +++CPlC+
   Q: 16   CPICMEILQD-PVTIDCGHNFCLQCISQV----GKTSEKIQCPLCK 56
           **********.999***************....779*********7 PP

Organism

Mus musculus

Functional Description
(View)

May have E3 ubiquitin-protein ligase activity (By similarity). Regulator of Src-induced anchorage independent cell growth.

Protein Sequence
(Fasta)

MAGQPLACQL QEEVTCPICM EILQDPVTID CGHNFCLQCI SQVGKTSEKI QCPLCKLSVN 60
KNTFRPNKLL ASLAEKIQSM DPADIQAEKE DSRCQRHKEK LHYFCEQDGA FLCVVCRDSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTTGAGA GACAGGGAGA GAGGACTGAC CATCTGTTTT CTTCTCTTTA GAATATTCCC 60
CATTTATCGC TGACTCTTTT CTGTCATTAT TTATTTAACC CCCCCTTCCC TCATTCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005739--C:mitochondrion
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0016567--P:protein ubiquitination
GO:1902186--P:regulation of viral release from host cell

KEGG

mmu:224762

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013042	Bos taurus	53.63	1.00e-152	533.00
IUUC-Cre-022597	Chlamydomonas reinhardtii	29.33	4.00e-09	55.80
IUUC-Cho-024490	Choloepus hoffmanni	42.73	3.00e-62	232.00
IUUC-Dno-029706	Dasypus novemcinctus	52.81	3.00e-91	329.00
IUUC-Dor-031004	Dipodomys ordii	54.52	3.00e-93	335.00
IUUC-Ggo-045224	Gorilla gorilla	54.74	4.00e-92	332.00
IUUC-Hsa-046979	Homo sapiens	54.43	8.00e-92	330.00
IUUC-Itr-049020	Ictidomys tridecemlineatus	50.20	8.00e-146	510.00
IUUC-Kpa-049137	Komagataella pastoris	30.00	4.00e-09	55.80
IUUC-Laf-053632	Loxodonta africana	52.76	1.00e-128	453.00
IUUC-Mla-059039	Melampsora laricipopulina	36.14	5.00e-09	55.80
IUUC-Nle-069068	Nomascus leucogenys	54.13	9.00e-91	327.00
IUUC-Opr-070792	Ochotona princeps	44.20	1.00e-63	236.00
IUUC-Ocu-074338	Oryctolagus cuniculus	52.60	4.00e-87	314.00
IUUC-Oar-089628	Ovis aries	53.24	2.00e-141	496.00
IUUC-Ptr-090661	Pan troglodytes	54.43	2.00e-92	332.00
IUUC-Pan-091882	Papio anubis	47.52	7.00e-109	387.00
IUUC-Pab-098566	Pongo abelii	53.82	1.00e-96	346.00
IUUC-Rno-104874	Rattus norvegicus	82.25	0.00e+00	823.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence